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Date Prepared August 28, 2015 Name Gregory M. Miller Ph.D. Office Address Northeastern University Bouve College of Health Sciences Department of Pharmaceutical Sciences and Center for Drug Discovery Mugar Hall Room 338 360 Huntington Ave., Boston, MA 02115 Home Address 21 Curtiss Circle, Sudbury, MA 01772 Work Phone (617)-373-6985 Cell Phone (508) 930-8027 Work Email [email protected] Work FAX (617)-373-6985 Place of Birth Bronx, New York Education 1986 B.A. Psychology Ithaca College, NY 1991 M.A. PsychologyNeuropsychology Queens College, City University of New York 1993 Ph.D. Biomedical Sciences Mount Sinai School of Medicine, City University of New York Postdoctoral Training 09/93-01/94 Research Fellow in Medicine, Division of Endocrinology and Metabolism Neuroendocrinology and Neurobiology of Reproduction Mount Sinai School of Medicine, New York, NY 01/94-01/97 Research Fellow in Medicine, Neuroendocrine Unit Neuroendocrinology and Pituitary Tumor Biology Massachusetts General Hospital and HMS, Boston, MA 01/10 Responsible Conduct of Research (RCR) HMS, Boston, MA 03/13 PRIM&R, Public Responsibility in Medicine and Research; IACUC 101 Training and IACUC Research Animal Oversight Baltimore, MD 2 Faculty Academic Appointments 01/97-05/97 05/97-12/04 01/05- 07/12 07/12- 08/14 08/14 – 08/14 – 08/14- 06/16 Instructor Instructor Assistant Professor Associate Professor Associate Professor Associate Scientist Visiting Assoc. Prof. Medicine Psychiatry Psychiatry Psychiatry Pharmaceutical Sciences Center for Drug Discovery Psychiatry Harvard Medical School Harvard Medical School Harvard Medical School Harvard Medical School Northeastern University Northeastern University Harvard Medical School Appointments at Hospitals/Affiliated Institution 1/95 – 5/97 9/14 – 6/16 Assistant in Biochemistry Visiting Scientist Neuroendocrine Unit, Medicine Dept. of Psychiatry Massachusetts General Hospital, Boston, Massachusetts Beth Israel Deaconess Medical Center Major Administrative Leadership Positions 1997-2005 Division Manager Division of Neurochemistry New England Primate Research Center, Harvard Medical School 2006-2008 Acting Chair, Division of Neurochemistry New England Primate Research Center, Harvard Medical School 2006-2014 Director, Primate Genetics Core New England Primate Research Center, Harvard Medical School 2007-2011 Director of Research and Compliance Mouse Behavioral Laboratory New England Primate Research Center, Harvard Medical School 2012-2014 Director, Summer Undergraduate and Summer Veterinary Training Programs New England Primate Research Center, Harvard Medical School Professional Service – Academic 2009 Member, Renovation Committee New England Primate Research Center, Harvard Medical School 2010/2011 Chair, Search Committee - Genetics Faculty New England Primate Research Center, Harvard Medical School 2012 Member, Animal Records Information Technology Team New England Primate Research Center, Harvard Medical School 3 Professional Service – Academic, cont. 2013 Appointed - NEPRC IACUC New England Primate Research Center, Harvard Medical School 2015 Honors Education Inquiry Group Northeastern University 2015 Graduate Student Committee Department of Pharmaceutical Sciences Northeastern University 2015 Department Chair Search Committee Department of Pharmaceutical Sciences Northeastern University 2015 Ph.D. Qualifying Exams Department of Pharmaceutical Sciences Northeastern University 2015 Ph.D. Thesis Proposal Defenses Department of Pharmaceutical Sciences Northeastern University 2015 Faculty Mentor for NU Masters Students Department of Pharmaceutical Sciences Northeastern University 2015 Capstone Project Supervisor Department of Pharmaceutical Sciences Northeastern University Professional Service, National and International 2007-2014 Genomic Banking Consortium National Center for Research Resources 2007-2014 Genetics Consortium National Center for Research Resources 2008-2009 Member, Publications Committee College on Problem of Drug Addiction 2009-2012 Chair, Publications Committee College on Problem of Drug Addiction 2012-2016 Board Member, Board of Directors College on Problem of Drug Addiction 2012-2014 Nominations Committee College on Problem of Drug Addiction 2014- Senior Oversight, Pub. Committee College on Problem of Drug Addiction Membership in Professional Societies 1992- Society for Neuroscience Member 2001- College on Problems of Drug Dependence Member 2005- Research Society on Alcoholism Member 2006- International Society of Psychiatric Genetics Member 2007- American Society for Pharmacology and Experimental Therapeutics Member 2013- Public Responsibility in Medicine and Research (PRIM&R) Member 4 Grant/Center Review Activities 2007 Grant Reviewer October, 2007 Neurological Foundation of New Zealand 2007-2008 The Mount Sinai Center for Personalized Medicine Review Panel October, 2007 June, 2008 Andrea and Charles Bronfman Philanthropies, New York, NY Center Reviewer Center Reviewer 2008 Grant Reviewer February, 2008 National Science Foundation, The Hague, the Netherlands 2008 Grant Reviewer May, 2008 Netherlands Genomic Initiative Ad hoc Reviewer 2008-2010 Grant Reviewer September, 2008 October, 2009 September, 2010 NSF Ad hoc Reviewer Ad hoc Reviewer Ad hoc Reviewer 2009 B/START study Section March, 2009 NIDA/ NIH Ad hoc Reviewer 2010 ZDA1 GXM-A (09) 1 March, 2010 NIDA/ NIH Ad hoc Reviewer 2011 INIA WEST May, 2011 NIAAA/NIH Reviewer 2011 INIA STRESS June, 2011 NIAAA/NIH Reviewer 2011 ZAA1 GG (21) July, 2011 Ad hoc Reviewer NIAAA/NIH 2012 Grant Reviewer February, 2012 Health Research Council of New Zealand 2012 Harvard Catalyst April, 2012 Harvard Medical School Reviewer 2013 ZRG1 NMB-A (02) S NIH Study Section May/June, 2013 CSR 2013 Grant Reviewer Visiting Professorship Grant The Leverhulme Trust London, UK 2014 ZRG1 MDCN-B(05) NIH Study Section CSR 2015 ZRG1 MDCN-B(05) NIH Study Section CSR 5 Editorial Activities (2007-) 2007, 2010, 2011 2007 2007, 2008, 2010 2007 2008 2008, 2009 2008 2008 2008 2009 2009 2009 2010 2010 2010 2010 2011 2011 2011 2011 2012, 2015 2012 2012 2012 2012 2012 2012 2013 2013 2014 2014 2014 2015 BMC Genomics American Journal of Primatology Molecular Psychiatry PNAS Archives of General Psychiatry Bioorganic and Medicinal Chemistry Journal of Molecular Biology Pharmacological Review BMC Neuroscience Journal of Lipid Research Molecular Pharmacology Biochemical Pharmacology Neuropharmacology Psychoneuroendocrinology Journal of Neural Transmission Human Genetics Schizophrenia Research Neuroscience & Biobehavioral Reviews Journal of Neuroimmune Pharmacology Psychopharmacology Neuropsychopharmacology Chemical