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PEAK 485 Exercise Test and Prescription The Heart of the Matter Cardiovascular health is key Poor blood supply = damage / death Cardiac muscle is the ultimate slow twitch fiber Cardiac function predicts health and performance Cardiology Cardiac Function Two cycle pump Receives blood from lungs and body Sends blood to lungs and body Closed circuit (“leaky” / volume changes) Arterial (systemic) vs. venous vascular systems Cardiac Anatomy Four Chambers 2 Atria and 2 Ventricles Left side vs. right side Key Features Left Ventricle is primary pump (systemic circulation) Right Atrium Sinoatrial node (SA node) Cardiac Anatomy Great Vessels Sup. & Inf. Vena Cava Pulmonary Arteries Pulmonary Veins Aorta Blood source for coronary arteries Cardiac Diagram Cardiac Anatomy Coronary Arteries (lesser vessels) Left Coronary Artery Anterior Descending Art. (ant. supply) (LAD) Left Circumflex Art. (lat. left V. supply) Right Coronary Art. (right A. & V.) Runs infer. to post. AV node supply Each supplies given part of myocardium with blood flow (nutrients and oxygen). Left Circumflex Cardiac Anatomy Coronary Arteries (lesser vessels) Capillary Beds Site of oxygen diffusion Capillary Beds Cardiac Anatomy Heart Layers Endocardium Myocardium* Epicardium Pericardium Cardiac Anatomy Myocardium – Heart Muscle Myocytes Intercalated discs Cell orientation Nervous stimulation Sympathetic system Parasympathetic system Cell communication Cardiac Anatomy Conduction System SA node AV node Bundle of His Bundle Branches (septal to apex to walls) Left Bundle Branch (LBB) o Right Bundle Branch (RBB) Purkinje fibers Cardiac Physiology Cardiac Physiology Properties of myocardial cells: Contractility Strength of contraction (tension) can vary Extensibility / Elasticity Cardiac Physiology Properties of myocardial cells cont’d Excitability / Irritability Can be electrically or chemically stimulated Balance of chemicals creates membrane potential Disruption of chemical balance leads to stimulation Ionotropic effect – speed up Ca Cardiac Physiology Automaticity Leaky / channels Spontaneous depolarization. Pacemaker Cells (SA Node) This tissue normally initiates the cardiac cycle. Cardiac Physiology Conductivity Action potential travels to other cells within the atria (or other cells) causing them to contract. Cardiac Physiology Properties of myocardial cells cont’d Extensibility / Elasticity Electrical Conduction AV Node – Delay station for electrical impulse. Delay allows atrial contraction to complete before ventricles begin. Bundle of His – Transmits electrical impulse across the annulus fibrosis (cartilage framework of atrioventricular valves). Bundle Branches (and fascicles) – conduct impulse rapidly throughout ventricles. Note: Process allows for sequential contraction of the myocardium to pump blood effectively in the proper direction. Questions So Far? ECG Principles ECG Principles ECG Principles ECG Paper Standard paper speed = 25 mm/s Small and large boxes Horizontally - time Small boxes represent .04 sec (40 msec) Large boxes represent .20 sec (200 msec) Vertically – strength of electrical activity (voltage) Small boxes represent .1 mV Large boxes represent .5 mV ECG Principles Electrical & Mechanical Events P wave Atrial depolarization Atrial contraction begins midway QRS wave Ventricular depolarization Ventricular contraction begins midway/late T wave Ventricular repolarization Ventricular relaxation ECG Tracing Diag. ECG Principles Timing of Electrical Events PR interval – atrial depol. .12 - .20 sec. PR segment – AV/His depol. – isoelectric QRS complex - < .12 sec ST segment –vent. cells depolarized - isoelectric QT interval - < .36 sec P-P / R-R - Atr. & Vent. rate dependent cycles ECG Tracing Diag. Timing changes (fast or slow) = Normal response Abnormal response ECG Waves and Electrodes Reference point is the positive electrode. Depolarization wave moves toward the positive electrode, recorded depolarization wave is positive. Depolarization