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( \)' (rr (3)'. { Lft} UNIVERSITY OF'CALICUT (Abstract) prograrnme in Chemistry under Credit Semester System (PG) Scheme and MSc Syllabus -approved -implemented-with effect from 2010 admission Orders-issued. GENERAL & ACADEMTC BRANCH.IV 'J' SECTION Dated, Calicut lJniversity PO, 30 .07.2010 No. GA lYlJ2l4684l10 Read: 1 . U.O.No. GAIV/JI 11373108 dated, 23.07 .2010. 2.ltemno.2 of the minutes of the meeting of the Board of Studies in Chemistry held on 21.06.2010 ORDER. As per University Order read as first, Credit Semester System was implemented to PG programmes in affiliated Arts and Science Colltges and Self Financing Centres of the University with effect from 2010 admission onwards. The Board of Studies in Chemistry ,vide paper read as second, considered the number of courses to be offered ,course content, evaluation and grading,etc of the MSc. Chemistry programme of affiliated colleges trnder CSS pattern to be implemented from the academic year 2010-1 1. The recommendations of the Board in respect of courrses to be offered for M.Sc Chemistry under CSS and the syllabus were also finalized. The Vice-Chancellor has approved the minutes subject to ratification by the Academic Council. Sanction has therefore been accorded for inrplenrenting the scheme and Syllabus of l't Semester of MSc programme in Chernistry with effect from 2010 admission. orders are issued accordingly. Scheme and syllabus appended. I sd/DEPUTY REGISTRAR (G & A I\r) Por REGISTRAR To The Principals of affiliated Colleges offering MSc prograrnme i'- Chemistry Copy to: PS to VC, PA to Registrar, chairman, B/s chemistry, cE, Ex, DRIII, DR, PG,EGI, Enquiry,System Administrator with a request to uploatl in the ' 'G'GAII,il University website, Information Centres, Forwarded/BY G NO Desktop/Saj i/chemi stry 4684 CER. LtionfuK tl u'o 6lrv[stl r+LBq\to Au 3o'o-]'to' UNIVERSITY OF CALICUT M.Sc. CHEMISTRY (CSS PA.TTERN) Regulations and Syllabus with effect from 2010 admission Preamble The Board of Studies in Chemistry (PG) at its meeting held on 21.O6.2Ot0 considered the introduction of Credit Semester System (CSS) in affiliated colleges for the PG programmes in Chemistry and resolved to implement the CSS pattern from 2010 admission onwards. The revised course pattern, syllabus, distribution of credits and scheme of evaluation, etc. approved by the Board are given below: 1. (a) The name of the course shall be M.Sc. Chemistry under CSS pattern. &) The course shall be offered in four semesters within a period of two Course Pattern academic years. (c) Eligibility for ad,mission wiII be as per the rules laid down by the University from time to time- (d) Course pattern: AII courses offered in the first two semesters are core courses. The instruction hours per week and number of credits of these courses are given in Table 1. Examination of the theory papers will be conducted ui th" end of each semester- Examination for the 1't and 2"d semester practical courses will be conducted at the end of second semester. In Third, semester two core theory papers (4 x 2 = 8 credits) and one elective theory (4 credits) and three core practicals (3x2 = 6 cred.its). In the fourth semester one core paper (4 credits) and two elective papers (4x2 = 8 credits). A research project having 8 credits is in IV Semester (Table 2). Practical Examination will conducted at the end of IV Semester. I included , Detailed. syllabus of the frrst semester courses are given below' be I TABLE CoursesofferedforM.Sc.ChemistryProgrammeunderCCSSin Affiliated Colleges Course Code E fEI F.t a f-l rI1 a Instruction/ Course Title Week I CH1CO1 Theoretical Chemistry CH1CO2 Inorsanic Chemistry CH1CO3 Orsanic ChemistrY CHlPO1 CH1PO2 Inorganic ChemistrY Ptttlgl Oreanic Chemistry Practical I CHlPO3 Phvsical ChemistrY Practical I I I 4 4 4 4 4 4 4 4 I 4 t2 Total Credits (Core) p1 f-] H a frl CH2CO4 Theoretical ChemistrY CH2CO5 Phvsical Chemistry CH2CO6 cH.zPO4 CHzPO5 tEI a CH2PO6 II I Oreanic Chemistry II Inorsanic Practical I Oreanic Practical I Phvsical Practical I 4 4 4 4 4 4 4 4 4 4 4 4 24 Total Credits (Core) F-l Er a 4 4 4 4 4 2 CH3CO8 II Inorsanic ChemistrY II CH3PO7 Inorsanic Practicals CH3PO8 Orsanic Practicals 4 2 CH3PO9 Physical 4 2 CH3CO7 fr Credits Phvsical ChemistrY III III Practicals III | frl Svnthetic Organic ChemistrY 4 4 t-I Natural Products 4 4 CH3EO3 Polymer ChemistrY 4 4 CH3EO4 Instrumental Methods of Analysis TheorY 4 4 a Total Credits - Core Elective t4 4 CH4CO9 Advanced Topics in Chemistry 4 4 CH4EO5 Computational Chemistry 4 4 CH4EO6 Solid State ChemistrY 4 4 Er CH4EO7 Industrial CatalYsis 4 4 frl CH4EO8 Bioinorganic ChemistrY 4 4 E.I CH4EO9 Organometallic Chemistry Research Project and Viva 4 4 L2 8 F4 frl a z a CH4PrOl Voce Total Credits - Core 4 Elective Project 8 8 TOTAL CREDITS OF THE PROGRAMME CORE 54 ELECTIVE t2 PROJECT 8 7 UNI\MRSITY OF CALICUT M.SC. CHEMISTRY CHICO1 - SEMESTBR I - THEORETICAL CHEMISTRY - I (4 Credits) (72 h) [Contents : Quantum Mechanics (8 units)] UNIT I : The Foundations of Quantum Mechanics (9 h) Historical background of quantum mechanics. Detailed discussion of postulates of quantum mechanics - State function or wave function postulate, Born interpretation of the wave function, weII behaved functions, orthonormality of wave functions; Operator postulate, operator algebra, linear and nonlinear operators, , Laplacian operator, Hermitian operators and their properties, eigen functions and eigen values of an operator; Eigen value postulate, eigen value equation, eigen functions of commuting operators; Expectation value postulate; Postulate of time-dependent Schr<idinger equation of motion, conservative systems and time-independent Schr<idinger equation. UMT II : Quantum mechanics of translational & vibrational motions (e h) Particle in a one-dimensional box with infinite potential walls, important features of the problem; Free particle in one-dimension; Particle in a one-dimensional box with frnite potential walls (or particle in a rectangular well) - tunneling; Particle in a three dimensional box, separation of variables, degeneracy. One-dimensional harmonic oscillator (complete treatment):- Method of power series, Hermite equation and Hermite polynohials, recursion relation, wave functions and energies, important features of the problem, harmonic oscillator model and molecular vibrations. UMT III : Quantum mechanics of Rotational motion (9 h) Co-ordinate systems:- Cartesian, cylindrical polar and spherical polar coordinates and their relationships. Rigid rotator (complete treatment): The wave equation in spherical polar coordinates, planar rigid rotor (or particle on a ring), the Phiequation, solution of the Phi-equation, handling of imaginary wave functions, wave functions in the real form; Non-planar rigid rotor (or particle on a sphere), separation of variables, the Phi-equation and the Theta-equation and their solutions, Legendre and associated Legendre equations, Legendre and associated Legendre polynomials, Rodrigue's 4 formula, spherical harmonics (imaginary and real forms), polar diagrams of spherical harmonics. operators Quantizatiort of angular momentum, quantum mechanical .or.".porrding to anlular momenta ((L*, 1*', L*), commutation relations between these operators, spherical harmonics as eigen functions of angular momentum operators L & L*, Ladder operator method for angular moqentum, space quantization' UNIT IV : Quantum Mechanics of Hydrogen-like Atoms (9h) Potential enerry of hydrogen-like systems, the wave equation in spherical polar-coordinates, separation of variables, the R, Theta and Phi equations and their solutions, LagUerre and associated Laguerre polynomials, wave functions and energies of hydrogen-Iike atoms, orbit"h, radial functions and. radial distribution functions and their plots. angular functions (spherical harmonics) and their plots' The postulate .of spin by Uhlenbeck and Goudsmith, Dirac's relativistic equation for hydrogen atom and discovery of spin (qualitative trlatment), spin orbiLls, construction of spin orbitals from orbirals and spin functions. UNIT V : Approximate methods in quantum mechanics (9 h) Many-body problem and the need of approximation methods; Independent pa*icle model; Variation method - variation theorem with [e.9., prooi illustration of variation theorem using a trial function il for.the e x (a-*)] for particle in a lD-box and using the trial function hydrogen uio*, variation treatment for the ground state of helium atom; Perturbation method - time-independent perturbation method (non-degenerate case only), illustration by application to particle in a ID-box with slanted. bottom, perturbation treatment of the ground state of the helium atom. UNIT VI : euant'um mechanics of many-electron atoms (9 h) Hartree Self-Consistent Field method for atoms; Spin orbitals for many electron atoms, symmetric and antisymmetric wave functions; Pauli's antisymmeiry principle; Slater determinants; Hartree-Fock SeIfConsistent .field GF-SCF) method for atoms, Hartree-Fock equations (derivation not required) & the Fock operator; Roothan's concept of basis functions - Slater type orbitals (sTo) and Gaussian type orbitals (Gro). . h) i oppenheimer schrcidinger equation for a molecule, Born Hz molecule, of theory VB approxim"ation; Valence Bond (\trB) theory Molecular uMT VII : Chemical bonding in diatomic molecule (9 singlet and triplet state functions (spin orbitals) of Hz; orbital (MO) theory - MO theory of Hz+ ion, MO theory of Hz molecule, t MO treatment of homonuclear diatomic molecules - Liz, Bez, Cz, Nz, 02 & Fz and hetero nuclear diatomic molecules - IjII, CO, NO & HF, bond order, correlation diagrams, non-crossing rule; Spectroscopic term symbols for diatomic molecules; Comparison of MO and VB theories. UNIT VIII : Chemical Bonding in polyatomic molecules (9 h) Hybridization quantum mechanical treatment of sp, spz & sp3 hybridisation; Semi empirical MO treatment of planar conjugated molecules Hiickel Molecular Orbital (HMO) theory of ethylene, butadiene & allylic anion, charge distributions and bond orders from the coefficients of IIMO, calculation of free valenee, HMO theory of aromatic hydrocarbons (benzene); formula for the roots of the Htckel determinantal equation, Frost-Hiickel circle mnemonic device for cyclic polyenes. References 1. 2. F.L. Pilar, Elementary Quanturn Chemistry, McGraw-HiII, 1968. I.N. Levine, Quanturn Chernistry,6th Edition, Pearson Education Inc., 2009. 3. I.N. Levine, Student Solutions Manual for Quantum Chemistry 6rh fldition, Pearson Education Inc., 2009. 4. P.W. Atkins and R.S. Friedman, Molecular Quantum Mechanics, . Edition, Oxford University 5. 