Download Slide ()

Neural crest cells differentiate into sympathetic and sensory neurons. The neuronal fates of trunk neural crest cells are controlled by transcription factor
expression. Expression of the bHLH protein Mash1 directs neural crest cells along a sympathetic neuronal pathway. Sympathetic neurons can acquire
noradrenergic or cholinergic transmitter phenotypes depending on the target cells they innervate and the level of gp130 cytokine signaling (see Figure 53–
11). Two bHLH proteins, neurogenin-1 and -2, direct neural crest cells along a sensory neuronal pathway. Sensory neurons that express the transcription
factor Runx1 and the tyrosine kinase receptor TrkA become nociceptors, whereas those that express Runx3 and TrkC become proprioceptors.
Source: Differentiation and Survival of Nerve Cells, Principles of Neural Science, Fifth Editon
Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available
at: http://mhmedical.com/ Accessed: April 28, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved