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Pharmaceutical Particles Taylor Cone When a sufficiently high voltage is applied to a liquid droplet, the body of the liquid becomes charged, and electrostatic repulsion counteracts the surface tension and the droplet is stretched; at a critical point a stream of liquid erupts from the surface. This point of eruption is known as the Taylor cone. Taylor cone Je t Fiber s Electro-hydrodynamic Atomization Process (Hydrospraying) Using electric field to break liquid drops into fine droplets Vn Vr Filter Particles Vn Vr Vacuum pump : the trace of protective Nitrogen; https://www.youtube.com/watch?v=ImLdSIGd : solvent with polymer & drugs; kGM : volatilized solvent; : collected polymer & drug particles; : high voltage used to break liquid drops; : high voltage applied to metal hoop; Electrospinning https://www.youtube.com/watch?v=87uRQ7K https://www.youtube.com/watch?v=JECE_6iK4 wbB0 i0 Supercritical AntiSolvent setup V1 P1 C2 F2 V3 PI CO2 V2 C1 P2 https://www.youtube.com/watch?v=fKpP0vw W68Q TC F1 https://www.youtube.com/watch?v=Rh2NiuFl pYg V1 P1 C2 U1 PI CO2 V2 C1 P2 TC F1 F2 V3 Conclusion • Different methods of producing drugs (particles) • How particle sizes are controlled in each production method • Gam-Sia-Hamida