4th Press, 2005. M-W. Hanna, Quantum Mechanics in Chernistry, 2"a Edition, W.A. Benjamin Inc., 1969. 6. Donald, A. McQuarrie, Quantum Chemistry, IJniversity Science Books, 1983 (frrst Indian edition, Viva books, 2003). 7. Thomas Engel, Quantum Chemistry & Spectroscopy, Pearson Education, 2006. 8. 9. J.P. Lowe, Quantum Chemistry, 2nd Horia Metiu, Physical, Chemistry Francis, 2006. 10. A.K. Chandra, Introduction Edition, Academic Press Inc., 1993. - Quantum Mechanics, Taylor & to Quantum Ch,emistry, 4th Edition, Tata McGraw-Hill, 1994. 11. L. Pauling and E.B. Wilson, Introductiott. to Quantum Mechanics, lMcGraw-Hill, 1935 (A good source book for many derivations). 12. R.L. Flurry, Jr., Quanhtm Chemistry, Prentice Hall, 1983. 6 13. R.K. Prasad, Quantum Chemistry,3'd Edition, New Age International, 2006. 14. M.S. .Pathania, Quantum Chemistry and Spectroscopy (Problems & Solutions), Vishal Publications, 1984. 15. C.N. Datta, Lectures on Chemical Bonding and Quantum Chenistry, Prism Books Pvt. Ltd., 1998. 16. Jack Simons, An Introduction to Theoretical Chemistry, Cambridge University Press, 2003. 7 UNIVERSITY OF CALICUT M.Sc. CHEMISTRY _ SEMESTER I CH1CO2 - INORGANIC CHEMISTRY - I (72 hours) CREDTT 4 (4 HOURSAnmEK) UNIT I:(9h) Acid base theories - strength of acids and bases, Factors governing acid strength, solvent leveling, effect of hard and soft acids and bases, super acids, chemistry of non aqueous solvents - liquid NHs, SOz, HzSOa and HF. Heterogeneous acid-base reactions - surface acidity, Solid and molten acids in industrial processes. UNIT Ir (e h) Electron d.efi.cient compound.s - synthesis, reactions, structure and bonding. Boron hydrides, styx numbers, Boron cluster compounds, Wade's rule, Hydroborate anions, Organoboranes and hydroboration, Polyhedral anions, Carboranes, Metalloboranes, Borazines and Borides. UNIT IrI i) Standard reduction potentials and their diagrammatic representations Ellingham diagram. Latimer and Frost diagram. Pourbaux diagrams. Metallic corrosion and passivity, Isopoly and heteropoly anions of early (18 h) transidion metals. ii) Phosphorus-nitrogen compounds, Phosphazene-cyclo and linear phosphazenes. Phosphorus-sulphur compounds. Sulphur-nitrogen compounds ring and chain compounds, SzHz, SaNa, SN cations and anions iii) - synthesis, structure, bonding and uses. Silicates and alumino silicates structure. Zeolites, Silicones Synthesis, structure and applications. Carbides and silicides. UNIT rV (e h) Errors and treatment of analytical data, limitations of analytical methods, accuracy and precision, classifrcation and minimization of errors, significant frgures, standard deviation, statistical treatment of data, students tests, confidence limit, Q test, Method of least squares. uNrT v (e h) Theory Indicators, Acid-base, redox, absorption, complexometric and luminescent indicators, Titrations in non-aqueous solvents, Complex fbrmation titrations, Principles of gravimetric analysis, Formation and properties of precipitates, Co-precipitation, Precipitation from 8 homogeneous solution, Washing of the precipitate, ignition precipitate, Fractional precipitation, Organic precipitants- of the UNIT \rI (e h) co-ordination Chemistry Stereochemistry of coordination compounds. Formation constants, factors influencing stability, methods of determination of stability constants, stabilization of unusual oxidation states. Chelate-macrocyclic and template effects, ambidentate and macrocyclic ligands. Valence bond theory and its limitations. Introduction to UNIT \rlr (e h) The crystal freld and ligand field theories, orbital splitting in octahed.ral, tetrahed.ral and square planar fields. Factors affecting crystal field splitting, spectrochemical and nephelauxetic series, Racah parameters, Jahn-Teller effect, MO theory - composition of Iigand group orbitals. MO diagram of complexes with and without pi-bonding. The f-orbitals and f-block complexes References 1. D.F. Shriver, P.W. Atkins and C.H. Langford, Inorganic Chemistry, ELBS, 1990. 