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Download Mycobacterium tuberculosis
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Mycobacterium tuberculosis J. Seo F2013 Modified by DYH • Discovered by a German scientist Robert Koch on March 24, 1882 • Acid-fast Gram-positive rod-shaped bacteria •Actinobacteria; Actinobacteria •Genome comprised of 3959 genes with 4 million base pairs •250 genes are for metabolism of fatty acid •39 of them are involved in generating the waxy coat http://www.nathnac.org/ds/c_pages/documents/TB_risk_areas.gif •Causes Tuberculosis in humans, turtles, frogs, birds, fish, and cattle •Contagious bacterial infection that can spread through air •Can be in either active or latent form of tuberculosis http://phil.cdc.gov/PHIL_Images/20040615/d094324845a24eb3a7bf e0d1f8e4a637/5789_lores.jpg Mycobacterium tuberculosis J. Seo F2013 Modified by DYH • Major virulence factor is the high lipid content in the cell membrane with its waxy coat • Can live through weak disinfectant • Able to live under a dry state for several weeks •Waxy coat protects it from lysosomal enzymes when engulfed by a macrophage •Invades mainly through respiratory tract into the lung •Common symptoms are nightly sweats, coughing of blood, fever, fatigue, and loss of appetite. •Multi-drug resistant Mycobacterium tuberculosis needs to be treated with multiple drugs consistently. http://www.public.asu.edu/~shaydel/research_001tb_2.html
