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CURRICULUM VITAE NAME: Martin I. Surks, M.D. OFFICE: Montefiore Medical Center 111 East 210 Street Bronx, New York 10467 Telephone: 718-920-4332 Fax: 718-920-5202 Email: [email protected] [email protected] EDUCATION, TRAINING, EXPERIENCE: College: Columbia College, A.B., June 1956 Medical School: New York University - Bellevue College of Medicine, M.D. - June 1960 Internship: Montefiore Hospital (mixed Medical - Surgical Internship), July 1960 to June 1961 (Chief: Dr. Louis Leiter) Junior Assistant: Montefiore Hospital, July 1961 to June 1962 Residency (Medicine): Chairman: Dr. Louis Leiter Senior Assistant: Veterans Administration Hospital, Bronx, NY Residency (Medicine): July, 1962 to June, 1963 (Chairman: Dr. Julius Wolf) Fellowship: Military Service: Postdoctoral Research Fellow, National Institute of Arthritis and Metabolic Diseases. July, 1963 to June, 1964, Montefiore Medical Center, Dr. Jack H. Oppenheimer U.S.Army, Captain M.C. –Chief, Radioisotope Section, 1 Laboratory: Physiology Division, U.S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital Denver, Colorado, July 1964 to July 1966 Sabbatical: Visiting Scientist, Dept of Developmental Biology & Cancer, Albert Einstein College of Medicine, Bronx, New York (Laboratory: Dr. Jerard Hurwitz), January 1980 - June 1980 APPOINTMENTS: Professor of Medicine, Albert Einstein College of Medicine, Bronx, New York, 1978- Professor of Pathology, Albert Einstein College of Medicine, Bronx, New York, 1994- Professor of Laboratory Medicine, Albert Einstein College of Medicine, Bronx, New York, 1985 - 1994 HOSPITAL RANK: Program Director, Division of Endocrinology Albert Einstein College of Medicine, Bronx, NY 1997Head, Division of Endocrinology and Metabolism Montefiore Medical Center, Bronx, New York, 1976-1997 Attending Physician, Montefiore Medical Center 1981- Attending Physician - Medicine-Consultant in Endocrinology, North Central Bronx Hospital, Bronx, New York 1976 –1999; 2000Co-Director: Endocrine Research Laboratory, Montefiore Medical 2 Center 1967-1976. 3 RESEARCH: Principal Investigator: US Army Medical Research Contract #DA49 193-MD02967, 1966-1974 Research Career Development Award: USPHS 1 K04 AM 19502, 1973-77 Principal Investigator: American Cancer Society, BC-199, "Triiodothyronine Receptors and Thyrotroph Neoplasia", 1975-77 Director, Training Grant in Investigative Endocrinology, Montefiore Medical Center and the Albert Einstein College of Medicine 1 T32 AM 07004, July 1, 1976 - 1995 Principal Investigator: National Cancer Institute 1 R01 CA 24604 "Triiodothyronine Receptors and Nonthyroidal Diseases", 1979 - 1991 Principal Investigator: USPHS 1 RO1 CA 16463, "Triiodothyronine Effects on Cell Regulation", 1974 - 1992 LICENSURE: 1. Diplomate, National Board of Medical Examiners, June, 1961. 2. New York State Medical License # 086301. 3. New York City Radioactive Materials License #146-3 and 146-8. 4. New York City Clinical Laboratory Director License #56-031284. 5. New York State - Laboratory Director License Endocrinology 2000- SPECIALTY CERTIFICATION: 1. Internal Medicine, December 6, 1967. 2. Endocrinology & Metabolism, October, 1977. 4 SOCIETIES: 1. New York Zoological Society, August, 1961 2. American Federation for Clinical Research, December, 1963- 1990 3. Endocrine Society, June, 1967 -. 4. Harvey Society, May, 1968 - 1988 5. American Physiology Society, 1968-1984. 6. American College of Physicians, 1971 7. American Thyroid Association, November, 1969 8. American Association for the Advancement of Science, 1970 -2008 9. American Society for Clinical Investigation, 1972 – 2005 (Emeritus) 10. European Thyroid Association, Corresponding Member, 1974 - 1988 11. Association of American Physicians, 1981 – 2005 (Emeritus) 12. American Society for Cell biology, 1985 - 1992. 13. Interurban Clinical Club, 1986 (Councilor 1987-89) 14. American Association of Clinical Endocrinologists, 1994 - AWARDS: 1. New York State Regents Scholarship, 1952. 2. Phi Beta Kappa, 1956. 3. Henry Moses Award (1st Prize), 1966, Montefiore Medical Center Alumni Association. 4. Schering Travel Fellow of the Endocrine Society for the Third International Congress of Endocrinology, Mexico City, June 1968. 5. Fellow, American College of Physicians, 1971- 2001. 5 6. The Annual Van Meter Prize, American Thyroid Association, Seattle, Washington, 1973. 7. Physician Recognition Award, American Medical Association, 1976;1980. 8. Alpha Omega Alpha, N.Y.U. Bellevue College of Medicine, 1986 (Distinguished Alumnus). 9. Special Honoree Award, The Staff and Alumni Association of Montefiore Medical Center, March 31, 2001. 10. Master, American College of Physicians, 2002 11. Distinguished Service Award, American Thyroid Association, 2002 12. Endocrine Fellows Foundation Visiting Lectureship, 2002-2003 13. Sidney H. Ingbar Distinguished Service Award, Endocrine Society, 2010 INVITED MAJOR LECTURES AND SYMPOSIA: 1) "ENDOCRINE ADAPTATIONS TO HIGH ALTITUDE EXPOSURE" Acclimatization Panel of the Symposium on Biomedical Problems Associated with Living and Working at High Terrestrial Elevations, Natick, Massachusetts, October, 1967. 2) "ALTERATIONS IN THYROID PHYSIOLOGY DURING EXPOSURE TO HIGH ALTITUDE" Symposium on Military and Environmental Nutrition, Denver, Colorado, October, 1969. 3) Van Meter Award Lecture, American Thyroid Association, Seattle, Washington, September, 1973. 4) "STUDIES ON THE MECHANISM OF THYROID HORMONE ACTION" Gordon Research Conference on Hormonal Action, August 1974. 5) "NUCLEAR RECEPTORS FOR THYROID HORMONES: APPLICATION TO THYROID HORMONE ACTION" 30th Annual Postgraduate Assembly, Endocrine Society, Miami, Florida, October 1978. 6 6) "L-THYROXINE FOR HORMONAL REPLACEMENT AND TSH SUPPRESSION" Dedication Seminar, Shaare Zedek Medical Center, Jerusalem, November, 1978. 7) "SELECTION AND INTERPRETATION OF THYROID FUNCTION TESTS" 31st Annual Postgraduate Assembly, Endocrine Society, Rochester, Minnesota, October, 1979. 8) "ASSESSMENT OF THYROID FUNCTION" 32nd Annual Postgraduate Assembly, Endocrine Society, New York, NY, October 1980. 9) "METHODS FOR STUDYING T3 NUCLEAR RECEPTORS" Meet the Professor Seminar, 63rd Annual Meeting, The Endocrine Society, June, 1981. 10) Visiting Professor, University of Toronto Medical School, Toronto, Canada, May, 1982. 11) Fourth Research Workshop, The Thyroid Foundation, Mechanisms of Action of the Thyroid Hormones, Tucson, Arizona, October 15-16, 1983. 12) "BIOLOGY OF THYROID HORMONE NUCLEAR RECEPTORS" Symposium: Molecular Biology of Thyroid Hormone; 3rd Joint Meeting of British Endocrine Societies, Edinburgh, U.K., March, 1984. 13) Endocrine Update, Annual Meeting of the American College of Physicians, Atlanta, Georgia, April, 1984. 14) "CLINICAL IMPLICATIONS OF NONTHYROIDAL DISEASE" Annual Meeting of the American Thyroid Association, Phoenix, Arizona, September, 1986. 15) Thyroid Hormone Therapy, 69th Annual Meeting, The Endocrine Society, June, 1987. 16) "THE DIAGNOSIS OF THYROID DISORDERS IN THE CRITICALLY ILL AND THE ELDERLY". American Thyroid Association Workshop on Thyroid Disease, New York, New York, November 1988. 17) TREATMENT OF HYPOTHYROID PATIENTS. Ibid. 18) "THYROID HORMONE REPLACEMENT: TRIUMPHS AND PROBLEMS", "THYROID FUNCTION IN NONTHYROIDAL DISEASES", and "CELL CYCLE REGULATION OF T3 RECEPTOR FUNCTION". Fifth Boris Catz Thyroid Lectureship, Cedars-Sinai Medical Center, Los Angeles, CA. November 1988. 