Download Leukaemia Section +3 or trisomy 3 in non Hodgkin's lymphoma (NHL)

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Leukaemia Section
Short Communication
+3 or trisomy 3 in non Hodgkin's lymphoma (NHL)
Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203,
Ferrara, Italy (AC)
Published in Atlas Database: January 2001
Online updated version: http://AtlasGeneticsOncology.org/Anomalies/tri3NHLID2008.html
DOI: 10.4267/2042/37711
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2001 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
+3 (right) and partial trisomy 3 due to i(3)(q10) (left) FISH - Courtesy Hossein Mossafa.
exception of marginal zone lymphomas (MZL) and
mantle cell lymphoma (MCL); in MZL, total or partial
trisomy 3 may occur in 50-70% of cytogenetically
abnormal cases, with a reported incidence by interphase
FISH in the 50-85% range; the incidence does not
appear to vary according to the clinicopathologic
features, with similar frequency in the extra-nodal
MALT lymphoma, in the nodal and the splenic form of
MZL; trisomy 3/3q was reported in 10-15% of MCL
with an higher incidence (up to 40%) by molecular
cytogenetic techniques; sporadically, other low-grade
and high grade B-lymphoid tumors may carry trisomy
3/3q.
Clinics and pathology
Disease
Trisomy 3 occurs more frequently in T-cell lymphomas
than in B-cell lymphomas.
Globally, 20-30% of T-NHL may carry trisomy 3, the
highest
incidence
having
been
noted
in
lymphoepithelioid lymphoma, in low-grade peripheral
T-cell
lymphoma,
in
angioimmonoblastic
lymphadenopathy and in adult T-cell leukemialymphoma.
Trisomy 3 is relatively rare in B-NHL, with the
Atlas Genet Cytogenet Oncol Haematol. 2001; 5(1)
44
+3 or trisomy 3 in non Hodgkin's lymphoma (NHL)
Cuneo A, Castoldi GL
on Chromosomes in Leukemia-Lymphoma. Blood. 1987
Nov;70(5):1554-64
Prognosis
The prognostic significance of trisomy 3 in T-cell and
B-cell lymphomas is unknown; there does not appear to
be a role for trisomy 3 in tumor progression from lowgrade MALT lymphoma to the high grade form,
whereas gains of 3q may be associated with the
aggressive blastoid variant of MCL.
Schlegelberger B, Himmler A, Gödde E, Grote W, Feller AC,
Lennert K. Cytogenetic findings in peripheral T-cell lymphomas
as a basis for distinguishing low-grade and high-grade
lymphomas. Blood. 1994 Jan 15;83(2):505-11
Dierlamm J, Pittaluga S, Wlodarska I, Stul M, Thomas J,
Boogaerts M, Michaux L, Driessen A, Mecucci C, Cassiman
JJ, De Wolf-Peeters C, Van den Berghe H. Marginal zone Bcell lymphomas of different sites share similar cytogenetic and
morphologic features. Blood. 1996 Jan 1;87(1):299-307
Cytogenetics
Cytogenetics morphological
Michaux L, Dierlamm J, Wlodarska L, Criel A, Louwagie A,
Ferrant A, Hagemeijer A, Van den Berghe H. Trisomy 3q11q29 is recurrently observed in B-cell non-Hodgkin's lymphomas
associated with cold agglutinin syndrome. Ann Hematol. 1998
May;76(5):201-4
Trisomy 3 may be total or partial; commonly
overrepresented segments in partial trisomy 3 include
the q21-23 region and the q25-29 region; total/partial
trisomy 3 may occur as an isolated anomaly in a
minority of cases.
Beà S, Ribas M, Hernández JM, Bosch F, Pinyol M,
Hernández L, García JL, Flores T, González M, LópezGuillermo A, Piris MA, Cardesa A, Montserrat E, Miró R,
Campo E. Increased number of chromosomal imbalances and
high-level DNA amplifications in mantle cell lymphoma are
associated with blastoid variants. Blood. 1999 Jun
15;93(12):4365-74
Cytogenetics molecular
The anomaly is readily detectable by G- and R-banding
in most cases; however, FISH using a centromeric
probe is more sensitive than conventional cytogenetics,
allowing for the study of non-dividing cells and for the
detection of partial trisomy in complex karyotypes with
marker chromosomes.
Hoeve MA, Gisbertz IA, Schouten HC, Schuuring E, Bot FJ,
Hermans J, Hopman A, Kluin PM, Arends JW, van Krieken JH.
Gastric low-grade MALT lymphoma, high-grade MALT
lymphoma and diffuse large B cell lymphoma show different
frequencies of trisomy. Leukemia. 1999 May;13(5):799-807
Genes involved and proteins
Bigoni R, Cuneo A, Milani R, Roberti MG, Bardi A, Rigolin GM,
Cavazzini F, Agostini P, Castoldi G. Secondary chromosome
changes in mantle cell lymphoma: cytogenetic and
fluorescence in situ hybridization studies. Leuk Lymphoma.
2001 Feb;40(5-6):581-90
Note
The gene(s) involved in the transformation process by
gene dosage effect or by other mechanisms are not
known.
This article should be referenced as such:
Cuneo A, Castoldi GL. +3 or trisomy 3 in non Hodgkin's
lymphoma (NHL). Atlas Genet Cytogenet Oncol Haematol.
2001; 5(1):44-45.
References
. Correlation of chromosome abnormalities with histologic and
immunologic characteristics in non-Hodgkin's lymphoma and
adult T cell leukemia-lymphoma. Fifth International Workshop
Atlas Genet Cytogenet Oncol Haematol. 2001; 5(1)
45