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Exploring Mendelian Genetics http://www.eslkidstuff.com/images/tallshort.gif http://sps.k12.ar.us/massengale/genetics%20tutorial.htm GENES are more complicated than Mendel thought ENVIRONMENT influences the ____________________________ ________________________. expression of genes “Nature vs Nurture” = ________________________ provide the plan Genes ________ ______ for development, but how plan unfolds also depends on ______________conditions. environmental _______ GENES are more complicated than Mendel thought Some traits have choices ____________ MORE than 2 allele __________ MULTIPLE ALLELE TRAIT = ____________________ EX: blood type B ___ O A ___ Allele choices ___ GENES are more complicated than MENDEL thought Some traits are determined by ____________________________ MORE THAN ONE GENE POLYGENIC TRAIT = __________________ EX: human height. intelligence, skin & eye color http://www.bcps.org/offices/lis/models/life/images/grow.JPG GENES are more complicated than MENDEL thought Traits determined by ____________ MORE than ONE gene have _____ _________ many “___________” in-between phenotypes There aren’t just SMART people and DUMB people…. there is a ________________ whole range of intelligences in-between http://www.newtonswindow.com/problem-solving.htm GENES are more complicated than MENDEL thought KINDS OF DOMINANCE ____________________ COMPLETE DOMINANCE INCOMPLETE DOMINANCE ____________________ CO-DOMINANCE ____________________ COMPLETE DOMINANCE Dominant allele _______ masks __________ the ___________ recessive one PATTERN ? Recessive allele ____________ ________ returns in a _____ratio in the 3:1 ____ F2 generation http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookTOC.html INCOMPLETE DOMINANCE DON’T SEE expected __________ _____ 3:1 ratio in F2 generation Heterozygous organisms with one _____________ dominant and one recessive allele show a _________ BLENDED in-between trait Image modified from: http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookTOC.html INCOMPLETE DOMINANCE • Tay Sachs Disease- Missing an enzyme important for brain development. TT=normal Tt=half the amount of enzyme produced, but sufficient for normal development. tt=no functional enzyme; expression of Tay Sachs disease. http://www.bio.miami.edu/dana/104/104F02_6.html CO-DOMINANCE BOTH traits are expressed at ___________ _______ SAME TIME (_____________________) in heterozygote NO BLENDING ROAN A ________HORSE has ______________ BOTH RED hair and __________ WHITE hair side by side CO-DOMINANCE Both traits are expressed together (NO BLENDING) in heterozygote Persons with an A allele AND a B allele have blood type AB REMEMBER Membrane proteins with _______ sugars attached that help cells recognize self = ______________ GLYCOPROTEINS http://www.mannanw.com/super-sugars.htm BLOOD TYPES have more than 2 allele choices MULTIPLE ALLELE TRAIT = _________________________ The pattern of sugars that is attached is determined by genes Allele choices are: A B O _____ ____ ____ BLOOD TYPES An A allele tells the cell to put “A” glycoproteins on its surface BLOOD TYPES A B allele tells the cell to put a different “B” glycoprotein on its surface BLOOD TYPES An O allele tells the cell NOT to put anything on the surface A and B are CO-DOMINANT A cell with BOTH an A and a B allele has BOTH “A” and “B” glycoproteins on its surface BLOOD TYPES & ALLELES GENOTYPE AA AO BB BO OO AB PHENOTYPE (BLOOD TYPE) A A B B O AB DONOR BLOOD A and AB see A as “like me” Body images modified from: http://www.new-fitness.com/images/body_shapes.jpg B and O see A as Different! IMMUNE SYSTEM ATTACKS! DONOR BLOOD B and AB see B as “like me” Body images modified from: http://www.new-fitness.com/images/body_shapes.jpg