19) Recent Advances in the Diagnosis and Treatment of Endocrine Disorders. American College of Physicians, New York Scientific Meeting, New York, N.Y. March 1992. 20) Seventh Annual Isidore N. Rosenberg Lecture. Framingham MA, November 9, 1992, 7 Molecular Advances in the Understanding of Thyroid Disease. 21) Issues in Management of Thyroid Cancer: Endocrine Society, Las Vegas, NE, June 1993. 22) Visiting Professor in Endocrinology - University of Miami School of Medicine (3 lectures). January 1994. 23) Thyroid Cancer - A Case - Based Approach, Endocrine Society, 1994. 24) Visiting Professor - Emory University, September 1994 (2 lectures). 8 25) Thyroid Grand Rounds - American Association of Clinical Endocrinology - Annual Meeting - April 1995. 26) Visiting Professor - University Southern California, April, 1996 (2 Lectures) 27) Visiting Professor - University of Florida, July 1996 28) Visiting Professor - University of Connecticut Medical Center, October 1996 29) Visiting Professor - Hahneman-Jefferson Medical College, October 1996 30) Visiting Professor - University of Toronto Medical College, January 1997 31) Visiting Professor - Johns Hopkin's Medical School, April 1997 32) Visiting Professor - SUNY - Stoneybrook, May 1997 33) Thyroid Disease in the Elderly: Screening out the Consequences Annual Meeting American Association of Clinical Endocrinologists, April 1997 34) Treatment Issues in Hypothyroidism. Annual Meeting of the Endocrine Society, June 1997 35) Visiting Professor - New York Medical College - November 1997 36) Visiting Professor - Tufts New England Medical Center - January 1998 37) Meet the Professor: Evaluation of the Thyroid Nodule. Endocrine Society – June 1999 38) Visiting Professor: Cornell University College of Medicine – March 2000. 39) Why Treat Mild Thyroid Failure Anyway? CME Program: Annual Meeting of the Endocrine Society – June, 2000. 40) Visiting Professor, Boston University College of Medicine: ‘Thyroid disorders due to abnormal regulation of c AMP’ – February 2001. 41) Visiting Professor, University of Louisville School of Medicine, February 2001 42) Visiting Professor, University of Medicine and Dentistry of New Jersey, April 2002 43) Faculty: AACE Endocrine University, Mayo Clinic, Rochester , MI April 2002: 9 Clinicians Approach to the Thyroid Nodule. 44) Visiting Professor: Sinai Hospital, Baltimore. MD March 2004 44) Visiting Professor, New York Medical College, March 2005 45) Visiting Professor, University of Toronto College of Medicine, May 2005. 46) The TSH Normal Range, New York Thyroid Club, October 2005 47) Visiting Professor, Case Western Reserve College of Medicine, April 2006 48) Invited speaker, Philadelphia Endocrine Club; St-Lukes Roosevelt Endocrine rounds; 49) Visiting Professor, New York University School of Medicine (2009) 50) Visiting Professor, Cornell, Division of Endocrinology (2009) 51) Visiting Professor, New York Medical College (2010) 52) Visiting Professor, Columbia College of Physicians and surgeons EDITORIAL BOARDS: Endocrinology, 1974 - 1978 Endocrine Research, 1974 - 2007 American Journal of Physiology: Endocrinology & Metabolism, 1982-1985 Journal of Clinical Endocrinology and Metabolism, 1991 - 1994 Thyroid, 2001 - 2010 ASSOCIATE EDITOR: Endocrinology, January 1986 - December 1987. 10 AMERICAN BOARD OF INTERNAL MEDICINE: Member, Subspecialty Committee on Endocrinology, Diabetes & Metabolism, 19861995 Chairman, Subspecialty Committee on Endocrinology, Diabetes & Metabolism, 1991-1995 Director, American Board of Internal Medicine, 1991-1995 Member: Committee on Credentials, 1991-1995 Committee Subspecialty Internal Medicine, 1991-1995 Membership Nominating Committee, 1993 - 1994 Examination Selection Committee, 1994 - 1995 Certifying Examination Committee, 1995 - 1997 Clinical Competence Program, 1991 - 1995 Emeritus Member, 1995 Hospital Visit Program, 1991 – 2004. AMERICAN COUNCIL FOR GRADUATE MEDICAL EDUCATION: Residency Review Committee: Previewer of Endocrinology Programs, 1994 – 1998 INSTITUTE OF MEDICINE: Consultant: Review of Recombinant TSH, April 1998 11 WORLD HEALTH ORGANIZATION: Consultant: Stable Iodine Prophylaxis Following Nuclear Accidents, September 1998 GRANT REVIEWS: Veterans Administration Merit Review Board in Endocrinology, 1976-1979 Ad Hoc Reviewer, Endocrinology Study Section, NIAMDD, NIH, 1976-1981 l985, 1988, 1989 Member, Endocrinology Study Section, NIH 1981-1985 Thyroid Research Advisory Council, 1995 – 1996 OTHER PROFESSIONAL RESPONSIBILITIES: LOCAL: Coordinator: Thyroid Core Curriculum, Albert Einstein College of Medicine, 1969Service on other University committees: Curriculum, Ad Hoc Promotions, Graduate Medical Education. Coordinating Committee, Department of Medicine, Albert Einstein College of Medicine, 1975-1977; 1978-1980 Member, Faculty Senate of Albert Einstein College of Medicine 1976-1978 Member, Radioisotope Committee for Human Use, Albert Einstein College of Medicine 1976-1979 Member, Research Drug Subcommittee of Research Committee, Montefiore Medical Center 1976-1980 Internal Scientific Advisory Committee, Diabetes Research and Training Center, Albert Einstein College of Medicine 1977-1979 Library Committee, Montefiore Medical Center, 1976-1979 12 Research Space Committee, Montefiore Medical Center 1979-1980 13 Member, Radioisotope Committee for Nonhuman Use, Montefiore Medical Center 1979Search Committee for Chairman, Obstetrics & Gynecology, Albert Einstein College of Medicine 1986-1987 Research Committee, Montefiore Medical Center 1980-1981 Chairman, Montefiore Medical Center Research Group, 1980-1981 Lecturer, Advanced Biochemistry, Albert Einstein Col. of Med. 1982-1984 Research Policy Advisory Group, Montefiore Medical Center, 1985-1987 Search Committee for Chairman of Ophthalmology, Albert Einstein College of Medicine, 1986-1987 Research Committee, Department of Medicine, Albert Einstein College of Medicine, 19861987, 1991 Biomedical Science Pathways, Seminar Speaker, Albert Einstein College of Medicine l987l989 Faculty Advisor, Class of 1989, Albert Einstein College of Medicine 1987-1989 Committee for Renovation of Klau Pavillion, 1987-1989 Research Misconduct Policy Committee 1989-1990 Finance Committee, Department of Medicine 1985-1990 Director, Department of Medicine Research Seminar 1976 - 1995 Research Policy Advisor Group 1988 - 1992 Managed Care Committee 1990 - 1994 Residency Committee 1991 - 1994 Joint Advisory Committee, Department of Medicine 1988 –2000. Research Committee 1991-1994 Search Committee - Director, Cancer Center, Albert Einstein College of Medicine, 1994 1995. 