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Can a biologist fix a radio? what I learned studying apoptosis. (Lazebnik Y. 2004) or, Gold (field) Rush Stage 1: Pioneering Few scientists find interest in a problem Stage 2: Discovery! Funding + applications Gold rush Stage 3: Saturation Completion/destruction of models, theory/drugs fail, confusion It is is difficult to find a cat in a dark room, especially if there is not cat. ~ Chinese saying The anticipated gold deposits exist, finding them is not guareteed! ~ David Papermaster Solututions ...to getting caught in a competitive and complex field of investigation? Develop good tools and keep mind clear in adverse circumstances. ~ David Papermaster Stagnation is eventually interrupted by new development. ~ Joe Gall Is the biologists approach flawed? ~ Lazebnik Test the approach in a system that has a solution. ~ Mathematicians approach A problem with a solution Begining Funding Description Classifcation Component Systematic mailfunctions Phenotype Knock-out approach SRC Serendipitously Recovered Component MIC Most Important Component RIC Really Important Component U-MIC Undoubtly Most Important Component Is the accumulated information useful? Sometimes (pharmacy: give me a target!) Intervention vs Tuning Gene therapy Stress Atagonists Nutritions Breeding Hygiene Perspective Biologist Engineer Language Massive information + formal language = limited overview Massive information + standardized language = simple overview Increased productivity More meaningful research Thank you Breen MS, Lazebnik RS, Nour SG, Lewin JS, Wilson DL. Three-dimensional comparison of interventional MR radiofrequency ablation images with tissue response. Comput Aided Surg. 2004;9(5):185-91. PMID: 16192060 [PubMed - indexed for MEDLINE]