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Madison, WI, USA • Title: Dual-Modality PET and Optical Imaging of CD105 Expression in Breast Cancer • Authors: Yin Zhang, Hao Hong, Yunan Yang, Jonathan Engle, Charles Theuer, Todd Barnhart, Weibo Cai • Institution: University of Wisconsin - Madison • Abstract #: 70 • Session: RPSC Young Investigator Award Symposium (June 10, 2012 from 4:15 PM to 5:45 PM) CD105/Endoglin Expression in Solid Tumors • CD105 is selectively expressed on proliferating endothelial cells at very high levels (up to 3×106 copies per cell) • TRC105 is a human/murine chimeric IgG1 monoclonal antibody that binds to both human and murine CD105 FACS Analysis of 64Cu-NOTA-TRC105-800CW Zhang Y, Hong H, et al., Mol Pharm, 2012. In Vivo PET and Optical Imaging PET 4T1 Breast Cancer Model Optical Zhang Y, Hong H, et al., Mol Pharm, 2012. Ex Vivo PET and Optical Imaging Optical PET T: Tumor L1: Liver Zhang Y, Hong H, et al., Mol Pharm, 2012.