Access Presentation
... proteins in the tetramer. Cells heterozygous for p53 can still make perfectly functional homotetramers, but only 1/16 of the possible combinations is healthy. In human tumor cells mutant at p53 locus, p53 locus found to have undergone loss of heterozygosity (LOH), in which wild type allele is discar ...
... proteins in the tetramer. Cells heterozygous for p53 can still make perfectly functional homotetramers, but only 1/16 of the possible combinations is healthy. In human tumor cells mutant at p53 locus, p53 locus found to have undergone loss of heterozygosity (LOH), in which wild type allele is discar ...
Biology II Final Exam Practice
... ____ 26. The following sequence could be a tRNA anticodon: GTG. _________________________ ____ 27. A mutation is a random change in genetic material. _________________________ ____ 28. Humans born with either below-normal or above-normal birth weights have a lower chance of survival than those born ...
... ____ 26. The following sequence could be a tRNA anticodon: GTG. _________________________ ____ 27. A mutation is a random change in genetic material. _________________________ ____ 28. Humans born with either below-normal or above-normal birth weights have a lower chance of survival than those born ...
Full Text - The International Journal of Developmental Biology
... sequentially coordinated to give rise to a functional seed in a matter of few weeks. Any of these processes is so intricately complex and precisely regulated that it becomes no wonder that each involves more specific genes and cellular processes than any other function in the plant life cycle. While ...
... sequentially coordinated to give rise to a functional seed in a matter of few weeks. Any of these processes is so intricately complex and precisely regulated that it becomes no wonder that each involves more specific genes and cellular processes than any other function in the plant life cycle. While ...
- Wiley Online Library
... The cohesin complex The discovery that the ubiquitin protein ligase called the Anaphase Promoting Complex or Cyclosome (APC/C) responsible for destroying mitotic cyclins at the metaphase-toanaphase transition is also required for sister chromatid separation provided an impetus to the search for cohe ...
... The cohesin complex The discovery that the ubiquitin protein ligase called the Anaphase Promoting Complex or Cyclosome (APC/C) responsible for destroying mitotic cyclins at the metaphase-toanaphase transition is also required for sister chromatid separation provided an impetus to the search for cohe ...
Origin and Distribution of Calvin Cycle Fructose and
... fast-evolving additional plastid homologs (pla2) of plants and diatoms (supplementary Fig. S1a and 1b). The remaining FBP sequences (pla1) comprise a highly supported subtree of green plants (chlorophytes and streptophytes; 100/100% BP) branching as a sister group to a clade composed of rhodophytes ...
... fast-evolving additional plastid homologs (pla2) of plants and diatoms (supplementary Fig. S1a and 1b). The remaining FBP sequences (pla1) comprise a highly supported subtree of green plants (chlorophytes and streptophytes; 100/100% BP) branching as a sister group to a clade composed of rhodophytes ...
Presence of multiple group I introns closely 23S rRNAs of lichen-forming
... and archaea [37]. One reason for the wide distribution of these proteins appears to be their ability to invade unrelated types of intervening sequences, including group I introns. Although LAGLIDADG proteins display almost no similarity in terms of primary sequence, they share a conserved three-dime ...
... and archaea [37]. One reason for the wide distribution of these proteins appears to be their ability to invade unrelated types of intervening sequences, including group I introns. Although LAGLIDADG proteins display almost no similarity in terms of primary sequence, they share a conserved three-dime ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... 1518 nucleotides. Numerous splice variants (24 according to Ensembl). A small isoform of ATF2, ATF2-small (ATF2-sm), with a calculated mass of 15 kDa, has no histone acetyltransferase (HAT) activity, but, still, has the ability to bind CRE-containing DNA. ...
... 1518 nucleotides. Numerous splice variants (24 according to Ensembl). A small isoform of ATF2, ATF2-small (ATF2-sm), with a calculated mass of 15 kDa, has no histone acetyltransferase (HAT) activity, but, still, has the ability to bind CRE-containing DNA. ...
Quantitative expression of cholera toxin mRNA in Vibrio cholerae
... showed that the level of CT in the classical strain was higher than that in the El Tor strain because of the influence of toxR on CT production in the classical strain. Both classical and El Tor strains have been shown to express equivalent levels of ToxR. In contrast, the classical strain expresses ...
