Download For identification of acetylsalicylic acid chemist used dilute sodium

For identification of acetylsalicylic acid chemist used dilute sodium hydroxide
solution R. After boiling and next cooling he added dilute sulphuric acid R.
What product of reaction is formed?
A. Smoke
B. Opalescense
C. Green precipitate
D. Brown gas
E. White precipitate
ANSWER: E
The method of assay for salicylamide is:
A. Iodometry, direct titration
B. Cerymetry, back titration
C. Permanganatometry
D. Argentometry, back titration
E. Modified Keldal method
ANSWER: E
Salicylanilide use as agent:
A. Purgative
B. Anaestetic
C. Keratolytic
D. Analgesic and antipyretic
E. Antibacterial
ANSWER: E
The molar weight of equivalent (Em) at assay of acetylsalicylic acid by means
of acidimetry after saponification alcoholic solution (back titration) equals:
A. М m.
B. М m./4
C. 2М. M.
D. М m./3
E. М m./2
ANSWER: E
What functional groups are available in a molecule salicylamide?
A. Keto-group, amide group
B. Integrally connected chlorine
C. Alcoholic hydroxyl, amino group
D. Amino group, benzene cycle
E. Amide group, phenolic hydroxyl
ANSWER: E
Assay of acetylsalicylic acid, according to Pharmacopoeia, makes by means of
such method:
A. Alkalimetry, back titration
B. Argentometry
C. Acidimetry, non-aqueous direct titration
D. Alkalimetry in alcoholic solution, direct titration
E. Acidimetry, after saponification alcoholic solution, back titration
ANSWER: E
The pharmacopoeial method of assay for furazolidone is:
A. Cerimetry
B. Chelatometry
C. Thin-layer chromatography
D. UV-spectrophotometry
E. Argentometry
ANSWER: D
The characters of furazolidone, according to Pharmacopoeia, is:
A. A white crystalline powder, very soluble in water, soluble in
alcohol
B. A white or almost white, crystalline powder, soluble in water and
in ethanol
C. A yellow, crystalline powder or yellow crystals, odourless or
almost odourless, very lightly soluble in water and in alcohol,
soluble in dimethylformamide
D. A yellow, crystalline powder, very slightly soluble in water and in
ethanol (96%); practically insoluble in ether
E. A yellow or brownish-yellow, crystalline powder, very slightly
soluble in water, slightly soluble in alcohol
ANSWER: D
In the medical practice nitrofurantoin use as agent:
A. Diuretic
B. Membrane-promoting
C. Expectorant
D. Anaesthetic
E. Antibacterial
ANSWER: E
The initial substance for synthesis nitrofurantoin is:
A. Oxadiazole
B. Oxazole
C. Thiophene
D. Pyrrole
E. 5-Nitrofurfurol
ANSWER: E
The pharmacopoeial method of assay for nitrofurazone is:
A. Refractometry
B. Thin-layer chromatography
C. IR-spectroscopy
D. Photocolorimetry
E. UV-spectrophotometry
ANSWER: E
At interaction solution of nitrofurazone in the dimethylformamide with
alcoholic potassium hydroxide solution can be observed:
A. Formation of a white precipitate
B. Ammonia allocation
C. Yellow colouring, which passes in the violet
D. Violet-red colour of solution
E. Brown colour of solution
ANSWER: D
As antioxidant in medical practice use:
A. Piracetam
B. Furazolidone
C. Nitrofurantoin
D. Nitrofural
E. Thiotriazolinum
ANSWER: E
The chemist makes pyrolysis of Thiotriazolinum dry substance (burning
substance in crucible) with the next revealing of sulphides-ions by means of
filter paper moistened by solution of:
A. Starch
B. Barium chloride
C. Potassium iodide
D. Lead acetate
E. Water
ANSWER: D
The pharmacopoeial method of assay for clonidine hydrochloride is:
A. lkalimetry, back titration
B. Acidimetry, back titration
C. Acidimetry direct non-aqueous titration
D. Alkalimetry in the alcohol medium, direct titration
E. Acidimetry, direct titration
ANSWER: D
Clonidine hydrochloride is derivative of such heterocyclic compound:
A. Pyridine
B. Pyrimidine
C. Imidazoline
D. Imidazole
E. Furan
ANSWER: C
What analytical effect of reaction furazolidone with dimethylformamide and
alcoholic potassium hydroxide?
