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Back to Basics 2017 Environmental and Occupational Health Dr. Jennifer LeMessurier MD MPH PGY4 Public Health and Preventive Medicine University of Ottawa Acknowledgements • This lecture material is based on previous presentations by Drs. M. Afanasyeva, M. Maher, B. Pinard, G. Dunkley, R. Spasoff, and N. Birkett, with material from Dr. A Thompson Outline • • • • Relevant MCC Objectives Environmental Health Occupational Medicine Practice Questions Part I: Environmental Health MCC Objectives: Population Health Environment 78-6 Rationale: • Environmental issues are important in medical practice because exposures may be causally linked to a patient's clinical presentation and the health of the exposed population. A physician is expected to work with regulatory agencies and allied health professionals (e.g., occupational hygienists), where appropriate, to help implement the necessary interventions to prevent future illness. Physician involvement is important in the promotion of global environmental health. MCC Objectives: Population Health Environment 78-6 Key Objectives: • Recognize the implications of environmental hazards at both the individual and population level. • Respond to the patients concerns through appropriate information gathering and treatment. • Work collaboratively with local, provincial and national agencies/governments as appropriate to address the concerns at a population level. • Communicate with patients, communities, and employers, where appropriate, concerning environmental risk assessment. MCC Objectives: Population Health Environment 78-6 Enabling objectives: • Identify common environmental hazards and be able to classify them into the appropriate category of chemical, biological, physical and radiation. • Identify the common hazards that are found in air, water, soil and foods. • Conduct a focused clinical assessment of exposed persons in order to determine the causal linkage between exposure and the clinical condition. • Describe the steps in an environmental risk assessment and be able to critically review a simple risk assessment for a community. • Be aware of local, regional, provincial and national regulatory agencies that can assist in the investigation of environmental concerns. • Describe simple interventions that will be effective in reducing environmental exposures and risk of disease (e.g. sunscreen for sunburns, insect repellent for prevention of West Nile Virus infection). • Communicate simple environmental risk assessment information to both patients and the community. Environmental Hazards How are we exposed to environmental hazards? • Natural and human-made environment • Types of hazards: – Chemical, biological, physical • Reservoirs: – Air, water, soil, food • Routes of exposure: – Inhalation, ingestion, absorption • Exposure setting: – Workplace: occupational health (high level exposure, acute or chronic) – Outside workplace: environmental health (low level exposure, chronic) 8 Classification of common hazards Type of hazard Examples Biological Bacteria, parasites, viruses Health effects Specific syndromes associated with different agents e.g., salmonellosis from contaminated food Moulds Allergies Animals Allergies Zoonoses e.g., rabies Chemical Heavy metals Specific syndromes e.g., lead poisoning, mercury poisoning Benzene Cancers e.g., acute myeloid leukemia Carbon monoxide Asphyxiation Asbestos Asbestosis, mesothelioma Physical Noise Hearing loss (factors that can harm the body without necessarily touching it) Radiation DNA damage leading to cancer Ultraviolet light Skin damage, vision loss Temperature extremes Hypo- or hyperthermia, heat stroke Adapted from: http://phprimer.afmc.ca The most important risk factor for heat-related illness is: a. b. c. d. e. Age over 65 Age under 1 History of prior heat stroke Low socioeconomic status Obesity A 34-year-old woman is brought in from a sporting event complaining of headache, nausea, and weakness. She had been jogging outside in sunny weather where the temperature was 35°C with a relative humidity of 70%. She had started a training program two weeks before. She is hyperventilating, her skin is moist, and her core body temperature is 38.8° Celsius. She most likely suffers from: a. b. c. d. e. Sunstroke Heat cramps Heat exhaustion Heat stroke Heat syncope Common hazards in the environment Hazards in: Examples Air Carbon monoxide Smog Particulate matter Water E. coli Cryptosporidia Blue-green algae Soil Heavy metals Petroleum by-products Food Listeria Salmonella Mercury Adapted from: http://phprimer.afmc.ca A 28-year-old woman presents with nausea, vomiting, and diarrhea. She has no fever. Her history reveals that she attended a reception about six hours ago. She ate roast beef with gravy, salad, and had cream-filled pastries for dessert. 