Download Spørsmål kapittel 24:

Spørsmål kapittel 24:
1.
Why are transforming retroviruses advantageous for studying oncogenes?
2.
What are the differences and similarities between the transforming genes of retroviruses and those
of DNA tumor viruses?
3.
Describe a gain-of-function mutation.
4.
Describe a loss-of-function mutation.
5.
Mutation of p53 is described as a dominant-negative mutation. Describe the mechanism by which
this mutation causes the dominant-negative phenotype.
6.
What is the common factor in the mechanisms by which mutated growth-factor receptors and
signal-transduction proteins cause cancer?
7.
Would alteration in structure or expression of proteins other than Rb, p16, and cyclin D1 lead to
loss of the restriction point?
8
The activity of telomerase may be critical to the development of human cancers. Why is
telomerase likely to be less critical in the development of rodent cancers?
9
What activities of p53 are critical to its activities regulating the G 1 checkpoint?