A. White colour
B. Ammonia allocation
C. *Blue colour
D. Red gas
E. Brown colour
ANSWER: C
For synthesis furazolidone can be used condensation of 5-nitrofurfurol with:
A. Aniline
B. Morpholine
C. 3-aminooxazolidone-2
D. 1-Aminohydantoin
E. Semicarbazide
ANSWER: C
Alkalimetry, non-aqueous titration – is a method of assay for nitrifurantoin. As
titrant in his method use standard solution of:
A. Perchloric acid in the presents of ice acetic acid
B. Sodium methylate in the presents of DMFA (dimethylformamide)
C. Potassium hydroxide in the presents of ethanol and benzene
D. Sodium hydroxide in the presents of benzene and methylene
E. Water solution of sodium hydroxide
ANSWER: B
What characters of nitrifurantoin, according to Pharmacopoeia?
A. A white crystalline powder, very soluble in water, soluble in
alcohol
B. A white or almost white, crystalline powder, soluble in water and
in ethanol
C. A yellow, crystalline powder, very slightly soluble in water and in
ethanol (96%); practically insoluble in ether
D. A yellow or brownish-yellow, crystalline powder, very slightly
soluble in water, slightly soluble in alcohol
E. A yellow, crystalline powder or yellow crystals, odourless or
almost odourless, very slightly soluble in water and in alcohol,
soluble in dimethylformamide
ANSWER: E
For identification of nitrifurazone can be used reaction with:
A. Perhydrol in the alkaline medium
B. Nesler reagent
C. 10 % copper sulphate solution
D. Water solution of alkali
E. Dimethylformamide and alcoholic potassium hydroxide solution
ANSWER: E
The chemical name of nitrifurazone is:
A. morpholine 3-methyl-1,2,4-triazolyl-5-thioacetate
B. 2,6-dichloro-N-(imidazolidin-2-ylidene)aniline
C. 2-[(5-nitrofuran-2-yl)methylene]diazanecarboxamide
D. 3-(5-nitrofurfurylideneamino)oxazolidin-2-one
E. 1-[[(5-nitrofuran-2-yl)methylene]amino]imidazolidine-2,4-dione
ANSWER: C
The chemical name 3-methoxy-4-oxybenzylidenehydrazide pyridine-4carboxylic acid hydrate is for a preparation:
A. Nicodine
B. Isoniazid
C. Cordiamine
D. Nikethamide
E. Phthivazid
ANSWER: E
Tocopherol acetate has the following chemical name:
A. Pregnane–4-ol-21-dione-3,20-21 acetate
B. Pregnene–4-diol-17-2,21-trione-3,11,20-21 acetate
C. Pregnene–4-triol-11,17, 21-dione-3,20-21 acetate
D. Trans-9,13-dimethyl-7-(1,1,5-trimethyl-cyclogen-5-yl6)nontetraene-7,9,11,13-one–15 acetate
E. (+)-2,5,7,8,-tetramethyl-2-(4',8',12'-trimethyltridecyl)-6acetoxychromane
ANSWER: E
Routine is present in the following tablets content:
A. Papazol
B. No-spa
C. Ascoroutine
D. Reoperin
E. Citramone
ANSWER: C
Steroid cycle in the molecules of cardiac glycosides is revealed by the reaction
of:
A. Lieberman - Burhardt
B. Legal
C. Raymond
D. Baljet
E. Keller-Kilian
ANSWER: A
Pentamerous lactone cycle in the molecules of cardiac glycosides is revealed by
the reaction of:
A. Raymond
B. Legal
C. Lieberman - Burhardt
D. Keller-Kilian
E. Baljet
ANSWER: B
Source of obtaining cardiac glycosides are different types of:
A. Belladonna
B. Poppy
C. Digitalis
D. Hemp
E. Ephedrine
ANSWER: C
Quantitative determination of cardiac glycosides according to the procedures
DF X is carried out by the method of:
A. Photocolorimetry
B. Acidimetry
C. Infrared spectroscopy
D. Alkalimetry
E. Biological method
ANSWER: E
What monosaccharide is nonspecific for cardiac glycosides?
