Download 2010-2011 Exam current 2nd Semester

UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 203
COURSE TITLE: GENERAL MICROBIOLOGY II
CREDIT UNIT: 3
TIME ALLOWED: 2.5 HRS.
INSTRUCTION: ATTEMPT ANY FOUR (4) QUESTIONS
1a. Define mutation.
(b). Discuss the differences in the different types of mutation.
(c). How can mutation be repaired?
2. Write short notes on the following:
(a). Plasmids.
(b). Bacterial conjugation.
(c). Differences between transformation and transduction.
(d). The ames test.
3a. Explain the three main functions of the specific immune response.
(b). How do the following defend the body against microbial invasion?:
i. Interferons.
ii. Iron-binding proteins.
iii. Phagocytosis.
4. Write notes on:
(i). Legionaires disease.
(ii). Histoplasmosis.
(iii). Botulism.
(iv). Genital herpes.
5a. List any four factors that may influence the number and distribution of
microbes in the soil.
(b). Discuss bacteria as microbial flora of the soil.
6a. Enumerate any five (5) water-borne diseases.
(bi). Describe the membrane – filtration technique and State any four (4)
advantages of the technique.
UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 204
COURSE TITLE: PRINCIPLES OF STERILIZATION, DISINFECTION
& CHEMOTHERAPHY
CREDIT UNIT: 2
TIME ALLOWED: 2 HRS.
INSTRUCTION: ATTEMPT ANY THREE (3) QUESTIONS
1a. Define sterilization and disinfection.
(b). List the qualities of a good disinfectant.
(c). Describe a named experiment that could be used to evaluate the
effectiveness of a given chemical disinfectant.
2a. Why are antimetabolites referred to as ‘decoys’.
b. Write notes on the different classes of antimetabolites given appropriate
examples in each case.
3. Write notes on the following:
i. Mechanical sterilization.
ii. Tyndallization.
iii. Autoclaving.
4. Write short notes on the mode of action and examples of:
i. β – lactams.
ii. Tetracyclines.
iii. Aminoglycosides.
iv. Quinolones.
v. Polymixins.
5. Discuss the different types of chemotherapeutic agents that can be used to
treat viral infections and their targets.
UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 406
COURSE TITLE: ANALYTICAL MICROBIOLOGY & QUALITY
CONTROL
CREDIT UNITS: 3
TIME ALLOWED: 2.5HRS
INSTRUCTIONS: ATTEMPT FOUR QUESTIONS ONLY
1. (a) What are the objectives of microbiological quality control.
(b) Why is sample handling so important in microbiological quality control.
(c) Describe how you will carry out the microbiological sampling of the
following:
(i) Frozen chicken.
(ii)Tap water.
(iii)Vegetables from a consignment.
2. Write short notes on the following
(a) Food legislation and its importance.
(b) Total quality concept.
(c) Enumeration of microorganisms in a food sample
3. (a) Give the advantages of nucleic acid diagnostic tools over immunologic
procedures.
(b) Discuss the general principles of immunoassays and outline the
procedures for the identification of pathogens.
4. (a) Outline the major differences between conventional and rapid assays
methods used in the identification of pathogens.
(b) Describe the application of nucleic acid based methods in the detection of
microorganisms.
5. (a) Show the differences between analytical and conventional microbiological
techniques.
(b) Describe the principles and procedures involved in the quantification of
lysine in a drug formulation using a named microorganism.
6. (a) Outline the steps involved in the concept of HACCP and with the aid of a flow chart
show the “critical control points” and “microbiological hazard” in the production of
packaged water or yoghurt.
(b) What are the differences between “retrospective” and “Intervention” quality control?
UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 408
COURSE TITLE: PETROLEUM MICROBIOLOGY
CREDIT UNITS: 3
TIME ALLOWED: 2.5HRS
INSTRUCTIONS: ATTEMPT FOUR QUESTIONS ONLY; ATLEAST 2
QUESTIONS FROM EACH SECTION
SECTION A
1.(a) What are fossil fuel?.
(b).Describe briefly the two popularly upheld theories on the formation of
petroleum and coal.
(c).Show in a tabular form the various forms of phytoremediation and their
applications to cleansing environmentally polluted soil and water.
