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Role of Bioinformatics
in the Genomic Era
Limsoon Wong
Kent Ridge Digital Labs
Singapore
Show & Tell
What are the Themes of
Bioinformatics?
Bioinformatics =
Data Mgmt + Knowledge Discovery
Data Mgmt =
Integration + Transformation + Cleansing
Knowledge Discovery =
Statistics + Algorithms + Databases
Show & Tell
What are the Benefits of
Bioinformatics?

To the patient:


To the pharma:


Save time, save cost, make more $
To the scientist:

Show & Tell
Better drug, better treatment
Better science
Transcription Start
Prediction
Show & Tell
Transcription Start
Prediction Results
Show & Tell
Medical Record Analysis
age
49
64
58
58
58

chol
266
211
283
284
224
ecg
Hyp
Norm
Hyp
Hyp
Abn
heart
171
144
162
160
173
Looking for patterns that are




Show & Tell
sex
M
M
F
M
M
valid
novel
useful
understandable
sick
N
N
N
Y
Y
Medical Record Analysis
Results
 DeEPs, the “emerging pattern’’ method
 Beats C4.5, CBA, LB, NB, TAN in 21 out
of 32 UCI benchmarks
 Works for gene expressions

ALL vs AML:
 DeEPS (1 gene) - 0/38 & 3/34
Slonim (50 genes) - 2/38 & 5/34
Colon:


Show & Tell

DeEPS (35 genes) - 4/62

Alon (1000 genes) - 6/62
Genome-Enabled Fruits

A lot of genes & proteins that are

candidate diagnosis indicators

candidate prognosis indicators

candidate drug targets
What’s Next?
Show & Tell
Evaluate & Choose the
Better Candidates

Easier to access

Uncomplicated to
modulate

Clear path to $

Has experience
To do that, you will need
to have ….
Show & Tell
A Molecular Connections
Database consisting of...
DISEASES
INTERACTIONS
PATENTS
EXPRESSION
MUTATIONS
RELATED
MOLECULES
STRUCTURE
Show & Tell
Thank You
Show & Tell