Elicited hippocampal theta rhythm: a screen for anxiolytic and
... that elicit and control theta makes a significant contribution to their behavioural and clinical profile. From this, we suggest that reticular-elicited theta can be used to detect both anxiolytic and, perhaps also, procognitive drugs. The hippocampus is well known for its involvement, together with ...
... that elicit and control theta makes a significant contribution to their behavioural and clinical profile. From this, we suggest that reticular-elicited theta can be used to detect both anxiolytic and, perhaps also, procognitive drugs. The hippocampus is well known for its involvement, together with ...
Dopamine and glucose, obesity, and reward deficiency syndrome
... and/or glycogenolytic pathways and found the main adrenergic receptor type beta 2, involved in glucose release. The hypothesis is that increasing the release of glucose from tissue would reduce cravings for carbohydrates and glucose. In this regard Shiroyama et al. (1998) supported this notion. Glyc ...
... and/or glycogenolytic pathways and found the main adrenergic receptor type beta 2, involved in glucose release. The hypothesis is that increasing the release of glucose from tissue would reduce cravings for carbohydrates and glucose. In this regard Shiroyama et al. (1998) supported this notion. Glyc ...
Glycine receptors in the central nervous system
... on clusters of symptoms described in diagnostic manuals (the upcoming 5th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM 5) and the International Classification of Disease 10th edition (ICD 10)). The common diagnostic tool for AUDs in the clinic are the guidelines provided by ...
... on clusters of symptoms described in diagnostic manuals (the upcoming 5th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM 5) and the International Classification of Disease 10th edition (ICD 10)). The common diagnostic tool for AUDs in the clinic are the guidelines provided by ...
Duloxetine Inhibits Effects of MDMA (``Ecstasy``) In Vitro and in
... pharmacologically blocked [7,10]. Therefore, we evaluated the effects of dual SERT and NET inhibition with duloxetine on the pharmacokinetics (PK) and pharmacodynamics (PD) of MDMA in humans. Duloxetine was used because it is the most potent and selective dual SERT and NET inhibitor, although it als ...
... pharmacologically blocked [7,10]. Therefore, we evaluated the effects of dual SERT and NET inhibition with duloxetine on the pharmacokinetics (PK) and pharmacodynamics (PD) of MDMA in humans. Duloxetine was used because it is the most potent and selective dual SERT and NET inhibitor, although it als ...
Study of the interaction between 3,4- methylenedioximethamphetamine and the endocannabinoid system
... the development of an adaptive state known as dependence. When unmasked by drug cessation, this adapted state can result in the production of cognitive, emotional or ‘physical’ withdrawal symptoms. Dependence resulting from long-term drug use may have both a somatic component manifested by physical ...
... the development of an adaptive state known as dependence. When unmasked by drug cessation, this adapted state can result in the production of cognitive, emotional or ‘physical’ withdrawal symptoms. Dependence resulting from long-term drug use may have both a somatic component manifested by physical ...
Opioid and Cannabinoid Modulation of Precipitated Withdrawal in
... on Drug Abuse (Bethesda, MD). Naloxone hydrochloride was purchased from Sigma Chemical Co. (St. Louis, MO). ⌬9-THC and SR 141716A were dissolved in ethanol, followed by addition of Emulphor-620 (Rhone-Poulenc, Princeton, NJ), and diluted with 0.9% saline to form a vehicle mixture of ethanol/Emulphor ...
... on Drug Abuse (Bethesda, MD). Naloxone hydrochloride was purchased from Sigma Chemical Co. (St. Louis, MO). ⌬9-THC and SR 141716A were dissolved in ethanol, followed by addition of Emulphor-620 (Rhone-Poulenc, Princeton, NJ), and diluted with 0.9% saline to form a vehicle mixture of ethanol/Emulphor ...
Alpha-2 Adrenergic Regulation of Melatonin Release in Chick
... rhythm of melatonin biosynthesis, with elevated levels at night and low levels during the day. The rhythm of melatonin is regulated both by circadian oscillators located within the gland itself and by adrenergic input from the sympathetic nervous system. Previous work has shown that norepinephrine a ...
... rhythm of melatonin biosynthesis, with elevated levels at night and low levels during the day. The rhythm of melatonin is regulated both by circadian oscillators located within the gland itself and by adrenergic input from the sympathetic nervous system. Previous work has shown that norepinephrine a ...
Volume 48 Number 4
... in Pharmacological Reviews, the Abel number, and other surprises. Public Affairs: ASPET continues its leading advocacy to increase training for integrative organ systems pharmacology. ASPET is also committed to making significant contributions through its new affiliation with The FDA Alliance to inc ...
