Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Carbapenem-resistant enterobacteriaceae wikipedia , lookup
Neglected tropical diseases wikipedia , lookup
Dirofilaria immitis wikipedia , lookup
Epidemiology of HIV/AIDS wikipedia , lookup
Sexually transmitted infection wikipedia , lookup
Oesophagostomum wikipedia , lookup
Anaerobic infection wikipedia , lookup
Coccidioidomycosis wikipedia , lookup
Neonatal infection wikipedia , lookup
Poster #19 The burden of serious fungal diseases in Japan Koichi Izumikawa1, Masato Tashiro1, Takahiro Takazono1, Shintaro Kurihara1, Tomomi Saijo2, Kazuko Yamamoto2, Yoshifumi Imamura2, Taiga Miyazaki1, Misuzu Tsukamoto1, Katsunori Yanagihara3, Hiroshi Mukae2, Shigeru Kohno2 and David W. Denning4 1 Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences 2 Department of Respiratory Diseases, Nagasaki University Graduate School of Biomedical Sciences 3 Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences 4 The University of Manchester and The National Aspergillosis Centre in association with the LIFE program at www.LIFE-Worldwide.org,. Contacts: Prof. Koichi IZUMIKAWA, M.D. [email protected] Phone: +81 (95) 819-7730 FAX: +81 (95) 819-7766 1-7-1 Sakamoto Nagasaki 852-8501, JAPAN Abstract Methods Recent syudies revealed the fungal infections have acquired high relevance rate all over the We searched for existing data and estimated the incidence and prevalence of fungal diseases world. A fungal burden in Japan was preliminary estimated by deterministic scenario based on the populations at risk and available epidemiological data. Data were derived from modelling and published incidence and prevalence data. the World Health Organization (WHO), The Joint United Nations Program on HIV/AIDS Vaginal candidiasis was the most frequent fungal infection revealed in this study, followed (UNAIDS) and national and regional published reports. When no data existed, risk by esophageal candidiasis and severe asthma with fungal sensitization (SAFS) and allergic populations were used to estimate frequencies of fungal infections, using previously bronchopulmonary aspergillosis (ABPA). described methodology by LIFE [1,2]. The incidence or prevalence of the above referred fungal infections and ~ 2,370,300 (1.9%) people in Japan suffer from those fungal infections each year. Further epidemiological Results and Discussion studies are needed to validate and extend these estimations. The population of Japan is ~127 million in 2015; 13% are children, and 30% are women >65 years. Introduction An estimated 1,525/100,000 females suffer from recurrent vulvovaginal candidiasis (>4 episodes/year) each year. Fungal infections have been increasing over the past decades due to the increased number of immunocompromised hosts with immunosuppressant, solid organ transplant, hematopoietic Oesophageal candidiasis affects 280/100,000 per year. stem cell transplant and others. The few data is currently available for their prevalence in the Candidaemia affects 6,350 patients, 40% of the total of invasive candidiasis (15,875), including an estimated 476 with intra-abdominal candidiasis. world, and it is important to estimate the actual fungal burden all over the world to understand the current scenario of these emergent infections. million adult asthmatics Cutaneous and fatal fungal infections have been studied extensively in Japan, and latterly chronic pulmonary aspergillosis. However, no estimate of the nationwide incidence and Invasive aspergillosis is estimated to affect 1,308, mostly in acute leukemia and after allogeneic stem cell transplantation. prevalence of fungal infections has been attempted. Here we estimate the burden of serious fungal infections in Japan. ABPA and SAFS were estimated in 20.8/100,000 and 27.5/100,000 respectively, in ~1 An estimated 3,957 have CPA after pulmonary tuberculosis (19,615 survivors in 2012) 50% of the total burden. Objectives Mucormycosis may affect 254 patients annually. We attempt the first estimate of the burden of serious fungal disease in Japan using There are no incidence data on tinea capitis or fungal keratitis, but probably both uncommon or rare. deterministic scenario modelling and published incidence and prevalence data. Table 1. Total burden of fungal infections estimated in Japan Infection Oesophageal candidiasis None Number of infections per underlying disorder per year HIV/AIDS Respiratory Cancer/Tx ICU Rate/100,000 Total burden 354,762 696 - - - 280 355,458 - - - 4,445 1,905 5 6,350 1,937,000 - - - - 1,525* 1,937,000 Allergic bronchopulmonary aspergillosis (ABPA) - - 26,452 - - 20.8 26,452 Severe asthma with fungal sensitization (SAFS) - - 34,914 27.5 34,914 Chronic pulmonary aspergillosis - - 7,914 - - 6.2 7,914 Invasive aspergillosis - - ?? 1,255 103 1 1,308 Mucormycosis ? ? ? 254 ? 0.2 254 Cryptococcal meningitis - 20 - - - 0.02 20 Pneumocystis pneumonia - 9 - - - 0.01 9 Candidemia Recurrent vaginal candidiasis (4x/year +) Total burden estimated 2,370,314 * rate for females only Conclusion The present study indicates that around to 1.9% (2,370,300) of the population is affected by a serious fungal infection, predominantly recurrent VVC in women in Japan. This is a preliminary study but constitutes the first report of the global burden of fungal infections in Japan. Further epidemiological studies are needed to validate and extend these estimates. [1] Denning DW, et al. Bull World Health Organ 2011; 89:864-72. [2] Denning DW, et al. Med Mycol 2013; 51:361-70