14 AECOM Committee on Graduate Medical Education – 1995 - 1998 CME Curriculum Committee 1996 - 1997 Search Committee for Chairman of Department of Pathology 1996 - 1997 Research Biohazards Committee 1996 Montefiore Guidelines Committee 1997 – 1999 Housestaff Training Program Committee 2001- 2002. Search Committee for Head, Division of Cardiology 2001-2003 Search Committee for Program Director Internal Medicine 2009- 15 NATIONAL: American Thyroid Association: Program Committee, 1975 - 1977 Third Vice President, 1976 - 1977 Membership Committee, 1978 - 1981; Chairman, 1980 - 1981 Committee on Endocrine Related Societies, 1981 - 1986 Director, 1982 - 1983 Nominating Committee, 1982 - 1985; Chairman, 1984 – 1985 Chairman, Local Arrangements Committee, 60th Annual Meeting, New York, New York 1983-1984 Nomenclature Committee, 1985-1990 Director, 1986-1990 Publications Committee, 1990-1992 Ethics Committee, 1991-1993 Secretariat: 11th International Thyroid Congress, Toronto, Canada, Sept. 10 - 15, 1995 International Organizing Committee, 1993 - 2000 Secretary: 1993 - 1998 Recording Secretary: 12th International Thyroid Congress, Kyoto, Japan, 1995 - 2000 President Elect: 1998 – 1999 President: 1999 – 2000 16 Past-President: 2000 – 2001 Publications Committee; Chairman 2001 - 2005 Progam Organizing Committee, 13th International Thyroid Congress, Buenos Aires, Argentina, September 2002- 2005 Awards Committee: 2005 – 2009 Ethics Committee, 2008 - 17 Endocrine Society: Program Co-Chairman, Postgraduate Assembly, New York, New York 1980 Manpower Liaison Committee, 1983-1986 Advisory Committee on Scientific Programs, 1985-1987 Central Committee of International Society of Endocrinology – 1995-2000 Finance Committee, 1995 – 1998; Chairman, 1998 –2002. Editorial Board, Endocrine Self-Assessment Program ( ESAP) , 1997 –2002. Endocrine Self-Assessment Program, Editor-in-Chief, 2002 - 2007 Strategic Plan Implementation Committee, 2002-2003. Council, 2004 – Resigned 2004. Investment Advisory Task Force, 1998 - 2008 Association of Program Directors of Endocrinology & Metabolism Council: 1995 - 1997 Chairman: Committee on Curriculum, Certification and Training Requirements: 1995 - 1997 President: 1997 – 1999 Council: 1997 –2001 Chairman: Endocrine Multi-Society Curriculum Development Project, 1999 – 2001 18 Treasurer – 2000 - 2001 Association of Subspecialty Professors: Education Committee: 2000-2001 Other: American College of Physicians - New York State Chapter, Councilor - 1993-1995 Scientific Council, The Thyroid Foundation, Inc. New York, New York 1979-1984 Medical Advisory Council, The Thyroid Foundation of America 1988-1992 Federated Societies Diabetes, Endocrinology & Metabolism Council 1996 -1998 American Association of Clinical Endocrinologists; Endocrine Training Liaison Committee 1997 – 2000 19 PUBLICATIONS (EXCLUSIVE OF ABSTRACTS) 1. Surks, M.I. and Levenson, D. Pseudohypoparathyroidism. Case report and observations on the difficulty in confirming the diagnosis. Ann. Int. Med. 56:282, 1962. 2. Surks, M.I. and Oppenheimer, J.H. Effect of penicillin on thyroxine-binding by plasma proteins. Endocrinology 72:567, 1963. 3. Oppenheimer, J.H., Squef, R., Surks, M.I. and Hauer, H. Binding of thyroxine by serum proteins evaluated by equilibrium dialysis and electrophoretic techniques. Alterations in nonthyroidal disease. J. Clin. Invest. 43:1769-1782, 1963. 4. Surks, M.I. and Guttman, A. Esophageal involvement in Hodgkin's Disease. Am. J. Dig. Dis. 11:814, 1966. 5. Surks, M.I. and Oppenheimer, J.H. Postoperative changes in the concentration of thyroxinebinding prealbumin and serum free thyroxine. J. Clin. Endo & Metab. 24:794, 1964. 6. Oppenheimer, J.H. and Surks, M.I. Determination of free thyroxine in human serum. A theoretical and experimental analysis. J. Clin. Endo & Metab. 24:785, 1964. 7. Oppenheimer, J.H., Surks, M.I., Smith, J.C. and Squef, R. Isolation and characterization of thyroxine-binding prealbumin. J. Biol. Chem. 240:173, 1965. 8. Oppenheimer, J.H., Bernstein, G., Surks, M.I. and Smith, J.C. Metabolism of I131-labeled thyroxine-binding prealbumin in man. Science 149:748, 1965. 9. Smith, J.C., Bernstein, G., Surks, M.I. and Oppenheimer, J.H. A method of preparative starch gel electrophoresis. Biophys.Biochem. Acta 115:81, 1966. 20 10. Surks, M.I. Effect of hypoxia and high altitude on thyroidal iodide metabolism in the rat. Endocrinology 78:307, 1966. 11. Surks, M.I. Effect of high altitude exposure on the plasma concentrations of protein-bound iodine, free thyroxine, and the thyroxine-binding proteins in man. J. Appl. Physiol. 21:1185, 1966. 12. Surks, M.I. Metabolism of human serum albumin in man during acute exposure to high altitude (14,000 feet). J. Clin. Invest. 45:1442, 1966. 21 13. Surks, M.I., Beckwitt, H.J. and Chidsey, C.A. Changes in plasma thyroxine concentration and metabolism, catecholamine excretion and basal oxygen consumption in man during acute exposure to high altitude. J. Clin. Endo & Metab. 27:789, 1967. 14. Surks, M.I. Determination of iodide entrance and exit rate constants in incubated thyroid lobes. Endocrinology 80:1020, 1967. 15. Surks, M.I., Chinn, K.S.K. and Matoush, L.O. Alterations in body composition in man after acute exposure to high altitude. J. Appl. Physiol. 21:1741, 1966. 16. Surks, M.I., Weinbach, S. and Volpert, E.M. On the identification of 4-hydroxy-3,5diiodophenylpyruvic acid in normal rat thyroid glands. Endocrinology 82:1156, 1968. 17. Surks, M.I. Endocrine adaptation to high altitude exposure. Proceedings of Symposium on Biomedicine Problems of High Terrestrial Elevations. U.S. Army Research Institute of Environmental Medicine, Natick, Mass. Ed., A.H. Hegnauer, p. 186, 1969. 18. Surks, M.I. and Oppenheimer, J.H. Iodinated Lipids. A possible artifact in isotopic equilibration with dietary iodide. Endocrinology 83:897, 1968. 19. Oppenheimer, J.H. and Surks, M.I. Chapter V: Nature, Transport and Metabolism of the Thyroid Hormones, In The Thyroid. Eds., S.C. Werner and S.H. Ingbar, Harper and Row, N.Y., pp. 52-65, 1971. 20. Oppenheimer, J.H. and Surks, M.I. Chapter VI: Kinetic Aspects of Hormonal Distribution and Metabolism. In The Thyroid. Eds., S.C. Werner and S. H. Ingbar, Harper and Row, N.Y. pp. 66-78, 1971. 21. Oppenheimer, J.H., Bernstein, G. and Surks, M.I. Increased thyroxine turnover and thyroidal function following stimulation of hepatocellular binding of thyroxine by phenobarbital. J. Clin. Invest. 47:1399, 1968. 22. Oppenheimer, J.H., Surks, M.I. and Schwartz, H.L. The metabolic significance of exchangeable cellular thyroxine. Recent Progress in Hormone Research. Ed., E.B. Astwood, Academic Press, N.Y. 25:381, 1969. 23. Surks, M.I. The effect of thyrotrophin on thyroidal iodine metabolism during hypoxia. Amer. J. Physiol. 216:436, 1969. 24. Schwartz, H.L., Kozyreff, V., Surks, M.I. and Oppenheimer, J.H. Increased deiodination of L-thyroxine and L-triiodothyronine by liver microsomes from phenobarbital treated rats. Nature 221:1262, 1969. 25. Surks, M.I. and Oppenheimer, J.H. Formation of iodoprotein during the peripheral 22 metabolism of 3,5,3'-triiodo-L-thyronine [I125] in the euthyroid man and rat. J. Clin. Invest. 48:685, 1969. 26. Surks, M.I., Schwartz, H.L. and Oppenheimer, J.H. Tissue iodoprotein formation during the peripheral metabolism of the thyroid hormones. J. Clin. Invest. 48:1268, 1969. 27. Surks, M.I. and Shapiro, H.C. Preparation of high specific activity non-phenolic ring [I125] and 14C-labeled thyroxine. J. Clin. Endo & Metab. 29:1263, 1969. 28. Surks, M.I. Effect of hypoxia on the in vitro incorporation of protein. Amer. J. Physiol. 218:842, 1970. 29. Kozyreff, V., Surks, M.I. and Oppenheimer, J.H. Demonstration of membrane-linked iodoprotein in hepatic microsomes following the metabolism of the thyroid hormones. Endocrinology 86:781, 1970. 30. Oppenheimer, J.H., Schwartz, H.L., Shapiro, H.C., Bernstein, G., Martinez, M. and Surks, M.I. Differences in the intrinsic cellular metabolism of 3,5,3'-triiodothyronine and Lthyroxine. J. Clin. Invest. 