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1 For the week of 9thMay, 2011 All the work is due on Friday,13th May, 2011 For the diagrams, please refer your text book. The Skeletal System The human skeleton is composed of a type of connective tissue called bone. Bones and other connective tissues, such as cartilage and ligaments, form the skeletal system. The Skeleton Functions of the skeletonThe skeleton supports the body, protects internal organs, provides for movement, stores mineral reserves, and provides a site for blood cell formation. 1. Bones The bones that make up the skeletal system support and shape the body. Bones protect the internal organs of the body. They provide a system of levers on which muscles act to produce movement. Levers are rigid rods that can be moved about a fixed point. Bones contain reserves of minerals, mainly calcium salts, that are important to many body processes Bones are the site of blood cell formation. Blood cells are produced in the soft marrow tissue that fills the internal cavities in some bones. There are 206 bones in the adult human skeleton. Bones can be divided into axial skeleton ( it consists of the skull, the vertebral column, and the rib cage) and appendicular skeleton ( bones of arms and legs, along with the bones of the pelvis and shoulder area) Structure of BonesBones are solid network of living cells and protein fibres that are surrounded by deposits of calcium salts. The bone is made up of the following parts: Periosteum-The bone is surrounded by a tough layer of connective tissue called the periosteum. Blood vessels that pass through the periosteum carry oxygen and nutrients to the bone. Compact bone- Beneath the periosteum is a thick layer of compact bone. This bone is dense but not very solid. Running through 2 compact bone is a network of tubes called Haversian canals that contain blood vessels and nerves. Osteocytes- They are mature bone cells and are embedded in the bone matrix. Two other kinds of bone cells – osteoclasts and osteoblasts line the Haversian canals and the surface of the bony and spongy bone. Osteoclasts breakdown the bone and osteobalsts make the bone. Spongy bone- Spongy bone is a less dense tissue found inside the outer layer of compact bone. It is found in the ends of long bones and in the middle part of short, flat bones. It is a very strong bone. The latticework structure of the spongy bone helps to add strength to bone without adding mass. Bone marrow- Within bones are cavities that contain a soft tissue called bone marrow. There are two types of bone marrow- yellow and red. Yellow marrow is made up primarily of fat cells. Red marrow produces red blood cells, some kind of white blood cells and cell fragments called platelets. DEVELOPMENT OF BONESThe skeleton of an embryo is composed almost entirely of a type of connective tissue called cartilage. Unlike bone, cartilage does not contain blood vessels. Cartilage cells rely on diffusion of nutrients from the tiny blood vessels in surrounding tissues. Because cartilage is dense and fibrous, it can support weight, despite its extreme flexibility. Cartilage is replaced by bone during a process of bone formation called ossification. TYPES OF JOINTS A place where one bone attaches to another bone is called a joint. Depending on its type of movement, a joint is classified as immovable, slightly movable, or freely movable. Immovable Joints- They allow no movement. The bones are interlocked and held together by connective tissue or they are fused. For example- the bones of the skull. Slightly Movable joints – They permit a small amount of restricted movement. The bones are separated from each other. For exampleThe joints between the two bones of the lower legs and the joints between the adjacent vertebrae. Freely Movable Joints – They permit movement in one or more directions. They are grouped according to the shapes of the surfaces of the adjacent bones. For example- ball-and-socket joints permit movement in many directions; Hinge joints permit 3 back and forth motion, like the opening and closing of a door; Pivot joints allow one to slide in two directions. STRUCTURES OF JOINTS The joint capsule consists of two layers. One layer forms strips of tough connective tissue called ligaments which are attached to the membranes that surround bones. Cells in the other layer of the joint capsule produce a substance called synovial fluid. Synovial fluid enables the surfaces of the joint to slide over each other smoothly. THE MUSCULAR SYSTEM The main function of muscular system is movement. Types of muscle tissue There are three types of muscle tissue: skeletal, smooth, and cardiac. Skeletal Muscles Skeletal muscles are usually attached to bones. Skeletal muscles are responsible for voluntary movements. They are controlled by the central nervous system. Skeletal muscle cells are large, have many nuclei. And vary in length from 1 mm to about 30 cms. Complete skeletal muscles consist of muscle fibres, connective tissues, blood vessels and nerves. Smooth Muscles Smooth muscles are usually not under voluntary control. A smooth muscle cell is spindle- shaped, has one nucleus, and is not striated. They are found in the walls of hollow structures such as the stomach, blood vessels and intestines. Most smooth muscle cells can function without nervous stimulation. They are connected to one another by gap junctions that allow electrical impulses to travel directly from one muscle cell to a neighbouring muscle cell. Cardiac Muscle Cardiac muscles are found only in the heart. It is striated like skeletal muscle, although its cells are smaller. It is like smooth muscle because it is normally not under the direct control of the central nervous system and cardiac cells are connected to their neighbours by gap junctions. Muscle Contraction The muscle fibres in skeletal muscles are composed of smaller structures called myofibrils which in turn are made up of filaments. The striations in skeletal muscle cells are formed by thick filaments- myosin and thin filaments made of protein actin. The filaments are arranged in units called sacromeres, which are separated from each other by regions called Z lines. 