A. Digitoxose
B. D-cymarose
C. L-rhamnose
D. Oleandroze
E. Fructose
ANSWER: E
The aglycone structure of the cardiac glycosides, which are called cardenolides,
is formed of such lactone cycle:
A. Pentamerous
B. 6-membered
C. Heptatomic
D. 4-membered
E. Octatomic
ANSWER: A
Bufadienolides are the part of:
A. Digitalis
B. Hellebore
C. Adonis
D. Lily of the valley
E. Strophanthus
ANSWER: B
2-deoxysaccharides in the molecule of cardiac glycosides is revealed by the
reaction of:
A. Legalov
B. Pezets
C. Raymond
D. Baleta
E. Lieberman – Burhardt
ANSWER: B
Which of the saccharides is included in the structure of the ouabain molecule?
A. Lactose
B. Digitoxose
C. D-Cymarose
D. L-Rhamnose
E. D-Oleandroze
ANSWER: D
Aglycone in the celanidum molecule is :
A. Strofantidine
B. Gitoxigenin
C. Digitoxigenin
D. Digoxigenine
E. Oleandrogenine
ANSWER: D
The bearer of the biological activity in the cardiac glycosides is:
A. Saccharic part
B. Pentamerous lactone cycle
C. Aglycone
D. Radical in the position of the 10th aglycone
E. OH-group in the position of the 14th aglycone
ANSWER: C
Six-membered lactone cycle in the molecule of cardiac glycosides may be
detected with a solution:
A. FeCl3
B. H2SO4
C. AlCl3
D. SbCl3
E. CuSO4
ANSWER: D
Steroid cycle in the molecules of cardiac glycosides is revealed by the reaction
of:
A. Rosenheim
B. Legalov
C. Keller-Kilian
D. Pezets
E. Balet
ANSWER: A
Pentamerous lactone cycle in the molecules of cardiac glycosides is revealed by
the reaction of:
A. Lieberman-Burhardt
B. Raymond
C. Rosenheim
D. Keller-Kilian
E. Pezets
ANSWER: B
2-deoxysaccharides in the molecule of cardiac glycosides is revealed by the
reaction of:
A. Legalov
B. Raymond
C. Pezets
D. Rosenheim
E. Lieberman-Burhardt
ANSWER: C
According to their chemical structure cardiac glycosides belong to:
A. Heterocyclic carboxylic acids
B. Aromatic amines
C. Esters
D. Ethers
E. Polyhydric alcohols
ANSWER: C
Cardiac glycosides are extracted from various plants, one of which is:
A. Belladonna
B. Snakewood (Rauvolfia serpentina)
C. Senecio platyphyllos
D. Spring Adonis(Adonis vernalis)
E. Henbane (Hyoscyamus niger L)
ANSWER: D
Which of the saccharides does not belong to the cardiac glycosides structure?
