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Revista de Saúde Pública ISSN: 0034-8910 [email protected] Universidade de São Paulo Brasil Aki Tanikawa, Aline; Fiorelli Dias Barreto, Sarita; Tommasini Grotto, Rejane Maria; de Moura Campos Pardini, Maria Inês Coexistência de variantes HIV-1 com inserção dipeptídica no gene da transcriptase reversa Revista de Saúde Pública, vol. 47, núm. 4, agosto, 2013, pp. 821-823 Universidade de São Paulo São Paulo, Brasil Available in: http://www.redalyc.org/articulo.oa?id=67240207020 Abstract ABSTRACTThe aim of this communication was to describe the detection of the coexistenceof HIV-1 variant with dipeptide insertion between codons 69 and 70 of reversetranscriptase. These variants were isolated from a 16-year-old male patient,undergoing treatment in the city of Marilia, SP, Southeastern Brazil. Afterconfirmation of treatment failure, resistance to antiretroviral drugs testing wasperformed and two variants with the insertions of the aminoacids Ser-Gly/Ser-Ala at codon 69 of reverse transcriptase were detected, besides the T69Smutation. These insertions have low prevalence, have not been reported insituations of coexistence in Brazil and are related to multidrug resistance, whichmakes this epidemiologicalfinding relevant.DESCRIPTORS:HIV-1, genetics. HIV Reverse Transcriptase. HumanImmunodeficiency Virus Proteins. Drug Resistance, Multiple, Viral. Keywords HIV-1, genética, Transcriptase Reversa do HIV, Proteínas do Vírus da Imuno deficiência Humana, Farmaco rresistênciaViral Múltipla, Comunicação Breve. How to cite Complete issue More information about this article Journal's homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative
