Download Reproductive Medicine

Reproductive Medicine
1. Maternal risk factors for low birth weight for term births in a developed
region in China: a hospital-based study of 55,633 pregnancies. J Biomed Res,
2013,27(1):14-22
Yihua Biana, b, Zhan Zhanga, Qiao Liua, Di Wua, Shoulin Wanga
a
State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China;
b
Department of Reproductive Health Care, Wuxi Maternal and Child Health Hospital
Affilaited to Nanjing Medical University, Wuxi, Jiangsu 214002, China.
Abstract: Low birth weight (LBW) is an important risk factor for neonatal and infant
mortality and morbidity in adults.. How-ever, no large scale study on the prevalence
of LBW and related maternal risk factors in China has been published. To explore the
effects of maternal factors on LBW for term birth in China, we conducted a
hospital-based retrospective study of 55, 633 Chinese pregnancy cases between 2001
and 2008. Maternal sociodemographic data, history of infer-tility and contraceptive
use were obtained. Their medical status and diseases during pre-pregnancy were
examined by physical examination at the first antenatal care visit. Maternal medical
status before childbirth and pregnancy outcomes, including body weight, infant
gender, multiple pregnancy and congenital anomalies, were recorded. Univariate and
multivariate logistic regression, and linear regression were used to investigate the
relationship be-tween maternal factors and term LBW. The general incidence of term
LBW was 1.70% in the developed area of China. After preliminary analysis using the
univariate model, low primary education, anemia, hypertensive disor-ders, placental
previa, oligohydramnios and premature rupture of membrane were predicted as
independent factors of term LBW in the multivariate model. Furthermore, the
decrease in annual frquencies of these risk factors were major causes of gradual
decline in the incidence of LBW (from 2.43% in 2001 to 1.21% in 2008). The study
dem-onstrated that among maternal factors, primary education, anemia and
hypertensive disorders could contribute to LBW for term birth even in the most
developed area of China.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR130102&flag=1
2. Asymptomatic seminal infection of herpes simplex virus: impact on male
infertility. J Biomed Res, 2013,27(1):51-55
Seyed Hamidreza Monavaria, Mostafa Salehi Vazirib, Mohammadali Khalilic,
Mahmoud Shamsi- Shahrabadib, Hossein Keyvanib, Hamidreza Mollaeib, Mehdi
Fazlalipourb
a
Department of Virology and Anti -Microbial Resistant Research Center, Tehran
University of Medical Sciences, Tehran 1417613151, Iran;
b
Department of Virology, Tehran University of Medical Sciences, Tehran
1417613151, Iran;
c
Research and Clinical Center of Infertility, Yazd 8916877391, Iran.
Abstract: In more than half of infertile men, the cause of their infertility is unknown.
Several studies revealed the role of viral infections in male infertility. The aim of the
present study was to determine the prevalence of herpes simplex virus-1 (HSV-1) and
HSV-2 in semen from asymptomatic infertile male patients, and its association with
altered semen parameters. A total of 70 semen samples were collected from infertile
men who attended the Research and Clinical Center for Infertility in Yazd, Iran.
Semen analysis and diagnostic real-time PCR using specific primers and probes for
HSV-1 and HSV-2 DNA were performed. Comparison of semen parameters between
virally in-fected and non-infected samples were performed with independent t-test and
Mann-Whitney test. Semen analysis showed that infertile men fell into two groups,
the male factor group and the unexplained group. HSV-1 and HSV-2 DNA was
detected in 16 (22.9%) and 10 (14.3%) of 70 semen samples, respectively. All
HSV-positive samples had abnormal semen parameters (the male factor group).
Although HSV infection was not associated with sperm motility and morphological
defects, it was correlated with lower sperm count in the seminal fluid. The findings
suggest that asymptomatic seminal infection of HSV plays an important role in male
infertility by adversely af-fecting sperm count.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR130108&flag=1
3. Etiological risk factors for subfertility among Palestinian women in Gaza. J
Biomed Res, 2013,27(2):127-134
Mahmoud Mohammed Sirdaha, Abdelnasser Kassem Abushahlaa, Bahaa Yousif
Ghalayenib,c, Ahmed Gamel Aburamadana
a
Biology Department, Al Azhar University Gaza, Palestine;
b
c
Alawda Maternity Hospital, Gaza, Palestine;
Al Basma Fertility Center, Gaza, Palestine.
Abstract: The inability to procreate is frequently considered a personal tragedy and a
hardship for couples, impacting on the entire family and even the local community. In
Gaza strip, Palestine, there has been no study on etiological risk factors for subfertility.
The present study aimed to identify risk factors associated with subfertility among
women in Gaza, Palestine. One hundred and sixty-nine women in the study group and
115 women in the control group were included. Cases were selected randomly from
those referred to the Al Basma Fertility Center, Gaza, Palestine. Data were collected
through close-ended questionnaire, sonography, hormonal analysis and thrombophilia
profile that included the methylenetetrahydrofolate reductase (MTHFR 677 C > T),
factor V leiden (1691 G > A) and prothrombin (20210 G > A) genes. By using
univariate analyses, the effects of different patient-related variables on the presence of
subfertility were evaluated. A multiple logistic regression model was constructed,
crude and adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were
calculated. The findings showed that 73.5 % (169/230) of the women referred to the
Al Basma Center sought treatment for subfertility. Different etiological risk factors
were associated with subfertility, the most frequent of which in descending order were:
thrombophilic disorders, fallopian tube problems, sex hormone abnormalities and
polycystic ovary syndrome with an adjusted OR of 21.42, 13.63, 11.69 and 10.29,
respectively. In conclusion, several etiological risk factors are responsible for
subfertility among women in Gaza. Comprehensive evaluation of infertile women
should be considered in the course of treatment; otherwise, the duration of sterility
may be extended.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR130206&flag=1
4. Low dose bisphenol A impairs spermatogenesis by suppressing reproductive
hormone production and promoting germ cell apoptosis in adult rats. J
Biomed Res,2013,27(2):135-144
Pengpeng Jina,b,c, Xiaoli Wangb, Fei Changb, Yinyang Baia,b, Yingchun Lib, Rong
Zhoub, Ling Chena, b
a
State Key Laboratory of Reproductive Medicine, Nanjing Medical University,
Nanjing, Jiangsu 210029, China;
b
Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 210029,
China;
c
Department of Physiology, Wenzhou Medical College, Wenzhou, Zhejiang 325000,
China.
Abstract: Bisphenol A (BPA), an estrogenic chemical, has been shown to reduce
sperm count; however, the underlying mechanisms remain unknown. Herein, we
show that oral administration of BPA (2 μg/kg) for consecutive 14 days in adult rats
(BPA rats) significantly reduced the sperm count and the number of germ cells
compared to controls. The serum levels of testosterone and follicle-stimulating
hormone (FSH), as well as the level of GnRH mRNA in BPA rats were lower than
those of control rats. Testosterone treatment could partially rescue the reduction of
germ cells in BPA rats. Notably, the number of apoptotic germ cells was significantly
increased in BPA rats, which was insensitive to testosterone. Furthermore, the levels
of Fas, FasL and caspase-3 mRNA in the testicle of BPA rats were increased in
comparison with controls. These results indicate that exposure to a low dose of BPA
impairs spermatogenesis through decreasing reproductive hormones and activating the
Fas/FasL signaling pathway.
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR130207&flag=1