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Cell reproduction Cell Division and Mitosis Cell cycle Mitosis and cell divisions Asexual reproduction Sexual Reproduction and Meiosis Sexual reproduction Meiosis and Sex Cells DNA What is DNA Genes Mutations Cell Division and Mitosis Why is cell division important In multi celled organisms an increase in the numbers of cells is how they grow In single celled organisms cell division is the only way cells reproduce Cell cycle Length of Cycle Vary in time depending on cell Can be a matter of seconds or days to divide Cycle of a cell is the time between the start of cell division and the beginning of cell division of the next generation Interphase cycle Eukaryote cells spend most of their life in period of growth and development during interphase During interphase the cell copies its genetic information and prepares for cell division Some cells spend all of their lifetime in interphase (muscles, nerve cells) and never divide At the end of interphase, all genetic information has been duplicated Mitosis and Cell Division Process in which the nucleus divides to form two identical nuclei is mitosis Steps of Mitosis Chromosomes are structures in nucleus that contains hereditary material (these are duplicated in interphase) Chromosomes become thickened after duplication and are called chromatids Prophase Nuclear membrane begin to disintegrated Centrioles move to opposite ends of cell Attached to centrioles are threadlike spindle fibers stretched across cells Plant cells do not have centrioles but do have spindle fibers Metaphase Pairs of chromatids line up in middle of cell Centromeres hold the identical chromosomes and are attached by spindle fibers when lined up in center Spindle fibers attached to centrioles to opposite end of cell Anaphase Chromatids separate at centromeres and move to opposite ends The separated chromatids become the identical chromosomes of new cells Telophase Nuclear membrane begins to form and two new cells begin to close In animal cells, the cell pinches off to form two new cells Plant cells form a cell plate that develops into cell wall that separates into two new cells This ends mitosis and the cell goes into interphase until it begins the cell cycle over again Mitosis steps http://www.cellsalive.com/mitosis.htm http://microscopy.fsu.edu/micro/gallery/mitosis/mito sis.html Results of Mitosis and Cell Division Three things to remember about mitosis 1. results in division of nucleus 2. produces two new nucleus identical to the original and to each other 3. original cell doesn’t exists after division Cells of organisms have a specific number of chromosomes in their nucleus (humans have 46 chromosomes) fruit fly has 8 Asexual Reproduction New organisms are produced from one individual New organisms are identical to parent organisms Cellular Asexual Reproduction Eukaryotic cells reproduce by mitosis and cell division Sweet potato produces runners with same hereditary as parent plant Bacteria (prokaryotic cell) doesn’t have nucleus so it reproduces by fission Cell copies its genetic material and then divides into two identical organism Asexual Reproduction Budding and Regeneration When an organisms grows from the side of an organisms and drops off as a new organism it is called budding (Figure 8) Hydra is an example of budding Uses mitosis and cell division as source of new individual Regeneration is process that uses mitosis and cell division to regrow body parts Starfish, planarian are example Regeneration rre Budding Sexual Reproduction section 2 The reproduction of a new organism due to union of two sex cells is sexual reproduction Egg and sperm cells are sex cells Sperm is formed from male reproductive organs Egg is produced from female reproductive organs When the egg and sperm unite it is called fertilization Cell that is produced from fertilization is called zygote After fertilization the zygote mitosis and cell division begins Diploid cells Human body contains two types of cells Body cells and sex cells Human cells are composed mostly of body cells (muscle, nerve, blood, bones, tissues and organ cells) Sex cells are only egg or sperm cells Body cells have pairs of similar chromosomes and are called diploid cells Human body cells have 46 chromosomes in 23 pairs of similar size, shape, and DNA Haploid cells Sex cells do not have pairs of chromosomes and are called Haploid cells Contain