Download Clumping Reaction of ABO Blood-Typing Sera

Multiple Alleles
Some human traits are controlled by a single gene that has more than two alleles. Such a
gene is said to have multiple alleles –three or more forms of a gene that code for a single trait. You
can think of multiple alleles as being like flavors of pudding. Pudding usually comes in more
flavors than just chocolate and vanilla!
Even though a gene may have multiple alleles, a person can carry only two of those alleles.
This is because chromosomes exist in pairs. Each chromosome in a pair carries only one allele for
each gene.
One human trait that is controlled by a gene with multiple alleles is blood type. There are
four main blood types – A, B, AB, and O. Three alleles control the inheritance of blood types. The
allele for blood type A and the allele for blood type B are codominant. The allele for blood type O
is recessive. The chart below shows the allele combinations that result in each blood type.
Blood Type
A
B
AB
O
Blood Types
Combination of Alleles
AA or AO
BB or BO
AB
OO
Blood Typing
Clumping Reaction of ABO Blood-Typing Sera
Reaction
Anti-A Serum
Anti-B Serum
Clumping
No clumping
No clumping
Clumping
Clumping
Clumping
No clumping
No clumping
Blood Type
Type A
Type B
Type AB
Type O
Clumping Reaction of Rh Serum
Reaction
Rh Type
Clumping
+
No Clumping
Example: B+ Individual
Clumping
Blood Typing Game
http://nobelprize.org/educational_games/medicine/landsteiner/index.html
In this game you have to blood type each patient
and give them a blood transfusion. Are you able to
do that? If not, maybe you should read the
introduction to blood typing before you start,
otherwise you will put the patients' lives in danger!
1.
2.
3.
Read the introduction if your emergency room team needs more details on blood typing.
When your team is ready, click on “Play Game”.
Click on your first patient. Record your results for all three patients below. Please explain
how you determined their blood type.
Questions:
1. What is the patient’s blood type?
2. How did you determine this?
3. What type of blood did you use for the transfusion?
4. Did you save the patient?
5. How many tries did it take your team?
Questions:
1. What is the patient’s blood type?
2. How did you determine this?
3. What type of blood did you use for the
transfusion?
4. Did you save the patient?
5. How many tries did it take your team?
Questions:
1. What is the patient’s blood type?
2. How did you determine this?
3. What type of blood did you use for the
transfusion?
4. Did you save the patient?
5. How many tries did it take your team?
SCORE: ______________________________________