2. J.E. Huheey, e.A. Keiter and R.L. Keiter, Inorganic Chemistry, Principles, Structure and Reactiuity, Pearson Education, 1990. 3. F.A. Cotton and G. Wilkinson, Aduanced Inorganic Chemistry, 5th Edition, John Wiley and Sons, 1988. 4. B. Douglous, D.H. McDanials and J.J. Alexander, Concepts a,nd Models in Inorganic Chemistry, Oxford and IBH Publishing Co.Pvt. Ltd-, 1965' 5. L.V. Azaroff,Introduction to Solids, McGraw HiIl, NY, 1960' 6. 7. 8. 9. 10. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denny, Vogel's Text book of Quantitatiue Chemicals An'alysis, 5th Edition, ELBS, 1989' Skoog, West and Holler, Fund,amentals of Arualytical Chenustry, 8rh Edition, Thomson and Brooks,2004C.E. Houecroft, Cluster molecules of p-bloch elements. Oxford Scientifrc Publications, 1994. D. Sutton, Electronic Spectra of Transition Metal Complexes, McGraw HiIl, 1968. J.C. Blair, Jr. (Ed.), The Chemistry of Coordination Compounds, Reinhold Pub. Cor., 1960. 9 11. L.F. Lindoy, The Chemistry of Macrocyclic Ligands and Cambridge University Press, 72. 1989. Complexes, I J.D. Lee, Concise Inorganic Chemistry, sth Edition, Oxford University Press, 2008. Wahid U Malik, G.D. TuIi, R.D. Madan, Selected Topics in Inorganic Chemistry, S. Chand and Company Reprint 2009. 10 UNIVERSITY OF CALICUT - SEMESTER I -,ORGANIC CHEMISTRY - I (4 Credits) M.SC. CHEMISTRY CH1COB (72 h\ UNITI:(10h) Delocalized chemical bonding, Electron Delocalization, Resonance and Aromaticity: Qualitative application of Huckel Mo theory and perturbatiori theory to systems containing delocalized electrons. Delocalized electrons and Resonance, Resonance hybrid and resonance energy. Criteria for Aromaticity and Antiaromaticity, MO description of Aromaticity and Aatiaromaticity. Homoaromaticity, Mobius twist and Aromaticity. Aromaticity of Annuelens and heteroannulenes, Fullerines, and fused ring systems. Stability of benzylic cations and radicals. Effect of delocalized electrons on pKaHydrogen bond.ing: Inter- and. intramlecular hydrogen bonding. Range of the enerry of hydrogen bonding. Effect of hydrogen bond on conformation, physical and chemical properties of organic compounds, vilatility, acidity, basicity and stability of hydrates of carbonyl compounds. Stabilization of hyd.rates of glyoxal and chloral, and ninhydrin. High acid strength of maleic acid compared to fumaric acid. UNIT II : (10 h) Basic concepts in the study of organic reaction mechanisms: Application of Experimental criteria to mechanistic studies, Thl.modynamic and. kinetic data, Curtius-Hammet principles, Kinetic versus thermod.ynamic control. Acidity constant, Hammet acidity function. Reactive intermediates and their characterizatin. Isotope effect (tabelin g experiments), stereochemical correlations. Neighbouring group participation, participation of carboxylate ion, halogen, hydroxyl Broup, acetoxy souP, phenyl group and pi-bond. Structure and reactivity, Transition state theory, Potential enerry vs Reaction co-ordinate curve, Substituent effects (inductive, mesomeric, ind.uctomeric, electomeric and freld. effects) on reactivity. Qualitative study of substitution effects in SN1-SN2 reactions. Semiquantitative study of substituent effects on the -_acidity of carboxylic acids' free euantitative correlation of substituent effects on reactivity. Linear enerry relationships. Hammet and Taft equation for polar efl,ects and Taft's steric, substituent constant for steric effect. 