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BLOOD Blood is a connective tissue. It acts as a Carrier. That is, it provides one of the means of communication between the cells of different parts of the body and the external environment. So, as a carrier, it carries: Oxygen from the lungs to the tissues and carbon dioxide from the tissues to the lungs. Nutrients from the alimentary canal (digestive tract) to the tissues and cell wastes to the excretory organs like kidneys. Hormones secreted by endocrine glands to their target glands and tissues. Heat produced in active tissues to other less active tissues. Protective substances, e.g. antibodies, to areas of infection. Clotting factors that coagulate blood, minimizing its loss from ruptured blood vessels. Facts to Remember Blood makes up about 7% of body weight. There is nearly 5.6 liters of blood in men. Blood is always in motion (circulation). Blood volume and the concentration of its many constituents are kept within narrow limits by homeostatic mechanisms. Plasma The constituents of plasma are water (90 – 92%) and dissolved substances (8 – 10%). The dissolved substances are: Plasma Proteins: Albumins, globulins (including antibodies), fibrinogen, clotting factors. Inorganic slats (mineral salts): sodium chloride, sodium bicarbonate, potassium, magnesium, phosphate, iron, calcium, copper, iodine, cobalt. Nutrients: specially from digested food e.g. monosaccharides (mainly glucose), amino acids, fatty acids, glycerol and vitamins. Organic waste materials: e.g. urea, uric acid, creatinine. Hormones. Enzymes, e.g. certain clotting factors. Gases, e.g. oxygen, carbon dioxide, nitrogen. Cellular Component of Blood There are three types of cells in the blood: Red blood cells (RBCs) or Erythrocytes. White blood cells (WBCs) or Leukocytes. Platelets or Thrombocytes. Leukocytes (White Blood Cells) These cells have an important function in defending the body against microbes and other foreign materials. There are two main types of leukocytes: Granulocytes: these have granules in their cytoplasm. There are three types of cells in this category: Neutrophils, Eosinophils and Basophils. Agranulocytes: these do not have granules in their cytoplasm. There are two types of cells in this category: Monocytes and Lymphocytes. Granulocytes All granulocytes have multilobed nuclei in their cytoplasm. Their names represent the dyes (stains) they take up when stained in the laboratory. Eosinophil takes up red acid dye eosin. Basophils take up alkaline methylene blue and Nutrophils are purple because they take up both dyes. THANK YOU