1. Identify the organism responsible for her symptoms: 2. Prevention of this food-borne illness could have been achieved by: a. Freezing the food b. Heating the food to 140° Fahrenheit c. Proper hand washing by food handlers d. Proper cleaning of contaminated surfaces e. Control of flies Taking an Environmental History • Clues that illness is caused by environmental factors: – Patient suspects it – Illness pattern is atypical (absent usual risk factors, unusual age group or course, no response to treatment) – Temporal pattern of illness (weekends/weekdays, holidays/home) – No obvious other cause – Signs/symptoms suggest specific agent 14 Adapted from: http://phprimer.afmc.ca Components of an Environmental History (CH20PD2) • Community: neighborhood sources of hazard; industry, waste storage • Home: year of construction, renovations; materials used in construction and decoration; moulds; garden and house plants; use of cleaning products, pesticides, herbicides • Hobbies and leisure: exposure to chemicals, dusts, or microorganisms • Occupation: current and previous occupations; longest occupation; work with known hazards; air quality; use of PPE • Personal habits: hygiene products; smoking; recreational drugs • Diet: sources of food and water; cooking methods; food fads • Drugs: prescription, non-prescription, and alternative (naturopathic, Ayuverdic); health practices Adapted from: http://phprimer.afmc.ca Focused Environmental History • If a scanning question reveals a possible hazard, ask detailed questions about the nature and level of the hazard and then check: • Time: When did symptoms begin? When did exposure begin? When do symptoms get worse? When do they improve? • Place: Where is the patient when symptoms get worse? Where is the likely hazard? What is the channel through which the hazard reaches the patient? • Person: Does anyone else have similar symptoms? Who? When? Where? Adapted from: http://phprimer.afmc.ca What is an Environmental Risk Assessment? • Process of evaluating the likelihood of occurrence and probable severity of health effects due to a hazard • Conducted by: occupational health agencies, environmental protection agencies, public health authorities, specialist clinicians How do we assess a health risk? Hazard Risk is determined by the characteristics of the hazard, whether or not an exposure has occurred, and the degree of susceptibility Risk Exposure Susceptibility Steps in Risk Assessment Hazard identification: Identifies the agent responsible for the problem, its adverse effects, the target population, and the conditions of exposure* Hazard (risk) characterization: Describes the potential health effects of a hazard and answers the clinician’s question about whether the identified hazard could possibly cause the patient’s symptoms. • Dose-response • Toxicology Exposure assessment: Quantifies the exposure of a person or population to a hazard through direct measurements or through estimation* Magnitude, frequency, duration, route, etc. Risk estimation: Quantifies the likelihood that a hazard will affect a specific person or population as well as the size or severity of the effect. • Individual level: How much has the hazard contributed to the patient’s condition? • Population level: How much extra risk of the condition in the population is attributable to the exposure? *The environmental history informs these steps Adapted from: http://phprimer.afmc.ca Hazard Identification Workplace Hazardous Material Information System (WHMIS) Canada's national hazard communication standard; the key elements of the system are: • Hazard classification • Labelling of containers • Provision of (material) safety data sheets [(M)SDS] – – – – – Identification: for the product and supplier Hazards: physical (fire and reactivity) and health Prevention: steps to reduce or prevent exposure, or in an emergency Response: appropriate responses in various situations (e.g., first-aid) http://www.ccohs.ca/oshanswers/chemicals/whmis_ghs/sds.html • Provision of worker education and training programs WHMIS 2015 Pictograms Not adopted in WHMIS 2015 21 Hazard Identification International Agency for Research on Cancer (IARC) • Group 1 Carcinogenic to humans (117 agents) – Arsenic, asbestos, benzene, diesel engine exhaust, radon, processed meat, tobacco smoke • Group 2A Probably carcinogenic to humans (74 agents) – Red meat, cisplatin, shift work • Group 2B Possibly carcinogenic to humans (287 agents) – Coffee, welding fumes • Group 3 Not classifiable (503 