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Transcript
BBS3027 2000: Infectious Diseases Dr Garwin Sing [email protected] http://trishul.sci.gu.edu.au/courses/bbs3027/ Gut Mucosa Gut Mucosa Mucosal Epithelium Epithelial Barriers to Microbial Infection: Physical • Epithelial cells joined by tight junctions • Exfoliation of surface cells • Mucous flow by ciliated epithelia (respiratory tract) Epithelial Barriers to Microbial Infection: Chemical • Enzymes: Lysozyme (tears, saliva, sweat) Pepsin (stomach) • pH: Fatty Acids/amino acids (skin) Gastric acids (stomach) • Antimicrobial: Transferrin (mucus) Epithelial Barriers to Microbial Infection: Competition • Gut Flora Protection from Infectious Agents • Innate Immunity • Adaptive Immunity Fever, interferon, neutrophils, macrophages, NK cells B cells, T cells Congenital Infections Viruses Anatomy Bacteria Physiology Fungi Immunity Parasites Commensals Sources of Infection: Exogenous • Inhalation • Ingestion • STD • Wound • Insect Bite Common cold, flu, Legionnaire’s Disease, Coccidioidomycosis Typhoid fever, tapeworm, cryptosporidium, Hepatitis A Gonorrhea, HIV Tetanus, Rabies Malaria, Yellow Fever, Dengue Sources of Infection: Endogenous • • • • • • Gut Skin Tonsils Throat Blood Lungs e.g E coli e.g. staphylococcus e.g streptococcus e.g. EBV e.g Candida, CMV, streptococcus
