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DIFFUSSE
NEUROENDOCRINE
SYST(DNES)
OR
APUD SYST
OR
CHROMAFFIN
CELLS
DIFFUSSE NEUROENDOCRINE
SYST(DNES)
Major site – Adrenal
Medulla
Other Sites In Body…
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Skin – melanoblast
Lungs -kulchitsky cells
Heart – myoendocrine
Urogenital tract
Hypothalamus Git
ENDOCRINE GLANDS
Gastric Mucosa
Skin layers - Melanoblast
DNES cells in lungs kluchisky cells
Other Sites In Body…
•
•
•
•
•
•
Skin – melanoblast
Lungs -kulchitsky cells
Heart – myoendocrine
Urogenital tract
Hypothalamus Git
APUD SYSTEM
• The name APUD is derived from
Amine - for high amine content.
Precursor Uptake - for high uptake of
(amine) precursors.
Decarboxylase - for high content of
the enzyme amino acid
decarboxylase (for conversion of
precursors to amines).
DNES
• Deviation in relative levels of
secretions of different cells in this
system may cause psychosomatic
diseases
• Awareness about APUD or
DNES system will lead to improved
method of treatment – Grays Anatomy