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MRI Marker
Active MRI Stents &
Vena Cava Filter
-brief introductionAndreas Melzer
University of Applied Sciences Gelsenkirchen
Institute for Innovative Technologies and Management in
Medicine, INSITE med.
& Biophan Europe GmbH
[email protected]
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MRI Visualization of Catheters and Guide Wires
Resonator technology can be applied to catheters and
guide wires and used without wiring to the MRI Scanner
which eliminates risk of heating.
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resonator
G coil
MR-signal
• MR Guided Catheterization
• MR Tip Tracking,
• MR endovascular imaging
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Resonators on Laparoscopes and
Neuroendoscopes
5 mm Endoscope,
Olympus, with „wire
less“ Tip tracking
coil „aMRIs“
Coils
Positive contrast
display of
endoscopes for
MR localization and
automatically
aligned slice
orientation
Laparoscopic MR guided
RF tumor ablation
A. Melzer. M. Wendt, J.
Duerk, J Lewin, CWRU,
Cleveland 1998
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MRI Guided Neuroendoscopy, A. Melzer, Chinzei, R.Kikinis,
F Jolesz BWH, Harvard, Boston 1999
Balloon expandable aMRIs in different Diameter
8 mm
7 mm
6 mm
4500
9 mm
5 mm
10 mm
4000
3739.5
3500
Signal
3000
2500
Average m
Max
2143
2000
Min
1500
1473.9
1000
956.7
837.6
500
406.1
0
5
6
7
8
Diameter [mm]
9
10
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Self expanding resonant Nitinol Stent
1.5 Tesla Siemens Magnetom
Vison
fl2d TR300 TE6 FoV150sq256sq
FA40 SL3 AC2 1T5, 0.9 % NaClwater 0,2 mmol Magnevist/l fr =
66,6 MHz, Q = 6,2
2002 In cooperation with Admedes,
(ex Euroflex Schüssler, Pforzheim)
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MR guided aMRIs Implantation
PC controlled blood flow
Vascular phantom
Resonant Marker
proximal and
distal to the
crimped stent
Stent after
expansion and
partial withdrawal of
the balloon catheter
Experiments in co-operation with: Dept. of Radiology, University
Frankfurt, Germany,1.5 Tesla Siemens
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aMRIs Evaluation
•
•
In stent imaging intraluminal substrate
Simulation of intimal hyperplasia
(aortic wall) and liquid
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aMRIs Evaluation
•
•
In stent imaging: intraluminal substrate
depiction
Thrombus: clotted and liquid blood
aMRIs thrombus, TR=300ms, TE=6ms, FA=40°, transversal Tesla, Philips NT, head coil,
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MR Guided VCF Implantation and explantation
Vascular Phantom with simulation of venous flow in 1.5 Tesla,
Siemens Magnetom Vision, flash 2D GRE
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Active MRI Vena Cava Filter
Approval of MRI imaging of Thrombus capture „in vitro“ with fresh blot
Open VCF
without thrombus
Clotted VCF
with thrombus
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Experiments at Dept. of Radiology, University Aachen, Germany, 1. 5 Tesla Philips NT,
Nitinol aMRI Vena Cava Filter
•
•
•
Laser cut active MRI VCF with biocompatible inductivity and capacity
through micro structured coatings
Delivery catheter with resonant Marker
fresh human blood thrombus imaging
Signal intensity
profile, 1.0 Tesla
Siemens Harmony
Delivery system
Fresh
thrombus
2002 In cooperation with Admedes,
(ex Euroflex Schüssler, Pforzheim)
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• RWTH Aachen Drs. Spüntrup and Bücker
1st animal trial Laser Cut VCF
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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1st animal trial Laser Cut VCF
• RWTH Aachen Drs. Spüntrup and Bücker
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Summary
•
•
Biophan Europe’s proprietary aMRIs technology
provides a large platform to improve imaging of
vascular and other implants as well as interventional
devices during MRI guided vascular and non vascular
interventions
–www.amris.de
Biophan is working on a variety of proprietary
technologies to avoid the risk of pacing lead heating
and voltage induction to improve safety of cardiac
pacemaker an other stimulation devices
–www.biophan.com
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