half the number of chromosomes Human haploid sex cells have 23 chromosomes When the sperm (23 chromosomes) unite with egg (23 chromosomes) it then re-establishes the correct number of chromosomes in new individual In order to cut the number of chromosomes in half Meiosis takes place to reduce the number of chromosomes Meiosis and Sex Cells Meiosis is the process that produces haploid cells with half the number of chromosomes Two divisions occurs during meiosis Meiosis I and Meiosis II Steps have similar names to mitosis and are numbered for the division Meiosis I First step begins with duplication of chromosomes (like mitosis) Prophase I : similar to mitosis Metaphase I: lines up in middle Anaphase I: doubled chromosomes move toward each end Telophase I: two cells form identical to original Meiosis I is similar to mitosis Figure 11 Meiosis II The two cells produced in Meiosis I begin Meiosis II Prophase II : chromitids (paired chromosomes) appear Metaphase II: chromatids line up in middle with spindle fibers attached to centroiles Anaphase II: spindle fibers pull the chromatid pairs apart toward the centroiles Telophase II : Four cells are produced, each with half the number of chromosomes Human sex cells contain 23 chromoso Figure 11 http://www.youtube.com/watch?v=D1_-mQS_FZ0 http://www.cellsalive.com/meiosis.htm Mistakes in Meiosis Sex cells are produced many times in reproductive organs Mistakes are more commonly made in plants Too many or too few chromosomes might be produced Often in animals the zygote will die New individual does not grow normally if it survives the incorrect number of chromosomes DNA Deoxyribonucleic Acid Carries the code that is stored in its hereditary material When cells divides, the DNA code is copied and passed on to new cells DNA Structure and Model Looks like a spiral staircase with handrails on each side Handrails are composed of sugar(deoxyribose ) and-phosphate molecules Rungs of the staircase composed of nitrogen bases Four nitrogen bases compose DNA Adenine(A), guanine(G), cytosine(C), thyamine (T) Paired in specific combinations A-T, C-G, T-A, G-C The interlocking ends of each bases only fits these combinations Copying DNA The two handrails and a nitrogen base separate and pick up nitrogen bases on each handrail and base Results in producing two strands of identical DNA http://www.stolaf.edu/people/giannini/flashanimat/ molgenetics/dna-rna2.swf http://www.stolaf.edu/people/giannini/flashanimat/ molgenetics/dna-rna2.swf Genes Characteristics that you have are based on the types of proteins that are produced (hair and eye color, skin color, height, weight etc) Proteins build cells or work as enzyme Instructions for making a specific protein are found in a gene Genes are a specific section of DNA on a chromosome Proteins are made up of amino acids and genes determine the order of amino acids in protein Making Proteins Genes are found in nucleus but protein is made on ribosomes in cytoplasm Codes are carried from nucleus to ribosomes by RNA (ribonucleic acid) RNA RNA is made in the nucleus on a DNA pattern that is different from DNA RNA is like the ladder cut in half with 1 handrail (ribose sugar ) and only 1 nitrogen base and instead of thymine, RNA has uracil (U) The pairs match up C-G, G-C, A-U, U-A Three kinds of RNA are Messenger RNA (mRNA) Transfer RNA (tRNA) Ribosomal RNA (rRNA) RNA Protein production begins when mRNA enters with the code, to the cytoplasm mRNA attach to the ribosomes which are made of rRNA Amino acids, in groups of 3, are brought to ribosomes by tRNA molecules, where they are matched in correct combination for protein production Controlling Genes Production of protein is based on directions of genes Genes turn on and off for the production of different type of cells Cells must control the genes by turning some genes off and others on If incorrect proteins are produced, the organism can’t function Mutations If DNA isn’t copied correctly, proteins made would not be correct and a mistake takes place called mutations Mutations are permanent changes in the DNA sequence of gene or chromosome X-rays, sunlight and some chemicals can cause mutations Mutations if occur in body cells, may or may not be life threatening Mutations in sex cells often are harmful, but if the mutation is beneficial to organism, and makes organism more advantageous in its environment, it may be able to pass that on to offspring