Print - Circulation
... extrusion. The importance of the Na+-Ca`+ exchanger in regulating the resting level of calcium within cardiac myocytes was demonstrated most directly by the experiments of Sheu and Fozzard,9 who measured intracellular sodium and calcium activities in cardiac Purkinje cells with ion-sensitive microel ...
... extrusion. The importance of the Na+-Ca`+ exchanger in regulating the resting level of calcium within cardiac myocytes was demonstrated most directly by the experiments of Sheu and Fozzard,9 who measured intracellular sodium and calcium activities in cardiac Purkinje cells with ion-sensitive microel ...
Liposomes in drug delivery
... (0.025 /~m) to large (2.5 /~m) vesicles. Furthermore, liposomes may have single or multiple bilayer membranes (Fig. 1). The vesicle size is a critical parameter in determining circulation halflife of liposomes, and both size and number of bilayers influence the extent of drug encapsulation in the li ...
... (0.025 /~m) to large (2.5 /~m) vesicles. Furthermore, liposomes may have single or multiple bilayer membranes (Fig. 1). The vesicle size is a critical parameter in determining circulation halflife of liposomes, and both size and number of bilayers influence the extent of drug encapsulation in the li ...
Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors
... and in vivo studies. Most of these compounds are derived from human medicine and are used in the treatment of HIV-infected patients (HARTMANN, 2012). Experimental studies with antiviral compounds are generally conducted in three stages. In vitro experiments are usually performed first and assess the ...
... and in vivo studies. Most of these compounds are derived from human medicine and are used in the treatment of HIV-infected patients (HARTMANN, 2012). Experimental studies with antiviral compounds are generally conducted in three stages. In vitro experiments are usually performed first and assess the ...
G6PD deficiency: a classic example of pharmacogenetics with
... but some of the soldiers receiving the drug became jaundiced and anaemic. This was relatively more common among African Americans, and this complication, toxic effect or side effect, was called the primaquine sensitivity syndrome (Dern et al, 1955). A.S. Alving’s group (Chicago) performed experiment ...
... but some of the soldiers receiving the drug became jaundiced and anaemic. This was relatively more common among African Americans, and this complication, toxic effect or side effect, was called the primaquine sensitivity syndrome (Dern et al, 1955). A.S. Alving’s group (Chicago) performed experiment ...
[27] Kumar, RMNV- Eds. Handbook of Particulate Drug Delivery,2008
... primary structure of the protein was deduced from th sequences of cDNAs that were derived from the most abundant mRNAs found during cocoon spinning [9-10]. Silk fibroin is through to be a block copolypeptide consisting of crystalline and amorphous domain.[11] The secondary structure of crystaline do ...
... primary structure of the protein was deduced from th sequences of cDNAs that were derived from the most abundant mRNAs found during cocoon spinning [9-10]. Silk fibroin is through to be a block copolypeptide consisting of crystalline and amorphous domain.[11] The secondary structure of crystaline do ...
Conditional expression of Mycobacterium smegmatis
... phospholipids on these interactions have been investigated (Yamamoto et al., 2002). At the deduced amino acid sequence level, mycobacterial DnaA proteins are approximately 82 % similar, with differences noted in the amino acids located between residues 100 and 160. The conserved regions are believed ...
... phospholipids on these interactions have been investigated (Yamamoto et al., 2002). At the deduced amino acid sequence level, mycobacterial DnaA proteins are approximately 82 % similar, with differences noted in the amino acids located between residues 100 and 160. The conserved regions are believed ...
Spatiotemporal Patterns of Expression of NGF and the Low
... ends of the limb persisted throughout limb development, with some of the highest levels of expression occurring at the limb axillary sites, which were not highly innervated. We have also found ~75”” expression at sites of mesenchymal/epithelial interactions in several developing organs that do not a ...
... ends of the limb persisted throughout limb development, with some of the highest levels of expression occurring at the limb axillary sites, which were not highly innervated. We have also found ~75”” expression at sites of mesenchymal/epithelial interactions in several developing organs that do not a ...