Biology & Drug Design Progress in Neuro-Psychopharmacology & Biological Psychiatry Genes, Brain and Behavior Journal of Neurochemistry Journal of Medical Primatology Synapse Translational Developmental Psychiatry Pharmacogenetics and Genomics Journal of Pharmacology and Experimental Therapeutics International Journal of Neuropsychopharmacology Physiology and Behavior Scientific Reports/Nature Publishing Group 6 Other Editorial Roles 2009 Issue Editor, Genetic Tools for Understanding the Primate Genome Methods 2009-2012 Editor, News and Views Section Drug and Alcohol Dependence Awarded NIH Grants 1991-1994 Endocrinology Training Grant NIDDK/ T32DK07645 Graduate Trainee Terry Davies, MD (PI) 1994-1995 Endocrine Training Grant NIDDK/ P32DK07028 Postdoctoral Trainee Anne Klibanski, MD (PI) 1996-1997 Somatostatin Receptors in Pituitary Tumors NIDDK/ NRSA F32DK09281 PI 1997-2006 Evaluation of novel cocaine medications NIDA/R01 11558 Co-I; PI Bertha K. Madras 1998-2008 Molecular probes for cocaine recognition sites NIDA/ R01 06303 (Merit Award to Bertha K. Madras) Co-I (1998-2006); PI Bertha K. Madras Managing PI (2006-2008; $731,859) To explore neurochemistry of psychostimulant drugs of abuse and therapeutics that target the brain monoamine transporters. 2004-2014 P51OD011103 (NEPRC Base grant) NIH/OD/ORIP Core Scientist; Jeffrey Flier PI New England Primate Research Center Base Grant Institutional support 2004-2010 Trace amine receptors in nonhuman primates NIDA/ R01 016606 PI ($1,160,534) To explore a newly-identified receptor family in primate brain. 7 Awarded NIH Grants, cont. 2006-2009 A monkey model of human mu-opioid receptor physiogenetics NIDA/ R21 021180 PI ($457,399) To explore comparable functionality of rhesus and human opioid receptor polymorphisms. 2007-2010 Alcohol abuse pharmacogenomics: building naturalistic rhesus monkey models NIAAA/ R21 016194 PI ($443,823) To assess novel polymorphisms and explore genotype/phenotype relationships in rhesus monkeys related to human alcoholism. 2007-2010 Methamphetamine effects via Trace Amine Associated Receptor 1 NIDA/R21 022323 PI ($472,788) To assess Trace Amine Associated Receptor 1 functionality with regard to mechanisms of methamphetamine action in brain. 2008-2011 Neurogenetics of serotonin regulation: building naturalistic rhesus monkey Models NIMH/ R21 077995 PI ($429,413) To assess neurogenetic effects of polymorphisms in serotonergic genes. 2009-2011 TAAR1 polymorphisms in rhesus monkeys NIDA/ R03 025802 PI ($173,500) To identify and characterize Trace Amine Associated Receptor 1 genetic variants in rhesus monkeys and humans. 2009-2010 Alcohol abuse pharmacogenomics: building naturalistic rhesus monkey Models NIAAA/ R21 Supplement 016194-02S1 PI ($111,749) To continue the productive research assessing novel polymorphisms and exploring genotype/phenotype relationships in rhesus monkeys related to human alcoholism. 8 Awarded NIH Grants, cont. 2009 Methamphetamine Effects via Trace Amine Associated Receptor 1 NIDA/ R21 Supplement 022323-02S1 PI ($11,267) To fund a summer student, Kate Sullivan, to work on a project using Trace Amine Associated Receptor 1 Knockout Mice. 2009-2014 Drug Abuse-related Neurobiology and Genetic Variance Modeled in Rhesus Monkeys NIDA/ K02 025697 PI ($615,275) Independent Scientist Award (for salary support/career development) 2009-2014 Opioid Receptor Polymorphisms and Nonhuman Primate Models of Alcohol Abuse NIAAA/ R01 016828 Co-I; Donna Platt PI ($2.060,315) To assess a novel polymorphism and explore naltrexone pharmacogenomics in rhesus monkeys related to human alcoholism. *This grant succeeds R21 021180 (GMM-PI) 2012-2014 Naltrexone and AIDS progression NIDA/ 1R21DA034420 PI ($437,500.00) To investigate Low Dose Naltrexone as a novel therapeutic intervention for HIV using previously SIV-infected rhesus macaques. 2010-2015 Epigenetic Regulation of Serotonin: Relevance to HIV and Methamphetamine Abuse NIDA/ R21 030177 (3 yr RFP) PI ($947,744 ) To investigate epigenetic mechanisms of serotonergic genes in normal and SIV-infected rhesus monkeys. 2010-2015 Functional genetic evolution of human brain behavior NIAAA/ 5R01AA19688 Co-I; Eric Vallender PI ($1,956,412) To investigate functional polymorphisms in rhesus monkeys 9 Competitive Institutional Awards 2005-2007 NEPRC New Lab Start-up Package/ Promotion to Assistant Professor New England Primate Research Center, Harvard Medical School PI (two years of salary plus $50,000/year for two years) To establish an independent laboratory at NEPRC. 2007-2009 Naturalistic modeling of alcoholism genotype/ phenotype relationships and naltrexone pharmacogenomics in rhesus monkeys NEPRC Pilot Project (competitive) PI ($80,000 Direct Cost) To establish a pharmacogenomic preclinical platform using rhesus monkeys for medications development for alcoholism. 2009-2011 Development of a cognitive biomarker for alcoholism NEPRC Pilot Project (competitive) Originator, Co-I; Donna Platt PI ($100,000 Direct Cost) Identify biomarkers of cognitive function in genetically-characterized alcoholdrinking rhesus monkeys prior to and after alcohol exposure. 2010-2011 A marmoset model of methamphetamine-induced cognitive, motor and neurological effects NEPRC Pilot Project (competitive) PI ($40,000 Direct Cost) To investigate behavioral effects of methamphetamine mediated by Trace Amine Associated Receptor 1. 2015- Unrestricted Faculty Research Funds PI ($187,000) These funds were gifted to me from Harvard University and were transferred to Northeastern University for my professional use. Funding of Student Mentees 2006 Irene and Eric Simon Brain Research Foundation Summer Fellowship to fund Liz Calder, undergraduate student “A monkey model of mu-opioid receptor physiogenetics” 2007-2012 Supervision and training of one undergraduate summer student each year funded through the Department of Psychology University of Massachusetts, Amherst MA 2009 NIH R21 Supplement 022323-02S1 Funding for Kate Sullivan, undergraduate student “Methamphetamine Effects via Trace Amine Associated Receptor 1” 10 Funding of Student Mentees, cont. 2011 College on Problems of Drug Dependence Travel Award NIDA Mini-convention - Frontiers in Addiction Research Kiran Akila, foreign student from India 2015 Northeastern University Provost Undergraduate Research and Creative Endeavors Award to fund Paige Dickson, undergraduate student “Elucidation of the chemically-induced methamphetamine immune response and its potential mediation by a receptor target, Trace Amine Associated Receptor 1" Addiction Sciences Lab, Miller PI, Northeastern University ($2,625) 2015 Northeastern University Undergraduate Honors Program Early Research