49:1016, 1970. 31. Surks, M.I. and Oppenheimer, J.H. Composition of nonextractable ratioactivity formed after injection of labeled L-thyroxine and 3,5,3'-triiodo-L-thyronine in rats. Endocrinology 87:567, 1970. 32. Surks, M.I. Alterations in thyroid physiology during exposure to high altitude. Symposium on Military & Environmental Nutrition. Ed., Eugene Baker, U.S. Government Printing Office (1971). 33. Shapiro, H.C., Surks, M.I. and Oppenheimer, J.H. Cellular and plasma protein determinants in the differential distribution and metabolism of D- and L-thyroxine in the rat. Endocrinology 88:93, 1971. 34. Oppenheimer, J.H. and Surks, M.I. Quantitative aspects of hormonal production, distribution, metabolism and activity. Chapter 13, vol. III "Thyroid", Section 7, Endocrinology, in Handbook of Physiology (D.H. Solomon & M.O. Greer, editors), pp197214, American Physiological Society, Washington, D.C. 1974. 35. Surks, M.I. and Berkowitz, M. Rat hepatic polysome profiles and in vitro protein synthesis during hypoxia. Amer J. Physiol. 220:1606, 1971. 36. Surks, M.I. and Oppenheimer, J.H. Metabolism of phenolic- and tyrosyl- ring labeled Lthyroxine in human beings and rats. J. Clin. Endo & Metab. 33:612, 1971. 37. Oppenheimer, J.H., Shapiro, H.C., Schwartz, H.L. and Surks, M.I. Dissociation between thyroxine metabolism and hormonal action in phenobarbital-treated rats. Endocrinology 23 14 C-leucine into rat liver 88:115, 1971. 38. Kozyreff, V., Surks, M.I. and Oppenheimer, J.H. Formation of nondissociable hormoneprotein complexes during the in vitro incubation of L-thyroxine and 3,5,3'-triiodo-Lthyronine with hepatic microsomes. Endocrinology 89:749, 1971. 39. Schwartz, H.L., Surks, M.I. and Oppenheimer, J.H. Quantitation of extrathyroidal conversion of L-thyroxine to 3,5,3'-triiodo-L-thyronine in the rat. J. Clin. Invest. 50:1124, 1971. 40. Gordon, A., Surks, M.I. and Oppenheimer, J.H. Thyroxine stimulaton of amino acid incorporation into mitochondrial protein: Differences between in vitro effects. Acta Endocrinol. 72:684, 1973. 41. Oppenheimer, J.H., Surks, M.I. and Schwartz, H.L. Slow fractional removal of nonextractable iodine from rat tissue following injection of [I125]-labeled L-thyroxine and 3,5,3'-triiodo-L-thyronine: a possible clue to the mechanism of initiation of hormonal action. J. Clin. Invest. 51:2796, 1972. 42. Oppenheimer, J.H., Schwartz, H.L. and Surks, M.I. Propylthiouracil (PTU) inhibits the conversion of L-thyroxine (T4) to L-triiodothyronine (T3): a possible explanation of the antiT4 effect of PTU and further support of the concept that T3 is the primary thyroid hormone. J. Clin. Invest. 51:2493-2497, 1972. 43. Schadlow, A.R., Surks, M.I., Schwartz, H.L. and Oppenheimer, J.H. Specific triiodothyronine binding sites in rat anterior pituitary. Science 176:1252, 1972. 44. Oppenheimer, J.H., Koerner, D., Schwartz, H.L. and Surks, M.I. Specific nuclear triiodothyronine binding sites in rat liver and kidney. J. Clin. Endo & Metab 35:330, 1972. 45. Surks, M.I., Schadlow, A.R. and Oppenheimer, J.H. A new radioimmunoassay for plasma Ltriiodothyronine: Measurements in thyroid disease and in patients maintained on hormonal replacement. J. Clin. Invest. 51:3104-3113, 1972. 46. Koerner, D., Surks, M.I. and Oppenheimer, J.H. In vitro formation of apparent covalent complexes between L-triiodothyronine and plasma protein. J. Clin. Endo & Metab 36:239, 1973. 47. Surks, M.I., Schadlow, A.R., Stock, J.M. and Oppenheimer, J.H. Determination of iodothyronine absorption and conversion of L-thyroxine (T4) to 3,5,3'-triiodo-L-thyronine using turnover rate techniques. J. Clin. Invest. 52:805-811, 1973. 48. Schwartz, H.L., Schadlow, A.R., Faierman, D., Surks, M.I. and Oppenheimer, J.H. Heparin administration appears to decrease cellular binding of thyroxine. J. Clin. Endo & Metab. 36:598, 1973. 24 49. Surks, M.I. and Oppenheimer, J.H. Methods for determining the conversion of L-thyroxine (T4) to L-triiodothyronine (T3). METHODS IN ENZYMOLOGY, III J.G. Hardman & B.W. O'Malley, editors), Academic Press, Inc. New York, 50. Oppenheimer, J.H., Koerner, D., Surks, M.I. and Schwartz, H.L. Limited binding capacity sites for L-triiodothyronine in rat liver nuclei: Nuclear cytoplasmic interrelation, binding constants, and crossreactivity with L-thyroxine. J. Clin. Invest. 53:768-777, 1974. 51. Surks, M.I., Koerner, D., Dillman, W. and Oppenheimer, J.H. Limited capacity binding sites for L-triiodothyronine (T3) in rat liver nuclei: Localization to the chromatin and partial characterization of the T3-chromatin complex. J. Biol. Chem. 248:7066, 1973. 52. Oppenheimer, J.H., Schwartz, H.L., Dillman, W. and Surks, M.I. Effect of thyroid hormone analogues on the displacement of [I125]-L-triiodothyronine from hepatic and heart nuclei in vivo: Possible relationship to hormonal activity. Biochem. Biophys. Res. Comm. 55:544, 1973. 53. Stock, J.M., Surks, M.I. and Oppenheimer, J.H. Replacement dosage of L-thyroxine in hypothyroidism. A re-evaluation. New Engl. J. Med. 290:529, 1974. 54. Oppenheimer, J.H. and Surks, M.I. Biochemical basis of thyroid hormone action in Biochemical Actions of Hormones, Vol. 3, G. Litwack, editor, Academic Press, Inc., New York, New York, 1975. 55. Dillman, W., Surks, M.I. and Oppenheimer, J.H. Quantitative aspects of iodothyronine binding by cytosol proteins of rat liver and kidney. Endocrinology 96:492, 1974. 56. Koerner, D., Surks, M.I. and Oppenheimer, J.H. In vitro demonstration of specific triiodothyronine binding sites in rat liver nuclei. J. Clin. Endo & Metab. 38:706, 1974. 57. Oppenheimer, J.H., Schwartz, H.L. and Surks, M.I. Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: Liver, kidney, pituitary, heart, brain, spleen and testes. Endocrinology 95:897, 1974. 58. Surks, M.I., Koerner, D.H. and Oppenheimer, J.H. In vitro binding of L-triiodothyronine to receptors in rat liver nuclei: Kinetics of binding, extraction properties, and lack of requirement for cytosol proteins. J. Clin. Invest. 55:50, 1975. 25 59. Oppenheimer, J.H., Schwartz, H.L. and Surks, M.I. Nuclear binding capacity appears to limit the hepatic response to L-triiodothyronine (T3). Endo. REs. Comm. 2:309, 1975. 60. Oppenheimer, J.H., Schwartz, H.L. and Surks, M.I. Determination of common parameters of iodothyronine metabolism and distribution in man by noncompartmental analysis. J. Clin. Endo & Metab. 41:319, 1975. 61. Bermudez, F., Surks, M.I. and Oppenheimer, J.H. High incidence of decreased serum triiodothyronine concentration in patients with nonthyroidal disease. J. Clin. Endo & Metab 41:27-40, 1975. 62. Oppenheimer, J.H., Schwartz, H.L., Surks, M.I., Koerner, D.H. and Dillman, W. Physiological significance of nuclear receptor sites. Proc. Int. Conf. Thyroid Horm. Metabolism. Glasgow, Scotland, Academic Press, 1975. 63. Koerner, D.H., Schwartz, H.L., Surks, M.I., Oppenheimer, J.H. and Jorgensen, E.C. Binding of selected iodothyronine analogues to receptor sites of isolated rat hepatic nuclei: High correlation between structural requirements for nuclear binding and biological activity. J. Biol. Chem. 250:6417-6423, 1975. 64. Oppenheimer, J.H. and Surks, M.I. The peripheral action of the thyroid hormones, in, Medical Clinics of North America, Vol. 59, No. 5, Gerard N. Burrow, ed., W.B. Saunders Co., New York, 1975. 