Download Competitive Inhibitors

Competitive Inhibitors
Adam Asterito
Mario Ciao
Ilian DeCorte
Brian Needles
What is it ?
• It is a protein that attaches to an enzyme
at the active site, where the substrates
would normally bind.
• This protein has a similar shape of the
substrate that binds to the enzyme, it will
cause the enzyme to stop working (inhibit).
• An inhibitor can be reversible if the
concentration of the substrate is increased
enough.
Disulfiram
• The drug inhibits
aldehyde oxidase
which causes the
buildup of
acetaldehyde that
causes side-effects
such as nausea and
vomiting.
– Helps people overcome
alcoholisms
• Occurs in the
Sarin Gas
• Sarin gas inhibits the
muscle cells, specifically
in your back inhibiting
you nervous system
from receiving oxygen.
The Sarin molecules fit
into the active site on an
enzyme and keeps the
oxygen molecules from
reaching the enzyme.
DDT Insecticide
• Insecticide that effects
ATPase activity
– ATPase makes ATP from
ADP
• DDT is a competitive
inhibitor that binds with the
active site on ATPase,
thus stopping the
synthesis of ATP in the
mitochondria in the body
THE
END