11 r References: (Unit I and 1. II) J. March, Aduanced organic ch,emistry, 4th Edition, John wiley and Sons, 1992. 2- T.H. Lowry and K.s. Richardson, Mechan\sm and rheory in organic Chemistry, Harper Collins, 1987. 3. F.A. carey and R.J. sundberg, Aduanced organic chem,istry (parts A & B), 3.a Edition, Plenum Press, 1990. 4- R.A.Y. Jones, Physical and Mechanistic Organic Chemistry, Cambridge University Press, 1979. UNIT III : Isomerism-I (10 h) of Chirality, Recognition of symmetry elements and chiral structures, conditions for optical activity, optical purity, specific Concept rotation and its variation in sign and magnitude under different conditions, Relative and absolute confrgurations, Fisher projection formula, Sequence rule - R and S notations in cyclic and acyclic c;ompounds. Optical isomerism of compounds containing one or more asymmetric carbon atoms, Enantiotopic, Homotopic, Diastereotopic hyd.rogen atoms, Prochiral centre. Optical isomerism in Biphenyls, Allenes and Nitrogen and Sulphur compounds, conditions for optical activity, R and s notations. Restricted rotation in biphenyls - Molecular overcrowd.ing. Chirality due to folding of helical structures. Geometrical isomerism - E and Z notation of compounds with one and more double bonds in acyclic systems. Methods of d."t"r*ination of the configuration of geometrical isomers in acyclic acid cyclic systems, inter conversion of geometrical isomers. stereochemistry of Aldoximes and ketomines methods of determining configurations. - Naming - isomerism - UNIT IV : Isomerism-Il (10 h) Asymmetric Synthesis The chiral pool: Alpha amino acids in the synthesis of benzodiazepines, carbohydrates (!enzyl D mannose to Swainsonine/preparation of tomolol from D-mannitol), Felkin-Ahn model and Cramis chelation t:ontroI. t2 Chiral auxili,aries: Oxazolid'inones, Chiral sulfoxides in controlling the reduction of ketones, Camphor derivative in Dieis Alder reaction and radical reactions. Chiral reagents: BINOL, tartrates, Iithium di(l-phenyl ethyl) arnide' Chiral catalysts: Rhodium and ruthenium ca'talysts with chiral phosphine ligands like (R)BINAP, (R,R)DIOP' Enzymatic methods using enzymes' References 1. J. March, Ad,uanced, organic chemistry, 4th Edition, John wiley and' Sons, L992. 2. New Age Nasipuri, stereochemistry of organic compounds, 2'd Edition, International- 3.Kalsi,stereochemistryoforganicCompou,lr,ds,WileyEastern. 4. J. Clayden, N. Greeves, S. Warren and P. Wothers, organic Chemistry, Oxford UniversitY Press, 2001' 5. John E. EIieI and s.H. wilen, stereochemistrl' of organic compourzds' WiIeY, 1994- UNIT V : Conformational Analysis - Part I Internal factors Difference between confrguration and confrrmation' bond opposition affecting the stability of molecules - dipole interaction, projections strain, bond. angle strain. Perspective and Newman acyclic of Conformation rformationsre, alkene dih.alides,glycols, chloro o and' threo isomers, aldehYdesand chair conformation Interconversion of axial and' equatorial bonds in in both chair and distance between the various Ii atoms and C atoms boat conformations' Monosubst cyclohexanes flexible disubstituted cYclohexanes substituted an (1: cYclohexanone- hexanone,(cis&trans),2-bromo-4,4-dimethylcyclohexanone. Anchoring group and