... showed that the level of CT in the classical strain was higher than that in the El Tor strain because of the influence of toxR on CT production in the classical strain. Both classical and El Tor strains have been shown to express equivalent levels of ToxR. In contrast, the classical strain expresses ...
Insulin-like growth factor (IGF) signalling is required for early dorso
... To further characterise the phenotype of DN-IGF-1R expressing embryos, we examined the expression of a number of genes that are critical for normal neural development and for notochord and somite formation. We initially examined expression of Pax6.2, Six3.1, Rx3 and Otx2 in 10 hpf embryos. At 10 hpf ...
... To further characterise the phenotype of DN-IGF-1R expressing embryos, we examined the expression of a number of genes that are critical for normal neural development and for notochord and somite formation. We initially examined expression of Pax6.2, Six3.1, Rx3 and Otx2 in 10 hpf embryos. At 10 hpf ...
Defining characteristics of Tn5 Transposase non
... While non-specific DNA plays a role in target localization for many recombinases, transcription factors and restriction enzymes, the importance of nonspecific DNA interactions for transposases has not been investigated. Here, we discuss non-specific DNA-Tn5 Transposase (Tnp) interactions and suggest ...
... While non-specific DNA plays a role in target localization for many recombinases, transcription factors and restriction enzymes, the importance of nonspecific DNA interactions for transposases has not been investigated. Here, we discuss non-specific DNA-Tn5 Transposase (Tnp) interactions and suggest ...
Gene Section EVI1 (ecotropic viral integration site 1 (EVI1) and
... absent limb buds, a pale yolk sac and placenta, abnormal development of the nervous system and the heart, and massive haemorrhaging. EVI1 is thought to exert its biological functions mainly by acting as a transcription factor. In addition, however, EVI1 has been reported to inhibit c-jun Nterminal k ...
... absent limb buds, a pale yolk sac and placenta, abnormal development of the nervous system and the heart, and massive haemorrhaging. EVI1 is thought to exert its biological functions mainly by acting as a transcription factor. In addition, however, EVI1 has been reported to inhibit c-jun Nterminal k ...
Disruption and aberrant expression of HMGA2 as a
... domain. In addition to direct truncation by gene fusion, several chromosomal translocations involving HMGA2 have been shown to result in the expression of aberrantly spliced transcripts that may also encode truncated forms of HMGA2. These mRNAs are structurally similar to those formed by gene fusion ...
... domain. In addition to direct truncation by gene fusion, several chromosomal translocations involving HMGA2 have been shown to result in the expression of aberrantly spliced transcripts that may also encode truncated forms of HMGA2. These mRNAs are structurally similar to those formed by gene fusion ...
Replication timing and transcriptional control: beyond
... 137 ribosomal protein genes (accounting for about 50% of RNA polymerase II expression), small nucleolar RNA and tRNA genes [38••]. At first glance, this result may appear to reveal a fundamental difference between yeast and higher eukaryotes. However, the number of mammalian genes analysed for repli ...
... 137 ribosomal protein genes (accounting for about 50% of RNA polymerase II expression), small nucleolar RNA and tRNA genes [38••]. At first glance, this result may appear to reveal a fundamental difference between yeast and higher eukaryotes. However, the number of mammalian genes analysed for repli ...
FinalPresentation_ccb2012_marc_shangying_yan
... => Laptinib is able to stimulate FOXO, crucial to apoptosis 09/13 ...
... => Laptinib is able to stimulate FOXO, crucial to apoptosis 09/13 ...
Press release
... The oKtopure from LGC was developed to speed up breeding programs and many other molecular biological analyses. The robot allows 8 x 96 Deepwell plates to be purified in parallel, enabling up to 5,000 samples to be extracted in the course of a normal eight-hour working day. The precise throughput de ...
... The oKtopure from LGC was developed to speed up breeding programs and many other molecular biological analyses. The robot allows 8 x 96 Deepwell plates to be purified in parallel, enabling up to 5,000 samples to be extracted in the course of a normal eight-hour working day. The precise throughput de ...
Cooperative Effects of Bacterial Mutations Affecting A N Gene
... RifR mutants derived from the nusA-1 strain do not permit A growth at 32”. In order to test if this added effect might be due to an increase in. inhibition of N expression, we determined whether the RifR nusA-1 mutants permitted the growth of the partially N-independent phage Abyp. This phage has be ...
