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Non-communicable diseases (NCDs) 1 Non-communicable diseases (NCDs) Is a disease which is not infectious. Such diseases may result from genetic or lifestyle factors. A non-communicable disease is an illness that is caused by something other than a pathogen. It might result from hereditary factors, improper diet, smoking, or other factors. Those resulting from lifestyle factors are sometimes called diseases of affluence. Examples include hypertension, diabetes, cardiovascular disease, cancer, and mental health problems, asthma, atherosclerosis, allergy etc. The non-communicable diseases are spread by: heredity, surroundings and behavior. 2 The risks of high blood pressure and high blood cholesterol, tobacco and alcohol consumption, obesity and physical inactivity were more commonly associated with affluent societies. Warning: becoming dominant in all middle and low income countries and not limited to the effluent countries. NCDs, is responsible for almost 60% of world deaths (31.7 million deaths) and 43% of the global burden of diseases. 3 This increase is clearly related to changes in global dietary patterns and increased consumption of industrially processed fatty, salty and sugary foods. 4 NCDs Situation in Palestine: NCDs are the leading cause of death among adult population in the Palestinian society, contribute to more than 50% of causes of death among adults common Risk factors to NCDs in Palestinian population. Tobacco consumption is among the highest in the world. Diet rich in saturated fat, and in simple sugars, with the decreased consumption of fibers and whole grain foods has lead to the increased prevalence of these illnesses. 5 Health services today will not be able to meet the challenges of (NCDs) In Palestine Weak national data is available on the overall incidence and prevalence of NCDs. In general we depend on mortality data to estimate the impacts of these diseases. No classification by age or gender. No any information on disabilities resulting from any of the chronic diseases The current system counts mainly the visits of the patients to PHC centers, which does not reflect the real prevalence and incidence. Fragmentation in reporting and managing system regarding NCDs in general. This lack of information leads to: - Inability to estimate the cost; resources required e.g. drugs, policy; and decision making regarding prevention and treatment 6 Some Continuing Challenges Lack of national policies for NCD prevention and control Low resources for NCD prevention & control. Lack of NCD surveillance systems Fragmented and uncoordinated care PHC capacity to deal with NCDs is poor … 7 NCD CHALLENGES Cost Pressures Disease burden, interventions, drugs CHANGES NEEDED Quality of Care Care teams, medical records, & financial incentives Information flows Continuity Organized Care Communication With policy/legislation support Coordination Prevention Fragmentation, lack of protocols, lack of financial incentives/support Poverty Comprehensiveness Orient. on self management Community linkages 8 How to strengthen health systems for NCDs? Financing (increased, better and sustained Regulation (assured quality and affordability) Service Delivery (ensured access and availability) Governance (improved performance) 9 Obesity 10 11 12 Obesity is a condition in which people have an excess of body fat. According to the National Institutes of Health, almost one-third of Americans are obese. Obesity is growing problem across the globe. Worldwide, more than 300 million adults are obese, according to (WHO). Obesity is the second-leading cause of preventable death in the U.S, surpassed only by smoking. At least 300,000 Americans die each year as a result of factors attributed to obesity, American Obesity Association 13 Obesity is a major risk factor for a number of serious health conditions, including: Coronary heart disease. Cancer. Diabetes. Fatty liver disease. Gallbladder disease. High blood pressure.. Osteoarthritis. Stroke. Sleep apnea and other breathing problems. 14 Classification Obesity, in absolute terms, is an increase of body adipose tissue (fat tissue) mass. BMI Body mass index or BMI is a simple and widely used method for estimating body fat mass. 15 BMI is an accurate reflection of body fat percentage in the majority of the adult population. It is less accurate in people such as body builders and pregnant women in whom body composition is affected. BMI is calculated by dividing the subject's weight by the square of his or her height: BMI = kg / m2 16 BMI Classification Less than 18.5 underweight 18.5–24.9 normal weight 25.0–29.9 is overweight 30.0–34.9 is class I obesity 35.0–39.9 class II obesity 17 Questions ?? 18 The literature breaks down "class III" obesity into further categories: Any BMI > 40 is severe obesity A BMI of 40.0–49.9 is morbid obesity A BMI of >50 is super obese Finish 19 Cancer 20 Cancer medical term: (malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth, invasion and sometimes metastasis (spread to other locations in the body via lymph or blood) . 21 Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. 22 23 24 25 26 2006 Estimated US Cancer Deaths* (last) Lung & bronchus 31% Colon & rectum 10% Men Women Lung & bronchus 26% Breast 15% Prostate 9% Colon & rectum 10% Pancreas 6% Pancreas 6% Leukemia 4% Ovary 6% Liver & intrahepatic bile duct 4% Leukemia 4% 3% Esophagus 4% Non-Hodgkin lymphoma Uterine corpus 3% Multiple myeloma 2% Non-Hodgkin lymphoma 3% Urinary bladder 3% Kidney 3% All other sites Brain/ONS 2% All other sites 23% 23% ONS=Other nervous system. Source: American Cancer Society, 2006. 27 Cardiovascular Disease 28 Introduction Non communicable disease account for a large and increasing burden of disease worldwide. It is currently estimated that non communicable disease accounts for approximately 59% of global deaths and 43% of global disease burden. This is projected to increase to 73% of deaths and 60% of disease burden by 2020. 29 Introduction, cont. The worldwide burden of cardiovascular disease is substantial. In most industrialized countries, cardiovascular disease are the leading cause of disability and death. Developing countries, with previous low rate are now seeing increased rates as economic develop, infectious disease are controlled and life expectancy improves. 30 Definition Cardiovascular disease refers to the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system, it is usually used to refer to those related to atherosclerosis (arterial disease). 31 CVD are present in many forms and have different categories and include: Hypertension (high blood pressure) Coronary heart disease (heart attack) Cerebrovascular disease (stroke) Peripheral vascular disease Heart failure Rheumatic heart disease Congenital heart disease Cardiomyopathies 32 Risk factors for cardiovascular disease Non-modifiable Risk Factors Age Gender, men under the age 64 are much more likely to die of coronary heart disease than women, although anyone can die from it. Genetic factors/Family history of cardiovascular disease. Race (or ethnicity), Studies show that blacks are twice as likely to develop high blood pressure as Caucasians. Environment, your chances can increase because of areas with a lot of smog or other form of air pollution, including passive smoking 33 Risk factors, cont. Modifiable Risk Factors cigarette smoking, high cholesterol and high blood Pressure, lack of exercise, diabetes, obesity, alcohol, certain infections and inflammation, estrogens, androgens, and certain psychosocial factors. 34 Risk factors for CVD in Palestine There is little published information on the cardiovascular disease risk factors of Palestinian population. A study done to identify the most common coronary heart disease risk factors among adult population in Gaza Strip to develop preventive health education and health promotion programs 35 This study showed that the most common identified CHD risk factors were physical inactivity 53%, hypertension and obesity 43% for each, family history 38%, diabetes mellitus 34%, high LDL 34%, elevated cholesterol level 33%, smoking 29%, low HDL 27%, hyperuricemia 25%, and elevated triglycerides level 14% 36 The result of previous study seems to be that most of the identified CHD risk factors could be preventable. These results may highlight the problem as a public in nature that need community-based intervention programs integrated to health education programs. 37 Global Burden of Cardiovascular Disease Cardiovascular disease is the number one cause of death globally and is projected to remain the leading cause of death. An estimated 17.5 million people died from cardiovascular disease in 2005, representing 30 % of all global deaths. Of these deaths, 7.6 million were due to heart attacks and 5.7 million were due to stroke. 38 Statistics, cont Around 80% of these deaths occurred in low and middle income countries . If appropriate action is not taken, by 2015, an estimated 20 million people will die from cardiovascular disease every year, mainly from heart attacks and strokes. (WHO, 2005) 39 Cardiovascular disease in Palestine Cardiovascular disease (CVDs), principally heart diseases is the first leading cause of death among population in Palestine in the year 2005 exactly as it is in the whole world. 40 There are no available data to suggest the overall prevalence or incidence of cardiovascular disease and hypertension, we depend on mortality data from the different health centers to estimate the impact of theses diseases on society. finish 41 Diabetes Mellitus 42 Definition of DM Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin, or alternatively, when the body cannot effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar 43 Glucose Tolerance Categories 2-hr PG on OGTT FPG mg/dL 126 100 and <126 <100 mg/dL Diabetes Mellitus Prediabetes Glucose Normal 200 Diabetes Mellitus 140 and <200 Prediabetes Tolerance <140 Normal The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2002;25(suppl):S5 44 Etiologic Classification of Diabetes Mellitus Type 1 b-cell destruction with lack of insulin Type 2 Insulin resistance with insulin deficiency Other specific types exocrine Genetic defects in b-cell pancreas diseases drug- or chemical induced, and other rare forms Gestational Insulin resistance with b-cell dysfunction Adapted from The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183-1197. 45 Complications of Diabetes Macrovascular Brain Cerebrovascular disease • Transient ischemic attack • Cerebrovascular accident • Cognitive impairment Heart Coronary artery disease • Coronary syndrome • Myocardial infarction • Congestive heart failure Extremities Peripheral vascular disease • Ulceration • Gangrene • Amputation Microvascular Eye Retinopathy Cataracts Glaucoma Kidney Nephropathy • Microalbuminuria • Gross albuminuria • Kidney failure Nerves Neuropathy • Peripheral • Autonomic 46 "Diabetes is a major threat to global public health that is rapidly getting worse, and the biggest impact is on adults of working age in developing countries. At least 171 million people worldwide have diabetes. This figure is likely to more than double by 2030 to reach 366 million." 47 GLOBAL PROJECTIONS FOR THE DIABETES EPIDEMIC: 2003-2030 (millions) World 2003 = 194 million 2030 = 366 million Increase 75% 48 Epidemiology Diabetes is in the top 10 and perhaps the top 5 of the most significant diseases in the developed world. 49 Prevalence of DM in Palestine The prevalence of DM in Palestine is about 9% in 2005. It is around the reported prevalence rate in Egypt and Tunisia (9%) and less than in Saudi Arabia (12%) and Oman (13%). 50 The gap between the expected prevalence rates of DM and cases under supervision reflects under registration and underreporting and also requires special efforts to accelerate early case finding activities in order to avoid high cost of treating the complications and disability consequences of the disease . 51 Major risk factors Family history Obesity Age (older than 45) History of gestational diabetes High cholesterol Hypertension 52 Prevention of effects combination approach Increased exercise Decreases need for insulin Reduce calorie intake Improves insulin sensitivity Weight reduction Improves insulin action 53 Triad of Treatment Diet Medication Oral hypoglycemics Insulins Exercise 54 Diet Lower calorie Fewer foods of “high glycemic index” Spread meals evenly 55 Diabetic Meal Plan Using the Food Guide Pyramid 56 Anti-Diabetic medications Oral hypoglycemic agents Insulin 57 58 Thanks … 59