Assistantship, Inaugural. Only faculty member awarded two awards Selected students: Nina L Tamashunas, Kevin S Freeman Addiction Sciences Lab, Miller PI, Northeastern University ($1000 each) 2015 Northeastern University Scholars Independent Research Fellowships (SIRFs) To fund two Honors Scholars Students under my mentorship Jared Ontko and Cindy Wu "Central and microbiomic circadian disruptions during finals week: How biological clocks in the gut and brain interact to effect cognitive performance during diet change and sleep deprivation.” ($10,000) 2015 Northeastern University Scholars Independent Research Fellowships (SIRFs) To fund two Honors Scholars Students under my mentorship Kristen Brown and Christine Boutros "Exploring co-use of marijuana and alcohol (“crossfading”): order effects of marijuana constituents on ethanol self-administration in a mouse model." ($10,000) 2015 Northeastern University Undergraduate Honors Program Early Research Assistantship, Summer 2015. Two awards Selected students: Nicholas Mortillaro, Lauren Abbott($1000 each) 2015 Nu Rho Psi Undergraduate Research Grant – 1 of 2 National Awards Kristen Brown, Sophomore, Honors Scholars Undergraduate, Behavioral Neuroscience; and Christine Boutros, Sophomore, Honors Scholars Undergraduate, Behavioral Neuroscience "Exploring co-use of marijuana and alcohol (“crossfading”): order effects of marijuana constituents on ethanol self-administration in a mouse model" ($400) 11 Unfunded and/or In Submission NIH Grants 2014 2R01DA011558-10A1 (MPI) Novel psychostimulant drugs of abuse: behavior, biology, pathology. Miller PI; Madras PI Impact Score: 44, Percentile Score: 46.0 2014 1R21DA036708-01 Immunological actions of methamphetamine via trace amine associated receptor 1 Miller-PI Impact Score: 58 2014 1R01AA021189-01A1 Trace amine associated receptor 1 in alcohol behaviors and treatments Miller-PI Impact Score: 49 2014 TAAR1-Cannabinoid Receptor Signaling Interactions in Drug Abuse R21 submission 10/16/14 not discussed Resubmitted 5/15 2015 Alternative REST Splicing and Neural Gene Expression R21 submission 2/19/15 not discussed 2015 Alternative Splicing of REST in Neuroepigenetics R01 submission 6/3/15 Teaching and Training Teaching of Students in Courses 1988, 1989 Psychology 101 Undergraduate City University of New York 1998 Substance Abuse: Addictive Process ABS PS 521 M.O. 4th year medical students Harvard Medical School 2014 PHSC6300 11556 Pharmaceutical Science Seminar SEC 01 - Fall 2014 Graduate Northeastern University 12 Teaching of Students in Courses, cont. 2014 PHSC6984 17881 Pharmaceutical Science Research SEC 05 - Fall 2014 Graduate Northeastern University 2015 PHSC6300 31639 Pharmaceutical Science Seminar SEC 01 - Spring 2015 Graduate Northeastern University 2015 PHSC6984 37349 Pharmaceutical Science Research SEC 03 - Spring 2015 Graduate Northeastern University 2015 PMCL6261 36820 Pharmacology 2 SEC 01 Spring 2015 Graduate Northeastern University 2015 PHSC4502 50013 Pharmacology/Med Chemistry 2 SEC 01 - Summer Full 2015 Undergraduate Northeastern University 2015 PHSC 4501 – Pharmacology/Medicinal Chemistry 1 SEC 01 – Fall 2015 Undergraduate Northeastern University Teaching of Students (Assistantships, Lecture Series) 1991-1992 Neuroendocrinology Arthur M. Fishberg Center for Neurobiology Mount Sinai School of Medicine, New York, NY 2003, 2005 Cell Biology of Addiction Cold Spring Harbor Course Assistant 2008 Beth Israel Deaconess Medical Center Psychiatry Residents training in Neuroscience Department of Psychiatry Residents Initiated and organized NEPRC tour and lecture series presented by NEPRC Neuroscience faculty. Presented 1 lecture: Comparable Functional Polymorphisms in Rhesus Monkey and Human Neuropsychiatric Genes 13 Teaching in Continuing Medical Education Courses 1997 Neurobiology of Addiction CME: Treating the Addictions Cambridge Health Alliance and Department of Psychiatry, Harvard Medical School Boston, MA 2008 The Neurobiology and Genetic Susceptibility of Addiction CME: Treating the Addictions. Cambridge Health Alliance and Department of Psychiatry, Harvard Medical School Boston, MA Ratings by 661 Attendees (mean): Teaching ability: 3.56/4 Level of Knowledge: 3.84/4 The objective was met: 3.55/4 New Concepts Learned: 3.56/4 Training and Mentorship in Research Mentoring of Postdoctoral Research Associates From 1996-2005, I had the opportunity to mentor postdoctoral research associates working under my supervisory assignment: 1996-1997 Mentoring of an Endocrinology Resident: Joseph Pinzone, MD Neuroendocrine Unit, MGH Daily mentorship, 1 year 1997-1998 Mentoring and training of an Assistant Professor: Larry Gracz, PhD Division of Neurochemistry, NEPRC Daily mentorship, two consecutive summers 1997-2005 Mentoring of Postdoctoral Fellows: Richard De La Graza, PhD Martin Goulet, PhD Jeffrey Brown, PhD Servet Yatin, PhD Danqing Xiao, PhD Christopher Vericco, PhD Amy Jassen, PhD Over 8 years in the Division of Neurochemistry and Instructor in Psychiatry, I mentored seven postdoctoral fellows; daily mentorship. All seven have co-published manuscripts with me. 14 Mentoring of Postdoctoral Research Associates, cont. Mentored postdoctoral research associates funded under my NIH grants: 2005-2013 Guo-lin Chen, Ph.D. Research Assistant Professor, Department of Pharmaceutical science and Center for Drug Discovery, Northeastern University Instructor in Psychiatry (promoted 12/13) Division of Neuroscience, NEPRC, HMS; Postdoctoral Fellow, Miller Lab, NEPRC 2005-2013 15 publications in my lab/ 10 are first authorship Co-I and major contributor; R21 DA030177 Epigenetic Regulation of Serotonin: Relevance to HIV and Methamphetamine Abuse, 6/10-2/14 Winner of Best Paper in Neuroscience at NEPRC - 2012 Winner of the 3rdt Annual Roger T. Kelleher Award for Excellence in Neuroscience and Behavior for: Chen G-L and Miller GM. Advances in Tryptophan Hydroxylase-2 Gene Expression Regulation: New Insights into Serotonin-Stress Interaction and Clinical Implications. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Mar;159B(2):2012, 152-71. 2005-2012 Zhihua Xie, Ph.D. Independent Consultant, Biobanking Strategies Research Associate, Division of Neuroscience, NEPRC Postdoctoral Fellow, Miller Lab, NEPRC 2005-2009 11 publications in my lab/ 7 are first authorship Best paper in Neuroscience at NEPRC: 2010 Winner of the 1st Annual Roger T. Kelleher Award for Excellence in Neuroscience and Behavior for: Xie Z and Miller GM. A Receptor Mechanism for Methamphetamine Action in Dopamine Transporter Regulation in Brain. J. Pharmacol. Exp. Ther. 2009;330(1):316-25. 