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Archivos Venezolanos de Puericultura y Pediatría ISSN: 0004-0649 [email protected] Sociedad Venezolana de Puericultura y Pediatría Venezuela Leal M., Jorymar; Ortega, Pablo; Romero A., Tania CITOCINAS SÉRICAS EN NIÑOS INFECTADOS CON GIARDIA LAMBLIA Archivos Venezolanos de Puericultura y Pediatría, vol. 71, núm. 1, enero-marzo, 2008, pp. 1316 Sociedad Venezolana de Puericultura y Pediatría Caracas, Venezuela Available in: http://www.redalyc.org/articulo.oa?id=367935541003 Abstract Introduction: Intestinal giardiasis is a public health problem in developing countries. Although the innate and adaptative immunity mechanisms are necessary for proper control of the infection, few studies have been published in humans on the role of cytokine Th1- Th2 in infection control. The aim of the present study was to analyze the serum concentration of Th1 cytokine (IL-2 and IFNgamma) and Th2 (IL-4 and IL-10) in euthrophic children infected or not with Giardia lamblia (G. lamblia). Methods:Were analyzed 101 children (3-6y; F=52, M=49) nutritionally eutrophic. Sixty two children free of G. lamblia and 39 infected. The serum concentration of IFN-gamma, IL-4 and IL-10 (pg/mL) were determined by ELISA method and IL-2 (U/mL) by EAISA method. The Student’s t test was applied to compare the groups. We considered 95% statistical significance (p<0.05). Results: Cytokine values in children infected with G. lamblia were not statistically different from values in not infected children, probably due to the labile capacity of antigenic proteins to stimulate the immune response. Other in vivo and in vitro studies are necessary to detect the role of cytokine Th1-Th2 in infection control. Arch Venez Pueric Pediatr 71 (1): 13 - 16 Keywords Cytokines, children, Giardia lamblia. How to cite Complete issue More information about this article Journal's homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative
