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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION – BIOMED.INSTRUMENTATION SC. FOURTH SEMESTER – APRIL 2010 BI 4954 - BIOMEDICAL INFORMATICS Date & Time: 22/04/2010 / 9:00 - 12:00 Dept. No. Max. : 100 Marks PART-A Answer ALL the questions 10x2=20 Marks 1. Comment on BLAST 2. Define ORF. What is the online software tool available to identify ORF? 3. Define Cheminformatics. 4. Comment on SOPMA? 5. Give the significance of Gap penalties. 6. List out the search engines for biological information. 7. What are web browsers? Give two examples. 8. Enumerate the activities of EMB net. 9. Comment on dendrogram. 10. Write a note on OMIM PART-B Answer any FOUR of the following 4x10=40 Marks 11. Describe the dot plot method for comparison of two sequences. 12. Explain Blast and types of blasts. 13. Give a detail account of FASTA. 14. Write notes on DNA sequence databases. 15. Describe Multiple Sequence Alignment and its significance. 16. Give an account on information resources. PART-C Answer any TWO of the following 2x20=40 Marks 17. Describe the Needleman and Wunsch and Smith - Waterman algorithm. 18. Explain in detail Structure and classification of proteins. 19. Describe the various ways to identify lead compound? Describe the steps involved in the development of a new drug. 20. Discuss the available biological databases for proteins. ************ 1