Development of nanovectors for the targeted drug delivery of antimalarials Patricia Urbán
... of age1. Early diagnosis and treatment of malaria reduce disease, incidence and transmission of the parasite, thus contributing to the reduction of death toll. Access to diagnostic testing and treatment should be seen not only as a component of malaria control but as a fundamental right for all popu ...
... of age1. Early diagnosis and treatment of malaria reduce disease, incidence and transmission of the parasite, thus contributing to the reduction of death toll. Access to diagnostic testing and treatment should be seen not only as a component of malaria control but as a fundamental right for all popu ...
"VESICLE IN A BASKET" A Morphological Study of
... function as the binding sites of the food from outside . The glycocalyx (3) is supposed to have such functional aspects, and many studies have speculated on the structure and function of the surface coat (4-6) in accord with this supposition . Roth and Porter (7) also suggested that it is more frui ...
... function as the binding sites of the food from outside . The glycocalyx (3) is supposed to have such functional aspects, and many studies have speculated on the structure and function of the surface coat (4-6) in accord with this supposition . Roth and Porter (7) also suggested that it is more frui ...
Interaction of PIN and PGP transport mechanisms in auxin
... parts of the plant and are almost universally required for all aspects of auxin-related plant development, including embryogenesis (Friml et al., 2003), organogenesis (Benková et al., 2003; Reinhardt et al., 2003), root meristem patterning and activity (Friml et al., 2002a; Blilou et al., 2005), tis ...
... parts of the plant and are almost universally required for all aspects of auxin-related plant development, including embryogenesis (Friml et al., 2003), organogenesis (Benková et al., 2003; Reinhardt et al., 2003), root meristem patterning and activity (Friml et al., 2002a; Blilou et al., 2005), tis ...
The mitochondrial compartment - Plant Mitochondrial dynamics
... of the Arabidopsis dynamin-like gene family (Hong et al., 2003), the closest being DRP3B, At2g14120; Rbd1p/ Pcp1p=At1g18600. At the time of writing, only DRP3B has been shown to be required for normal mitochondrial morphology (Arimura and Tsutsumi, 2002), but no information is available on the inter ...
... of the Arabidopsis dynamin-like gene family (Hong et al., 2003), the closest being DRP3B, At2g14120; Rbd1p/ Pcp1p=At1g18600. At the time of writing, only DRP3B has been shown to be required for normal mitochondrial morphology (Arimura and Tsutsumi, 2002), but no information is available on the inter ...
–plasma-membrane junctions by Kv2.1 Induction of stable ER potassium channels
... high level of expression – as expected of a structural or scaffolding protein. Indeed, there is a growing list of ion channels that possess functions unrelated to ion conduction (Kaczmarek, 2006). Consistent with this idea, we have recently discovered that in both HEK 293 cells and hippocampal neuro ...
... high level of expression – as expected of a structural or scaffolding protein. Indeed, there is a growing list of ion channels that possess functions unrelated to ion conduction (Kaczmarek, 2006). Consistent with this idea, we have recently discovered that in both HEK 293 cells and hippocampal neuro ...
Exploring morphology and drug interactions in pancreatic cancer
... adenocarcinomas are characterised as having a highly dense and poorly vascularised stroma that is made up of extracellular matrix (ECM) components and host cells. This complex tumour microenvironment has been implicated in the chemoresistance profiles observed in pancreatic tumours. An ECM-based thr ...
... adenocarcinomas are characterised as having a highly dense and poorly vascularised stroma that is made up of extracellular matrix (ECM) components and host cells. This complex tumour microenvironment has been implicated in the chemoresistance profiles observed in pancreatic tumours. An ECM-based thr ...
Spatial Frequency Analysis in the Visual System
... The value of spatial frequencyanalysis can be seen in dealing with the problem of howto describe the receptive field of a retinal ganglion cell. Weuse this as an example, and then go on to discuss other major insights that have been provided by this approach. It is often useful to knowthe distributi ...
... The value of spatial frequencyanalysis can be seen in dealing with the problem of howto describe the receptive field of a retinal ganglion cell. Weuse this as an example, and then go on to discuss other major insights that have been provided by this approach. It is often useful to knowthe distributi ...
The Differential Degradation of Two Cytosolic Proteins As a Tool to
... (1990), who followed sequential steps in autophagy after inducing artificial protein complexes in the ER. However, their observations were restricted to the degradation of these complexes while, in general, autophagy is thought to be a nonspecific process in which cytoplasmic proteins are degraded r ...
... (1990), who followed sequential steps in autophagy after inducing artificial protein complexes in the ER. However, their observations were restricted to the degradation of these complexes while, in general, autophagy is thought to be a nonspecific process in which cytoplasmic proteins are degraded r ...
AcmA of Lactococcus lactis is an N-acetylglucosaminidase
... that of muramidase-2 of Enterococcus hirae, however, RP-HPLC analysis of muropeptides released from Bacillus subtilis peptidoglycan, after digestion with AcmA, shows that AcmA is an N-acetylglucosaminidase. In the C-terminus of AcmA three highly similar repeated regions of 45 amino acid residues are ...
... that of muramidase-2 of Enterococcus hirae, however, RP-HPLC analysis of muropeptides released from Bacillus subtilis peptidoglycan, after digestion with AcmA, shows that AcmA is an N-acetylglucosaminidase. In the C-terminus of AcmA three highly similar repeated regions of 45 amino acid residues are ...
Cytolysin-dependent delay of vacuole maturation in
... bacterial escape (Prada-Delgado et al., 2005). In addition to its role in perforating membranes for Lm escape into cytosol, LLO could influence the dynamics of Lm vacuole maturation. This issue is difficult to address experimentally. The simplest approach of using fluorescence microscopy of fixed ce ...
... bacterial escape (Prada-Delgado et al., 2005). In addition to its role in perforating membranes for Lm escape into cytosol, LLO could influence the dynamics of Lm vacuole maturation. This issue is difficult to address experimentally. The simplest approach of using fluorescence microscopy of fixed ce ...
Reactive oxygen species are linked to the toxicity of the
... ABSTRACT: Short-term experiments were conducted to examine the response of the ciliate Tiarina fusus and the heterotrophic dinoflagellate Polykrikos kofoidii to 3 strains in the Alexandrium tamarense species complex, each with a different paralytic shellfish toxin (PST) content. Both protist species ...
... ABSTRACT: Short-term experiments were conducted to examine the response of the ciliate Tiarina fusus and the heterotrophic dinoflagellate Polykrikos kofoidii to 3 strains in the Alexandrium tamarense species complex, each with a different paralytic shellfish toxin (PST) content. Both protist species ...
Pentamidine-Induced Long QT Syndrome and Block of hERG
... analyze current densities, membrane capacitances were measured using the analog compensation circuit of an Axon 200B patch-clamp amplifier (Axon Instruments Inc., Foster City, CA). pCLAMP software (Axon Instruments) was used to generate voltage-clamp protocols and for data acquisition. All recording ...
... analyze current densities, membrane capacitances were measured using the analog compensation circuit of an Axon 200B patch-clamp amplifier (Axon Instruments Inc., Foster City, CA). pCLAMP software (Axon Instruments) was used to generate voltage-clamp protocols and for data acquisition. All recording ...
PDF
... Fig. 1. Thymus structure. (A)Structure of the thymus. The thymus is an epithelial organ surrounded by a mesenchymal capsule. It can be divided into a central medulla (m) region, which contains medullary thymic epithelial cells (mTECs), and an outer cortex (c), which contains cortical thymic epithel ...
... Fig. 1. Thymus structure. (A)Structure of the thymus. The thymus is an epithelial organ surrounded by a mesenchymal capsule. It can be divided into a central medulla (m) region, which contains medullary thymic epithelial cells (mTECs), and an outer cortex (c), which contains cortical thymic epithel ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.