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AnoXcell in AnoBase 2001 – 2010 Decade to Roll Back Malaria (WHO) 300 million acute cases - 1 million deaths / year Africa: 500k children / 20% die / 7% PND Vaccines (40% delay) /Insecticide treated net (ITNs) Figure 1 Overview of Ensembl Gene Build O O O O RepeatMasker GeneScan tRNAscan BLAST searches AnoBase Gene tool Known status Known symbol Predicted genes AnoXcel Met @ position 1 - 20 AnoXcel sections MW and pI calculated from individual values for each aa Frequency of each aa in proteome. BLAST vs NR BLAST vs GO BLAST vs SMART BLAST BLAST BLAST BLAST BLAST BLAST BLAST vs vs vs vs vs vs vs PFAM COG KOG Drosophila C. elegans Human Anopheles Clustering via blastp Blastp vs the database itself Join criteria as described per category Gaps are calculated before 2 proteins to be joined in the same cluster. Things to be done Full incorporation of ENSEMBL’s genes submitted by the community AnoEST Integration of the tool into Vectorbase