Download LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIO TECHNOLOGY
SECOND SEMESTER – APRIL 2010
BT 2953 - NANOTECHNOLOGY & MEDICAL BIOTECHNOLOGY
Date & Time: 26/04/2010 / 1:00 - 4:00
Dept. No.
Max. : 100 Marks
PART – A
(20marks)
Answer all the questions
1. Choose the best answer:
(5 x 1 = 5 marks)
(1) The term nanotechnology was first coined by
(a) Norio Taniguchi
(b) Richard Feynman
(c) Eric Drexler
(d) James Maxwell
(2) Which one of the following was used to produce fullerenes
(a) argon
(b) helium
(c) nitrogen (d) sulphur
(3) Francis Collins is associated with
(a) HGP (b) PCR (c) FACS (d) Nanotubes
(4) Which is known as “Junk” DNA
(a) ESTs (b) cDNA (c) Repetitive DNA
(d) mt DNA
(5) BRCA2 causes which one of the following cancers?
(a) breast
(b) ovarian
(c) liver (d) colon
II. State whether the following are true or false, if false give reason
(5 x 1= 5 marks)
(6) Nanocrystalline silver shows antibacterial activity.
(7) Protein nanoparticles can cross the blood brain barrier.
(8) The chances of inheriting autosomal dominant disorder is 75%
(9) STRs are used for DNA profiling
(10) Flow Cytometry cannot be used for cancer diagnosis
III. Complete the following:
(5 x 1 = 5 marks)
(11) _______ can be used as an organic phase for the synthesis of albumin nanoparticles.
(12) To make particles/fibres magnetic, they can be coated with _______ nanoparticles.
(13) Carrier frequency of cystic fibrosis is ___________
(14) VNTR stands for ______________________
(15) Retinoblastoma is a cancer of the _______
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IV. Answer the following, each within 50 words only
(16)
(17)
(18)
(19)
(20)
(5 x 1 = 5marks)
What are dendrimers?
How can gold nanoparticles be bound on to viral capsids?
What are multifactorial disorders?
Define DNA fingerprinting.
Expand: ELSI.
PART – B
(5 x 8 = 40 marks)
Answer any five of the following, each within 350 words only
(21) Describe polypeptide nanowires and mention their applications.
(22) Define the following and mention their application:
(i) Dendrimers
(ii) Buckyballs
(iii) Nanomachines
(iv) Cantilevers
(23) Explain the use of ATPase as a biomolecular motor.
(24) Write a note on nanostructured crystals.
(25) Schematically explain the blood coagulation cascade of hemophilia.
(26) Discuss how tissue identification is done in forensic sciences?
(27) Distinguish between proto-oncogenes and oncogenes.
(28) Explain the obstacles to widespread DNA testing for familial cancer syndromes.
PART - C
Answer any two of the following, each within 1500 words only
(29a) Discuss in detail the p53 gene and its role in cancer.
(2 x 20 = 40 marks)
(10 + 10 marks)
OR
(29b) Describe
(i) Aminiocentesis procedure
(ii) Explain the procedure used for paternity testing
(30a) Discuss the applications of nanotechnology in the diagnosis and treatment of diseases.
OR
(30b) Discuss the following:
(i) Alignment of nanoparticles using viruses
(ii) Carbon nanotubes
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