GPCR ontology: development and application of a G protein
... the assay environment. Molecular target reflects a protein (or nucleic acid) modulated by a perturbagen. Filters can be adjusted based on a desired type of analysis. Analysis was initially performed per single screening campaign with compound categories defined as follows: an ‘active’ compound was o ...
... the assay environment. Molecular target reflects a protein (or nucleic acid) modulated by a perturbagen. Filters can be adjusted based on a desired type of analysis. Analysis was initially performed per single screening campaign with compound categories defined as follows: an ‘active’ compound was o ...
Chemotherapy-Induced Nausea and Vomiting
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
Document
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
... sources of afferent input to the key hindbrain areas that can initiate the emetic reflex after exposure to chemotherapy. Abdominal vagal afferents appear to have the greatest relevance for chemotherapy-induced nausea and vomiting.28 A variety of receptors, including 5-hydroxytryptamine3 (5-HT3), neu ...
Piracetam reverses haloperidol-induced - Tubitak Journals
... Despite having a striatal D2 receptor occupancy similar to classical agents, atypical antipsychotics are less likely to cause extrapyramidal side effects because of their ability to activate 5-HT1A receptors (43). Piracetam is a drug used to enhance memory and cognitive performance in the elderly or ...
... Despite having a striatal D2 receptor occupancy similar to classical agents, atypical antipsychotics are less likely to cause extrapyramidal side effects because of their ability to activate 5-HT1A receptors (43). Piracetam is a drug used to enhance memory and cognitive performance in the elderly or ...
The Serotonin Syndrome - Department of Psychiatry
... akinesia, “lead pipe” muscular rigidity, hyperthermia, fluctuating consciousness, and autonomic instability.44 Signs and symptoms of the neuroleptic malignant syndrome typically evolve during several days, in contrast to the rapid onset and hyperkinesia of the serotonin syndrome. Knowledge of the pr ...
... akinesia, “lead pipe” muscular rigidity, hyperthermia, fluctuating consciousness, and autonomic instability.44 Signs and symptoms of the neuroleptic malignant syndrome typically evolve during several days, in contrast to the rapid onset and hyperkinesia of the serotonin syndrome. Knowledge of the pr ...
Which neuroreceptors mediate the subjective effects of MDMA in
... and self-con®dence. Cardiovascular and adverse effects of MDMA were also attenuated by citalopram. Haloperidol selectively reduced MDMA-induced positive mood but had no effect on other subjective effects of MDMA or the cardiovascular or adverse responses to MDMA. Ketanserin selectively reduced MDMA- ...
... and self-con®dence. Cardiovascular and adverse effects of MDMA were also attenuated by citalopram. Haloperidol selectively reduced MDMA-induced positive mood but had no effect on other subjective effects of MDMA or the cardiovascular or adverse responses to MDMA. Ketanserin selectively reduced MDMA- ...
icrs2015 programme - The International Cannabinoid Research
... International Cannabinoid Research Society, Research Triangle Park, NC, USA, Page #. ...
... International Cannabinoid Research Society, Research Triangle Park, NC, USA, Page #. ...
CLENBUTEROL TABLETS 40mcg/tab
... Clenbuterol is a prescribed Asthma medication which is catabolic to fat and anabolic to muscle. Clenbuterol’s most valid application seems to be as a pre-contest, cutting drug. It is a Beta-2 adrenergic agonist. This means it acts just like adrenaline (epinephrine) at a certain type of receptor name ...
... Clenbuterol is a prescribed Asthma medication which is catabolic to fat and anabolic to muscle. Clenbuterol’s most valid application seems to be as a pre-contest, cutting drug. It is a Beta-2 adrenergic agonist. This means it acts just like adrenaline (epinephrine) at a certain type of receptor name ...
Update on Marijuana and Cannabinoid
... 3) CBD was placebo-like on all measures tested and there was no signal for CBD to decrease marijuana subjective effects 4) In this acute interaction study, there was no signal for CBD as a treatment for marijuana abuse ...
... 3) CBD was placebo-like on all measures tested and there was no signal for CBD to decrease marijuana subjective effects 4) In this acute interaction study, there was no signal for CBD as a treatment for marijuana abuse ...