2006-2009 Eric J. Vallender, Ph.D. Associate Professor, University of Mississippi Medical Center, 2015 Assistant Professor in Psychiatry 2012, Division of Neuroscience, NEPRC, HMS Postdoctoral Fellow, Miller Lab, NEPRC 2005-2009 Instructor, Miller Lab, NEPRC 2009-2012 Promotion to Assistant Professor 6/12, Harvard Medical School >20 publications 2005-2013; Awarded NRSA MH082507, Modeling the Neurogenetics of Serotonin Regulation Awarded R01 AA019688 Functional Genetic Evolution of Human Brain and Behavior, 8/10-7/15 Vallender-PI; Miller Co-I Selected as an NEPRC “Super-Instructor” following a national search and given an extensive laboratory start-up package 15 Mentoring of Postdoctoral Research Associates, cont. 2009-2010 Spencer Lynn, Ph.D. Research Assistant Professor, Northeastern University, Dept. Psychology 1 publication in my lab Awarded R01 MH093394-01 The Utility of Threat Detection in Generalized Social Anxiety Disorder: Score 14, percentile 6.0 Mentoring of Post-Bachelorette Research Technicians Reflects my strong commitment to the academic advancement of post-bachelorette young adults who were hired as research technicians in my lab. Jacob Bendor, PhD Postdoctoral Fellow, UCSF Neurology Trained at Rockefeller University with Paul Greengard Summer student in my lab 2001 and 2002; Research Technician I in my lab 2003 and 2004 Publication: Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak M, Madras BK. A Mu-opioid receptor single nucleotide polymorphism in rhesus monkey: Association with stress response and aggression. Molecular Psychiatry 2004; 9(1):99-108. Sara Hakim Graduate Student, The Albert Einstein College of Medicine Summer student in my lab 2005 and 2006; Research Technician I in my lab 2007 and 2008 Publications: Chen GL, Novak MA, Hakim S, Xie Z, Miller GM. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Molecular Psychiatry, 2006;11(10):914-28; Vallender EJ, Priddy CM, Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in the 3’ UTR of the serotonin transporter in human and rhesus macaque. Genes, Brain and Behavior 2008;7(6):690-7. Cassandra Priddy Graduate Student, Carnegie Mellon University Research Technician I 2006-2007; Research Technician II 2007-2008 Publications: Vallender EJ, Priddy CM, Chen G-L, Miller GM. Human Expression Variation in the mu Opioid Receptor is Paralleled in the Rhesus Macaque. Behavior Genetics, 2008;38(4):390-395; Vallender EJ, Priddy CM, Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in the 3’ UTR of the serotonin transporter in human and rhesus macaque. Genes, Brain and Behavior 2008;7(6):690-7. Caroline Sweeney Graduate Student University of Massachusetts Research Technician 2011-2013 Lisa Ogawa Graduate student, Yale University Research Technician 2012-2014 Publication: Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics. 2013 Oct 11;14:703. 16 Mentoring of Undergraduate Students 1997-2005 Supervision and training of undergraduate summer students in the Division of Neurochemistry New England Primate Research Center Summer Undergraduate Training Program (SUTP) Over 8 years, I supervised 2-4 students per summer. 2005-2013 Supervision and training of undergraduate summer students in my lab New England Primate Research Center Summer Undergraduate Training Program (SUTP) >30 undergraduate summer students trained in my lab over this period, averaging 6-7/summer 2014-2015 Originated a research mentorship program for undergraduate students Program overview: I initiated a “skunkworks” educational program on my own initiative and time, born out of my interest in recruiting students into biomedical research. Students were first taken through EH&S training and introduced to how to search the biomedical literature and use library resources. After studying and commenting on three review papers that I had written on one of the receptors that we study, students were granted access to a community database of electronic folders containing scientific literature by topic – centered on the concepts they were introduced to in the reviews - as a guide to help them develop their interests. Students were invited to add relevant literature to any folder, or to create their own folder. Students were assisted in gravitating towards an interest focus and in partnering with others who share a similar interest. The process created several “think tanks” where collaborative ideas got generated, fostered by Journal Club-like meetings in the evenings in Snell library, which students attended and participated in voluntarily. In doing so students built enthusiasm, comradery and a team mentality. Throughout this process, students followed a “graphic syllabus” that I created which instructs on how one goes about getting involved in scientific research of highest impact and meaning. Concurrent with these activities, students were introduced to working in the lab. Each student learned basic cell culture and many learned basic molecular biology skills. In addition to learning the specific laboratory techniques, students were exposed to a spectrum of knowledge and skills related to productive lab work, research methods, data presentation, ethics and personal integrity. Most notably, students learned how to work collaboratively together, developed laboratory skills and were introduced to issues related to the use of animal models in biomedical research. Outcomes: Students fulfilled all EH&S requirements Students were mentored in hypothesis generation and study design Students were taught laboratory techniques and methodologies Students were introduced to Research Ethics and a related mandate - a focus on animal research ethics was used to teach skills related to defending personal opinions with facts Students ran journal clubs at night that introduced the structure of the scientific manuscript and the research grant, as well as manuscript reviews related to their proposed projects Students recruited others into their team who were interested in the topic they were covering Students developed a long-term mentor/mentee relationship See “Funding of Student Mentees” above. See graphic syllabus http://www.northeastern.edu/bouve/assets/uploads/2014/10/Graphic-Syllabus-for-students.pdf 17 Local, Regional, National and International Invited Scientific Presentations Presentation within my local institution 2000 Molecular Approaches to Attention Deficit Hyperactivity Disorder NEPRC Summer Internship Program New England Primate Research Center, Southborough, MA 2002 Genes and Drug Addiction NEPRC Summer Internship Program New England Primate Research Center, Southborough, MA 2002 Point mutations of the human dopamine transporter reveal differential binding of an amine and a nonamine ligand Neuroscience Seminar Series McLean Hospital, Belmont, MA 2003 