A. Lactose
B. Digitoxose
C. D-cymarose
D. L-rhamnose
E. D-oleandroze
ANSWER: A
Bufadienolidy are the part of:
A. Digitalis
B. Adonis
C. Lily of the valley
D. Sea onion (Urginea maritima)
E. Strophanthus
ANSWER: D
Saccharic component, which is attached at position 3 to the cardiac glycoside
aglycone, affects:
A. Medical product form
B. The duration of drug action
C. Directions for use
D. Specific action of cardiac glycosides
E. Side effects
ANSWER: B
Cardiac glycosides of the cardenolide group include in their molecule:
A. Steroid cycle
B. Double bond between C atoms
C. Triple bond between C atoms
D. Six-membered lactone cycle
E. Pentamerous lactone cycle
ANSWER: E
Quantitative determination of cardiac glycosides is carried out by the method
of:
A. Photocolorimetry
B. Acidimetry
C. UV- spectroscopy
D. Alkalimetry
E. Precipitation titration
ANSWER: C
Cardiac glycosides genins are derived from:
A. Cyclohexane
B. Cholesterol
C. Cyclopentaneperhydrophenanthrene
D. Adrostan
E. Ergocalciferol
ANSWER: C
In the digitoxin molecule the aglycone is:
A. Strophantidine
B. Gitoksigenine
C. Digitoxigenin
D. Digoxigenine
E. Oleandrogenine
ANSWER: C
Cardiac glycosides aglycones are the derivatives of:
A. Cholesterol
B. Steranes
C. Cyclopentaneperhydrophenanthrene
D. Androstane
E. Pregnenolone
ANSWER: C
Pentamerous lactone cycle in the cardiac glycosides molecule is revealed by the
reaction of:
A. Raymond
B. Sakagush
C. Lugol
D. Ovchinnikov
E. Rosenkheim
ANSWER: A
Steroid cycle in the structure of cardiac glycosides is revealed by the reaction
of:
A. Legalov
B. Raymond
C. Balet
D. Lieberman-Burhardt
E. Keller-Kilian
ANSWER: D
Aglycone in the digoxin molecule is:
A. Strophantidine
B. Gitoksigenine
C. Digitoxigenin
D. Digoxigenine
E. Oleandrogenine
ANSWER: D
Konvalyatoksin the medical product of cardiac glycosides is extracted from
such plant:
A. Strophanthus Combe
B. Strophanthus gratus
C. Convallaria majalis
D. Erysimum diffuse
E. Digitalis lanata
ANSWER: C
Cardenolides are identified by the maximum absorption at  = 220 nm,
comparing with the standard sample of preparation. Specify which
physicochemical method is used then
A. Refractometry
B. Fluorometry
C. Polarimetry
D. Spectrophotometry
E. Polarography
ANSWER: D
Saccharid part in the cardiac glycosides molecules may be detected after acid
hydrolysis by the reaction of:
A. Formation of silver mirror
B. Dragendorf reagent
C. Lieberman-Burhardt reagent
D. Pezets reagent
E. Schiff
ANSWER: A
The drug ouabain is also known as:
A. Strophanthin-G
B. Strophanthin-K
C. Korglikon
D. Adonisid
E. Kardiovalen
ANSWER: A
Saccharic part of the digitalis secondary glycosides consists of three molecules:
A. D-Glucose
B. Digitoxose
C. D-Cymarose
D. L-Rhamnose
E. D-Oleandroze
ANSWER: B
By the chemical structure glucose is related to:
A. Polysaccharides
B. Disaccharides
C. Monosaccharides
D. Ketopentose
E. Aldopentose
ANSWER: C
Indicate starch formula:
A. C12H22O11
B. C5H10O5
C. (C6H10O5)n
D. C6H14O7
E. C6H12O7
ANSWER: C
Sucrose aqueous solution heating generates:
A. Beet sugar
B. Cane sugar
C. Lactose
D. Invert sugar
E. Tautorotation sugar
ANSWER: D
What analytical reaction effect is observed during the interaction of glucose
with the Feling reagent?
A. Crimson-violet formations
B. A yellow sediment
C. Formations of violet colour
D. Formations of red sediment
E. CO2 bubbles separation with the subsequent identification
ANSWER: D
One of the methods of glucose quantitative determination is the method of:
A. Acidimetry
B. Alkalimetry
C. Iodinometry
D. Permanganatometry
E. Complexometry
ANSWER: C
Which of the following saccharides relates to non-restorable glycosacchara:
A. Glucose
B. Lactose
C. Maltose
D. Sucrose
E. Fructose
ANSWER: D
Which molecule property results the optical activity of the glucose solution?