65. Surks, M.I. and Oppenheimer, J.H.: Isolation and characterization of thyroid hormone receptors in, Hormone-Receptor Interaction: Molecular Aspects, ed. Gerald S. Levey, Marcel Dekker, Inc., New York, 1976. 66. Goslings, B., Schwartz, H.L., Dillman, W., Surks, M.I. and Oppenheimer, J.H. Comparison of the metabolism and distribution of L-triiodothyronine and triiodothyroacetic acid in the rat. A possible explanation of differential hormonal potency. Endocrinology 98:666, 1976. 67. Dillman, W., Silva, E., Surks, M.I. and Oppenheimer, J.H. Studies of thyroid hormone and androgen dependent protein in rat liver cytosol. Acta Endocrinologica 84:548, 1977. 68. Dillman, W., Schwartz, H.L., Silva, E., Surks, M.I. and Oppenheimer, J.H. Effect of alphaamanatin on the induction of hepatic enzymes by triiodothyronine. Proc. 7th Int. Thyroid Conf., Boston, 1975. Excerpta Medica, 378:326, 1976. 69. Oppenheimer, J.H., Schwartz, H.L., Surks, M.I., Koerner, D.H. and Dillman, W. Nuclear receptors and initiation of thyroid hormone action. Rec. Prog. Horm. Res. 32:529, 1976. 70. Jorgensen, E.C., Dietrich, S.W., Koerner, D.H., Surks, M.I. and Oppenheimer, J.H. Thyroid hormones: comparative structural requirements for activity in vivo and for binding to rat liver 26 nuclei. Proc. West. Pharmac. Soc. 18:389, 1975. 71. Dillman, W.H., Schwartz, H.L., Silva, E., Surks, M.I. and Oppenheimer, J.H. Alphaamanitin administration results in a temporary inhibition of hepatic enzyme induction by triiodothyronine: Further evidence favoring a long-lived mediator of thyroid hormone. Endocrinology, 100:1621, 1977. 72. Oppenheimer, J.H., Surks, M.I., Schwartz, H.L., Koerner, D.H. and Dillman, W.H. Quantitative relationships between nuclear occupancy and enzyme response to thyroid hormone administration. Proceedings of the Workshop Conference on Biochemical Basis of Thyroid Stimulation and Thyroid Hormone Action, Celle, Germany, September, 1975. 73. Oppenheimer, J.H., Surks, M.I., Schwartz, H.L., Koerner, D.H. and Dillman, W.H. Evidence in support of a nuclear site for the initiation of thyroid hormone action. Proceedings of the International Thyroid Symposium. Regulation of Thyroid Function, Dusseldorf, Germany, October, 1975. 74. Surks, M.I. and Oppenheimer, J.H. Incomplete suppression of thyrotropin secretion after single injection of large L-triiodothyronine doses into hypothyroid rats. Endocrinology 99:1432-1440, 1976. 75. Surks, M.I. and Oppenheimer, J.H. Treatment of hypothyroidism, in Current Therapy, 1977, Howard F. Conn, ed., W.B. Saunders, New York. 76. Hoffman, D.P., Surks, M.I., Oppenheimer, J.H. and Weitzman, E.D. Response to thyrotropin-releasing hormone: An objective criterion for the adequacy of thyrotropin suppression therapy. J. Clin. Endo & Metab. 44:892, 1977. 77. Surks, M.I. and Oppenheimer, J.H. Concentration of L-thyroxine (T4) and L-triiodothyronine (T3) specifically bound to nuclear receptors in rat liver and kidney: Quantitative evidence favoring a major role of T3 in thyroid hormone action. J. Clin. Invest. 60:555-562, 1977. 78. Oppenheimer, J.H., Silva, E., Schwartz, H.L. and Surks, M.I. Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and "malic enzyme" by Ltriiodothyronine: I. Characteristics of the response with specific nuclear thyroid hormone binding sites full saturated. J.Clin. Invest. 59:517, 1977. 79. Surks, M.I. and Lifschitz, B.M. Biphasic TSH suppression in euthyroid and hypothyroid rats. Endocrinology 101: 769-775, 1977. 27 80. Surks, M.I. and DeFesi, C.R. Determination of the absolute cell number of each cell type in the anterior pituitary of euthyroid and hypothyroid rats, Endocrinology 101:946-958, 1977. 81. Surks, M.I. Laboratory aids in the diagnosis of hypothyroidism. Thyroid Today, December, 1977. 82. Lifschitz, B.M., DeFesi, C.R. and Surks, M.I. Thyrotropin (TSH) response to thyrotropinreleasing hormone (TRH): Dose response, time course and demonstration of partial refractoriness to a second dose of TRH. Endocrinology 102:1775-1782, 1978. 83. Surks, M.I., Grajower, M.M., Tai, M. and DeFesi C.R. Decreased hepatic nuclear Ltriiodothyronine receptors in rats and mice bearing transplantable neoplasms. Endocrinology 103:2234-2239, 1978. 84. Surks, M.I. Nuclear Receptors for Thyroid Hormones: Relation to thyroid hormone action. Syllabus, Thirtieth Annual Postgraduate Assembly of the Endocrine Society, Miami, Florida, October, 1978, pp 270-288. 85. Giddings, H.B. and Surks, M.I. Cerebral embolization atrial fibrillation complicating hyperthyroidism. JAMA 240:2567-2568, 1978. 86. Surks, M.I. Simple goiter, in Current Therapy, 1979, Howard F. Conn, ed., W.B. Saunders, New York. 87. Grajower, M.M. and Surks, M.I. Effect of decreased hepatic nuclear L-triiodothyronine receptors on the response of hepatic enzymes to L-triiodothyronine in tumor-bearing rats. Endocrinology 104:697-703, 1979. 88. DeFesi, C.R., Astier, H.S. and Surks, M.I. Kinetics of thyrotrophs and somatotrophs during development of hypothyroidism and L-triiodothyronine treatment of hypothyroid rats. Endocrinology 104:1172-1180, 1979. 89. Grajower, M.M., Levin, J., Kream, J. and Surks, M.I. Twenty-four hour plasma cortisol profiles in Chushing's syndrome due to bilateral nodular adrenocortical hyperplasia 90. Astier, H.A., DeFesi, C.R. and Surks, M.I. Kinetics of deoxyribonucleic acid synthesis and replication of thyrotrophs and somatotrophs during development of hypothyroidism and Ltriiodothyronine treatment of hypothyroid rats. Endocrinology 106:1537-1548, 1980. 91. Aleem, F.A., Spenillo, A.R., Oberlander, S., and Surks, M.I. Hilar cell tumor of the ovary: preoperative localization by selective retrograde venous sampling. Obstetrics and Gynecology, 56:99-102, 1980. 92. Surks, M.I. Selection and interpretation of thyroid function tests. Syllabus, Thirty-first 28 Annual Postgraduate Assembly of the Endocrine Society, Rochester, Minnesota, VIII, 65-77, 1979. 93. Rosenbaum, R.L., Maturlo, S.J. and Surks, M.I. Changes in thyroidal economy in rats bearing transplantable Walker 256 carcinoma. Endocrinology 106:1386-1391, 1980. 94. Maturlo, S.J., Rosenblum, R.L., Pan, C. and Surks, M.I. Variable thyrotropin response to thyrotropin-releasing hormone following small decreases in plasma free thyroid hormone concentrations in patients with nonthyroidal diseases. J.Clin. Invest. 66:451-456, 1980 95. DeFesi, C.R. and Surks, M.I. 3,5,3'-triiodothyronine effects on the growth rate and cell cycle stages of cultured GC cells. Endocrinology 108:259-267, 1981. 96. Shuman, S., Surks, M.I., Furneaux, H. and Hurwitz, J. Purification and characterization of a GTP-Pyrophosphate Exchange Activity from Vaccinia Virions: Associaton of the GTPPyrophosphate Exchange Activity with Vaccinia mRNA Guanylyl Transferase RNA (Guanine-7) Methyltransferase Complex (Capping Enzyme). J. Biol. Chem. 255:11,58811,598, 1980. 97. Surks, M.I. Clinician's Guide to Tests of Thyroid Function, A. Retlaw & Assoc., Inc., Evanston, Illinois, 1980. 98. Las, M.S. and Surks, M.I. Dissociation of serum triiodothyronine concentration and hepatic nuclear triiodothyronine binding capacity in streptozotocin-induced diabetic rats. Endocrinology 109:1259-1263, 1981. 99. Cohen, M.V., Schulman, I.C., Spenillo, A. and Surks, M.I. Effects of thyroid hormone on left ventricular function in patients treated for thyrotoxicosis. Amer. J. Cardiology 48:33-38, 1981. 