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Epilepsy Seizure Detection
Algorithms
Farnaz Nassirinia
DSP, 2015
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The Nervous System
●
Interconnected network of
neurons
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Neurons: primary structural units
of nervous system
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Ubiquitous in the body(10^11
neurons)
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Chemically and electrically
transmitting signals
●
Sensory Input >> Integration >> Motor output
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Electrocorticography (ECoG)
ECoG recording setup at Erasmus MC
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Multi-channel ECoG
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Multi-channel ECoG
Essential for a healthy functioning brain: neurons fire asynchronously
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Epilepsy
● Neural disorder
● Normally neurons fire asynchronously
● Neurons fire highly synchronous in epilepsy: seizure
● Symptoms:
○ Unconsciousness
○ Jerky movement
○ Neurotrauma
● Many types of seizures. Focus of this project:
■ Absence seizure
■ Grand mal seizure
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Absence & Grand Mal Seizures
Absence seizures
Tonic-clonic seizures
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Synchronization
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Synchronization
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Synchronization
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Synchronization
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Synchronization
Synchronicity is the key!
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Wavelet filter
Closed-loop circuit for detection and suppression of epileptic seizures being used at Erasmus MC
Taken from M. Van Dongen, 2014
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Problem
Develop an algorithm to detect :
- Absence seizures within 300 ms.
- Grand-mal seizures within 5 seconds of
the tonic phase
Data provided by Erasmus MC Neuroscience
department: (Recordings from mice)
- 24 hours of ECoG with absence seizures
- 24 hours of ECoG with Grand-mal seizures
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Absence & Grand Mal Seizures
Absence seizures
Tonic-clonic seizures
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