agents) – Magnetic fields, fluorescent lighting • Group 4 Probably not carcinogenic to humans (1 agent) – Caprolactam Risk management • Interventions to manage the risk of common environmental hazards: – Carbon monoxide: CO home detector – Salmonella: well-cooked poultry and eggs, safe food handling – Listeria: avoidance of unpasteurized cheese for pregnant women – West Nile Virus: clothing, insect repellent (DEET) – UV light: sunscreen, sunglasses, shade, hat, long sleeves – Radon: ventilation, air exchanger, radon test kits Risk Communication • How we facilitate understanding of a particular risk, and inform how to take action to reduce that risk UV Index Image from: http://www.who.int/uv/intersunprogramme/activities/uv_index/en/index1.html Image from: https://www.on.lung.ca/document.doc?id=1722 Penetration of particulate matter The Lancet 2014 383, 1581-1592 Risk Perception Risk = Hazard + Outrage • Factors increasing perception of danger: – Characteristics of exposure: • Involuntary; not under personal control • Unnatural; unfamiliar • No trust in institution involved; media attention – Characteristics of outcome: • Catastrophic (not chronic); immediate; irreversible • Unknown, uncertain outcome, dreaded outcome • Affect children or identifiable people Environmental Health Jurisdiction – Local (or Regional) Public Health • Enforcement of water and food safety regulations, sanitation, local hazard assessment, reportable diseases – Municipal • Garbage disposal, recycling, water distribution – Province/territory • Toxic waste disposal, air/water standards • Ontario Ministry of the Environment (monitors air quality across ON) – Federal • Health Canada - food regulations, designation and regulation of toxic substances • CFIA (Canadian Food Inspection Agency) – enforcement of regulations • Environment Canada - The Asbestos Mines and Mills Release Regulations – International • Multilateral agreement (Kyoto Protocol) • Whom to Consult? • Local public health - Ottawa Public Health (613) 580-6744 – environmental exposures • Ontario Ministry of Labour – occupational hazards • Poison Control Centre – specific toxicants • Motherisk – effects on fetus Part II: Occupational Medicine MCC Objectives: Population Health Work-related health issues 78-8 Rationale • Workplace health and safety hazards can contribute to many different health problems. Physicians play an important role in the prevention and management of occupational injury, illness and disability. Causal Conditions (list not exhaustive) • Ergonomic hazards (e.g. awkward postures and movements, poor lighting) • Chemical hazards (e.g. organic solvents, metals, asbestos, toxic gases) • Physical hazards (e.g. noise, vibration, radiation) • Biological hazards (e.g. blood or other body fluids, animal and bird droppings) • Psychological and work organization hazards (e.g. workplace stressors, workplace bullying) Key Objectives Given a patient with a health problem, the candidate will evaluate the possible workplace etiological factors, to assess the contribution of occupational exposures for the most common pathologies, to assess the impact of the condition on the ability to work, and develop an appropriate management plan. Particular attention should be paid to the identification of occupational risks for the patient and his/her co-workers. MCC Objectives: Population Health Work-related health issues 78-8 Enabling Objectives Given a worker with a health problem, the candidate will 1. list and interpret critical clinical findings, including: a. perform a history and focused physical examination to identify the illness and determine the possible relationship of symptoms to work; b. identify hazards in the workplace that could have had an impact on the health problem (work and exposure history); c. identify protective equipment being used and environmental controls that are in place; d. identify non occupational factors that could influence the condition. 2. list and interpret critical investigations, including: a. appropriate laboratory or radiologic investigations depending on the presenting health problem (e.g. chest radiography, ultrasound); b. physiologic and/or functional assessments (e.g. PFTs , audiograms, occupational therapy assessment). 