conforma of 1:4 cis and trans disubstit substituent is l-butYl and thei of an axial or equatorial s adamentane, sucrose and lactose' I 13 t/ ,l ,/ UNIT VI : Conformational Analysis - Part 2 Effect of conformation on the course and rate of reactions in (a) Debromination of dl and meso 2,3-dibromobutane or stilbene dibromide using K[. (b) Semipinacolic deamination of erythro and threo l,Zdiphenyl-1-(p-chlorophenyl)-2-amino ethanol. (c),Action of methyl magnesium bromide on 2-phenylpropionaldehyde (Stereo chemical direction of asymmeetric induction). (d) Dehydrohalogination of stilbenedihalide (dl and meso) and erythreo threo- bromo-1,2-diphenyl propane. Effect of conformation on the course and rate of reactions in cyclohexane systems illustrated by: (a) Sr.r2 and SNl reactions for (i) an axial substituent, and (ii) an equatorial substituent in flexible ana rigia systems. @) 81, E2 eliminations illustrated 'by the following compounds. (r) 4-t-Butylcyclohexyl tosylate (cis and trans) (ii) iPhenylcyclohexanol (cis and trans) (iir) Menthyl and neomenthyl chlorides and benzene hexachlorides. (c) Pyrolytic elimination of esters (cis elimination) (d) Semipinacolic deamination of cis and trans-2aminocyclohexanol (e) Esterffieation of axial as well as equatorial hydroxyl and hydrolysis of their esters in rigid and flexible systems. (Compare the rate of esterification of methanol, isomenthol, neomenthol and neoisomenthol). (0 Esterffication of axial as well as equatorial carboxyl groups and hydrolysis of their esters. (g) Hy&olysis of axial and equatorial tosylates. (h) Oxid.ation of secondary axial and equatorial hydroxyl group to ketones by chronic acid. UNIT VII : (10 h) (i) Reactions of Carbon-heteromultiple bonds (g h) Addition of carbon-oxygen multiple bond: Addition of water, alcohols, amines and hydrazine. Aldol, Perkin, Clainson, Dieckmann, Stobbe and benzoin condensation. Darzons, Knoevenagel, Reformatosky, wittig, cannizaro, Mannich and prins reactions. Mpv reduction u.rd Oppenaur oxidation. Cram's rule. Hydrolysis, alcoholysis and reduction of nitriles- Ritter reactin and rhorpe cond.ensation. (ii) Esterification and Hydrolysis (2 h) Mechanism of Ester hydrolysis and esterifrcation, Acyl-oxygen and alkyl oxygen cleavage. Esterification hydrolysis. of axial and equatorial alcohols and acids their References 1- J. March, Aduanced organic chemistry, lth Edition, John wiley Sons, 1992. 14 and Morrison & Boyd, Organic Chemistry, Prentice Hall*Parts A & F.A. Carey and R.J. Sundberg, Aduanced Organic Chenistry B), 3.d Edition, P1enum Press, 1990. 4. E.S. Gould,, Mechanism and structure in organic chemistry, Holt, Rinehart and Winston, 1959. UNIT VIII : Introduction to Polymer Chemistrv (10 h) Principles of polymerization, Classes of polyrners, Synthetic and biopolymers. Synthetic polYmers: Chain reaction polymerization and step reaction polymer:izationLinear, crosslinked and network polymers. Copolymers, Free-radical and ionic polymerization. Natural and synthetic rubbers. Biopolymers: Primary, secondary and tertiary structure of proteins, solid phase peptide synthesis, Protecting groups, Sequence determination of p"ptia". and proteins, Structure and synthesis of glutathione, Structure of RNA and DNA, Structure of cellulose and starch, Conversion of cellulose to RaYon. References 1. 2. saunders , organ,ic Polymer chemistry, chapman and HalI. 3. 4. I.L. Finar, organic chem.istry, vo}. II, s.H. Pine, J.B. Hendrickson, D.J. Cram and G.s. Hammond, organic chemistry, McGraw HiIl International Book company, 1981. 