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Case #92: Say Ahhhh! BY AMI ALANIZ Gross Overview Note the: Soft palate: general appearence Tonsil: size and general appearance The Patient Profile  female  11 years old  Caucasion Past Medical History Ear infections at ages 3 & 4  Chickenpox at age 6  Viral-like URI at age 9  No previous episodes of streptococcal pharyngitis or rheumatic fever  Up to date immunizations Social History  Attends 6th grade  Plays baseball  Mother and mother’s boyfriend smoke in the house The Symptoms Case Question #1 List 18 patient-specific clinical features (including signs and symptoms, medical history, findings on physical examination, and laboratory blood test results) that support a diagnosis of group A betahemolytic streptococcal pharyngitis. Case Question #2 “What is the single major risk factor for acute streptococcal pharyngitis in this case study?” Present Illness  “My throat hurts and its hard to swallow. I’m cold, too.”  appetite has been poor for 48 hours (steady fluid intake)  “strep has been going around at her school for the past two weeks” Case Question #2: Answered Involvement in sports as well as the strep throat going around at her school. Present Illness (cont’d)  appears…  ill  pale  shivering Present Illness (cont’d)  ill for three days  sore throat  temperature of 102.3  chills  pain with swallowing Testing Terms to Know o edema o swelling o general response to injury or inflammation o erythema o redness o results from capillary congestion o exudate o a “mass of cells and fluid that seep out of blood vessels or organs” o especially prevalent in inflammation Testing, Testing!  Vital Signs  temperature: 103.1 F Head, Eyes, Ears, Nose, and Throat  tonsillar edema and erythema with yellow-white exudate  soft palate erythema  prominent “strawberry” tongue Tonsilllar edema and erythema with yellow-white exudate Soft Palate Erythema (extreme!) Not a Strawberry Tongue Prominent “Strawberry” Tongue Testing, Testing (cont’d)  Neck  small, mobile anterior lymph nodes (tender to touch)  Skin  warm  pale  no rash Lab Results HB Hct Plt WBC 13.2 g/dL Neutrophils 43.9% Lymphocytes 390,000/mm^3 Monocytes 15,500/mm^3 Eosinophils 72% Basophils 1% 21% ESR 18 mm/hr 5% CRP 2.3 mg/dL 1% (+) Rapid streptococcal antigen test Case Question #1: Answered  fever  Warm skin  Pale skin  Absence of rash  Tonsillar edema  prominent “strawberry”  chills tongue  lack of appetite  white blood cell count  tiredness  neutrophils  possible weak immune  lymphocytes system  “strep has been going  pain with swallowing  Tonsillar erythema with around school for the past yellow-white exudate  tender with palpitation two weeks” lymph nodes  soft palate erythema  participation in sports (presumably at school) Final Notes What is the official diagnosis? group A beta-hemolytic streptococcus pharyngitis “Bacteria are responsible for approximately 5 to 10 percent of pharyngitis cases, with group A beta-hemolytic streptococci being the most common bacterial etiology. A positive rapid antigen detection test may be considered definitive evidence for treatment; a negative test should be followed by a confirmatory throat culture when streptococcal pharyngitis is strongly suspected.” Case Question #3 “What are the drugs of choice for this patient?”  penicillin  cephalorsporins (like cephalexin)  erythromycin-based medications  clindamycin  azithromycin Case Question #4 “For which type of heart disease is this patient at risk if treatment is not started?” Rheumatic fever. Sources/Citations http://www.livestrong.com/article/207279-normal-wbc-range-in-children/ http://www.itpsupport.org.uk/childhooditp.htm http://www.childrensmn.org/manuals/lab/hematology/018981.asp http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm http://www.nlm.nih.gov/medlineplus/ency/article/003051.htm http://www.medicinenet.com/strep_throat_gas/page4.htm http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682733.html http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682381.html http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682399.html http://www.nlm.nih.gov/medlineplus/druginfo/meds/a697037.html