3. construct an effective initial management plan, including: a. initiate specific therapy as required for the health problem; b. determine whether the patient should be assigned to a different work, or stop work and advise the patient on this topic; c. determine follow up care and whether further consultation, counselling and/or a multi-disciplinary approach to care is needed; d. advise the patient on workers compensation; e. advise the relevant authorities if necessary (notifiable disease, reporting a dangerous situation). Occupational Medicine (OM) in MCCQE Part 1 • As a primary question • Integrated into options for other questions • Think about classic occupational skin and lung issues • Also think about other domains in which OM can play a role, such as psychiatry, and also specific conditions which have occupational causality such as abnormal liver enzymes/function tests, fatigue, hypertension etc. Types of clinical scenarios that may involve occupational exposure • • • • • • • • • • • • • • • Cough Hand and wrist injuries; overuse tendinopathies (DeQuervain’s tenosynovitis) Numbness / tingling / altered sensation Fatigue (shiftwork; CO exposure) Allergic reactions and atopy (occupational asthma) Altered hemoglobin levels (anemia in lead poisoning) Syncope and pre-syncopy (heat) Dysmenorrhea Proteinuria Sleep disorders Bone or joint injury Back pain Neck pain Poisoning Prenatal care Some examples of occupational diseases Common, non-specific work-related diseases include dermatitis, asthma, and musculoskeletal disorders. Condition Agent Example of at risk occupation Berylliosis Beryllium Aerospace industry Byssinosis Cotton dust (numerous agents) Cotton industry Farmer’s lung Mould in hay Farming Asbestosis, Mesothelioma Asbestos Demolition work; shipbuilding Hepatitis A Hepatitis A virus Sewer workers Silicosis Silica dust Stone workers Adapted from: http://phprimer.afmc.ca Occupational Health as a Public Health Concern • Work-related injuries include injuries, illnesses, diseases or disabilities resulting from work-related accidents or exposure to a noxious substance. • Most of the world’s population spend 1/3 of their adult life at work • In Canada: – 920 workplace deaths in 2001; 919 in 2014 – 1 of 68 employed workers in 2010 was injured/harmed on the job and received workers compensation as a result This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Occupational Health Outcomes • The most significant chemical exposures tend to be solvents and heavy metals: – Most solvents cause CNS depression, irritation and dermatitis – Some solvents causes PNS, hepatic and/or renal toxicity – Heavy metals primarily cause CNS, PNS, haem, and renal toxicity This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Occupational Health Outcomes • Many chemical and biological exposures can cause allergy resulting in: • Asthma (occupational or work-exacerbated) – 18% of asthma is work related – If true allergy – sensitizer-induced asthma (vs. irritantinduced asthma) – Skin prick testing (immediate hypersensitivity type I) • Allergic contact dermatitis (vs irritant contact dermatitis) – Patch testing (delayed hypersensitivity type IV) This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Occupational Health Outcomes • Approximately 10% of all cancers are occupational – Common occupational cancers are lung, bladder, and mesothelioma – Common occupational carcinogens are asbestos, polyaromatic hydrocarbons (PAHs), and aromatic amines This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Some classic occupational exposures Asbestos • Pulmonary fibrosis (asbestosis) – exertional dyspnea and bibasilar endinspiratory rales • Localized and diffuse pleural thickening, rounded atelectasis, mesothelioma, and lung cancer; may be associated with cancer at extra-thoracic sites • Most important route of exposure is inhalation • Miners, shipbuilding facility workers, demolition worker • Asbestos in the air adheres to work clothing, even if the clothes are brushed • Cleaning of clothes at home liberates asbestos fibers and has been shown to cause cancer in family members (para-occupational disease) Which of the following diseases is found almost exclusively among persons who have worked with or have been exposed to asbestos? a. Bronchogenic carcinoma b. Byssinosis c. Pleural mesothelioma d. Laryngeal carcinoma e. Emphysema Noise-induced hearing loss • High-frequency sensorineural loss • Usually is similar in both ears • Hearing is relatively normal between 250 -1,000 Hz (the loss at the low frequencies rarely exceeds 40 dB) • “Noise notch” between 3000-6000 Hz, typically centered at 4,000 Hz (which rarely exceeds 75 dB) • Recovery at the higher frequencies of 6,000-8,000 Hz • Word recognition is fairly good ( > 75%) Work-related health issues: Prevention • Primary prevention – Preventing the onset of disease by altering behaviours or exposures that can lead to disease, or by protecting against the effect of exposure to a disease agent – Achieved using hierarchy of controls • Elimination • Substitution • Engineering • Administrative • Personal Protective