Download biological sciences 354

BIOLOGICAL SCIENCES 565
Eukaryotic Gene Regulation
Spring 2011
Lapham 252, TR 9:30-10:45
Instructor: Dr. Ava J. Udvadia
Office hours: TR 11-12:30, Lapham SB80
Email: [email protected]
Phone (emergencies only): 414-382-1750 (office at WATER), 414-382-1761 (lab at WATER)
Prerequisites: Students must have Graduate Standing or passed BioSci 325 (P) or BioSci 315
(P) with C or better
Course Content: The goal of this course is to provide students with a comprehensive
understanding of transcriptional and post-transcriptional regulation of eukaryotic genes. This
goal will be achieved using a combination of lecture, textbook readings, recent reviews, and
readings from the current literature. The course will cover the evidence for regulation at the
level of transcription as the primary form of gene regulation in eukaryotes, mechanisms of posttranscriptional regulation, the role of micro RNAs in gene regulation, as well as the roles of
chromatin remodeling, DNA sequence regulatory elements, and transcription factors in
mediating transcriptional regulation. Finally, the course will explore how differential gene
regulation is involved in the processes of evolution, development, and disease.
Required Text:
 Gene Control, by David Latchman; Taylor and Francis 2010 (ISBN: 978-0-8153-65136) - Absolutely required reading!
Optional Texts:
 Molecular Biology 4th ed, by Robert F. Weaver; McGraw Hill 2007 (ISBN: 0073319945)
 Transcriptional Regulation by Neuronal Activity, ed by Serena M. Dudek; Springer 2008
(ISBN: 978-387-73608-2)
Detailed Syllabus will be posted on D2L site prior to the first day of classes