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Chapter 12: The Cell Cycle
Text Vocabulary:
Cell division
Meiosis
Embryos
Gametes
Mitosis
Somatic cells
Cytokinesis
Asexual reproduction
Chromosome
Histones
Chromatid
Centromere
Sister chromatids
M-Phase
Interphase
S-Phase
Cell Cycle
G1 Phase
G2 Phase
Chromatin
Prophase
Spindle Apparatus
Polar Microtubules
Centrosome
Centrioles
Kinetochores
Preometaphase
Kinetochore microtubules
Metaphase
Metaphase plate
Astral Microtubules
Anaphase
Telophase
Cell plate
Cleavage furrow
Binary fission
M-phase Pomoting Factor
Cyclins
Cyclin-dependent kinase
Negative feedback
Cell-cycle checkpoint
Tumor
P53
Apoptosis
Tumor suppressors
Cancer
Malignant tumors
Benign tumors
Metastasis
Growth factors
Serum
Rb proteins
Lecture 10 “Control of Cell Cycle” PPT review:
1.) Watch the Mitosis video from lecture. What are the different phases of mitosis? What happens
at each phase?
2.) What are the phases of the cell cycle? What occurs during Gap phases? Explain the G0 phase.
3.) Define the following:
a. MPF
b. Cdk
c. Cyclin
4.) How are Cdks activated? Explain the accumulation and degradation of cyclin in cells.
5.) What is the relationship between concentrations of cyclin and activity of MPF?
6.) What is the function of Cdk? (include the reaction it’s involved in)
7.) There are 3 cell cycle checkpoints we discussed in lecture:
a. What occurs at each checkpoint/What is being “checked”?
b. State whether MPF is present or absent.
8.) Explain how the G1 checkpoint is subject to social control using the slides from lecture or book.
What is acting as the “social control” in this? (p. 234 in text)
9.) What characterizes cancer on a cellular level?
10.) If a cancer cell divides without growth factors, which checkpoint does it bypass? Explain why
cancer cells passing through this checkpoint is a problem—think about what occurs at the phase
following G1.
11.) During what phases in the cell cycle would you expect there to be large changes in the
polymerization or depolymerization of microtubules?
12.) When actively growing cells are treated with Taxol, they often are unable to complete the cell
cycle. Based on what you have learned about cell-cycle checkpoints, which checkpoint likely
causes these cells to arrest?