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Brochure More information from http://www.researchandmarkets.com/reports/3328968/ Proteomics Research Markets: Instruments & Consumables (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other), Market Share and Trends Description: Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays. Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways. This report defines the proteomics research market for major technologies. Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis. As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups: Mass SpectrometryLiquid ChromatographyElectrophoresis Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world. Proteomics is only one strand of systems biology or one of several “omics” fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the “omics,” proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment. This report also explores proteomics research market by the current and forecast size of disease group market segments that include: - Oncology- Neurology- Cardiovascular- Other As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis. The report notes the background, products and revenue of the major market players. Companies profiled include: AB Sciex (Danaher) Agilent Technologies Bruker Corporation Thermo Fisher Scientific Waters Corporation Bio-Rad Laboratories GE Healthcare Life Sciences JEOL Ltd. Shimadzu Corporation No market assessment of proteomics research is complete without a thorough discussion of its instrumentbased core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie. The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis. Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively ‘antibody-less’ workflow. This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications: - Triple Quadrupole (QqQ)- Time-of-flight (TOF)- Quadrupole-TOF (Q-TOF)- Ion Traps (IT,QIT,LIT)- OrbitrapsFT-ICR The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials. Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically. The following is among the topics addressed in this report: Current Practices in Drug DiscoveryThe Translational Research WorkflowProteomics in Biomarker Research Biomarker Discovery Biomarker Verification Biomarker Validation Company Market Shares by Research InstrumentCompany Revenues and Detailed Product OfferingsAnalyst Conclusions Regarding the Present and Future Market Kalorama Information's market analysis is worldwide and this report breaks out the market for proteomic research into geographic regions. North America is the dominant regional market for proteomics research with instrumentation distributed widely among universities, research centers, medical centers, core pharmaceutical laboratories, and specialty contract research organizations (CROs) focusing on biomarker development. Asia-Pacific is expected to see build-up of proteomics instrumentation capacity following the same trajectory of genomics research development in the region. The report defines the geographic trend in the market and provides specific proteomic research market sizes for the following regions. - United States- Europe - Asia-Pacific- Rest of World (ROW) Contents: ONE: EXECUTIVE SUMMARY Background Proteomics in Translational Research Proteomics in Biomarker Research Proteomics in Drug Target Research Proteomics Research Instruments Mass Spectrometry Liquid Chromatography Electrophoresis Industry Landscape – Major Competitors AB Sciex Agilent Technologies Bruker Corporation Thermo Fisher Scientific Waters Corporation Major Conclusions TWO: INTRODUCTION TO PROTEOMICS RESEARCH Background Translational Research Proteomics and the ‘Omics Landscape The Role of Proteins in Biological Functioning and Disease Proteins as Biomarkers Proteomics Research Samples Conclusion THREE: PROTEOMICS RESEARCH TECHNOLOGIES Background Mass Spectrometry Triple Quadrupole Time-of-Flight Ion Trap / Orbitrap Ion Sources Ion Activation Reagents Electrophoresis Gel Electrophoresis Off-Gel Electrophoresis GelFree / Continuous Flow Electrophoresis / Free Flow Electrophoresis Capillary Electrophoresis Liquid Chromatography Conclusion FOUR: PROTEOMICS RESEARCH PROCESSES – BIOMARKER AND DRUG TARGET DEVELOPMENT Background Proteomics in Biomarker Research Biomarker Discovery Biomarker Verification Biomarker Validation Proteomics in Drug Target Research (Chemical Proteomics) Target Deconvolution Conclusion FIVE: PROTEOMICS RESEARCH INSTRUMENT MARKETS Background Mass Spectrometry Market in Proteomics Research Liquid Chromatography Market in Proteomics Research Electrophoresis Market in Proteomics Research Proteomics Research Market Overview – Technologies, Geographies and Disease Conclusion SIX: COMPANY PROFILES AB Sciex (Danaher) Background Products Revenues Agilent Technologies Background Products Revenues Bruker Corporation Background Products Revenues Thermo Fisher Scientific Background Products Revenues Waters Corporation Background Products Revenue Second-Tier Market Players Bio-Rad Laboratories Background Products GE Healthcare Life Sciences Background Products JEOL Ltd. Background Products Shimadzu Corporation Background Products LIST OF EXHIBITS ONE: EXECUTIVE SUMMARY Figure 1-1: Translational Research Workflow Schematic Table 1-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT, Orbitrap, FT-ICR) – Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost Table 1-2: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020) Table 1-3: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020) Figure 1-2: Proteomics Research Market by Company Share (AB Sciex, Agilent, Bio-Rad Laboratories, Bruker, GE Healthcare Life Sciences, Thermo Fisher Scientific, Waters, Other) (2015) TWO: INTRODUCTION TO PROTEOMICS RESEARCH Figure 2-1: Translational Research Workflow Schematic Figure 2-2: Systems Biology Schematic (Genome, Transcriptome, Proteome,Metabolome) Table 2-1: Proteomics Research Sample Comparison by Advantages/Disadvantages –Cell Culture, Dried Blood Spot, Plasma, Serum, Tissue, Whole Blood THREE: PROTEOMICS RESEARCH TECHNOLOGIES Table 3-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,Orbitrap, FT-ICR) – Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost Table 3-2: Triple Quadrupole Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages) Table 3-3: Time-of-Flight / TOF Hybrid Parameters and Summary (Resolution,Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages) Table 3-4: Fourier Transform Ion Cyclotron Resonance Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages) Table 3-5: Quadrupolar, Linear and Hybrid Ion Trap Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages) Table 3-6: Orbitrap Parameters and Summary (Resolution, Mass Accuracy,Sensitivity, Mass Range, Dynamic Range, Cost, Speed,Advantages/Disadvantages) Table 3-7: Major Vendor Electrospray Ionization Innovations Summary Table 3-8: Surface Analysis Ionization Technique Advantages/Disadvantages(MALDI, SELDI, DESI, LAESI) Table 3-9: Ion Activation Method Advantages/Disadvantages (Low-Energy CID,High-Energy CID, SID, PSD, ISD, UVPD, IRMPD, ECD, ETD) Table 3-10: Electrophoresis Method Advantages/Disadvantages (SDS-PAGE, 2DGE,DIGE, OFFGEL, GELFREE, Continuous and Free Flow, Capillary) FOUR: PROTEOMICS RESEARCH PROCESSES – BIOMARKER AND DRUG TARGET DEVELOPMENT Table 4-1: Shotgun Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages) Table 4-2: Gel-Based Discovery Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages) Table 4-3: Capillary Electrophoresis-Based Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages) Table 4-4: Data-Independent Acquisition Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages) Table 4-5: Major Vendor DIA Product Comparison (Waters MSE, Thermo Fisher AIF,AB Sciex SWATH, Thermo Fisher MSX, Thermo Fisher PRM) Table 4-6: Selected and Multiple Reaction Monitoring (SRM/MRM) Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages) Table 4-7: Chemical Proteomics/Drug Target Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages) FIVE: ROTEOMICS RESEARCH INSTRUMENT MARKETS Table 5-1: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020) Table 5-2: Proteomics Research Mass Spectrometry Market by Company Share(2015) Table 5-3: Proteomics Research Liquid Chromatography Market (2015/2020) Table 5-4: Proteomics Research Liquid Chromatography Market by Company Share(2015) Table 5-5: Proteomics Research Electrophoresis Market (2015/2020) Table 5-6: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020) Table 5-7: Proteomics Research Market by Geography (North America, Europe, Asia-Pacific, ROW) (2015/2020) Table 5-8: Proteomics Research Market by Disease Area (Cardiovascular, Neurology, Oncology, Other) (2015) SIX: COMPANY PROFILES Table 6-1: AB Sciex Proteomics Products Table 6-2: AB Sciex Revenue (2009-2014) Table 6-3: Agilent Technologies Proteomics Products Table 6-4: Agilent Technologies Revenue (FY 2009-2014) Table 6-5: Bruker Corporation Proteomics Products Table 6-6: Bruker Corporation Revenue (2009-2014) Table 6-7: Thermo Fisher Scientific Proteomics Products Table 6-8: Thermo Fisher Scientific Revenue (2009-2014) Table 6-9: Waters Corporation Proteomics Products Table 6-10: Waters Corporation Revenue (2009-2014) Table 6-11: Bio-Rad Laboratories Proteomics Products Table 6-12: GE Healthcare Life Sciences Proteomics Products Table 6-13: JEOL Ltd. 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