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About Me • Matt Danzi • Third year Ph.D. candidate • B.S. from UNC Chapel Hill in Biology with minors in Computer Science and Chemistry • Research Mentors – Vance Lemmon and John Bixby • Departments: Miami Project to Cure Paralysis and Department of Neurological Surgery • Research interest: axon regeneration • Computational Mentor – Stefan Wuchty • Department of Computer Science • Research interest: biological network modelling and prediction Identifying the Regulators in RNA-Seq Data Log2(Fold Change) of Gene Expression 46,078 Genes 4 2 0 -2 -4 Yellow = gene regulated by transcription factor Blue = gene not regulated by transcription factor 95 Transcription Factors What I hope to accomplish by April • Written and debugged the two planned approaches • Applied these two approaches to four data sets • Ideally, see a large degree of similarity between the results from each of the four data sets