100. Surks, M.I. Assessment of Thyroid Function, Syllabus, Thirty-second Annual Postgraduate Assembly of the Endocrine Society, New York, New York, 1980. 101. Kumara-Siri, M.H., Lee, K.Y. and Surks, M.I. Regulation of thyrotropin release in tumorbearing rats. Endocrinology 109:1760-1768, 1981. 102. Wilker, R.E., Fleischman, A.R., Saenger, P., Pan, C. and Surks, M.I. Decreased thyroid hormone levels in diabetic mothers and their infants. Amer. J. of Perinatology 1:259-262, 1984. 103. Surks, M.I. Clinical Update in Thyroid Disease, A. Retlaw Assoc. Inc. Evanston, Illinois, 1981. 104. Surks, M.I. Assessment of thyroid function. Ophthalmology 88:476-478, 1981. 29 105. Surks, M.I. Treatment of adult hypothyroidism, Thyroid Clinics, Volume I No 4, Arthur Retlaw & Assoc., Inc., Wilmette, Illinois, 1981. 106. DeFesi, C.R., Fels, E.C. and Surks, M.I. Nuclear T3 receptor concentration is related to DNA synthesis in synchronized GC cell cultures. Endocrinology 111:1156-1165, 1982. 107. Ordene, K.W., Pan, C., Barzel, U.S. and Surks, M.I. Variable thyrotropin response to thyrotropin releasing hormone after small decreases in plasma thyroid hormone concentrations in patients of advanced age. Metabolism 32:881-888, 1983. 108. Surks, M.I., Ordene, K.W., Kumara-Siri, M.H. and Mann, D.N. Effect of diphenylhydantoin on TSH secretion in man and in the rat. J. Clin. Endo & Metab. 56:940-945, 1983. 109. Surks, M.I. Hyperthyroidism, in Current Endocrinologic Therapy, Eds. Krieger, D.T. and Bardin, C.W., M.C. Dekker, Inc. Burlington, Ontario 1983, Page 60-65. 110. Las, M.S. and Surks, M.I. Hypopituitarism associated with systemic amyloidosis. New York State Journal Medical 83:1183-1185, 1983. 111. Surks, M.I. Physiologic basis for assessment of thyroid function. Medical Times, 110:3445, 1982; Resident and Staff Physician 29:40-51, 1983. 112. Mann, D.N. and Surks, M.I. 5,5'-Diphenylhydantoin (DPH) decreases specific T3 binding by rat hepatic nuclear T3 receptors. Endocrinology 112:1723-1731, 1983. 113. Mann, D.N., Kumara-Siri, M.H. and Surks, M.I. Response of hepatic enzymes to Ltriiodothyronine and 5,5'-diphenylhydantoin. Endocrinology 112:1732-1738, 1983. 114. Surks, M.I. and Kumara-Siri, M.H. Increase in nuclear thyroid and glucocortcoid receptors and growth hormone production during the DNA synthesis phase of the cell growth cycle. J. Biol. Chem. 114:873-879, 1984 . 115. DeFesi, C.R., Fels, E.C. and Surks, M.I. T3 stimulates growth of cultured GC cells by action early in the G1 period. Endocrinology 114:293-295, 1983. 116. Klein, R.S., Mann, D.N., Friedland, G. and Surks, M.I. Normal adrenal cortical function in patients with the acquired immune deficiency syndrome. Annals Internal Medicine 99:566, 1983. 117. Sawin, C.T., Surks, M.I., Ordene, K.W., London, M., Ranganathan, C. and Larsen, P.R. Oral thyroxine: Variation in biologic action and content of tablets. Annals Internal Medicine 100:641-645, 1984. 30 118. Surks, M.I. Hyperthyroidism in Current Therapy in Internal Medicine. Eds Bayless, T.M., Brain, M.C. and Cherniack, R.M. BC Decker Inc., Burlington, Ontario, 1984. page 421-426. 119. Surks, M.I., Fels, E.C. and DeFesi, C.R. Induction of Amino Acid Transport by Ltriiodothyronine in Cultured Growth Hormone-Producing Rat Pituitary Tumor Cells (GC Cells) J. Biol. Chem. 259:5726-5733, 1984 . 120. Tibaldi, J.M., Sahnoun, N. and Surks, M.I. Response of hepatic mitochondrial glycerophosphate dehydrogenase and malic enzyme to constant infusion of Ltriiodothyronine in rats bearing the Walker 256 carcinoma: Evidence for divergent postreceptor regulation of the thyroid hormone response. J.Clin. Invest. 74:705-714, 1984. 121. Smith, P.J. and Surks, M.I. 5,5'-diphenylhydantoin (Dilantin) decreases cytosol and specific nuclear T3 binding in rat anterior pituitary in vivo and in cultured GC cells. Endocrinology 115:283-290, 1984. 122. Smith, P.J. and Surks, M.I. Multiple effects of 5,5'-diphenylhydantoin (Dilantin) on the thyroid hormone system. Endocrine Reviews 5:514-524, 1984. 123. Tibaldi, J.M. and Surks, M.I. Effects of nonthyroidal illnesses on thyroid function. Med. Clin. North America 69:899-912, 1985. 124. Tibaldi, J.M. and Surks, M.I. Animal models of nonthyroidal disease. Endocrine Reviews 6:87-102, 1985. 125. DeFesi, C.R., Fels, E.C. and Surks, M.I. L-triiodothyronine (T3) stimulates growth of cultured GC cells by action early in the G1 period: Evidence for mediation by the nuclear T3 receptor. Endocrinology 116:2062-2069, 1985. 126. Gingrich, S.A., P.J.Smith, L.E. Shapiro and M.I. Surks. 5,5'Diphenylhydantoin (Phenytoin) attenuates the action of 3,5,3'-Triiodo-LThyronine in cultured cells. Endocrinology, 116:2036-2313,1985 127. Kumarasiri, M.H., L.E.Shapiro and M.I.Surks: Regulation of the rat growth hormone gene during DNA synthesis (S) phase of the cell cycle in cultured GC cells: Regulation of growth hormone mRNA synthesis by 3,5,3'-Triiodo-L-Thyronine in cultured growth hormoneproducing rat pituitary tumor cells (GC cells). J. Biol. Chem. 260:1452-1458, 1985. 128. Kumara-Siri, M.H., L.E. Shapiro and M.I. Surks. Association of the 3,5,3'-Triiodo-L-Thyronine with the nuclear matrix of cultured growth hormone-producing rat pituitary tumor cells (GC)cells. J. Biol. Chem. 261 2844-2852, 1986. 129. Tibaldi, J., Barzel, U.S., Albin, J. and Surks, M.I. Thyrotoxicosis in the "old" old. Amer. J. Med. 81:619-622, 1986. 31 130. 131. Surks, M.I. and Shapiro, L.E. Hypothyroidism, in Principles and Practice of Endocrinology and Metabolism, Editor-in-Chief, Becker, K.L., J.B. Lippincott Co., Phila, PA; 1990;pp 363370. Shapiro, L.E., Patel, K.R. and Surks, M.I. The rate of appearance of thyroid hormone nuclear receptors is increased during the S-phase of the cell cycle: analysis of thymidine-treated GC cells using dense amino acid labeling. Endocrinology 119:2076-2081, 1986. 132. Fine, E.J. Finkelstein, M., Rudavsky, A., Sugarman, L.A., Surks, M.I. and Freeman, L.M. Ambulatory divided dose adminstration of 50 to 90 mCi [I131] for thyroid remnant ablation after surgery for thyroid cancer. J. Nuc. Med. European Assoc. Nuclear Med. Congress 1989. 133. Zemel, L.R., D.R. Biezunski, L.E. Shapiro and M.I. Surks. 5,5'-Diphenylhydantoin (Dilantin) decreases the transport of 3,5,3'-triiodo-L-thyronine (T3) but not L-thyroxine (T4) in cultured GC cells. Acta Endo 117:392-398, 1988. 134. Miller, M.J., E.C. Fels, L.E. Shapiro and M.I. Surks. L-triiodothyronine stimulates growth by induction of an autocrine/paracrine growth factor. J.Clin. Invest 79:1773-1781, 1987. 135. Kumara-Siri, M.H., Shapiro, L.E. and Surks, M.I. Cell cycle-dependence of thyroid hormone nuclear receptors in cultured GC cells: Relationship to nuclear matrix. Endocrinology 122:1897-1904, 1988. 136. Larsen, P.R., Alexander, N.M., Chopra, I.J., Hay, I.D., Hershman, J.M., Kaplan, M.M., Mariash, C.N., Nicoloff, J.T., Oppenheimer, J.H., Solomon, D.H. and Surks, M.I. Revised Nomenclature for Tests of Thyroid Hormones and Thyroid-Related Proteins in Serum. J. Clin. Endo & Metab. 64:1089-1094, 1987. 137. Surks, M.I. Thyroiditis, in Current Endocrinologic Therapy, Ed. Bardin, C.W., M.C. Dekker, Inc., Toronto p 88-01, 1988. 138. Surks, M.I., Hupart, K.H., Pan, C. and Shapiro, L.E. Normal free thyroxine in critical nonthyroidal illnesses measured by ultrafiltration of undiluted serum and equilibrium dialysis. J.Clin. Endocrinol & Metab. 