Equipment (PPE) This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Conceptualizing the control of occupational risks Source Path Receiver Potential approaches to risk control Eliminate Modify Redesign Substitute Relocate Enclose Engineering controls: Absorb, block, dilute, ventilate Administrative controls: Regulate exposure duration Enclose Protect Relocate PPE Work-related health issues: Prevention • Secondary prevention – Preventing the establishment or progression of a disease – Examples • Screening to detect disease at an early stage when intervention may be more cost-effective • Medical surveillance This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Work-related health issues: Prevention • Tertiary prevention – Preventing the return of a disease that has been treated in its acute phase. It seeks to limit or delay the impact caused by the disease on the patient’s function, longevity, and quality of life. – Examples • Disability management • Return to work This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Work-related health issues: Prevention • 1o prevention – Minimize Exposure, prevent Outcome – Approach using hierarchy of controls • 2o prevention – Early detection of Outcome – Screening, surveillance • 3o prevention – Mitigate effects of Outcome – RTW +/- accomodation once effectively treated and controls have been put into place to prevent recurrence This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Applying the principles of prevention: Worker exposed to lead at a battery recycling plant • 1o prevention – Substitute tin for lead – Enclose process, increase ventilation – Optimize hygiene – no eating/drinking/smoking, separate clothes, shower post shift, housekeeping – Fit tested lead cartridge respirator • 2o prevention – Surveillance: annual Hx, physical, CBC, blood lead level (BLL) • 3o prevention – Chelation if indicated – RTW when BLL acceptable and control measures in place Lead: Applying the Environmental/Occupational History • Occupational: manufacturing or use of batteries, pigments, solder, ammunitions, paint, car radiators, cable and wires, some cosmetics, ceramic ware with lead glazes, tin cans • Significant exposures in primary and secondary lead smelting and refinement • Hobbies: distillation of "moonshine" alcohol; home repairs; shooting at gun ranges (bullets have lead, particularly home-made) • Lead-glazed tableware and cookware; ceramic dishes (pottery) • Ayurvedic medicines, herbal medications, recreational drugs Lead: Health Outcomes Blood levels are elevated if ≥ 10 μg/dL = 0.48 μmol/L Main burden in adults is due to • Neurological effects (both CNS and PNS) • Hypertension • Short-term (< 1 year) – – – – – – – – – Spontaneous abortion Reduced birth weight Postnatal developmental delay Nonspecific symptoms Neurocognitive deficits Encephalopathy Sperm abnormalities Anemia (basophilic stippling) Colic • Additional long-term (> 1 year) – – – – Hypertension Nephropathy Peripheral neuropathy Gout Lead: Management • Eliminate the exposure • Education • Chelation is considered if ≥ 50 μg/dL Occupational Health Conditions: Clinical Assessment and Management • Confirm diagnosis, then address work relatedness – Work description and occupational profile – Prior and current exposure to hazards – Review of relevant workplace (materials) safety data sheets [(M)SDSs)] – Depending on the condition, there are various objective means to determine work relatedness • Prescribing return to work (with restrictions if necessary) is part of the treatment plan • If unsure, refer! (Occupational Medicine Specialist) This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Medico-Legal Aspects • 90% of workers are under provincial jurisdiction • 10% of workers are under federal jurisdiction: 16 federallyregulated industries (e.g. banks, airports, highway transport) – under Canada Labour Code • Ontario: Occupational Health and Safety Act – Enforced by Ministry of Labour (inspectors) – Employers • must protect health and safety • report workplace illnesses and injuries • accommodate injured/ill workers • pay cost of injury, illness • Compensation is tied to province of work, not province of residence Workplace Safety and Insurance Act (Ontario) • Establishes WSIB to oversee work-site injuries/disease • Funded by employers only • Non-fault protection but no right to sue • MD must submit medical report to WSIB (if WSIB requests); no need for patient waiver Ergonomics examines ways to adapt the working environment to ensure a safe and productive workplace. Which of the following factors is the most important to improve the physical design of a sedentary job? a. Maintaining a static position