Genetic Diversity of Drug Targets in the Brain NEPRC Summer Internship Program New England Primate Research Center, Southborough, MA 2004 Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and Humans New Faculty Search Seminar New England Primate Research Center, Southborough, MA 2005 Rhesus Monkey Models in Neurobiology, Neuropsychiatry and AIDS Boston University-NEPRC symposium New England Primate Research Center, Southborough, MA 2005 Naturalistic Modeling of Human Functional Polymorphisms in Rhesus Monkeys Research Symposium New England Primate Research Center, Southborough, MA 2008 What are the Roles of Trace Amine-Associated Receptor 1 in Primates? Division of Behavioral Biology, NEPRC New England Primate Research Center, Southborough, MA 2008 Trace Amine Receptor 1 in Brain Monoaminergic Systems Division of Comparative Pathology New England Primate Research Center, Southborough, MA 2008 Trace Amine Associated Receptor 1 in Brain Monoaminergic Systems Neuroscience Seminar Series McLean Hospital, Belmont, MA 18 2008 The Neurobiology and Genetic Susceptibility of Addiction NEPRC Summer Internship Program New England Primate Research Center, Southborough, MA 2008 Comparable Functional Polymorphisms in Rhesus Monkey and Human Neuropsychiatric Genes The Behavioral Genetics Laboratory McLean Hospital, Belmont, MA 2011 Drug addiction research at the New England Primate Research Center Division of Primate Resources Animal Care Staff New England Primate Research Center, Southborough, MA 2011 The Biogenic Amine/Amphetamine Receptor TAAR1: What’s It Doing in Brain Monoaminergic Systems? Neuroscience Seminar Series McLean Hospital, Belmont, MA 2013 Models of polygenetic psychiatric and addictive disorders Grand Rounds Center for Addiction Medicine Massachusetts General Hospital, Boston, MA Regional 2008 Trace Amine-Associated Receptor 1 in Brain Monoaminergic Systems Invited Speaker, Boston University Medical School, Boston, MA 2009 The Neurobiology and Genetic Susceptibility of Addiction Invited Speaker Summer Undergraduate Research Fellowship (SURF) Program Seminar Series The Massachusetts College of Pharmacy and Health Sciences, Boston, MA 2010 The Role of TAAR1 in Monoamine Transporter Regulation and Methamphetamine Action Invited Speaker, Center for Drug Discovery Annual Symposium Northeastern University, Boston, MA 2013 Trace Amine Associated Receptor 1 in the Monoamine System and its Role in Modulating the Effects of Drugs of Abuse Invited Speaker, Department of Pharmaceutical Sciences Bouvé College of Health Sciences Northeastern University, Boston, MA 2014 TAAR1 and Drugs of Abuse Invited Speaker, Center for Drug Discovery Annual Symposium Northeastern University, Boston, MA 19 National 1999 Point mutations in the human dopamine transporter reveal differential binding of an amine and a non-amine ligand Oral presentation/ selected abstract Society for Neuroscience Annual Meeting, Miami Beach, Florida 2000 Single Nucleotide Polymorphisms Distinguish Multiple Dopamine Transporter Alleles in Primates: Implications for Association With ADHD and Other Neuropsychiatric Disorders Oral presentation/ selected abstract Society for Neuroscience Annual Meeting, New Orleans, Louisiana 2001 Genetic Diversity of Drug Targets in the Brain: Relevance to Drug Response?, Oral presentation/ selected abstract College on Problems of Drug Dependence Annual Meeting, Scottsdale, Arizona. 2001 Single Nucleotide Polymorphisms Distinguish Multiple Dopamine Transporter Alleles in Primates Cold Spring Harbor Laboratory Cold Spring Harbor, NY 2002 Cloning of rhesus monkey TAR-1, a novel GPCR for “trace” amines Oral presentation/ selected abstract Society for Neuroscience Annual Meeting, Orlando, Florida 2003 A Mu-opioid Receptor Single Nucleotide Polymorphism in Rhesus Monkey: Association With Stress Response And Aggression Oral presentation/ selected abstract Society for Neuroscience Annual Meeting, New Orleans, Louisiana 2003 Genetic Variations And Phenotypic Associations Common To Rhesus Monkeys And Humans Invited Presentations Cell Biology of Addiction Course Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 2006 Rhesus monkey Trace Amine Receptor 1 Invited Presentation Lundbeck Research USA Inc., Mahwah, NJ 2006 Neurobiology and Physiogenetics of Neuropsychiatric Invited Presentation NCRR Workshops on the Rhesus Monkey Genome, NIH, Bethesda, MD 2006 Trace amine receptor 1 in Brain Monoaminergic Systems Invited Presentation Eli Lilly, Indianapolis, IN 20 2007 Using non-human primates to model the genetics of human neuropsychiatric Disorders Invited Presentation NCRR Workshops on the Rhesus Monkey Genome, NIH, Bethesda, MD 2008 Developing Non-Human Primate Genetic Models of Human Neuropsychiatric and Addictive Disease Oral presentation/ selected abstract Society for Neuroscience Annual Meeting, Washington, DC 2008 Session 314.Stress, depression and monoamines Session Chair Society for Neuroscience Annual Meeting, Washington, DC 2008 What are the Roles of Trace Amine Associated Receptor 1 in Primates? Session Organizer and Invited Presentation The 41st Winter Conference on Brain Research, Snowbird, UT 2008 Trace Amine-Associated Receptor 1 in Brain Monoaminergic Systems Selected by the Department of Physiology & Pharmacology Graduate Students as the annual invited speaker Oregon Health & Science University Portland, OR 2008 Monkey Genes Come in Human Flavors: Translational Models of Human Neuropsychiatric and Substance Abuse Disorders in Rhesus Monkeys Invited by the APA Committee on Animal Research and Ethics The 116th Annual Meeting of the American Psychological Association Boston, MA 2009 Non-Human Primate Genetic Models of Human Neuropsychiatric and Addictive Disease. The Behavioral Genetics of Co-Morbidity: More Than Just Overlapping Phenotypes Invited NIDA-sponsored Presentation The 42st Winter Conference on Brain Research Copper Mountain, CO 2009 Trace Amine-Associated Receptor 1 (TAAR1) as a Monoaminergic Modulator Invited Presentation Oregon National Primate Research Center, Beaverton, OR 2010 Oral Communications Session 16. Transmitting Information on Serotonin Session Chair College on Problems of Drug Dependence Annual Meeting Scottsdale, Arizona. 