67:1031-1039, 1988. 139. Starosta, Z, Gasparini, F., Shapiro, L.E. and Surks, M.I. Diminished hepatic L-triiodothyronine (T3) nuclear receptor concentration in rats bearing the Walker 256 carcinoma is not due to a generalized decrease in non-histone protein synthesis. Endocrinology 123:1172-1177, 1988. 140. Shapiro, L.E., S. Sherf Wasserman, C.P. Katz and M. I. Surks. 3,5,3'-triiodothyronine (T3) determines the viability of GC cells after heat shock (HS). Endocrinology 124:1026-1032, 1989. 32 141. Shapiro, L.E., Franken, C., DeFesi, C.R. and Surks, M.I. Heat shock of cultured GC cells enhances the level of L-triiodothyronine (T3) induced growth hormone (GH) and GH mRNA. Endocrinology 125:180-185, 1989. 142. Surks, M.I., Ramirez, I.J., Shapiro, L.E., Kumarasiri, M.H. Effect of Zn(II) and other divalent cations on binding of 3,5,3'-triiodo-L-thyronine to nuclear receptors from cultured GC cells - J. Biol. Chem 264:9820-9826, 1989. 143. Hupart, K.H., DeFesi, C.R., Katz, C.P., Shapiro, L.E. and Surks, M.I. Decreaed anterior pituitary T3 nuclear receptors in a Walker 256 carcinoma-bearing rat model of nonthyroidal disease. Acta Endocrinologia 121:811-816, 1989. 144. Halperin, Y., Shapiro, L.E. and Surks, M.I. Characterization of a variant GC cell line with T3-independent growth and GH production - Endocrinology 125:778-784, 1989. 145. Surks, M.I., Chopra, I.J., Mariash, C.N., Nicoloff, J.T., Solomon, D.H. American Thyroid Association Guidelines for use of laboratory tests in thyroid disorders. J. Amer. Medical Association 263:1529-1532, 1990. 146. Hupart, K.H., DeFesi, C.R., Katz, C.P., Shapiro, L.E. and Surks, M.I. Differential response to L-triiodothyronine of anterior pituitary GH mRNA and -TSH mRNA in Walker 256 carcinoma-bearing rat model of nonthyroidal disease. Endocrinology 126:616-621, 1990. 147. Ramirez, I.J., Halwer, M., Shapiro, L.E. and Surks, M.I. Zinc (II) inhibits the release of thyroid and glucocorticoid receptors from chromatin of cultured GC cells - Hormone and Metabolic Research 23:155-161, 1991. 148. Halperin, Y., Shapiro, L.E. and Surks, M.I. L- triiodothyronine regulates cellular growth rate, growth hormone production, and down-regulation of nuclear T3 receptors via distinct dose-response ranges in cultured GC cells. Endocrinology 126:2321-2326, 1990. 33 149. Halperin, Y., Shapiro, L.E. and Surks, M.I. 3,5,3'-triiodo-Lthyronine (T3) and T3 generated from L-thyroxine (T4) are exchangeable in cultured GC cells. Endocrinology 127:1050-1056, 1990. 150. Khawaja, Y., Dobnig, H., Shapiro, L.E. and Surks, M.I. Increase in hepatic mitochondrial alpha-glycerophosphate dehydrogenase activity after surgical stress in chronically thyrotoxic rats: implications for thyroid storm - Endocrinology 127:387-393, 1990. 151. Shapiro, L.E., Katz, C.P., Wasserman, SHS, DeFesi, C.R. and Surks, M.I. Heat stress and glucocorticoids are independent stimulators of triiodothyronine (T3)-induced growth hormone. Acta Endocrinolgica (Cophen)124:417-424, 1991. 152. Surks, M.I. Management of Hypothyroidism, in The Thyroid: A Fundamental and Clinical Text, Sixth Edition, Eds, Braverman, L.E., Utiger, R.D., J.B. Lippincott Co. Philadelphia, PA, 1991. Fotadar, U., Shapiro, L.E. and Surks, M.I. Simultaneous use of standard and low-melting agarose for the separation and isolation of DNA by electrophoresis. Biotechniques vol 10, no. 2, 171, 1991. 153. 154. Hupart, K.H., Hodin, R.A., Lazar, M.A., Shapiro, L.E., Chin, W.W. and Surks, M.I. Correlationof erb-A mRNA transcripts encoding different forms of the nuclear thyroid receptor (TR) with nuclear T3 binding in anterior pituitary and liver of rats bearing the Walker 256 carcinoma - Thyroid 3:55-58, 1993. 155. Halperin, Y., Shapiro, L.E. and Surks, M.I. Role of L-thyroxine in nuclear thyroid hormone receptor occupancy and growth hormone production in cultured GC cells. J. Clin. Invest. 88:1291-1299, 1991. 156. Reynolds, A.M., Surks, M.I. and Shapiro, L.E. The effects of chronic exposure to supraphysiological concentrations of 3,5,3' triiodo-L-thyronine (T3) on cultured GC cells. J. Cell. Physio. 149:544-547, 1991. 157. Shapiro, L.E. and Surks, M.I. Managing Hypothyroidism. The Endocrinologist 1:343-347, 1991. 158. Surks, M.I. Thyroiditis, in Current Therapy in Internal Medicine, III Edition, Ed., Kassirer, J.P., B.C. Dekker Inc. Phila., 1991. 159. Surks, M.I. Thyroid-Stimulating Hormone: Reference Range Validity, J. Am. Med. Assoc. 266:1573, 1991. 34 160. Mokshagundam, S. and Surks, M.I. Congenital adrenal hyperlasia in an adult male diagnosed during work-up for bilateral adrenal masses. Arch Int. Med. 153:1389-91, 1993. 161. Mokshagundam, S., Surks, M.I., Shapiro, L.E. Heat stress of cultured GC cells enhances triiodothyronine-induced growth hormone production by action within the 5' flanking region of the rat growth hormone gene. Biochem. Biophys. Res. Comm 188:638-643, 1992. 162. Surks, M.I. Guidelines for Thyroid Testing. Laboratory Medicine 24:270- 274, 1993. 163. Halperin, Y., Shapiro, L.E., Surks, M.I. Down-regulation Type II L-thyroxine, 5'monodeiodinase by thyroid hormone in cultured GC cells: Different pathways of regulation by L-Triiodothyronine. Endocrinology 135: 1464-69, 1994. 164. Rudavsky, A., Fine, E.J., Freeman, L., Heller, S.L., Finkelstein, M., Surks, M.I., Sachs, B.A., Sugarman, L.A. and Saleemi, K. The effectiveness and regulatory conformity of Ambulatory divided-dose administration of [I131] for thyroid remnant ablation after surgery for thyroid cancer. Nuclear Medicine Annual, ed, Leonard Freeman, Raven Press, New York p. 223, 1993. 165. Surks, M.I. and Shapiro, L.E. Hypothyroidism, in Principles and Practice of Endocrinology and Metabolism, Editor-in-Chief, Becher K.L., J. B. Lippincott Co., Philadelphia, PA, 1994. 166. Surks, M.I. Papillary Thyroid Cancer - Commentary, Oncology 9: 154-157, 1995. 167. Surks, M.I. and Sievert, R. Drugs and Thyroid Function. New England Journal of Medicine 333: 1688 - 1694, 1995. 168. Surks, M.I. and Ocampo, E. Subclinical Thyroid Disease - American Journal of Medicine 100: 217 - 223, 1996. 169. Surks, M.I. and DeFesi, C. Normal Serum Free Thyroid Hormone Concentrations in Patients Treated With Phenytoin or Carbamazepine. Journal of the American Medical Association 275: 1495 - 1498, 1996. 170. Sievert, R., Goldstein M.B. and Surks, M.I. Graves' Disease and Autoimmune Factor VIII Deficiency. Thyroid 6:245-247,1996. 171. Langdon, L.O., Toskes P.P., and Kimball, H.R. and The American Board of Internal Medicine Task Force on Subspecialty Medicine. Future Roles and Training of Internal Medicine Subspecialties. Annals Internal Medicine - 124: 686 - 691, 1996. 172. Ocampo, E.L., and Surks, M.I. - Problems in the Management of Hypothyroidism, in Contemporary Endocrinology Diseases of the Thyroid, Braverman LE, Ed., Humana Press, Totowa, NJ. 1997 p 155-175. 35 173. Surks, M.I. Generosity of Spirit and Personal Dignity: The Story of Mr. S; in Caring for the Dying, American Board of Internal Medicine, 1996. 174. Surks, M.I. Drug Interactions with Thyroid Hormones. Up To Date in Medicine. CD-ROM 1997- 175. Surks, M.I. Iodine and Thyroid Function. Up To Date in Medicine. CD-ROM 199- 176. Surks, M.I. Lithium and the Thyroid. Up To Date in Medicine. CD-ROM 1997- 177. Surks, M.I. Overview of Clinical Manifestation of Hypothyroidism. Up To Date in Medicine . CD-ROM 1997- 178. Shapiro, L.E., Sievert, R., Ong, L., Ocampo, E.L., Chance, R.A., Lee, M., Nanna, M., Ferrick, K. and Surks, M.I. Minimal cardiac effects in asymptomatic athyreotic patients chronically treated with thyrotropin (TSH) - suppressive doses of LThyroxine (T4). J. Clin Endocrinol Metab 82:2592 - 2595, 1997. 