b. Maintaining a standing position c. Eliminating the waist motion d. Installing a soft floor e. Maintaining a static holding position “Duties” of the treating physician • Treat worker and assist in RTW process • File Worker’s Compensation claims • Report to Ministry of Labour if designated substance has resulted in disability • CMA Policy 2000 • – Be knowledgeable of workplace – Draft clear recommendations – Make use of available occupational health resources Occupational Health Physician assumes lead in advising on RTW/accommodation This material is courtesy of Aaron Thompson, MD, MPH, FRCPC 59 This material is courtesy of Aaron Thompson, MD, MPH, FRCPC This material is courtesy of Aaron Thompson, MD, MPH, FRCPC Practice Questions Which one of the following is not a typical feature of asbestosis? a) increased risk of cancer b) pleural thickening and calcification c) interstitial fibrosis d) obstructive pattern on pulmonary function tests e) none of the above The following statements regarding noise are true EXCEPT: a) temporary threshold shift recovers following cessation of noise exposure b) permanent threshold shift is characterized by a progressive pattern of hearing loss c) most cases of permanent threshold shift are surgically treatable d) higher frequency noise is more damaging than low frequency noise e) none of the above Lead exposure typically results in: a) chronic dermatitis b) resting and intention tremor c) extensor muscle weakness d) arrhythmias e) cerebellar ataxia Which of the following statements concerning the Worker’s Compensation Act is true? a) the worker reserves the right to sue the employer for negligence b) funding is provided by the provincial government c) the worker is guaranteed payment from the first day of injury/illness if it is deemed to be workrelated d) the Worker’s Compensation Board is an independent, private agency e) none of the above Which of following statements regarding radiation is false? a) natural background radiation accounts for about half of a typical person’s exposure b) ionizing radiation causes intestinal villi to become denuded c) exposure to non-ionizing radiation may result in cataracts d) ionizing radiation results in an increased incidence of neoplasia such as lung and thyroid e) none of the above Which of the following statements concerning exposure to solvents in the workplace is true? a) each solvent compound has a specific antidote that can be used to treat exposure b) a prominent symptom of solvent exposure is memory loss c) some solvents can cause skin dryness and loss of subcutaneous adipose tissue d) solvents do not affect the bone marrow e) all of the above Which one of the following gases is NOT irritating to the respiratory tract? a) ozone b) sulfur dioxide c) hydrogen chloride d) carbon monoxide e) chlorine How much radiation is an "average Canadian adult woman" typically exposed to each year from the following sources: background dose; one screening mammography, and one abdominal CT scan? a) Background 0.1 Sv; mammography 0.5 Sv; CT 1.0 Sv. b) Background 1.0 Sv; mammography 0.5 Sv; CT 0.1 Sv. c) Background 1.0 mSv; mammography 50.0 mSv; CT 5.0 mSv. d) Background 2.0 mSv; mammography 3.0 mSv; CT 10.0 mSv. e) Background 1.0 mSv; mammography 0.1 mSv; CT 0.1 mSv. More MCQs • Here are some more questions you can use to test your knowledge: http://www.medicine.uottawa.ca/sim/data/Selftest_Qs_Environmental_e.htm • (The questions contain comments on the answers, to illustrate why a given response is not correct) Resources for practice • • • • • • • • • • • MSDS are available on the web: http://www.hc-sc.gc.ca/ewh-semt/occup-travail/whmis-simdut/indexeng.php List of diseases reportable to the medical officer of health (and the reporting form): http://app06.ottawa.ca/online_services/forms/health/support/professionals/communicable_disease/for m_en.pdf?redirec=no Ottawa Public Health is available 24/7 (613 580-6744) List of regulations by Environment Canada: http://ec.gc.ca/lcpe-cepa/eng/regulations/detailReg.cfm?intReg=56 Check your local AQI and refer your patients to this site: http://www.airqualityontario.com/reports/summary.php Occupational Medicine Specialists of Canada: http://www.omsoc.org Case studies in Environmental Medicine: http://www.atsdr.cdc.gov/csem/csem.html Lange CURRENT Occupational & Environmental Medicine: Fourth Edition Joseph LaDou McGraw Hill Professional, Oct 23, 2006 Call Poison Control Centre 24/7 for all questions regarding toxicants (you can always ask to speak to a physician – toxicologist) Call and refer patients to Motherisk for all questions regarding exposures during pregnancy Questions about chemical spills – call CANUTEC