21 2011 Advancing the Rhesus Monkey Model for Opioid Research: Discovery of a Novel Nonsynonymous Variant in the Kappa Opioid Receptor Gene Oral presentation/ selected abstract College on Problems of Drug Dependence Annual Meeting Hollywood, Florida 2011 Oral Communications 2 Genetics: Code Read Session Chair College on Problems of Drug Dependence Annual Meeting Hollywood, Florida 2011 The Biogenic Amine/Amphetamine Receptor TAAR1: What’s It Doing in Brain Monoaminergic Systems? Invited Presentation Department of Physiology Emory School of Medicine, Atlanta, GA 2013 Trace Amine Associated Receptor 1 in the Monoamine System and its Role in Modulating the Effects of Drugs of Abuse. Invited Presentation Dept. Integrative Physiology and Neuroscience College of Veterinary Medicine Washington State University, Pullman, WA 2013 Studies on Trace Amine Associated Receptor 1 Invited Presentation TMED - Translational Medicine & Early Development Sunovion Pharmaceuticals Inc. Marlborough, MA 2013 Trace amine-associated receptor 1 is a methamphetamine receptor that differentially controls DAT and NET internalization Invited Presentation Symposium XIII: New Tools Provide New Insights Into Methamphetamine’s Actions College on Problems of Drug Dependence Annual Meeting San Diego, CA 2013 Trace amine associated receptor 1 modulation of the rewarding and immunological effects of drugs of abuse supports its relevance as a therapeutic target. Invited Speaker Session Chair Panel Session 1. Kicking Over the Traces Noncatecholic Biogenic Amines and Their Receptors American College of Neuropsychopharmacology 52nd Annual Meeting Hollywood, Florida 22 2015 TAAR1 And Drugs of Abuse Invited Plenary Symposium Speaker: 'TAAR1: from chemistry to behavior and its implications in drug abuse' Brain, Biology and Chemistry: Translational Research in Addiction UT Health Science Center ,March 14-15, 2015 San Antonio, TX 2015 Trace Amine Associated Receptor 1 is Implicated in the Central and Immunological Effects of Drugs of Abuse Invited Symposium Speaker American Society for Pharmacology and Experimental Therapeutics Annual Meeting Session Chair: EMERGING ROLES OF TRACE AMINE ASSOCIATED RECEPTOR 1 (TAAR1) IN DRUG ABUSE AND MENTAL DISORDERS Boston Convention & Exhibition Center March 29, 2015 Boston, MA International 2002 Genetic Diversity of Drug Targets in the Brain: Similarities Between Human and Rhesus Monkey m-Opioid Receptor Variants Oral presentation/ selected abstract College on Problems of Drug Dependence Quebec City Quebec, Canada 2005 Rhesus monkeys as naturalistic models for deciphering genotype/phenotype relationships relevant to human neuropsychiatric disorders Invited Session Speaker The 2nd International Conference on Primate Genomics & Human Disease Seattle, Washington. 2008 Comparable functional polymorphisms in rhesus monkeys and human neuropsychiatric genes Invited Session Speaker The 3nd International Conference on Primate Genomics & Human Disease Seattle, Washington. 2010 Translational Genetic and Pharmacogenomic Modeling of Human Neuropsychiatric and Drug Addiction Phenotypes Program Committee Member and Invited Session Speaker The 4th International Conference on Primate Genomics & Human Disease Seattle, WA 23 2010 Session 3. Primate Genomics and AIDS Session Chair The 4th International Conference on Primate Genomics & Human Disease Seattle, WA 2010 The TAAR1 Receptor Orchestrates Trace Amine, Common Biogenic Amine and Psychostimulant effects in Brain Monoaminergic Systems Invited Presentation The 14th Biennial International Amine Oxidase Workshop Edmonton, Alberta, Canada 2011 Exploiting the Parallel Functional Polymorphisms and Pharmacogenomic Responsivity Between Rhesus Monkeys and Humans for Drug Discovery: A New Avenue for Preclinical Modeling to Advance Personalized Medicine for Psychiatric and Addictive Disease. Target Meeting 1st World Drug Discovery Online Conference http://www.targetmeeting.com 2012 Session 2. Genomic and Primate Models of Health and Disease Session Chair The 5th International Conference on Primate Genomics & Human Disease Houston, TX 2012 A Systematic Phenotyping Strategy to Transform the Use of Rhesus Monkeys in Biomedical Research Invited Session Speaker The 5th International Conference on Primate Genomics & Human Disease Houston, TX 2012 Trace Amine Associated Receptor 1 is a Catecholamine Receptor that Differentially Controls DAT and NET Internalization Invited Session Speaker Theme B. Catecholamine Transporter Genetics The Tenth International Catecholamine Symposium Pacific Grove, California 2013 Trace Amine Associated Receptor 1 (TAAR1) Signaling Differentially Regulates Dopamine and Norepinephrine Transporter Internalization Invited Symposium Speaker Session: Anatomy and physiology of dopamine systems Topic: New Mechanisms by Which Trace Amine-Associated Receptors Modulate Dopamine Neuron Activity Dopamine 2013 Alghero, Italy 24 Education of Patients and Service to the Community Activities 2010- 2013 2013- Member, Executive Committee Member, Board of Directors Community Connections Outreach on Substance Abuse Sudbury, Massachusetts 2012 Organizer, “What were you thinking?” Presentation of the teen brain Lincoln Sudbury Regional High School Sudbury, Massachusetts 2015 Invited Speaker Nu Rho Psi National Honor Society in Neuroscience Northeastern University Chapter 2015 Invited Speaker Science Café Franklin High School Biology Department Franklin, Massachusetts 25 Scholarship Peer reviewed publications in print or other media 1. Gibson MJ, Miller GM, Silverman A-J. Pulsatile luteinizing hormone secretion in normal female mice and hypogonadal female mice with preoptic area implants. Endocrinology 1991;128:965-71. 2. Wu TJ, Segal AZ, Miller GM, Gibson MJ, Silverman A-J. FOS expression in gonadotropinreleasing hormone neurons: enhancement by steroid treatment and mating. Endocrinology 1992;131:2045-50. 3. Silverman A-J, Roberts JL, Dong KW, Miller GM, Gibson MJ. Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice. Proceedings of the National Academy of Sciences (USA) 1992;89:10668-72. PMCID: PMC50402 4. Miller GM, Silverman A-J, Roberts JL, Dong KW, Gibson MJ. Functional assessment of intrahypothalamic implants of immortalized gonadotropin-releasing hormone secreting cells in female hypogonadal mice. Cell Transplantation 1993;2(3):251-7. 5. Miller GM, Gibson MJ. Opioidergic modulation of N-methyl-D,L-aspartic acid (NMA)stimulated LH release in young adult but not older male mice. Neuroendocrinology 1994;59:27784. 6. Miller GM, Silverman A-J, Gibson MJ. Neuromodulation of transplanted GnRH neurons in male and female hypogonadal mice with preoptic area brain grafts. Biology of Reproduction 1995;52:572-83. 7. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. Somatostatin receptor subtype gene expression in pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 1995;80:1386-92. 8. Miller GM, Alexander JM, Klibanski A. Gonadotropin-releasing hormone mRNA expression in gonadotroph tumors and normal human pituitary. Journal of Clinical Endocrinology and Metabolism 1996;81:80-3. 