2. Describe (a) factors to consider (b) microorganisms and (C) biochemical
pathways involved in the bioremediation of soil with pollutant constituents as
follows: toluene (60%), propane (30%) and polychlorinated biphenyl (PCB)
(10%).
3. (a) Outline the procedures that can be used for microbial prospecting of oil and gas
(MPOG).
(b) What are the principles behind microbial enhanced oil recovery?
SECTION B
4(a) Define methanogenesis and describe methane production from agricultural wastes by
microbial succession .
(b) What is the ecological significance of methanogenesis?
5(a). Explain the metabolic mechanism by which methanotrophs mitigate global warming.
(b) Outline the economic importance of methanotrophs.
6(a) Explain the role of (i) Acid producing bacteria (ii) Slime-producing bacteria in the
corrosion of petroleum pipelines.
(b) Write a proposal to the Nigerian National Petroleum Corporation (NNPC) on how to
control the corrosion of its petroleum pipelines.
UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 409
COURSE TITLE: GENERAL TOXICOLOGY
CREDIT UNITS: 3
TIME ALLOWED: 2.5HRS
INSTRUCTIONS: ATTEMPT FOUR QUESTIONS ONLY
1. Discuss the safety concerns of the following in drinking water.
(i) Chlorination.
(ii) Nitrate.
(iii) Fluoride.
(iv) Aluminium.
2. Describe the major microbial groups that may affect drinking water quality.
What measures would you recommend for the treatment of drinking water.
3. Discuss major microbial species which may contaminate food and why this
may be dangerous.
4. Discuss the importance of pesticides.
5. Write an easy on the organochlorine pesticides and their implications in the
environment.
6. Write short notes on:
(i) Rodenticides.
(ii) Carbamate insecticides.
(iii) Fungicides.
(iv) Rotenoids.
UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 308
COURSE TITLE: IMMUNOLOGY AND IMMUNOCHEMISTRY
CREDIT UNITS: 4
TIME ALLOWED: 3 HRS
INSTRUCTIONS: ATTEMPT ANY FIVE QUESTIONS ONLY
1(a). Describe the immunologic reactions involved in Type I hypersensitivities.
(b) Give 4 examples of Type I hypersensitivities.
2(a). Describe the oxygen dependent mechanism of phagocytosis.
(b) How do microbial cells evade the action of phagocytes?
3(a). What is complement?
(b). List the pathways of complement activation.
(c) Explain in detail any one of the listed pathways.
4. Describe the origin and kinds of cells/ tissues involved in human immune
response.
5.What do you understand by the term transplantation? Discuss the mechanisms
of allograft rejection in an immunocompetent host.
6. What do you understand by the term tolerance? Explain the mechanisms of
tolerance induction.
7. Describe the production of monoclonal antibodies and their applications in
clinical practice.
UNIVERSITY OF JOS
FACULTY OF NATURAL SCIENCES
DEPARTMENT OF MICROBIOLOGY
SECOND SEMESTER EXAMINATION 2010/2011 SESSSION
COURSE CODE: MCB 101
COURSE TITLE: INTRODUCTION TO MICROBIOLOGY
CREDIT UNIT: 2
TIME ALLOWED: 2 HRS.
INSTRUCTION: ATTEMPT ANY THREE (3) QUESTIONS
1a. List and explain any eight general characteristics of microorganisms.
(b). List in order the seven(7) known stages or eras in the historical
development of Microbiology.
2a. Show in a tabular form the contributions of any ten (10) named pioneers in
the development of Microbiology.
(b) State and explain briefly Koch’s postulates.
3a. Write short notes on (i) Spontaneous generation of life and (ii) Experiment
by a named scientist to disprove the theory of ‘abiogenesis’.
(b) Two scientist contributed to the establishment of the ‘’Germ Theory of
Diseases’’. Name the scientists and their contributions accordingly.
4a. Draw a well-labelled diagram of a typical prokaryotic cell.
(b) Discuss the functions of the basic organelles of the prokaryotic and
eukaryotic cells.
5a. Briefly outline the similarities between prokaryotic and eukaryotic cells.
(b) Discuss the functions of the following in the microbial cell:
(i) Peptidoglycan.
(ii) Teichoic acid.
(iii) Porin protein.