179. Ortiz, R., Hupart, K., DeFesi, C.R. and Surks, M.I. Effect of early referral to an endocrinologist on efficiency and cost of diagnosis and development of treatment plan for patients with thyroid nodules. J Clin Endocrinol Metab 83:3803-3807, 1998. 180. Dabon-Almirante, C.L.M. and Surks, M.I. Clinical and laboratory diagnosis of thyrotoxicosis, in Thyrotoxicosis, Endocrinology and Metabolism Clinics, Kaplan, M.M., Ed., W.B.Saunders Co, Phila, PA, pp5 25-35, 1998. 181. Wozniak, R., Beckwith, L., Ratech, H., and Surks, M.I. Maltoma of the thyroid in a man with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 84: 1206-1209, 1999. 182. Shapiro, LE and Surks MI. Hypothyroidism, In: Principles and Practice of Endocrinology and Metabolism, ed. 3, Editor-in-Chief, Becker, KL. JB Lippincott Company, Philadelphia PA, 2001,Pages 445-454. 183. Surks, M.I.: Recognizing the Faces of Hypothyroidism: Case Commentary; Hospital Practice 34: 93-110, 1999. 184. Surks, M.I.: The Subspecialty Examination in Endocrinology, Diabetes and Metabolism. Endo Trends 5: 4, 1999 185. Surks, M.I.: Recognizing Thyrotoxicosis: Case Commentary; Hospital Practice 34: 43-58, 1999 186. Cases, J.A., Wenig, B.M., Silver, C.E., Surks, M.I. Recurrent acute suppurative thyroiditis 36 in an adult due to a pyriform-sinus (4th branchial pouch) fistula. J Clin Endocrinol & Metab 85:953-956, 2000. 187. Cases, J.A., Surks, M.I. Changing role of scintigraphy in the evaluation of thyroid nodules; Seminars in Nuclear Medicine, Volume 30:81-87, 2000. 188. Surks, M.I., ‘Hyperthyroidism’; ‘Hypothyroidism’; ‘Goiter’; ‘Iodine’;;Thyroid Disorders’; ‘Thyroid Function Tests’; in Encyclopedia of Public Health; Editor-in-Chief, Breslow, L., McMillan Reference USA, New York, 2002 189. Surks, M.I., Hyperthyroidism, Conn’s Current Therapy, 2003 Eds Rakel and Bope; Elsevier Science (USA) 717-720. 190. Dubenko, M., Breining, W., Surks, M.I. Sclerosing lymphocytic lobulitis of the breast in a patient with Graves’ disease. 2003 THYROID 13:309-311. 191. Rizza RA, Vigersky RA, Rodbard HW, Ladenson PW, Young WF Jr, Surks MI, Kahn R, Hogan PF. 2003. A model to determine workforce needs for endocrinologists in the United States until 2020. J Clin Endocrinol Metab 88: 1979-1987. 192. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ. Subclinical thyroid disease: Scientific Review and Guidelines for Diagnosis and Management. JAMA, 2004; 291: 228-238. 193. Col, NF, Surks MI. and Daniels GH: Subclinical thyroid disease: Clinical Applications. JAMA 2004; 291: 239 – 243. 194. Senzel L, Surks MI, and Buettner C: Polyuria and abdominal pain in a young Jamaican woman. Laboratory Medicine, 2004; 35: 100 – 103. 195. Surks MI: Response: (to Subclinical Thyroid Dysfunction: A joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association and The Endocrine Society) THYROID, 2005,15:32-33. 196: Surks MI: COMMENTARY: Subclinical Thyroid dysfunction: A joint statement on Management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine society. J Clin Endocrinol Metab 2005, 90: 586- 588 197: Surks, MI, Goswami G, Daniels GH: CONTROVERSY IN CLINICAL ENDOCRINOLOGY: The thyrotropin reference range should remain unchanged. J Clin Endcrinol Metab 2005; 5489 – 5496. 37 198. Surks, MI Hypothyroidism: New issues and controversies. The Endocrinologist. 2006.16: 203-208. 199. Meyerovitch J, Rotman-Pikielny P, Sherf M, Battat E, Levy Y, Surks MI: Serum thyrotropin measurements in the community: Five-year follow-up in a large network of primary care physicians. Arch Intern Med 2007; 167: 1533-1538. 200. Surks MI, Hollowell JG: Age-specific distribution of serum TSH and antithyroid antibodies in the United States Population; Implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol and Metab 2007; 92: 4575-4582. 201 Boucai L, Surks MI: 2008. Age- and race-specific distribution of serum thyrophin (TSH) and free thyroxine (Free T4) in an urban outpatient practice of medicine. Clinical Endocrinology 70:788-793. 202. Surks, MI. 2008. Should the upper limit of the normal reference range for TSH be lowered? Nature Clinical Practice: Endocrinology and Metabolism 4: 370-371 203. Surks MI. 2008 Editorial: New evidence against lowering the thyrotropin reference limits. Clin Thyroidology 20: 8 204. Surks MI 2008 Concise Review: TSH reference limits: Emerging concepts and implications for the prevalence of subclinical hypothyroidism. Clin Thyroidology 20: 4-5. 205. Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I: 2009 Extreme longevity is associated with increased serum thyrotropin. J Clin Endocrinol Metab 94:1251-1254. 206. Atzmon G, Barzilai N, Surks MI, Gabriely I 2009 Genetic Predisposition to Elevated Serum Thyrotropin is Associated with Exceptional Longevity. J Clin Endocrinol Metab 94: 4768-4775 207: Surks MI, Boucai L. 2010 CLINICAL REVIEW: Age- and Race- based Serum Thyrotropin Reference Limits. J Clin Endocrinol Metab. 95: 496-502. 208: Boucai L, Surks MI. 2011 An Approach for Develolpment of Age-, Gender-, and Ethnicity-Specific Thyrotropin Reference Limits. THYROID 21: 5 – 11. 209: Surks MI 2011 Milestones in Thyroid Research at Montefiore Medical Center: 1920 – 2011: History and Personal Reflections---in press 38 39 ABSTRACTS: More than 150 presentations at national and international meetings: Dr. Surks does not list ABSTRACTS individually. BOOKS 1. Surks, Martin I. The Thyroid Book, Consumer Reports Books; Yonkers, New York. 19931998; Revised 1999 Omnipress (http://www.thethyroidbook.com) 2. Surks, Martin I., Editor, Atlas of Clinical Endocrinology, Volume I. Thyroid Diseases. Current Medicine, Philadelphia PA. 1999. 3. Surks, M.I., Dalkin, A.C., Editors, Curriculum for Training in Endocrinology, Diabetes and Metabolism, Association of Program Directors of Endocrinology, Diabetes, and Metabolism, (http://www.APDEM.org ) December 2000, pages 1-94. LETTERS 1. Surks, M.I.: Ethics in Research, New York Times, Letter to the Editor, August 12, 1980. C 3. 2. Surks, M.I.: Research That Can't Do Without Animals, New York Times, Letter to the Editor, May 23, 1983, A 24. 3. Surks, M.I.: Hypothyroidism and Phenytoin, Letter to the Editor, Annals of Internal Medicine 102:871, 1985. 4. Tibaldi, J. M., Barzel, U., Albin, J. and Surks, M.I.: Thyrotoxicosis in the very old, Annals of Internal Medicine 82:1281, 1987. 5. Surks, M.I.: Reliable Hormone Levels, New York Times, Letter to the Editor, August 31, 1987, A 18. 40 6. Surks, M.I.: Thyroid-Stimulating Hormone: Reference Range Validity, JAMA: 266. 1573, 1995 7. Surks, M.I.: High-altitude cerebral edema, Letter to Editor, J.A.M.A. 281:1794, 1999. 8. Surks, M.I.: Neonatal Hyperthyroidism, Thyroid, 12:346, 2002. 9. Buettner C. and Surks MI: Police detainment of a patient following treatment with radioactive iodine. JAMA, 292: 2687, 2002. 10. Surks MI, Col NF, Daniels GH. Screening and treatment for Subclinical Thyroid disease. JAMA 291: 2266-2267. 11. Surks MI, Response to Position Statement on Subclinical Thyroid Dysfunction; 2005. Endocrine Practice 10; 513 – 514. 41