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報告者:fellow 1 陳筱惠 Name: 游O琴 Sex: female Age: 56-year-old Occupation: 餐飲業 Chart number: 8970369 Date of admission: 2011/09/25 Right flank pain and black urine for 1 week Small kidney with kidney stones was told at 亞東hospital 2~3 years ago. She received URS + SM then. Right flank/low abdominal pain and black urine for 1 week; associated symptoms: dysuria, frequency, and urgency; no fever or hematuria LMD visit twice, but no improvement under analgesic + oral antibiotic At ER, foley was inserted for urine retention Small kidney with kidney stones was told at 亞東hospital 2~3 years ago. She received URS + SM then. Urinary tract infection or chronic kidney diseases: denied No hypertension, diabetes mellutis, heart, liver, or other significant systemic diseases Current medicine: nil Allergy: no known allergy Alcohol: denied; betel-nut: denied; cigarette: denied Over-the-counter medication or chinese herb: nil No family history of diabetes mellutis, malignancy, bleeding diathesis, heart, liver, kidney, or hereditary diseases Vital signs: blood pressure: 142/81mmHg; temperature: 36‘C; pulse rate: 90/min; respiratory rate: 17/min General apperance: acute ill looking Eye: conjunctiva: not pale, sclera: no icteric Neck: supple, no lymphadenopathy or jugular vein engorgement Chest: symmetric expansion breathing sound: bilateral clear heart sound: regular heart beats, no S3 or S4, no murmurs Abdomen: soft, flat, diffuse tenderness, no muscle guarding or rebounding liver/spleen: impalpable bowel sound: normoactive Back: right flank knocking pain Extremities: no lower limb pitting edema Skin: intact, no rash WBC 8.7x1000/ul Urea N 17.6 mg/dl Hgb 13.2 g/dl Creatinine 0.75 mg/dl Hct 38.2 % GPT 53 IU/L MCV 89.3 fl NA 138 mEq/L PLT 442 x1000/uL K 3.8 mEq/L Sugar 127 mg/dl Segment 43 % Band 21 % Color Red Blood 3+ Turbidity Turbid bacteria + SP. Gravity 1.016 RBC 78/uL PH 6.5 WBC 129/uL Leukocyte 1+ Epithelial cell 0/uL Nitrite - Protein 1+ Glucose - Ketone 1+ Urobilinogen 0.1 Bilirulin - 9/24 urine culture: Viridans streptococcus (> 100,000) 9/25 blood culture: negative Left kidney Length: 11.2 cm Mild dilatation of the pelvocalcyeal systems A peri-pelvic echo-free lesion (2.0cm) in the lower pole Right kidney Length: 14.4 cm Irregular in contour, increased cortical echogenicity and decreased thickness Severe dilatation of the pelvocalcyeal systems and ureter; multiple tiny hyperechoic lesions without acoustic shadow kidney and soft tissue-like density Bladder: distended foley within it. A protruding mass (4.9x2.7cm) with connection of a peri-bladder lumen near right vesicle-ureter junction, a iso-echoic lesion (1.2cm) Right hydronpehrosis and hydroureter, due to ureterocele; complicated with infection and probably pyonephrosis and pyoyreter Multiple tiny stones inside Left minimal hydronephrosis Urinary bladder mucosal thickening and enhancement, suggesting chronic cystitis Infected purulent urine in an obstructed collecting system S/S: typically associated with fever, chills, and flank pain, although may be asymptomatic, too Etiologies: Ascending infection of the urinary tract Hematogenous spread of a bacterial pathogen Incidence: relatively uncommon The risk of pyonephrosis is increased in patients with upper urinary tract obstruction secondary to various causes (eg, stones, tumors, ureteropelvic junction [UPJ] obstruction Pathogen: Escherichia coli, Enterococcus species, Candida species, Enterobacter species, Acteroides species, Staphylococcus species, Salmonella species, Tuberculosis Complications: Sepsis and septic shock Irreversible damage to the kidneys Treatment: surgical emergency for decompression Disadvantages of retrograde decompression: ▪ General anesthesia, contraindicated in unstable patients ▪ Smaller-caliber urinary drainage catheter than with percutaneous