5th Edition, ELBS, 1975. Jordean, The Chemistry of Nucleic Acids, Buttorworths. 15 UNIVERSITY OF CALICUT M.Sc. CHEMISTRY _ SEMESTER CHIPO2 - ORGANIC CHEMISTRY -I I (z Credits) UNIT I : Laboratory Techniques of Separation and Purification of Organic Compounds fractional, steam and low-pressure distillations, fractional Methods crystallisation and sublimation. UNIT II : Separation and identification of the components of organic binary mixtures. Analysis of about ten mixtures, some of which containing compounds with more than one functional group. References 1. B.s. Furnis, A.J. Hannaford, p.w.G. Smith and A.R. Tatchell, vogel,s Textbook of Practical organic chemistry, ELBS/Longman, 1ggg. 2- shriner, Fuson and cartin, systematic Id,entification of organic Compounds,1,g14. 3. 4- Fieser, Experiments in Organic Chemistry, lgb7. Dey, sitaraman and Govindachari, A Laboratory Manual of organic Chemistry, 3.a Edition, 1g57. 5. P-R. singh- D.c. Gupta and K.s. Bajpal, Experimental organic Chemistry, Vol. I and II, 1990. 6. Vishnoi, Practical Organic Chemistry. 16 UNIVERSITY OF CALICUT iVT.S.. CUPNTTSTRY - SEMESTER I CHlPO1 - INORGANIC CHEMISTRY UNIT -l (2 Credits) I Separationandid.entifrcationoffourmetalionsofwhichtwoareless familiarelementslikeW'"S"-tt'tvto'Ce'-Th'Tr'Zt'V'UandLi' pr"*nt). confrrmation by spot tests' (Eliminating acid. rad,icals UNIT ,ro1 II Volumetric Determinations using: of water) (a) EDTA (Al' Ba' Ca' Cu' Fe' Ni' Co' hardness &) (c) CerimetrY (Fe2*' nitrite) Potassium Iodate (Iodide' Sn2*) References 1.G.H-Jeffery,J'Basseett'J'MendhamandR'C'Denny'Vogel'sText bookofQuantitatiueChemi'"ii""lysis'SthEdition'ELBS'1989' 2.D.A.SkoogandD.M,We;t,AnalyticalChernistry,Anlntroduction,4rh Ltd'' 1986' Edition, CLs p"ufishing Japan 3.E.J.Meehan,S.BruckensteinandI.M.KolthoffandE.B.Sandell, M acmillan Comp anv' at A;;;;;;;, JJ B aition, The chemic Quontiti,ti*-' 1969. 4.R.A.Day(Jr.)andA.L.Underwood,QuantitatiueAnalysis,6thEdition, Prentice HaIl of India' 1993' 17 \ --! UNTVERSITY OF CALICUT M.Sc. CHEMISTRY SEMESTER - I cHIpoB - pHysrcAl cHEMrsTRy - r (z credits) UNIT r : sorubility and Heat of solution (2 experiments) 1' Determination of molar heat of sorution of a substance (e.g., ammonium acid) from .otruiilt-vanarytital- method and ffirXhilf,.;ffi UNIT II : phase Equilibria (B irr, - 1'(a) Determination of phase -diagram of a simple eutectic system (e.g., .,\laphthalene _ Biphenyl, Napirtf,ut.;; _ Diphenyl amine) Determination of the composition of a binary sorid mixture. (b) 2' experiments) Determination of phase diagram of a binary sorid system forming compound (e. g., Naphtharene-m-dinitrobenzene)- a UNIT III : Viscosity 1' \/iscosity of mixtures verification of Kendall,s equation (e.g., nitrobenzene, water- alcohol) benzene- 2' (2 experiments) of molecular weight of a polymer (e.g., polystyrene in ,'jl"r_Tr':ation UNIT IV: Distribution Law (B experiments) 1' 2. 3. Ilretermination of distribution coefficient of Iz between ccla and Hzo. Determination of equrlibrium constant of KI * Iz = Kls. Determination of concentration of KI solution. References 1' 2' 3' 4' 5' 6' I' Finlay, practicar physicar chemistry. Longman,s Green & co. A'M' James, Practical Physical chemistry, J.A. churchil Ltd., 1961. F' Danier, J.w. rMilliams, p. bender, J'E' Harriman, Experiment:at physiit R.A. Alberty, c.D. cornwe, and Ci"*;rtry, Mc()ra* Hi,, 1970. S;i;"#;;"';:"r;Ue.ntat il;?riTiilri.o"" ir'lr"'o'v, Phvsicat chemist , 2,,a Edition, cambridge and c-w. Garland, Experintentat physicat chemistry, Aduanced, practicar ph.vsicai chemistry,Goer pubrications, 18