Download Exam III Sample Questions

Exam III Sample Questions - For Monday’s Review
True/ False
1. M-CDK activity is required for the metaphase to anaphase transition to occur during Mitosis
2. Duplication of DNA and Centrioles occurs during S phase.
3. Activation of initiator caspases can only occur as a result of cytochrome C release from the
mitochondria inner membrane space.
4. Assembly of newly synthesized collagen fibrils occurs inside the Golgi prior to secretion
5. The Basal Lamina is a specialized form of connective tissue underlying an epithelium.
6. Neural Crest Cells Escape from neural epithelium by downregulating N-cadherin expression
7. The assembly of cohesions and condensins onto sister chromatids is dependent upon M-CDK
activity
8. Nucleotide hydrolysis plays a similar role in actin polymerization and tubulin polymerization
9. ATP hydrolysis of actin monomers drives skeletal muscle contraction.
10. The Heads of Kinesin and Myosin II motors can associate with their respective filaments
independent of nucleotide.
11. Microtubules in the cell form a structural framework for all of the following except:
A) Holding internal organelles such as ER in place
B) Moving materials from one place to another in the cell
C) Strengthening the Plasma Membrane
D) Movement of Sister Chromatids during M-phase
E) None of the Above
12. A particular cell has half as much DNA as some of the other cells in a Mitotically
Active Tissue. The cell in question is most likely in:
A) G1
B) G2
C) Prophase
D) Metaphase
E) Anaphase
13. The Drug cytocholasin B blocks the function of Actin. Which of the following
aspects of the cell cycle would be most disrupted by cytocholasin B
A) Spindle Formation
B) Spindle Attachment to kinetochores
C) DNA synthesis
D) Cell elongation during anaphase
E) Cleavage Furrow Formation
14. Which of the following cell cycle defects would cause cells to arrest in early G1?
A) A mutation in a cell surface mitogen receptor that made it active even in the
absence of its mitogen ligand
B) A mutation that destroyed the kinase activity of S-CDK complex
C) A mutation that removed the phosphorylation sites of Rb protein.
D) A mutation that prevents RAS from hydrolyzing GTP.
E) None of the Above
15. Which of the following can be associated with an adherens junctions, but not
desmosomes and hemidesmosomes?
A) Cadherins
B) Integrins
C) Myosin
D) Intermediate filaments
E) Microtubules
16. Proteoglycans in the extracellular matrix of animal tissues:
A) Provide Tensile Strength
B) Are linked to microtubules through the plasma membrane
C) Are polysaccharides composed of glucose subunits
D) Provide resistance to compression
E) None of the Above
17. Any blastomere removed from an 8 cell mammalian embryo can develop into a
normal late stage embryo. This finding supports the idea that:
A) Only the fertilized egg is totipotent
B) Mammalian cleavage is rotational
C) Cell divisions producing the earliest blastomeres do not result in asymmetrical
distribution of cytoplasmic determinants
D) Zygotic Transcription in the mammal begins prior to the 8 cell stage.
E) None of the Above
18. An Oncogene:
A) Can be activated as a result of a single point mutation in a proto-oncogene.
B) Can be activated by overexpression of a proto-oncogene
C) Can encode proteins that are not directly involved in regulating cell-cycle
progression D) A and B
E) A, B and C
19. Which of these characteristics of cancer cells grown in vitro would likely most
directly arise from an alteration in Cell-ECM interactions?
A) Reduced Requirement for Growth Factors
B) Loss of Anchorage Dependence
C) Immortilization
D) Contact Inhibition
E) None of the Above