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Transcript
Heat Sh o ck Pro tein s BPS Bioscience offers a wide range of high purity HSPs for drug discovery research. Heat Shock Proteins Protein Catalog # Amount Heat shock or stress proteins (HSPs) HSP40 50285 100 µg are functionally related proteins found HSP70 50287 200 µg in unstressed cells. These molecular HSP70 (Q435A) 50288 100 µg chaperones play a key role in the HSP90α 50290 200 µg folding, unfolding and translocation of HSP90β 50292 200 µg other proteins. Expression levels of HSP90α (C-terminal), Biotinlabeled 50316 100 µg HSP90β (C-terminal), Biotinlabeled 50313 100 µg HSPs increase when cells are exposed to heat or other stressors such as pH shift or hypoxia. HSPs are ideal for the study and effectiveness of cancer vaccines, the discovery of anticancer Hop/STIP1 therapeutics, and the development of infectious disease treatments. BPS offers several HSP proteins, assay kits and SNX-2112 inhibitors as well as HSP90 screening services. 50322 100 µg 27653-1 5 µg 27653-2 10 µg 27653-3 50 µg HSP Assay Ki ts The HSP Assay kits are designed for screening for various HSP inhibitors. The kits include all of the reagents necessary to measure HSP inhibition in a convenient 96-well or 384-well %Activity format. 110 100 90 80 70 60 50 40 30 20 10 0 -10 IC50= 0.02 µM Purity and gel image of HSP90α (Cat. #50290). HSP I n hi bi to r s -3 -2 -1 0 1 Geldanamycin Log [µ µM] Determination of the IC50 of FITC-labeled Geldanamycin (Cat. #50312) on HSP90α (Cat. #50290), measured with the HSP90α Assay Kit (Cat. #50293/50298). Assay Kit 5x HSP90 Assay Buffer Catalog # Amount 50311 20 ml Inhibitor Catalog # Amount 17-AAG 27026 5 mg BIIB02 27046 5 mg Geldanamycin 27008 5 mg Geldanamycin, FITClabeled 50312 30 µl MS-275 (Entinostat, 27011 25 mg 27501 250 µl 50293 96 rxns Novobiocin 50298 384 rxns Novo-TRX 27500 20 µl 50317 384 rxns NVP-AUY922, HSP90 Inhibitor 27025 10 mg 50294 96 rxns 50299 384 rxns HSP90β (C-terminal) Inhibitor Screening Assay Kit 50314 384 rxns HSP90α (C-terminal) TRFRET Kit 50261 384 rxns HSP90β (C-terminal) TRFRET Kit 50262 384 rxns HSP90α (N-terminal) Inhibitor Screening Assay Kit HSP90α (C-terminal) Inhibitor Screening Assay Kit HSP90β (N-terminal) Inhibitor Screening Assay Kit TThhee ##11 SSoouurrccee ffoorr A Accttiivvee EEnnzzyym meess 6044 Cornerstone Court West, Suite E San Diego, CA 92121 858.829.3082 ph 858.481.8694 fax www.bpsbioscience.com Rev. Jan 2015 TThhee ##11 SSoouurrccee ffoorr A Accttiivvee EEnnzzyym meess
