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Penicillin Cures Gonorrhea and Syphilis! By:Marissa Allyn How Penicillin Works • Penicillin bind to the enzyme transpeptidease which links polypeptide chains in bacteria. • No tranpeptidease means very weak cell wall. • Since the cell has an osmotic imbalance it explodes and dies! • Excess polypeptide chains triggers the production of hydrolysis and autolysis which tell the bacteria to start digesting excess polypeptide chains. • Now that cell is really screwed! As well as the other ones around it! Well then How Does the Penicillin survive the Stomach Acid Lava!?!?! • Penicillin used to be injected into the body because the stomach acid would kill it before it had its chance in the spotlight of human digestive track! • Side chain modification can make penicillin resistant to the stomach acid in the stomach and other enzymes/body fluids so they can be ingested and put to work.