... in Pharmacological Reviews, the Abel number, and other surprises. Public Affairs: ASPET continues its leading advocacy to increase training for integrative organ systems pharmacology. ASPET is also committed to making significant contributions through its new affiliation with The FDA Alliance to inc ...
Butorphanol-Mediated Antinociception in Mice: Partial Agonist
... Least-squares linear regression analysis of the linear portion of the dose-effect curves was used to estimate the ED50 value, or the dose that would be expected to result in 50%MPE. The slopes of the dose-effect curves for the agonists in combination with antagonists were compared with those of the ...
... Least-squares linear regression analysis of the linear portion of the dose-effect curves was used to estimate the ED50 value, or the dose that would be expected to result in 50%MPE. The slopes of the dose-effect curves for the agonists in combination with antagonists were compared with those of the ...
HERE - INDIGO Biosciences
... for the predictions of toxic potentials for diclofenac and celecoxib were used as described previously [9]. The Pharmmapper, freely available web server (http://59.78.96.61/ pharmmapper), was used to predict potential target candidates for both drugs. The mol2 files for two molecules were submitted t ...
... for the predictions of toxic potentials for diclofenac and celecoxib were used as described previously [9]. The Pharmmapper, freely available web server (http://59.78.96.61/ pharmmapper), was used to predict potential target candidates for both drugs. The mol2 files for two molecules were submitted t ...
Striatal D2 / D3 Receptor Occupancy, ... and Side Effects with Amisulpride: An Iodine-123-Iodobenzamide SPET Study
... anticholinergic and sedative effects and EPS [11, 21]. A recent meta-analysis of 18 clinical trials showed that amisulpride is an effective and welltolerated atypical antipsychotic for the treatment of both positive and negative symptoms [8]. Up to now, there are different models about the mechanism ...
... anticholinergic and sedative effects and EPS [11, 21]. A recent meta-analysis of 18 clinical trials showed that amisulpride is an effective and welltolerated atypical antipsychotic for the treatment of both positive and negative symptoms [8]. Up to now, there are different models about the mechanism ...
Biological substrates of reward and aversion: A nucleus accumbens
... MSNs of the indirect pathway; and second, that events that would be expected to reduce the overall excitability of the NAc (e.g., stimulation of Gi-coupled opioid receptors, reduced stimulation of excitatory NMDA receptors, reduced excitatory input) are sufficient for reward. This interpretation led ...
... MSNs of the indirect pathway; and second, that events that would be expected to reduce the overall excitability of the NAc (e.g., stimulation of Gi-coupled opioid receptors, reduced stimulation of excitatory NMDA receptors, reduced excitatory input) are sufficient for reward. This interpretation led ...
Psilocybin links binocular rivalry switch rate to attention and
... observation that rhythmicity of binocular rivalry alternations was greatly increased 10 h after the reported consumption of lysergic acid diethylamide (Carter and Pettigrew 2003). 5-HT2A receptor activation has generally been considered to be the main factor contributing to the hallucinogenic proper ...
... observation that rhythmicity of binocular rivalry alternations was greatly increased 10 h after the reported consumption of lysergic acid diethylamide (Carter and Pettigrew 2003). 5-HT2A receptor activation has generally been considered to be the main factor contributing to the hallucinogenic proper ...
Pharmacology
... A. Blocks sodium channels in axonal membranes starts two days after her final dose of the MAOI. Since B. Blood pressure increase is due to its ability to release northe MAOIs used as antidepressants continue to exert epinephrine from sympathetic nerve terminals effects for 2 or more weeks after disc ...
... A. Blocks sodium channels in axonal membranes starts two days after her final dose of the MAOI. Since B. Blood pressure increase is due to its ability to release northe MAOIs used as antidepressants continue to exert epinephrine from sympathetic nerve terminals effects for 2 or more weeks after disc ...
Minireview The Neurokinin-1 Receptor in Addictive Processes
... behavior in rodents that is NK1R-dependent (Teixeira et al., 1996; Duarte et al., 2004; Ebner et al., 2004). In addition, mice with genetic deletion of the NK1R show decreased anxiety in the elevated plus maze, novelty-suppressed feeding paradigm, and ultrasonic vocalization during maternal separati ...
... behavior in rodents that is NK1R-dependent (Teixeira et al., 1996; Duarte et al., 2004; Ebner et al., 2004). In addition, mice with genetic deletion of the NK1R show decreased anxiety in the elevated plus maze, novelty-suppressed feeding paradigm, and ultrasonic vocalization during maternal separati ...