4 A muscle contracts when the thin filaments in the muscle fibre slide over the thick filaments. This process is called the sliding filament model of muscle contraction. For a muscle to contract, the thick myosin filament must form a crossbridge with the thin actin filament. As the cross-bridge changes shape, it pulls on the actin filament, which slides toward the centre of the sacromere. The distance between the Z lines decreases. The crossbridge detaches from the actin filament. The cycle is repeated when the myosin binds to another site on the actin filament. When hundreds of thousands of myosin cross- bridges change shape in a fraction of a second, the muscle fibre shortens with considerable force. This energy is supplied by ATP. Control of Muscle Contraction Motor neuron and central nervous system are connected at neuromuscular junction. Vesicles or pockets, in the axon terminals of the motor neuron release a neurotransmitter called acetylcholine. Acetylcholine molecules diffuse across the synapse, producing an impulse in the cell membrane of the muscle fibre. The impulse causes the release of calcium ions (Ca2+) within the fibre. The calcium ions affect regulatory proteins that allow actin and myosin filaments to interact. From the time a nerve impulse reaches a muscle cell, it is only a few milliseconds before these events occur and the muscle cell contracts. A muscle cell remains contracted until the release of acetylcholine stops and an enzyme produced at the axon terminal destroys any remaining acetylcholine. Then, the cell pumps calcium ions back into storage, the cross-bridges stop forming, and the contraction ends. Muscle and Bone interaction Skeletal muscles are joined to bones by tough connective tissues called tendons. Tendons are attached in such a way that they pull on the bones and make them work like levers. The joint functions as a fulcrum- the fixed point around which the levers move. The muscle provides the force to move the lever. Most skeletal muscles work in opposing pairs. When one muscle contracts , the other relaxes. For controlled movement, however, contraction of both the muscles is required. Regular exercise is important in maintaining muscular strength and flexibility. THE INTEGUMENTARY SYSTEM The Skin- 5 The integumentary system serves as a barrier against infection and injury, helps to regulate body temperature, removes waste products from the body, and provides protection against ultra violet radiation from the sun. The skin is made up of two main layers- the epidermis and the dermis. Beneath the dermis is a subcutaneous layer of fat (the hypodermis) and loose connective tissue that help insulate the body. Epidermis- It is the outermost layer which also has two layers- the outer epidermis is made up of dead cells and the inner epidermis is made up of living cells. Cells in the inner layer undergo rapid cell division, producing new cells that push older cells to the surface of the skin. As they move upward , the older cell become flattened and their organelles distintegrate. They also begin making keratin, a tough fibrous protein. Later on these keratin producing cells die and form a waterproof coating. The epidermis also has melanocytes which are the cells which produce melanin. The main function of melanin is to protect the body from the harmful ultra violet radiations. Epidermis lack blood vessels. Dermis- is the inner layer. It contains collagen fibres, blood vessels, nerve endings, glands, sensory receptors, smooth muscles and hair follicles. The dermis contains two major glands – sweat glands and sebaceous glands which help in maintaining the homeostasis in the body. Skin Cancer- An excessive exposure to the ultra violet radiation in sunlight can produce skin cancer, an abnormal growth of cells in the skin. Hair and NailsHair- hair has important functions. They are made up of keratin. The hair on the head protects the scalp from ultraviolet light from the sun and provides insulation from the cold. Class work questions: Page 936, Q1, Q2, Q3, Q4, Q5, Q6 Page 939, Reviewing Content: Q1-Q10 Home work questions: Total points : 20 1. List the different functions of the skeletal system. 2. Describe the structure of a typical bone. 3. What is a joint? List the three types of joints. 4. How does compact bone differs from the spongy bone? 5. Why do you think the amount of cartilage decreases and the mount of bone increases as a person develops? 6 6. List the three types of muscle tissue and explain the function of each. 7. Explain how a muscle contracts. 8. Describe the importance of regular exercise. 9. If a muscle cell receives a second stimulus while it is contracting, will it respond to the second stimulus? Explain. 10. Osteoporosis is a disease that usually occurs in older women. It involves a los and weakening of bone tissue. Doctors recommend that all women eat more calcium rich foods. How might this be helpful in preventing osteoporosis? Critical thinking Questions Total Points : 15 1. Suppose you want to build a robotic arm that works the same way the human elbow works. Describe or sketch three facts about the elbow that you could use in your planning. 2. Assume you have a habit of leaning on your elbow while reading. One day, you notice that you have developed a painful swelling on your elbow. Formulate a hypothesis to explain what might have caused it. 3. How does a skeletal disorder, such as arthritis, affect the functioning of the body as a whole? Project : Total points:20 Although exercising can increase your strength and endurance, over exercising can have some adverse effects on the body. Use resources in the library or on the internet to find out what these adverse effects are. Summarize your findings in a paragraph. (It is compulsary to use at least two print resources)