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces
... 1 interface and MED-PC software (MED Associates) was used to control schedule contingencies and to record data. Mice were trained to respond in one aperture following administration of 0.1 mg/kg CP55,940 and to respond in the opposite aperture following vehicle administration according to a fixed ra ...
... 1 interface and MED-PC software (MED Associates) was used to control schedule contingencies and to record data. Mice were trained to respond in one aperture following administration of 0.1 mg/kg CP55,940 and to respond in the opposite aperture following vehicle administration according to a fixed ra ...
Intracellular Modulation of NMDA Receptor Function by
... tions described by Rajadhyaksha et al. (1999). The proenk ephalin construct used, pEN K AT12, contained the human proenk ephalin minimal enhancer (EN KCRE-1 and EN KCRE-2) f used to chloramphenicol acetyltransferase (CAT), and included 1.2 kb of the 3⬘ flanking sequence (Comb et al., 1986, 1988). St ...
... tions described by Rajadhyaksha et al. (1999). The proenk ephalin construct used, pEN K AT12, contained the human proenk ephalin minimal enhancer (EN KCRE-1 and EN KCRE-2) f used to chloramphenicol acetyltransferase (CAT), and included 1.2 kb of the 3⬘ flanking sequence (Comb et al., 1986, 1988). St ...
What is the risk of developing Serotonin Syndrome following
... Tramadol may cause serotonin syndrome particularly when it is used at high doses or in combination with other agents increasing serotonin levels (5). The manufacturers of tramadol state that co-administration Available through NICE Evidence Search at www.evidence.nhs.uk ...
... Tramadol may cause serotonin syndrome particularly when it is used at high doses or in combination with other agents increasing serotonin levels (5). The manufacturers of tramadol state that co-administration Available through NICE Evidence Search at www.evidence.nhs.uk ...
The a7 Nicotinic Receptor Agonist ABT-107 Decreases L
... orally at 0.01 mg/kg, a dose that optimally reduced LIDs (Zhang et al., 2014). The decline in LIDs reached its plateau by 5 weeks of ABT-894 treatment. At week 6, the monkeys were also administered ABT-107 at 0.10 mg/kg (Fig. 4B). No further decline in LIDs was observed with ABT-894 and ABT-107 in c ...
... orally at 0.01 mg/kg, a dose that optimally reduced LIDs (Zhang et al., 2014). The decline in LIDs reached its plateau by 5 weeks of ABT-894 treatment. At week 6, the monkeys were also administered ABT-107 at 0.10 mg/kg (Fig. 4B). No further decline in LIDs was observed with ABT-894 and ABT-107 in c ...
Prevention, Diagnosis, and Management of Serotonin Syndrome
... Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonergic activity in the nervous system. It is characterized by mental status changes, autonomic instability, and neuromuscular hyperactivity. Most reported cases of serotonin syndrome are in patients using multip ...
... Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonergic activity in the nervous system. It is characterized by mental status changes, autonomic instability, and neuromuscular hyperactivity. Most reported cases of serotonin syndrome are in patients using multip ...
Evidence for Chronically Altered Serotonin Function in the Cerebral
... rodents8) resulted in the loss of serotonin axons9; this loss is greater for the fine diameter cortical serotonin axons that are most distal to the cell bodies of origin. In animals, MDMA spares the cell bodies of brainstem serotonin neurons.9 Whether dose regimens that more closely mimic those of ...
... rodents8) resulted in the loss of serotonin axons9; this loss is greater for the fine diameter cortical serotonin axons that are most distal to the cell bodies of origin. In animals, MDMA spares the cell bodies of brainstem serotonin neurons.9 Whether dose regimens that more closely mimic those of ...
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis
... and 10 l of glucose-6-phosphate dehydrogenase (0.2 mg/ml) were then added, and the tubes were vortexed and incubated at room temperature for 30 min. The fluorescence was again measured. The difference in the fluorescence values was corrected for sample, reagent, and enzyme blank. Glycogen values ar ...
