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Overview of Anatomy and Physiology Anatomy – the study of the structure of body parts and their relationships to one another Gross or macroscopic Microscopic Developmental Physiology – the study of the function of the body’s structural machinery Levels of Structural Organization • Chemical – atoms combined to form molecules • Cellular – cells are made of molecules • Tissue – consists of similar types of cells • Organ – made up of different types of tissues • Organ system – consists of different organs that work closely together • Organism – made up of the organ systems Organ Systems of the Body • Lymphatic system – Picks up fluid leaked from blood vessels and returns it to blood – Disposes of debris in the lymphatic stream – Houses white blood cells involved with immunity Organ Systems of the Body • Integumentary system – Forms the external body covering – Composed of the skin, sweat glands, oil glands, hair, and nails – Protects deep tissues from injury and synthesizes vitamin D Organ Systems of the Body • Urinary system – Composed of kidneys, ureters, urinary bladder, and urethra – Eliminates nitrogenous wastes from the body – Regulates water, electrolyte, and pH balance of the blood Anatomical Position • Body erect, feet slightly apart, palms facing forward, thumbs point away from body Directional Terms • Superior and inferior – toward and away from the head, respectively • Anterior and posterior – toward the front and back of the body • Medial, lateral, and intermediate – toward the midline, away from the midline, and between a more medial and lateral structure Directional Terms • Proximal and distal – closer to and farther from the origin of the body • Superficial and deep – toward and away from the body surface Regional Terms: Anterior View • Axial – head, neck, and trunk • Appendicular – appendages or limbs • Specific regional terminology Figure 1.7a Regional Terms: Posterior View Figure 1.7b Body Planes • Sagittal – divides the body into right and left parts • Midsagittal or medial – sagittal plane that lies on the midline • Frontal or coronal – divides the body into anterior and posterior parts • Transverse or horizontal (cross section) – divides the body into superior and inferior parts • Oblique section – cuts made diagonally Three Basic Shapes • Squamous – like scales, or pancakes (“being squashed like a pancake”) • Cuboidal – looks like cubes • Columnar – longer and look like columns Cell Organization • Simple – single layer of cells; typically found where absorption and filtration occur or a single layer of epithelial is needed simple squamous simple cuboidal simple columnar • Stratified – layers of cells; common in areas where protection is needed like the skin stratified squamous stratified cuboidal stratified columnar Review What You’ve Learned… Muscle Type Striated? # of nuclei Voluntary or Involuntary Skeletal Yes Multinucleated Voluntary Yes Single Nucleus Involuntary No Single Nucleus Involuntary Cardiac Smooth Smooth Muscle Cells – are small and pointed at their ends – can divide and regenerate new cells – non-striated, involuntary, and single nucleus – found in hollow organs like the intestine, bladder, lungs, and blood vessels – move substances through hollow opening by contracting slowly; they squeeze things through like a tube of toothpaste Skeletal Muscle Cells – Striated, voluntary, and multinucleated – are long, thin and cylindrical; they are attached to bones and move our skeleton – are usually called “muscle fibers” – do not divide to create new cells – new fibers are produced by stem cells – Striations -- cross stripes (bands) run perpendicular to the cells Cardiac Muscle Cells – are called “cardiocytes” and found in heart walls – branching cells connect at intercalated disks which allow contractions to occur faster – are regulated by pacemaker cells which control contraction of the heart muscles – striated, involuntary, and single nucleus Synovial Membranes (Connective) • Some joints are surrounded by a membrane (synovium) that produces a thick, synovial fluid. This fluid nourish the cartilage and keeps it slippery. Knee Joint Appendages of the Skin • Sweat glands – Produce sweat widely distributed in skin (2.5 million per person) – helps cool the body – Two types • Eccrine – Opens up to skin through a duct (pore) on skin surface – Most numerous on the body • Apocrine – Ducts empty into hair follicles – Found mostly in armpits and genital areas – Precise function is unknown but are they are activated during pain, stress and during sexual foreplay. Seven Functions of Skin • Mechanical/Chemical damage – keratin toughens cells; fats cells cushion blows; and pressure receptors to measure possible damage • Bacterial damage – skin secretions are acidic and inhibit bacteria. • Ultraviolet radiation – melanin produced to protect from UV damage Skin Functions • Thermal control – regulates body temperature – Heat loss: sweat to cool the skin – Heat retention: prevents blood to rush into capillary beds • Waterproofing – contains lipids to prevent drying out • Excretion of waste – urea and uric acid secreted in sweat • Makes vitamin D – modifies cholesterol molecules in skin and converts it to vitamin D Melanin • Pigment (melanin) produced by melanocytes • Melanocytes are mostly in the stratum basale • Color is yellow to red to brown to black • Amount of melanin produced depends upon genetics and exposure to sunlight Layers of the Epidermis • Stratum lucidum – Formed from dead cells of the deeper layers – Occurs only in thick, hairless skin of the palms of hands and soles of feet • Stratum corneum – Outermost layer of epidermis – Scale-like dead cells are filled with keratin which is a protective protein preventing water loss from skin Appendages of the Skin • Sebaceous glands – Produce oil • Lubricant for skin which keeps skin soft and moist • Prevents brittle hair • Kills bacteria (slightly acidic) – Most have ducts that empty into hair follicles; others open directly onto skin surface – Glands are activated at puberty and this is what causes teenage acne Sweat and its Function • Composition – – – – Mostly water Salts and excess vitamin C Some metabolic waste (urea and uric acid) Fatty acids and proteins (apocrine only) • Function – Helps rid body of excess heat – Excretes waste products – Acidic nature inhibits bacteria growth • Odor is from associated bacteria Classification of Bones Based of Shape Anatomy of a Long Bone • Epiphyseal plate – Flat plate of hyaline cartilage seen in young, growing bone (a.k.a. = growth plate) • Epiphyseal line – Remnant of the epiphyseal plate – Seen in adult bones Bone Surface Markings • Depressions and openings fro blood vessels and nerves to pass through – Foramen – round or oval opening in a bone – Meatus – canal-like – Fossa – shallow depression mostly to form a joint Types of Bone Cells • Osteocytes—mature bone cells • Osteoblasts—bone-forming cells • Osteoclasts—bone-destroying cells – Break down bone matrix for remodeling and release of calcium in response to parathyroid hormone • Bone remodeling is performed by both osteoblasts and osteoclasts Bones of the Skeleton • Know all of the bones of your skeleton! Simple and Compound Fractures • Simple – Clean break in the bone • Compound – Bone breaks and pierces skin Microscopic Anatomy of Skeletal Muscle • Sarcomere — contractile unit of a muscle fiber (muscle cell) • Organization of the sarcomere – Myofilaments • Thick filaments = myosin filaments • Thin filaments = actin filaments Microscopic Anatomy of Skeletal Muscle Figure 6.3c Muscle Anatomy Figure 6.1 Know your Muscles Naming Skeletal Muscles 1 – Location of the muscle 2 – Shape of the muscle 3 – Size of the muscle 4 – Direction/Orientation of the muscle fibers/cells 5 – Number of Origins 6 – Location of the Attachments 7 – Action of the muscle