A. The tautomery characteristic
B. Changing of the solution refraction angle
C. The ability to rotate the polarized light plane as it passes through
the solution
D. Inversion phenomenon
E. Changes in the EMF solution
ANSWER: C
By its chemical structure the starch belongs to the group of:
A. Disaccharides
B. Monosaccharides
C. Proteoglycans
D. Polysaccharides
E. Peptidoglycans
ANSWER: D
What chemical compound when it’s heated forms caramel?
A. Glucose
B. Lactose
C. Starch
D. Sucrose
E. Amylose
ANSWER: D
In medical practice sucrose is used:
A. For the treatment of shock
B. For trituration manufacturing
C. For the manufacture of syrups
D. For collapse
E. For the treatment of radiation sickness
ANSWER: C
Which hydrocarbon belongs to the hexose class?
A. Starch
B. D-Ribose
C. Sucrose
D. Lactose
E. D-glucose
ANSWER: E
Indicate the sucrose formula:
A. C5H10O5
B. C5H12O5
C. C6H12O6
D. (C6H10O5)n
E. C12H22O11
ANSWER: E
What monosaccharide is in the lactose molecule?
A. D-(+)-mannose
B. D-(-)-ribose
C. D-galactose
D. D-fructose
E. L-fucose
ANSWER: C
What glucose properties determine the reaction with ammonia solution of silver
nitrate:
A. The ability to rotate the polarization plane of polarized light
B. Regenerative
C. Oxidative
D. The ability to polymerization
E. The ability to absorb light in the UV-area spectrum
ANSWER: B
Pharmacist-analyst conducts quantitative determination of glucose by the
iodinometry method. What is the molar mass of equivalent?
A. 1/3 М.m.
B. ¼ М.m.
C. ½ М. m.
D. М.m.
E. 1,5 M.m.
ANSWER: B
What of the following succharides is characterized by the inversion
phenomenon?
A. Maltose
B. Cellobiose
C. Lactose
D. Sucrose
E. Glucose
ANSWER: D
The interaction of glucose with mineral acids at time of heating forms:
A. Furfural
B. Acetone
C. Benzol
D. Methylolfurfural
E. Toluene
ANSWER: D
Determine the type of reaction which is used for the glucose identification:
A. Recovery
B. Polymerization
C. Polycondensation
D. Oxidation
E. Expansions
ANSWER: D
Angle measurement of the 10% glucose solution conversion is carried out by:
A. UV-spectrophotometer
B. Refractometer
C. Infrared spectrophotometer
D. Polarimeter
E. Photoelectrocolorimeter
ANSWER: D
Sucrose is used in medical practice:
A. As a means of enveloping
B. To slow down the absorption of drugs
C. For the trituration preparation
D. Antidote to heavy metal poisoning
E. Auxiliary for the preparation of medicines
ANSWER: E
Due to its chemical structure glucose belongs to:
A. Aldopentoses
B. Ketopentoses
C. Aldogeksoses
D. Desoxisaccharides
E. Ketogexoses
ANSWER: C
Indicate the lactose formula:
A. C5H10O5
B. C5H12O5
C. C6H12O6
D. C12H22O11
E. (C6H10O5)n
ANSWER: D
Which monosaccharide is a component of sucrose?
A. alpha-D-galactose
B. Amylose
C. beta-D-fructose
D. Amylopectin
E. D-digitoxose
ANSWER: C
In the interaction with which reagent glucose constitutes osasone?
A. Nessler reagent
B. Tollens reagent
C. Phenylhydrazine
D. Sorrel acid
E. Feling reagent
ANSWER: D
One of the glucose identification reactions held by rapid analysis method is the
interaction with:
A. Sodium to sodium, weak chloride acid
B. Alkaline beta-naphthol solution
C. Thorium nitrate
D. Thymol, concentrated sulphate acid
E. Milon basis
ANSWER: D
With what reagent solution lactose aqueous solution while heated is painted in
red?