A and O see B as Different! IMMUNE SYSTEM ATTACKS! DONOR BLOOD O can donate to ____ EVERY BLOOD TYPE = _____________________ UNIVERSAL DONOR Nothing on surface to recognize as “NOT SELF” YOU DON’T HAVE ANYTHING I DON’T HAVE! Body images modified from: http://www.new-fitness.com/images/body_shapes.jpg DONOR BLOOD Only AB sees AB as “like me” Body images modified from: http://www.new-fitness.com/images/body_shapes.jpg A, B, and O see AB as Different! IMMUNE SYSTEM ATTACKS! AB can only GIVE to AB BUT . . . AB can RECEIVE FROM ______ EVERY BLOOD TYPE = ________________________ UNIVERSAL RECIPIENT Body image modified from: http://www.new-fitness.com/images/body_shapes.jpg BLOOD TYPE FREQUENCY IN USA A B AB O 40% 10% 4% 46% http://www.reachoutmichigan.org/funexperiments/agesubject/lessons/newton/BldTyping.html ABO SYSTEM is NOT THE ONLY ONE + Rh Rh OTHER BLOOD TYPES ____________________ IF: NO PROBLEMS Rh+ MOM is _____ & BABY is _____ Rh+ Image modified from: http://www.wsd1.org/lessonplans/images/Body.gif MOM is _____ Rh+ & BABY is ____ Rh- PROBLEM IF: Can be a ___________ Mom is _____ Rh- Baby is _____ Rh+ 1st baby OK but few baby cells entering mom’s bloodstream put mom’s immune system on alert for + cells. Next + baby, mom’s immune system can attack baby as it is growing Mom given shot after 1st birth prevents this Image modified from: http://www.wsd1.org/lessonplans/images/Body.gif Chromosomes that determine the sex of an organism = _________________ Sex chromosomes http://www.angelbabygifts.com/ All other chromosomes = _________________ autosomes Humans have two sex chromosomes X y and _____ 44 autosomes SEX DETERMINATION XX = female Xy = male Who decides? Mom can give X Dad can give X or y X X X XX XX y Xy Xy Dad determines sex of the baby. SO ____ If dad gives X with mom’s X = girl If dad give y with mom’s X = boy HEMOPHILIA CAUSE: Mutation in genes for Blood __________________ clotting proteins carried ______ on X chromosome Blood clotting proteins are missing so person with this disorder can’t stop bleeding when bleed to death from minor injured; can ________________ cuts or suffer internal bleeding from bruises or bumps. HEMOPHILIA Treatment: Need ____________ injections of normal clotting proteins to stop bleeding More commonin _____________ males because it is ______ TWO recessive X-linked, but females with ______ hemophilia alleles will also show the trait. 1 in 10,000 males has hemophilia COLORBLINDNESS CAUSE: Mutation in one of three genes for _______________ Color vision carried on X chromosome Persons with this disorder have trouble distinguishing colors. Red-green _________________ colorblindness is most common Seen in 1 in 10 males 1 in 100 females http://gizmodo.com/gadgets/peripherals/samsung-develops-lcd-for-colorblind-036306.php Males ONLY HAVE ONE X DEFECTIVE They either have the disorder NORMAL Or They are normal FEMALES HAVE TWO X CHROMOSOMES DEFECTIVE NORMAL DEFECTIVE Females have one normal gene that works. Femalesneed ________ 2 defective recessiv alleles to show the The X chromosome in males . . . flies WITHOUT a copilot! . . . there’s NO BACK UP X to help X-linked cross Xb Dad is not XB colorblind Mom is colorblind y Xb y Xb XB X b XB Xb Xb y What is the probability of having a colorblind boy? All boys will be colorblind What is the probability of having a colorblind girl?No girls will be colorblind Girls with this genotype: XB Xb don’t show the COLORBLIND trait They have a “backup” X. BUT. . . . They can pass the gene onto their offspring. A heterozygous person who carries a recessive allele for a genetic doesn’t disorder, but ________ show the trait themselves is called a _____________ CARRIER http://www.biochem.arizona.edu/classes/bioc460/spring/rlm/RLM36.1.html