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Reasons to Choose Taiwan UBI Asia in Partnership with UBI Chang Yi Wang, PhD Founder, UBI Chairperson, UBI Asia Core Technology Molecular Design of Functional Antigens Adjuvant & Formulation Technologies UBI / UBI Asia Antigenic Functional Antigenics Synthetic Peptide Technologies Combinatorial Library UBITh ® Technology Antibody Deimmunization Immunodiagnostics Vaccines and Immunotherapeutics Therapeutic Monoclonal Antibodies Product Portfolios Vaccines & Immunotherapeutics SARS Vaccine & Diagnostics Canine Allergy Therapeutic FMDV Vaccine & Diagnostics LHRH Vaccine as Pet Contraceptive LHRH Vaccine for Boar Taint Removal & Growth Promotion Animal Health Products Allergy Therapeutic HIV/AIDS Vaccine & Therapeutic LHRH Vaccine as Prostate Cancer Therapeutic Alzheimer Disease Therapeutic Functional Antigenics Human Health Products Business partners and Product Development Sponsors of UBI Division of AIDS, NIAID, NIH, USA [HIV Immunotherapeutics] NIAID, NIH, USA [Allergy Immunotherapeutic] NCI, NIH, USA [Prostate Cancer Immunotherapeutic] Baxter, USA BioMerieux (Lyon, France), formerly Organon Teknika of Akzo Nobel (Boxtel, Netherlands) Merial (Lyon, France) (JV of Merck and Aventis, largest animal health company in the world) The United Laboratories (Zhuhai, China) China Animal Husbandry Industry Corp. (Beijing, China) Synergy: Traditional Pharma / Innovative Bio Pharmaceutics Foundation in Taiwan cGMP Roche Peptide Pilot Plant Protein Drug Pilot Plant GSK Toll Manufacture BioPharmaceutics Foundation in Taiwan Biologics Manufacture Plant Specialty Injectables Compliance with FDA International BioPharmaceutics Company Business Model Survival cGMP Pharmaceutical Plants Synergy Pharma / Bio Synergy UBI / UBI Asia rowth Survival: Conservative Nurtures High Risk UBI 技術轉移 UBI Asia 技術承接 & 產品創新研發 cGMP Manufacture •Acquire Roche & GSK cGMP plants: Chemical drugs, Biologics 1999 2002 Innovative R&D •Peptide based: Vaccine & diagnostics •Protein based: Therapeutic monoclonal antibodies UBI Asia FMDV Vaccine: Ko-T Con ® 口蹄安 FMDV Diagnostics From Genomics to Products Innovation Through Design The Vision: Complete Replacement of Traditional Vaccines within 5 Years !! UBI Asia UBITh® LHRH Immunotherapeutic Boar Taint Removal Vaccine: Bota Con ® 寶特康 Pet Contraceptive Vaccine Human Prostate Cancer Therapeutic From Genomics to Products Innovation Through Design BotaCon ®寶特康: An Immunotherapeutic to eliminate Boar Taint and promote pig growth and Cattle UBI Asia Therapeutic Monoclonal Antibodies Monoclonal Antibody Engineering Monoclonal Antibody Humanization (Murine Ab to Human Ab) 1986 1975 1994 Fv Fc Hybridoma, Cesar Milstein & Georges Kohler Chimeric mAb, Genentech CDR grafting, PDL RePro, 1994, 447 M USD OKT3, 1986, 55 M USD Identification of T cell and B cell antigenic epitopes in Variable regions Rituxan, 1997, 298 M USD 1998 Deimmunization, Biovation Well-Characterized Monoclonal Antibody (B4) directed against HIV receptor complex for treatment of HARRT resistant AIDS patients through entry inhibition UBI Asia provides services to and collaborates with multiple commercial and research institutes 聯亞研發中心 UBI Asia R&D 產程發展 & 原料藥生產 先導工廠 聯亞生產中心 配方研發 臨床試驗 產品登記 聯亞 cGMP廠 西藥 & 生技藥品 劑型生產 Vision: Designer Immunological Products for the treatment, prevention, and diagnosis of globally significant diseases 美國、美洲 UBI Asia UBI國際 臨床&事業 研發&生產 中心 中心 台 灣 Synergy: UBI Asia / UBI Basic Research Field & Clinical Trials Process Development Reasons to Choose Taiwan UBI Asia in Partnership with UBI • • • • • • Taiwan government with policies to promote biotechnology Taiwan has diligent, entrepreneurial and well-educated human resources Operations can be cost effective when compared with the west Easy access to fast breaking first hand business information Access to huge China market due to similarity in language and cultural background Training and testing ground for worldmarket due to its extensive connections to the western world Join us, and Welcome to Taiwan!