... and 10 l of glucose-6-phosphate dehydrogenase (0.2 mg/ml) were then added, and the tubes were vortexed and incubated at room temperature for 30 min. The fluorescence was again measured. The difference in the fluorescence values was corrected for sample, reagent, and enzyme blank. Glycogen values ar ...
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis
... 100 l of ATP (2 mg/ml), and 10 l of NADP (10 mg/ml) were added to each tube. The tubes were vortexed and subjected to centrifugation at 10,000g for 5 min. The supernatants were transferred to other tubes, and the fluorescence (excitation 350 nm/emission 460 nm) was measured in a fluorescence spect ...
... 100 l of ATP (2 mg/ml), and 10 l of NADP (10 mg/ml) were added to each tube. The tubes were vortexed and subjected to centrifugation at 10,000g for 5 min. The supernatants were transferred to other tubes, and the fluorescence (excitation 350 nm/emission 460 nm) was measured in a fluorescence spect ...
Heart Glucocorticoids Activate Cardiac Mineralocorticoid Receptors
... To explore whether GR activation might also aggravate infarct size in response to ischemia and reperfusion, we used 10 and 100 nM dexamethasone in the perfusate, with or without spironolactone. The results were unanticipated; although dexamethasone increased infarct size at both concentrations, the ...
... To explore whether GR activation might also aggravate infarct size in response to ischemia and reperfusion, we used 10 and 100 nM dexamethasone in the perfusate, with or without spironolactone. The results were unanticipated; although dexamethasone increased infarct size at both concentrations, the ...
Blum et al. 2011 - Boston University
... substantiated the substance’s action as partial agonist at the mu-opioid receptor. These findings were underscored by the substance’s general pharmacological profile. Furthermore, buprenorphine was one of the first narcotic analgesics to be assessed for its abuse liability in humans. Buprenorphine w ...
... substantiated the substance’s action as partial agonist at the mu-opioid receptor. These findings were underscored by the substance’s general pharmacological profile. Furthermore, buprenorphine was one of the first narcotic analgesics to be assessed for its abuse liability in humans. Buprenorphine w ...
Autonomic Pharmacology
... atropine or another muscarinic antagonist should always be given in conjunction with neostigmine to prevent adverse CVS effects usual adult dose for the reversal of neuromuscular blockade at the end of anaesthesia ~ 2.5 - 3.0 ...
... atropine or another muscarinic antagonist should always be given in conjunction with neostigmine to prevent adverse CVS effects usual adult dose for the reversal of neuromuscular blockade at the end of anaesthesia ~ 2.5 - 3.0 ...
Reward Processing by the Opioid System in the Brain
... Opioid receptors are expressed primarily in the cortex, limbic system, and brain stem. Binding sites for the three opioid receptors overlap in most structures, but some structures exhibit higher expression of one receptor over the others. Mu is the most expressed opioid receptor in the amygdala [but ...
... Opioid receptors are expressed primarily in the cortex, limbic system, and brain stem. Binding sites for the three opioid receptors overlap in most structures, but some structures exhibit higher expression of one receptor over the others. Mu is the most expressed opioid receptor in the amygdala [but ...
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ
... Sheffler and Roth 2003; Chavkin et al. 2004). In vivo studies revealed that salvinorin A is a relatively low toxic substance after acute or chronic treatment in mice and rats even when given at doses many times greater than those used by humans (Mowry et al. 2003). In a range of doses between 0.5 an ...
... Sheffler and Roth 2003; Chavkin et al. 2004). In vivo studies revealed that salvinorin A is a relatively low toxic substance after acute or chronic treatment in mice and rats even when given at doses many times greater than those used by humans (Mowry et al. 2003). In a range of doses between 0.5 an ...
Serotonin Syndrome
... serotonin syndrome continue to increase and include many different combinations of serotonergic drugs. Some of the reported drug combinations are listed in Table 4. The most well-known combination is an SSRI with an MAOI. However, the combination of any 2 serotonergic drugs can possibly precipitate ...
... serotonin syndrome continue to increase and include many different combinations of serotonergic drugs. Some of the reported drug combinations are listed in Table 4. The most well-known combination is an SSRI with an MAOI. However, the combination of any 2 serotonergic drugs can possibly precipitate ...