A. Vanillin
B. Dimethylaminobenzaldehyde
C. Sodium nitroprusside
D. Ammoniac
E. Resorcin
ANSWER: E
Glucose is characterized by the phenomenon of:
A. Inversion
B. Dismutation
C. Polymerization
D. Gelatinization
E. Tautorotation
ANSWER: C
What glucose molecule fragment conditioned its property to rotate the polarized
light plane?
A. Aldehyde group
B. Alcoholic hydroxyls
C. Chirality centers
D. Carbon backbone chain
E. Tautomeric groups
ANSWER: C
One of the lactose identification reactions is the interaction with the reagent of:
A. Marky
B. Fisher
C. Copper-tartrate
D. Dragendorf
E. Molish
ANSWER: B
The quantitative content of glucose in solutions for injection is carried out by:
A. UV-spektoskopy
B. Refractometry
C. Photoelectrocolorimetry
D. Infared spectroscopy
E. Potentiometry
ANSWER: C
Chemical name of 2-Chlor-10-(3'-Dimethylaminopropyl)-Phenothiazine
Hydrochloride is:
A. Trifluoroperazine hydrochloride
B. Promethazine hydrochloride
C. Promazine hydrochloride
D. Chlorpromazine hydrochloride
E. Perphenazine hydrochloride
ANSWER: D
What reagent can be used for organic bounded sulfur in the bicillin-1 molecule?
A. Pb(CH3COO)2
B. NaOH solution
C. HNO3 conc.
D. HNO3 dil.
E. NaOH (solid), Pb(CH3COOH)2
ANSWER: E
Which of the following antibiotics has hygroscopic properties?
A. Bicillin-1, phenoxymethylpenicillin
B. Ampicillin sodium salt, benzylpenicillin sodium salt
C. Benzylpenicillin potassium salt, benzylpenicillin sodium salt
D. Cefazolin, ceftriaxone
E. Bicillin-5, benzylpenicillin Novocain salt
ANSWER: C
Biological activity of the natural penicillins is be expressed in:
A. DUA
B. RUA
C. CUA
D. UA
E. FUA
ANSWER: D
Which of the following antibiotics can be detected with ninhydrine solution?
A. Ampicillin, oxacillin
B. Amoxicillin, benzylpenicillin sodium salt
C. Ampicillin, amoxicillin
D. Cefalotin, cefalexin
E. Amoxiclav, bicillin-1
ANSWER: C
To the penicillins of the third generation the following preparation belongs:
A. Ceftriaxone
B. Amoxicillin
C. Amoxiclav
D. Ampicillin sodium salt
E. Oxacillin sodium salt
ANSWER: C
To the cephalosporin’s derivatives of 7-ADAC the following antibiotic belongs:
A. Cefalotin
B. Cephapirin
C. Cefuroxime
D. Cefaloridine
E. Cefaloglycine
ANSWER: D
Amoxiclav consists of:
A. Ampicillin, clavulanic acid
B. Amoxicillin, clavulanic acid
C. Amoxicillin, tienam
D. Amoxicillin, imipenem
E. Clavulanic acid, tienam
ANSWER: B
What reagent can be used for the carboxylic group detection?
A. NaOH
B. NH4OH
C. NaHCO3
D. Felling liquid
E. K3KFe(CN)6F
ANSWER: C
Antibiotic kefzol can be also named as:
A. Bicilllin-1
B. Bicillin-5
C. Cefazolin
D. Cefalexin
E. Cefaloridine
ANSWER: C
Which of the following preparations does belong to antibiotics-glycosides?
A. Gentamycin sulfate
B. Monomycin sulfate
C. Neomycin sulfate
D. Doxorubicin hydrochloride
E. Streptomycin sulfate
ANSWER: D
Medical drug amikacin sulfate belongs to the following antibiotic’s type:
A. beta-lactamide
B. Aminoglycoside
C. Macrolide
D. Polypeptide
E. Polyene
ANSWER: B