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ICD-10 Re-Code: What We Discovered ⢠MS-DRG changed due to change in principal diagnosis per sequencing instructions in ICD-10CM Official Coding Guidelines ⢠Anemia in chronic kidney disease is a classified as a manifestation of chronic kidney disease â Manifestation codes cannot be assigned as principal diagnosis ⢠Notes instruct to code first the underlying disease of ESRD ⢠Under ESRD, there is another instructional to code first any hypertensive chronic kidney disease