Modulation of ventral tegmental area dopamine receptors inhibit
... intra-amygdala infusion of D1 agonists and antagonists respectively (de la Mora et al., 2010). Nicotine has long been known to modulate synaptic transmission and plasticity in the amygdala (FU et al., 1998; Mansvelder et al., 2009) and acute nicotine has been shown to increase c-fos mRNA expression, ...
... intra-amygdala infusion of D1 agonists and antagonists respectively (de la Mora et al., 2010). Nicotine has long been known to modulate synaptic transmission and plasticity in the amygdala (FU et al., 1998; Mansvelder et al., 2009) and acute nicotine has been shown to increase c-fos mRNA expression, ...
Opioids - Waterloo Region Integrated Drugs Strategy
... Fentanyl is a potent opioid, used in anesthesia, for pain, chronic pain, pain in end of life care Typically administered as a patch placed on the skin Fentanyl is produced by pharmaceutical manufacturers Small chemical changes to fentanyl can result in drugs with very similar actions These “bootleg” ...
... Fentanyl is a potent opioid, used in anesthesia, for pain, chronic pain, pain in end of life care Typically administered as a patch placed on the skin Fentanyl is produced by pharmaceutical manufacturers Small chemical changes to fentanyl can result in drugs with very similar actions These “bootleg” ...
UTEROTONIC PROPERTIES OF NYMPHAEA ALBA ON ISOLATED MYOMETRIUM MODEL Original Article
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
Characterization of the Effects of the Partial Dopamine Agonist
... press resulted in an intravenous injection of 0.1 ml of cocaine hydrochloride (0.25 mg/injection) dissolved in 0.9% physiological saline and delivered over a period of 4 sec. A swivel system allowed free movement of the animal in the cage. Coincident with the onset of the injection, a stimulus light ...
... press resulted in an intravenous injection of 0.1 ml of cocaine hydrochloride (0.25 mg/injection) dissolved in 0.9% physiological saline and delivered over a period of 4 sec. A swivel system allowed free movement of the animal in the cage. Coincident with the onset of the injection, a stimulus light ...
http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf
... trials to criterion by =50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functio ...
... trials to criterion by =50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functio ...
Evidence that Diclofenac and Celecoxib are thyroid hormone
... The docking analysis was carried out using three TRβ crystal structure with three different ligands; diclofenac (Figure 2A) could bind to active sites of all three structures, while celecoxib (Figure 2B) could bind only into active site of 1Q4X PDB entry, as the ligand of this complex ([4-(3benzyl-4 ...
... The docking analysis was carried out using three TRβ crystal structure with three different ligands; diclofenac (Figure 2A) could bind to active sites of all three structures, while celecoxib (Figure 2B) could bind only into active site of 1Q4X PDB entry, as the ligand of this complex ([4-(3benzyl-4 ...
- University of Mississippi
... highly selective sigma-1 and sigma-2 receptor antagonist that binds with almost equal affinity to each subtype. This synthetic compound was derived from CM156, also a sigma receptor antagonist. AZ66 was developed for its longer half-life and an increased metabolic stability than its precursor CM156. ...
... highly selective sigma-1 and sigma-2 receptor antagonist that binds with almost equal affinity to each subtype. This synthetic compound was derived from CM156, also a sigma receptor antagonist. AZ66 was developed for its longer half-life and an increased metabolic stability than its precursor CM156. ...
The Serotonin Syndrome - University of Colorado Denver
... akinesia, “lead pipe” muscular rigidity, hyperthermia, fluctuating consciousness, and autonomic instability.44 Signs and symptoms of the neuroleptic malignant syndrome typically evolve during several days, in contrast to the rapid onset and hyperkinesia of the serotonin syndrome. Knowledge of the pr ...
... akinesia, “lead pipe” muscular rigidity, hyperthermia, fluctuating consciousness, and autonomic instability.44 Signs and symptoms of the neuroleptic malignant syndrome typically evolve during several days, in contrast to the rapid onset and hyperkinesia of the serotonin syndrome. Knowledge of the pr ...
Bioisosterism: A Rational Approach in Drug Design
... (QSAR) associated with a specific class of drugs. While in some instances such associations were detailed by the authors of these literature examples, others were developed on the basis of evident correlations. To further explain and rationalize the biological activity observed with nonclassical bio ...
... (QSAR) associated with a specific class of drugs. While in some instances such associations were detailed by the authors of these literature examples, others were developed on the basis of evident correlations. To further explain and rationalize the biological activity observed with nonclassical bio ...