Download Karyotyping Activity

VIRTUAL LAB: University of Arizona Karyotyping Activity
40 Points
In this activity, you will use a computer model to look at chromosomes and prepare a karyotype. You will
diagnose patients for abnormalities and learn the correct notation for characterizing karyotypes.
SITE 1
Go to: www.biology.arizona.edu - click on Karyotyping under human biology
OR
http://www.biology.arizona.edu/human_bio/activities/karyotyping/karyotyping.html
1. How are karyotype analyses conducted?
2. What are some uses of analyzing karyotypes?
3. What causes a dark band on the chromosome?
4. What is a centromere?
5. Which chromosome determines sex in humans? Is this an autosome or sex chromosome?
Click on Patient Histories. You will be completing a karyotype for Patient A, B & C.
Patient A (Click on the link to "Complete Patient A's Karyotype")
*Match the chromosome to its homolog. After all the matches are complete you'll analyze your patient. (Scroll down
to view your completed karyotype).
Look at the top left where it says place this chromosome etc. to see the chromosome,
then next to the sentence that says you got it correct to place the homologous
chromosomes after the first one.
6. What is patient A's history (summarize)
7.
How many total chromosomes are in your karyotype - count them _________
(The last set of chromosomes is the sex chromosomes, if you have two large chromosomes, your patient is XX (female),
one large and one small indicates and XY (male).
8. What sex chromosomes does your patient have ________
9. Which chromosome set has an extra + _______
10. What diagnosis would you give this patient (what disease)? ______________
Patient B - click on the link to go to Patient B and repeat the above process.
11. What is Patient B's history (summarize)
12. How many total chromosomes are in your karyotype - count them _________
13. What sex chromosomes does your patient have ________
14. Which chromosome set has an extra + _______
15. Finish the notation for this patient's karyotype : 47 X _____
16. What is the diagnosis? __________________________________
Patient C - click on the link to go to Patient C and repeat the above process.
17. What is patient C's history (summarize)? _________________________________
18. How many total chromosomes are in your karyotype - count them _________
19. What sex chromosomes does your patient have ________
20. Which chromosome set has an extra + _______
21. Write out the correct notation for this karyotype. ________
22. What is the diagnosis? _________________________________________
http://learn.genetics.utah.edu/content/chromosomes/karyotype/
Go to Making a Karyotype - Try it yourself
Create your own karyotype - turning on hints is okay.
23. What did you find difficult about matching the chromosomes? ____________________
SITE 2: Genetic Science Learning Center http://learn.genetics.utah.edu/content/chromosomes/
Click HOW DO SCIENTISTS READ CHROMOSOMES
(Browse all sections to learn more about Genetics)
Click on what is Heredity
24. What is heredity? __________________________________________
Click on what is a trait
25. List the types of traits that exist and what each trait means?
1._______________________________________________________________________
2._______________________________________________________________________
3._______________________________________________________________________
26. Alleles can also work together to produce_________________________.
27. What is the percent that all humans share identical DNA? ___________
Click on what are dominate and recessive
28. What is a sickle-cell disease? ___________________________________
29. The protest that causes malaria grows and reproduces in ________ blood cells
Click on Observable human characteristics
30. List at least 5 of the characteristics listed
1.___________________
2.___________________
3.___________________
4____________________
5.____________________
31. What percent of people can taste the PTC paper ___________? What percent of people can’t
taste the PTC paper___________?
Now click on PTC: Genes and bitter taste
32. How many common forms are there for the PTC gene? ______________
33. What are the three levels of tasting ability for PTC?
1._______________
2.______________
3.______________
Now click on genes and blood type
34. What it is blood?
_________________________________________________________________________
_________________________________________________________________________
_________________________________________________________________________
35. Blood plasma is packed with proteins called____________________________?
36. When conducting a blood transfusion, it is important to carefully match the _______and
__________ blood types.
37. List the different types of blood.
1.________
2.________
3.________
4.________
38-40.
Summarize what you have learned about Karyotypes
_____________________________________________________________
_____________________________________________________________
_____________________________________________________________