access ▪ Increased irritative urinary symptoms ▪ Lack of antegrade access for radiologic studies or inability to administer medications such as antibiotics via nephrostomy tube ▪ Bypassing the obstruction may not be possible in some patients. ▪ Pyelovenous, pyelolymphatic, and pyelosinus backflow of infected urine into the systemic circulatory system Ultrasonographic features of pyonephrosis: Dilated collecting system Echogenic debris in the in dependent areas of collecting system ▪ Strong echoes with acoustic shadowing ▪ Change position when patient moves Air can be seen in these infections. Ultrasonographic Evaluation of Renal Infections Radiol Clin N Am 44 (2006) 763–775 CT: depicts both hydronephrosis and often the underlying cause Contrast-enhanced imaging is more desirable as in infection parenchymal and functional changes can be assessed. ▪ ▪ ▪ ▪ Pelvic and ureteral wall thickness Renal enlargement Perinephric fat stranding Fluid–fluid levels and gas within the collecting system Imaging of urinary tract infection in the adult Eur Radiol (2004) 14:E168–E183 Name: 徐O華 Sex: female Age: 63-year-old Occupation: nil Chart number: 6425429 Date of admission: 2011/09/05 Low abdominal pain for 4 days Underlying diseases: rheumatoid arthritis, diabetes mellitus, and history of infectious spondylitis with left anterior epidural abscess post operation in 2011/03 (stool/urine incontinence under foley use and bedridden status since then) Turbid urine, suprapubic and right flank pain for 4 days; associated symptoms: poor appetite, nausea/vomiting; no fever Underlying diseases: Rheumatoid arthritis Hypertension Diabetes mellitus Osteoporosis Iatrogenic adrenal insufficiency History of infectious spondylitis with left anterior epidural abscess post operation operation at 802 hospital in 2011/03 No heart, liver, or other significant systemic diseases Current medicine: from our Rheuma OPD Allergy: no known allergy Alcohol: denied; betel-nut: denied; cigarette: denied Over-the-counter medication or chinese herb: nil No family history of diabetes mellutis, malignancy, bleeding diathesis, heart, liver, kidney, or hereditary diseases Vital signs: blood pressure: 124/92mmHg; temperature: 36.6‘C; pulse rate: 110/min; respiratory rate: 18/min General apperance: acute ill looking Eye: conjunctiva: mild pale, sclera: no icteric Neck: supple, no lymphadenopathy or jugular vein engorgement Chest: symmetric expansion breathing sound: bilateral clear heart sound: regular heart beats, no S3 or S4, no murmurs Abdomen: soft, flat, low abdominal tenderness, no muscle guarding or rebounding liver/spleen: impalpable bowel sound: normoactive Back: right flank knocking pain Extremities: no lower limb pitting edema Skin: intact, no rash WBC 7.2x1000/ul Creatinine 0.58 mg/dl Hgb 9.6 g/dl GPT 8 IU/L Hct 29.2 % NA 136 mEq/L MCV 92.7 fl K 3.9 mEq/L PLT 258 x1000/uL Sugar 104 mg/dl Lactate 9.1 mg/dl Segment 79.8 % Color Yellow Blood 2+ Turbidity Cloudy bacteria + SP. Gravity 1.010 RBC 10/uL PH 8.5 WBC 65/uL Leukocyte 3+ Epithelial cell 5/uL Nitrite + Protein Trace Glucose - Ketone - Urobilinogen 0.1 Bilirulin - 9/3 urine culture: Proteus mirabilis (>100,000) 9/3 blood culture: negative Left Kidney Length: 10.2 cm One isoechoic band extending from the cortex to central sinus Right Kidney Length: 10.4 cm One mass-like lesion (7.0x3.5cm) over middle portion The both kidneys are normal in size and contour. The cortical echogenicity and thickness are normal. No evidence of renal stone or cyst exists. Multifocal ill-defined low denity of bilateral renal parenchyma, C/W acute pylonepheritis Dilatation of bilateral renal pelvis and ureters to right middle ureter and left upper ureter level No definite dilatation of bilateral renal calyces No definite ureteral stones or tumor could be identified. DDx: extrarenal pelvis, retroperitoneal fibrosis/ adhesion, or ureteral stricture Ureteral catheter passing up to the left upper ureter at L4 level and right middle ureter at S3 level Mild bilateral hydronephrosis. No obvious filling defect in the collecting system. The right upper ureter and right renal collecting system are not well opacified. No definite radiopaque stone in the urinary tract The presence of extrarenal calyces is a very rare anomaly of the upper urinary tract. First described in 1925 The total number of cases reported so far is only 20. Kidney with extrarenal calyces is usually associated with other anomalies like bifid kidney, renal ectopia, horseshoe kidney and renal dysplasia. Extrarenal calyces: A rare anomaly of the renal collecting system Indian J Pathol Microbiol. 2009 Jul-Sep;52(3):368-9. The calyces were long and extrarenal in position. They drained into a cystic structure which represented either a grossly dilated pelvis (pelviureteric junction) or a ureteral cyst. The exact cause of extrarenal calyces is not very clear. Hypothesis: a disparity resulting from slow development of the metanephric tissue or to a relatively rapid development of the ureteric bud Many cases of collecting system anomalies including extrarenal calyces are detected incidentally or may be diagnosed because of its complications. Excretory urography often provides good anatomic information. A false impression of hydronephrosis or chronic pyelonephritis Rare disease, incidence of idiopathic form about 0.1~1.3 per 100,000 person-years Etiology: Idiopathic form: 70%, 40 ~ 60 years of age, 2 to 3:1 male-to-female predominance Secondary form ▪ Drugs: ergot-derivatives, methysergide, bromocriptine, beta blockers, methyldopa, hydralazine, analgesics ▪ Malignancy: carcinoid, Hodgkin's and non-Hodgkin lymphoma, sarcomas Infections: tuberculosis, histoplasmosis, actinomycosis Radiation therapy for testicular seminoma, colon, pancreatic cancer Surgery: lymphadenectomy, colectomy, aortic aneurysmectomy Pathology: Macroscopically: a hard, white plaque of varying thickness ▪ Typically, around the abdominal aorta and iliac vessels, as well as the inferior vena cava and the ureters Microscopically: sclerosis and infiltration of mononuclear cells in varying proportions, depending on the stage of disease Pathogenesis: chronic inflammation, fibroblast proliferation, and excessive extracellular matrix deposition Clinical manifestations: Early stage: pain in the lower back, flank or abdomen; characteristically dull, noncolicky, in a girdle distribution (> 90%) ▪ Other nonspecific symptoms: weight loss, malaise, anorexia, testicular pain, claudication, edema, and gross hematuria Late stage: vessel compromise and characterized ureteral obstruction Laboratory abnormalities: Elevated ESR and CRP Positive ANA (60%) Anemia, possibly related to renal insufficiency or chronic inflammation No hematologic or biochemical abnormalities diagnostic of this condition. The urinary sediment is most often normal. Ultrasonography: a poorly marginated, periaortic mass that is typically echo-free or hypoechoic and may be associated with hydronephrosis CT scan: The mass is confluent, encasing the anterior and lateral sides of the aorta and often encircling the inferior vena cava. Similar attenuation numbers to that of muscle Magnetic resonance imaging: comparable to those with CT scanning Intravenous urography: proximal hydroureteronephrosis, medial deviation of the ureters, and extrinsic compression of the ureters Retrograde or percutaneous antegrade pyelography: a smooth tapering of the ureters that is most pronounced at the level of the pelvic brim Biopsy: no guidelines The location of the mass is atypical Clinical, laboratory or radiologic findings suggest the presence of an underlying malignancy or infection Local experience is limited The patient does not respond to initial therapy. UpToDate