wave moves away from the positive electrode, recorded depolarization wave is negative. ECG Waves and Electrodes If the positive electrode is perpendicular (sits across the axis) to the depolarization wave, the recording is biphasic (both positive and negative). ECG Waves and Electrodes Limb Leads: I, II, III: each has two electrodes (bipolar leads – one positive; one negative) Limb Leads Diag. ECG Waves and Electrodes Limb Leads: Augmented Voltage Leads (AVR, AVL, AVF) - each has a positive electrode but shares an averaged (common) negative pole made up of the other electrodes. Augmented Leads Diag. ECG Waves and Electrodes Limb Leads: These six leads view the electrical activity in the vertical plane. ECG Waves and Electrodes Hexaxial Reference System Measured in degrees starting with positive side of Lead I being 0°. Rotation clockwise from 0° is positive; counterclockwise is negative. Hexaxial Diag. AVR AVL AVF ECG Waves and Electrodes Precordial Leads V1, V2, V3, V4, V5, V6 – each is a positive electrode with the entire body serving as the negative pole. These six leads view the electrical activity in the horizontal plane. Precordial Leads Diag. Heart level Xsect. Diag. Cross Section of the Heart at Level of T4 - T5 (Image from the Visible Human Project-NLM) V1 Horiz. Hexaxial Diag. V6 Cross Section of the Heart at Level of T4 - T5 (Image from the Visible Human Project-NLM) Vectors and Waveforms Vector = average electrical activity – direction Atria – downward & leftward AV Node & BB’s – not strong enough to detect Septum – leftward Ventricles – downward & leftward V. Repolarization – same direction Vector Diag. P Vectors and Waveforms Remember – Waveform changes for each lead – Tallest toward + electrode – Inverted away from + electrode – Biphasic perpendicular to line of + to – – View of multiple leads tells direction of depolarization Questions So Far? ECG Interpretation Basic Questions? ECG Interpretation What do you assess? What order do you follow? What meaning does a deviation have? What should be done? ECG Interpretation Rate Rhythm Axis Hypertrophy Infarction ECG Interpretation Rate Methods to determine heart rate: 1500/# small boxes between R waves. o o Most accurate; best for fast rhythms. Question: How much time is one small box? 300/# large boxes between R waves. o o o Good for slow rhythms. 300, 150, 100, 75, 60, 50 rule Question: How much time is one large box? # R waves in 6.0 s (30 large boxes) x 10 (3 sec. marks) o Good for irregular rhythms. ECG Interpretation Quick Visual: Rate at each heavy line (large box) 0 300 150 100 75 60 50 43 38 33 30 350 250 (4th) (6th) Heart rate determination ECG Interpretation Ventricular Rate Atrial Rate Nodal Rate What’s The Rate? What’s The Rate? What’s The Rate? ECG Interpretation Source? – atria, junction, ventricles? Normal rate = 60-80 bpm Tachycardia = > 100 bpm Bradycardia = < 60 bpm Flutter = > 250 – 350 “bpm” – Atrial source – “sawtooth” appearance – Ventricular pacing is not connected Fibrillation = > 350 “bpm” – Either atrial or ventricular source – “bag of worms” – no cardiac output – V. Fib. = immediate syncope, asystole is soon!!!! What’s the rate? – What’s it called? Sinus tachycardia What’s the rate? – What’s it called? Anything else you can see? Sinus bradycardia ECG Interpretation Rhythm Lead II is often best to observe rhythm. Analysis: 1. Determine regularity of rhythm. Index card method Calipers 2. Determine rate. 3. Examine P waves: Appearance is normal and consistent P before each QRS; one P wave for each QRS ECG Interpretation Rhythm 4. Measure PR interval Normally < .20 s 5. QRS complex width: normally narrow (< .12 s) ECG Interpretation Arrhythmias Four basic types of arrhythmias: 1. Sinus origin 2. Ectopic rhythms 3. Conduction blocks 4. Preexcitation syndromes ECG Interpretation Arrhythmias 1. Sinus Origin Sinus bradycardia (< 60 bts/min) Sinus tachycardia (>100 bts/min at rest) Sinus Arrhythmia: Could be normal rate but rate changes (does not remain regular) o Sinus Arrest o Escape