9. Gibson MJ, Wu TJ, Miller GM, Silverman A-J. What nature's knockout teaches us about GnRH Activity: Hypogonadal mice and neuronal grafts. Hormones and Behavior 1997;31(3):212-220. 10. Madras BK, Miller GM, Meltzer PC, Brownell A-L, Fischman AJ. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addiction Biology 2000;5:3519. 11 Miller GM, De La Garza R, Novak MA, Madras BK. Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: Implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Molecular Psychiatry 2001;6:50-8. 26 12 Miller GM, Yatin SM, De La Garza R, Goulet M, Madras BK. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Molecular Brain Reserach 2001;87(1):124-43. 13 Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse 2001;42:129-40. 14 Miller GM, Madras BK. Polymorphisms in the 3’-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Molecular Psychiatry 2002;7(1):4455. 15 Madras BK, Miller GM, Fischman AJ. The dopamine transporter: Relevance to attention deficit hyperactivity disorder (ADHD). Behavioral Brain Research 2002;130(1-2):57-63. 16 Yatin SM, Miller GM, Norton C, Madras BK. Dopamine transporter-dependent and – independent c-fos induction by dopamine transporter substrates and inhibitors. Synapse 2002;45(1):52-65. 17 Madras BK, Fahey MA, Miller GM, De La Garza R, Spealman RD, Meltzer PC, George SR, O’Dowd BF, Bonad AA, Livni E, Fischman AJ. Non-amine based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. European Journal of Pharmacology 2003;479:41-51 18 Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak M, Madras BK. A Mu-opioid receptor single nucleotide polymorphism in rhesus monkey: Association with stress response and aggression. Molecular Psychiatry 2004;9(1):99-108. 19 Madras BK, Miller GM, Yatin SM. Dopamine and norepinephrine transporter-dependent immediate early gene production in vitro: new insights into psychostimulant-induced presynaptic neuroadaptation. Journal of Neuroscience Methods 2005;143(1):69-78. 20 Madras BK, Miller GM, Fischman AJ. The Dopamine Transporter and Attention Deficit Hyperactivity Disorder (ADHD). Biological Psychiatry 2005;57(11):1397-1409. 21 Jassen AK, Brown JM, Panas HN, Miller GM, Xiao D, Madras BK. Variants of the primate vesicular monoamine transporter-2. Molecular Brain Research 2005;139(2):251-7. 22 Yatin SM, Miller GM, Madras BK. Dopamine and norepinephrine transporter-dependent cFos production in vitro: relevance to neuroadaptation. Journal of Neuroscience Methods 2005;143(1):69-78. 23. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R and Madras BK. Primate trace amine receptor 1 modulation by the dopamine transporter. Journal of Pharmacology and Experimental Therapeutics 2005;313(3):983-994. 27 24. Xiao D, Miller GM, Jassen AK, Westmoreland SV, Pauley D, Madras BK. Ephrin/Eph Receptor Expression in Brain of Adult Nonhuman Primates: Implications for Neuroadaption. Molecular Brain Research, 2006;1067(1):67-77. 25. Jassen AK, Yang H, Miller GM, Calder E, Madras BK. Receptor regulation of axon guidance molecule gene expression. Molecular Pharmacology 2006;70(1):71-7. 26. Kumar, R, Orsoni1 S, Norman1 L, Tirado1 G, Verma1 AS, Staprans S, Miller G, Buch SJ, Kumar A. Morphine Addiction Causes Pronounced Virus Replication in Cerebral Compartment and Accelerated Onset of AIDS in SIV/SHIV-infected Indian Rhesus Macaques. Virology 2006;354(1):192-206. 27. Chen GL, Novak MA, Hakim S, Xie Z, Miller GM. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Molecular Psychiatry 2006;11(10):914-28. 28. Madras BK, Xie Z, Lin Z, Jassen AJ, Panas H, Lynch L, Johnson RS, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ. Modafinil Occupies Dopamine and Norepinephrine Transporters in vivo and Modulates the Transporters and Trace Amine Activity in vitro. Journal of Pharmacology and Experimental Therapeutics 2006;319(2):561-9. 29. Newman RM, Hall L, Connole M, Chen G-l, Sato S, Yuste E, Diehl W, Hunter E, Kaur A, Miller GM and Johnson WE. Balancing selection and the evolution of functional polymorphism in old world monkey trim5alpha. Proceeding of the National Academy of Science (USA), 2006;103(50):19134-9. PMCID: PMC1679755 30. Verrico CD, Miller GM, Madras BK. MDMA (Ecstasy) and Human Dopamine, Norepinephrine and Serotonin Transporters: Implications for MDMA-Induced Neurotoxicity and Treatment. Psychopharmacology 2007;189(4):489-503. 31. Xie, Z, Westmoreland S, Bahn ME, Chen G-L, Yang H, Vallender E, Yao WD, Madras BK, Miller GM. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. Journal of Pharmacology and Experimental Therapeutics 2007;321(1):116-27. 32. Xie Z and Miller GM. Trace Amine-Associated Receptor 1 is a Modulator of the Dopamine Transporter. Journal of Pharmacology and Experimental Therapeutics 2007;321(1):128-36. 33. Zhang JP, Vinuela A, Neely MH, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Inhibition of the Dopamine D1 Receptor Signaling by PSD-95. Journal of Biological Chemistry. 2007;282(21):15778-89. PMCID: PMC2649122 34. Chen GL and Miller GM. Rhesus Monkey Tryptophan Hydroxylase-2 Coding Region Haplotypes Affect mRNA Stability. Neuroscience 2008;155(2):485-91. PMCID: PMC2644555 35. Chen G-L, Vallender EJ, Miller GM. Functional Characterization of the Human TPH2 5' Regulatory Region: Untranslated Region and Polymorphisms Modulate Gene Expression In Vitro. Human Genetics 2008;122(6):645-57. PMCID: PMC2734478 28 36. Lee AS, Gutierrez-Arcelus M, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO and Lee C. Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Human Molecular Genetics 2008; 17(8):1127-36. 37. Xie Z and Miller GM. -Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain. Journal of Pharmacology and Experimental Therapeutics 2008;325(2):617-628. 38. Xie Z, Westmoreland SV, Miller GM. Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in HEK293 Cells and Brain Synaptosomes. Journal of Pharmacology and Experimental Therapeutics 2008;325(2):629-640. 39. Vallender EJ, Priddy CM, Chen G-L, Miller GM. Human Expression Variation in the mu Opioid Receptor is Paralleled in the Rhesus Macaque. Behavior Genetics 2008;38(4):390-395. 40. Vallender EJ, Priddy CM, Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in the 3’ UTR of the serotonin transporter in human and rhesus macaque. Genes, Brain and Behavior 2008;7(6):690-7. 41. Xie Z, Vallender EJ, Yu N, Kirstein S, Yang H, Bahn M, Westmoreland SV, Miller GM. Cloning, expression and functional analysis of rhesus monkey trace amine-associated receptor 6: Evidence for lack of monoaminergic association. Journal of Neuroscience Research 2008;86(15):3435-46. PMCID: PMC2644554 42. Verrico CD, Lynch L, Fahey MA, Fryer A-K, Miller GM and Madras BK. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of Psychopharmacology 2008;22(2):187202. 43. Vallender EJ, Lynch L, Novak MA, Miller GM. Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2009;150B(4):467-75. PMCID: PMC2702718 44. Chen GL and Miller GM. 5'-Untranslated Region of the Tryptophan hydroxylase-2 Gene Harbors an Asymmetric Bidirectional Promoter but not Internal Ribosome Entry Site in vitro. Gene 2009;435(1-2):53-62. PMCID: PMC2670360 45. Xie Z and Miller GM. A Receptor Mechanism for Methamphetamine Action in Dopamine Transporter Regulation in Brain. Journal of Pharmacology and Experimental Therapeutics 2009;330(1):316-25. PMCID: PMC2700171 46. Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S, Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R. Resource brief: the National Non-Human Primate DNA Bank. Methods. 2009;49(1):3-4. PMCID: PMC3172814 29 47. Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O’Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for Genetic Management and Genomics Research on Non-Human Primates at the National Primate Research Centers (NPRCs). Journal of Medical Primatology 2009;38 Suppl 1:17-23. 48. Xie Z and Miller GM. Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochemical Pharmacology 2009 78(9);1095-04. Review. PMCID: PMC2748138 49. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. The Effect of Rearing Experience and TPH2 Genotype on HPA Axis Function and Aggression in Rhesus Monkeys: a Retrospective Analysis. Hormones and Behavior 2010;57(2):184-91. PMCID: PMC2815197 50. Vallender EJ, Ruedi-Bettschen D, Miller GM*, Platt DM. A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug and Alcohol * Dependence 2010;109(1-3):252-6. PMCID: PMC2875311 Corresponding author 51. Vallender EJ, Xie Z, Westmoreland SV, Miller GM. Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evolutionary Biology 2010;10:51. PMCID: PMC2838891 52. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. TPH2 5'- and 3'Regulatory Polymorphisms Are Differentially Associated with HPA Axis Function and SelfInjurious Behavior in Rhesus Monkeys. Genes, Brain and Behavior 2010;9(3):335-347. PMCID: PMC2990963 53. *Panas H, *Lynch L, Vallender E, Xie Z, Chen GL, Lynn S, Scanlan T and Miller GM. Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. Journal of Neuroscience Research 2010;88(9):1962-9. PMC Journal - In Process * Shared first-authorship; both are Research Assistant III’s in my lab. 54. Miller GM. The Emerging Role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity. Journal of Neurochemistry 2011;116(2):164-76. PMCID: PMC3005101 Review, contains new data not published elsewhere. 55. Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z, Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: Involvement of trace amine pathways in C. elegans and M. musculus. Brain Research 2011, Jun 1;1393:91-9. PMCID: PMC3107707 56. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth associated protein-43 and Ephrin B3 Induction in the Brain of Adult SIV-infected Rhesus Macaques. Journal of Neurovirology. 2011. In press. PMC Journal - In Process 30 57. Lewin AH, Miller GM, Gilmour B. Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorganic & Medicinal Chemistry Dec 1;19(23):7044-8, 2011. PMCID: PMC3236098 58. Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, Miller GM. Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol Biochem Behav. Apr;101(2):201-207, 2012. PMCID: PMC3288391 59. Chen G-L and Miller GM. Advances in Tryptophan Hydroxylase-2 Gene Expression Regulation: New Insights into Serotonin-Stress Interaction and Clinical Implications. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Mar;159B(2):152-171, 2012 PMC Journal - In Process 60. Miller GM. Avenues for the Development of Therapeutics That Target Trace Amine Associated Receptor 1 (TAAR1). Journal of Medicinal Chemistry, Mar 8;55(5):1809-1814, 2012. PMCID: PMC3618978 61. Panas MW, Xie Z, Panas HN, Hoener MC, Vallender EJ, Miller GM. Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes. Journal of Neuroimmune Pharmacology Dec;7(4):866-76, 2012 PMC Journal - In Process 62. Chen GL, Miller GM. Tryptophan Hydroxylase-2: An Emerging Therapeutic Target for Stress Disorders. Biochem Pharmacol. 2013 Feb 19 [Epub ahead of print], In press. 63. Chen GL, Miller GM. Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer. PLOSOne 2013 Apr 16;8(4):e62217. PMCID: PMC3628349 64. Lynch J*, Sullivan KA*, Vallender EJ, Rowlett JK, Platt DM, Miller GM. Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol. Substance Abuse: Research and Treatment. 2013, Jun 4;7:117-126. PMC Journal - In Process * both are Research Assistant III’s in my lab. 65. Vallender EJ and Miller GM. Non-Human Primate Models in the Genomic Era: A Paradigm Shift. Institute for Laboratory Animal Research Journal 2013 54: 154-165. 66. Dharmendra B Goswami DB, Ogawa LM, Ward JM, Miller GM, Vallender EJ. Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics 2013, 14:703. PMC Journal - In Process 67. Cho JA, Zhang X, Miller GM, Lencer WI, Nery FC. 4-phenylbutyrate attenuates the ER Stress Response and Decreases Cyclic AMP Accumulation in DYT1 Dystonia Cell Models. PLOSOne 2014, Nov 7;9(11):e110086 68. Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA., Wachtman LM., Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK., Gevers D, Huttenhower C. Morgan XC. Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque. In press. Cell Host and Microbe 2015, 17(3):385-91. 31 Non-peer reviewed scientific or medical publications/materials in print or other media 1. Madras B, Miller GM, De La Garza R, Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Fischman AJ. Brain Imaging of the dopamine transporter in ADHD. 6th International World Congress for Biomedical.Sciences 2000;113. PMC Journal - In Process 2. Gibson MJ, Saitoh Y, Miller GM, Silverman A-J. Functional GnRH neuronal transplants in the hypogonadal mouse. In: Crowley WF Jr, Conn PM, editors. Modes of Action of GnRH and GnRH analogs. New York, New York: Springer-Verlag, 1992:144-57. 3. Miller GM, Zhang X, Klibanski A. Pituitary tumors: future perspectives. In: Kovacs, K. editors. Diagnosis and management of pituitary tumors. Totowa, New Jersey: Humana Press Inc., 2001, pgs 462-6. 4. Miller GM and Madras BK. Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and Humans. In: SA Wolfe-Coote, editor. The Laboratory Primate. Tygerberg, South Africa: Medical Research Council of South Africa, Elsevier Publishing Inc., 2005. 5. Ferguson B, Miller GM. Genetic tools for understanding the primate genome. Methods 2009;49(1):1-2. Editorial. Thesis 1. Miller GM. Neuromodulation of luteinizing hormone secretion in the mouse [dissertation]. New York (NY): City Univ. New York, 1993.