... RifR mutants derived from the nusA-1 strain do not permit A growth at 32”. In order to test if this added effect might be due to an increase in. inhibition of N expression, we determined whether the RifR nusA-1 mutants permitted the growth of the partially N-independent phage Abyp. This phage has be ...
Summary of Some Ideas - NYU Computer Science Department
... by a transcriptional activator/factor, which attaches to a promoter (a specific sequence adjacent to the gene). • Regulatory sequences such as silencers and enhancers control the rate of transcription ...
... by a transcriptional activator/factor, which attaches to a promoter (a specific sequence adjacent to the gene). • Regulatory sequences such as silencers and enhancers control the rate of transcription ...
Classification of Centers for Disease Control Group Eugonic
... organisms found in the oral cavity of dogs and cats, although systemic infections in humans and animals have also been reported (Ganière et al., 1995). Two biotypes can be distinguished based on the presence (EF-4a) or absence (EF-4b) of arginine dihydrolase activity (Holmes & Ahmed, 1981). In addi ...
... organisms found in the oral cavity of dogs and cats, although systemic infections in humans and animals have also been reported (Ganière et al., 1995). Two biotypes can be distinguished based on the presence (EF-4a) or absence (EF-4b) of arginine dihydrolase activity (Holmes & Ahmed, 1981). In addi ...
What is Sequence Alignment?
... DNA or protein sequences • Not good for: generating alignment of closely related sequences Global and local alignments are fundamentally similar and differ only in optimization strategy used in aligning similar residues BCB 444/544 F07 ISU ...
... DNA or protein sequences • Not good for: generating alignment of closely related sequences Global and local alignments are fundamentally similar and differ only in optimization strategy used in aligning similar residues BCB 444/544 F07 ISU ...
The Mitochondrial Genome of Chara vulgaris
... Analysis of codon usage in conserved genes and unique ORFs indicates that Chara mtDNA is more like Marchantia mtDNA than Chaetosphaeridium mtDNA. The high similarity of codon usage observed for these mtDNAs also is seen at the level of stop codons. Five of the 11 Chara mitochondrial genes ending wit ...
... Analysis of codon usage in conserved genes and unique ORFs indicates that Chara mtDNA is more like Marchantia mtDNA than Chaetosphaeridium mtDNA. The high similarity of codon usage observed for these mtDNAs also is seen at the level of stop codons. Five of the 11 Chara mitochondrial genes ending wit ...
DNA Evolution 3.0 Administrator Guide
... Manager is the module responsible for interfacing with the LTO tape hardware and negotiating access to it for the different client software components. It can archive and restore data over direct connect sources on the machine it is installed on, or it can run in a networked mode, (e.g., on the Linu ...
... Manager is the module responsible for interfacing with the LTO tape hardware and negotiating access to it for the different client software components. It can archive and restore data over direct connect sources on the machine it is installed on, or it can run in a networked mode, (e.g., on the Linu ...
Separation of DNA Restriction Fragments by Ion
... (D) The fact that the two ion-exchange materials are made from the same basic support yet have differences should make possible comparisons between the relative importance ofthe basic support versus the charged substituents: Mono Q is a strong ion exchanger with a high density of quaternary amino gr ...
... (D) The fact that the two ion-exchange materials are made from the same basic support yet have differences should make possible comparisons between the relative importance ofthe basic support versus the charged substituents: Mono Q is a strong ion exchanger with a high density of quaternary amino gr ...
Primary transcript
A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. The primary transcripts designated to be mRNAs are modified in preparation for translation. For example, a precursor messenger RNA (pre-mRNA) is a type of primary transcript that becomes a messenger RNA (mRNA) after processing.There are several steps contributing to the production of primary transcripts. All these steps involve a series of interactions to initiate and complete the transcription of DNA in the nucleus of eukaryotes. Certain factors play key roles in the activation and inhibition of transcription, where they regulate primary transcript production. Transcription produces primary transcripts that are further modified by several processes. These processes include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found in cells. The modifications of primary transcripts have been further studied in research seeking greater knowledge of the role and significance of these transcripts. Experimental studies based on molecular changes to primary transcripts the processes before and after transcription have led to greater understanding of diseases involving primary transcripts.