beats ECG Interpretation Arrhythmias 2. Ectopic Rhythms – originate outside of the SA node • Supraventricular - Atrial focus = 60-80 • • When SA node does not fire Increased irritability of atrial tissue AV node – does no pacemaking – holds signal Junctional focus = 40-60 • • • • • Idiojunctinal – Bundle of His No signal from SA or atria Retrograde depolarization (P wave?) ECG Interpretation Arrhythmias 2. Ectopic Rhythms – originate outside of the SA node • Ventricular Focus = 20-40 • • • • Idioventricular No signal from SA, atria, or junction Larg, wide QRS wave P wave? - none ECG Interpretation Arrhythmias 2. Ectopic Rhythms – originate outside of the SA node • Rapid ectopic rhythms - tachyarrythmias • Paroxysmal Supraventricular Tachycardia (sudden) • Paroxysmal Atrial Tachycardia (PAT) Paroxysmal Junctional Tachycardia (PJT) Paroxysmal Ventricular Tachycardia (PVT) • Looks like rapid PVCs? It is ECG Interpretation Arrhythmias 2. Ectopic Rhythms – originate outside of the SA node • Atrial Flutter – sawtooth pattern • Atrial Fibrillation – sine wave pattern • MultiFocal Atrial Tachycardia – (rate?) Note: if a normal rate, then called a wandering pacemaker. Wandering Pacemaker ECG Interpretation Arrhythmias • • Non-sustained abnormal beats Premature • • Early – ectopic Focus discharging spontaneously Premature atrial contraction (PAC) o o o o Can occur on T wave May be nonconducted P wave may be missing Check P-P interval & R-R interval for early wave ECG Interpretation Arrhythmias • • Non-sustained abnormal beats Premature Premature junctional contraction (PJC) o o o Retrograde P waves P waves during or after QRS P wave may be missing Junctional Rhythm ECG Interpretation Arrhythmias Premature Ventricular Contraction (PVC) Early-before atria (P) can begin a new cycle Enormous QRS – deflections are tall, deep, wide Compensatory pause – refractory period Unifocal or multifocal Coupled with normal beats Bigeminy - every 2nd beat Trigeminy – every 3rd beat Quadrigeminy – every 4th beat ECG Interpretation Arrhythmias Premature Ventricular Contraction (PVC) Sign of parasystole – 2 pacemakers – sinus & vent. Runs of PVCs- sign of impending danger 6 PVC’s in one minute – warning of possible V tach. 3 or more in a row are technically considered V tach. ECG Interpretation Arrhythmias Premature Ventricular Contraction (PVC) PVC on T PVC falling on T is much too early Vulnerable period Called R on T phenomenon Can lead to V tach Ventricular Tachycardia Ventricular Fibrillation R on T phenomenon Practice Rhythms Practice Rhythm V tach Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ Practice Rhythm V tach Rate: 300 Rhythm: reg./rapid P-R interval: n/a QRS: wide P wave: none Rhythm interpretation: Vetricular Tachycardia Practice Rhythms Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ Practice Rhythms Rate: 75 Rhythm: regular P-R interval: .16 QRS: .08 Rhythm interpretation: normal sinus rhythm P wave: present norm. Practice Rhythms Sinus Bradycardia Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ Practice Rhythms Sinus Bradycardia Rate: 43 Rhythm: reg./slow P-R interval: .20 QRS: .08 Rhythm interpretation: sinus bradycardia P wave: pres. reg. Practice Rhythms Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ Practice Rhythms Rate: 125 Rhythm: reg./rapid P-R interval: .16 QRS: .08 Rhythm interpretation: sinus tachycardia P wave: pres. Atrial Flutter Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ V tach Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ V tach Rate: 300 Rhythm: reg./rapid P-R interval: n/a QRS: wide Rhythm interpretation: v - tach P wave: n/a Practice Rhythms A fib answer Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: _____________________ Practice Rhythms A fib answer Rate: A – 350+ Rhythm: irreg./rapid P wave: irreg. P-R interval: n/a QRS: none Rhythm interpretation: atrial fibrillation Atrial flutter Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ Atrial Flutter Rate: a-350/v-125 Rhythm: irreg./rapid P wave: rapid P-R interval: n/a QRS: .08 Rhythm interpretation: atrial flutter Junctional Escape Beat-Rhythm Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ Junctional Escape Beat-Rhythm Rate: a-0/v- 35-60 Rhythm: irreg./slow P wave: none P-R interval: n/a QRS: .08 Rhythm interpretation: junctional escape rhythm PVC Rate: __________ Rhythm: _____ P-R interval: ____ QRS: ________ P wave: _______ Rhythm interpretation: ____________________________ PVC Rate: 73 Rhythm: irreg. P-R interval: .12 QRS: 1 wide (.16) P wave: 1 missing Rhythm interpretation: PVC (premature ventricular contraction) Sinus Arrest ~ 3.5 sec between beats Triplet – run of pvc Triplet – run of pvc Trigeminy Trigeminy Quadrigeminy Quadrigeminy ECG Interpretation Arrhythmias 3. Conduction Blocks – electrical blocks which slow or prevent passage of electrical stimuli (depolarization) • Sinus Block – “sick sinus” • • • • Unhealthy SA node may skip or fail for at least one cycle No P or QRST – “lost beat” Resumes pacing as if nothing happened Same P waves before and after ECG Interpretation Arrhythmias Conduction Blocks 3. • Atrioventricular Blocks (AV Blocks) First Degree AV Block Prolonged P-R interval (> .20 sec) every cycle Consistent P-R - prolonged by same amount First Degree Block ECG Interpretation Arrhythmias Conduction Blocks 3. • Atrioventricular Blocks (AV Blocks) Second Degree AV Block – 2 types o Mobitz Type I (Wenckebach) o P-R interval progressively increases until a P is not followed by a QRS. o Last P stands alone o Always a P but eventually no QRS Second Degree – Mobitz I- Wenckebach ECG Interpretation Arrhythmias Conduction Blocks 3. • Atrioventricular Blocks (AV Blocks) Second Degree AV Block o Mobitz Type II o QRS is “dropped” - not conducted even though P wave is present and normal o All is normal before and after event o No lengthening P-R (no warning) o Sign of more serious conduction problems Second Degree Mobitz II - ECG Interpretation Arrhythmias Conduction Blocks 3. • Atrioventricular Blocks (AV Blocks) Third Degree AV Block Total lack of conduction through the AV node Rate and the interval between the QRS depend upon the origin of the escape mechanism. May progress to ventricular standstill Independent P waves and QRS's with no relationship between the two (AV dissociation – separate atrial & ventricular rates) Third Degree Block AV Block ECG Interpretation Arrhythmias 4. Preexcitation Syndromes Key Feature: Short PR interval Wolf-Parkinson-White (also note wide QRS with delta wave in some leads) Lown-Ganong-Levine (normal QRS; no delta wave) ECG Interpretation 12-Lead ECG Analysis: 1. 2. 3. 4. 5. 6. 7. 8. Determine regularity of rhythm. Determine rate. Examine P waves Measure PR interval QRS complex width Determine Axis Examine ST Segment (normal is < 1mm elevation or depression) Check T waves (upright except for aVR, V1, and possibly III) ECG Interpretation 12-Lead ECG Common Abnormalities: Axis Deviation 1. • Normal axis between 0° and 90° Bundle Branch Blocks 2. • Right Bundle Branch Block • Wide QRS RSR’ in V1 and V2; T wave inversion and ST depression Deep S wave in V5/V6 Left Bundle Branch Block Wide QRS Broad R waves in V5/V6; T wave inversion and ST depression Deep S waves in V1/V2 ECG Interpretation 12-Lead ECG Hemiblocks 3. • • Anterior: left axis deviation Posterior: right axis deviation Bifascicular block: right bundle branch block + hemiblock 5. Ventricular Hypertrophy • Right: R S in V1 • Left: R in V1 + S in V5 35 mm • T wave inversion and ST depression in both. 4. ECG Interpretation 12-Lead ECG Ischemia • ST depression; inverted symmetrical T waves 7. Infarct • Acute (also referred to as injury) ST elevation • Old Abnormal Q waves (.04 sec wide; 1/3 height of R wave) 6. Diagnostic Value of ECGs (Chapter 6, pages 124-129 in text) Sensitivity: percentage of people with CAD who have a positive ECG test. 70% for ECG stress test TP/(TP + FN) Specificity: percentage of people without CAD who have a negative ECG test. 77% for ECG stress test TN/(TN + FP) Questions? End Electrocardiography